ライフサイエンスコーパス: disruption

1 ve for post-stroke blood brain barrier (BBB) disruption.

2 or within oral biofilms, resulting in their disruption.

3 eplication without interfering with vacuolar disruption.

4 asive behaviour leading to basement membrane disruption.

5 lls and near regions of endocardial fibrosis/disruption.

6 shifts and responses to local environmental disruptions.

7 phorylation of JPH2 led to transverse-tubule disruption, a precursor of HF development in SPEG-defici

8 RG4 disruption abrogates tRNA fragments ability to trigger t

9 /white matter injury and blood-brain barrier disruption after ICH can be assessed with multimodal MRI

10 Remarkably, Abf1 site disruption also abolished Rpd3L complex recruitment in r

11 lthough a clinical association between sleep disruption and AD has long been appreciated, emerging cl

12 ssion and processing contributing to barrier disruption and AD, and therefore we present novel therap

13 erhang length increases with time after CTC1 disruption and at early times net G-strand growth is app

14 ted pathways involved in endothelial barrier disruption and cytokine storm in experimental lung injur

15 inflammatory diseases with similar epidermal disruption and overlapping epithelial inflammation.

16 ting fish oil encapsulates from heat induced disruption and oxidative deterioration during spray dryi

17 Carbenoxolone also prevented gut wall disruption and significantly reduced morphine-induced co

18 Antagonizing IL-4 prevented mucosal barrier disruption and tight junction downregulation in a mouse

19 is caused by widespread endothelial barrier disruption and uncontrolled cytokine storm.

20 fruit have increased the adoption of mating disruption and use of biological insecticides.

21 CFT, DRIL, IR cyst area, EZ disruption, and HRF had a strong association with VA.

22 million Americans suffer from chronic sleep disruption, and the development of effective treatments

23 Conversely, sleep and circadian disruptions are implicated in a variety of adverse healt

24 Moreover, selective effects of UBE3A disruption at late stages of in vitro development sugges

25 Pdcd1 (PD-1) disruption augmented CAR T cell mediated killing of tumo

26 Blood-brain barrier disruption (BBB) and release of toxic blood molecules in

27 e hybrids do not function by fungal membrane disruption, but instead by disruption of the ergosterol

28 Loss of PIMMS2 function through gene disruption by homologous recombination leads to normal d

29 ce supports a relationship between circadian disruption (CD) and PD, whether this is secondary to the

30 This niche disruption could be recapitulated by overexpressing upd3

31 The supply disruption did not nudge a system toward an appreciable

32 However, behavioral disruptions disappeared when lights were extinguished, s

33 f actigraphy, followed by slow wave activity disruption during polysomnogram, and cerebrospinal fluid

34 ant mice were subjected to chronic circadian disruption from the time of uterine implantation through

35 r regulator of nearly all physiology and its disruption has major consequences on health.

36 aks in 2014-2015 compared to 2010-2013; such disruptions have been associated with outbreaks in other

37 The disruption in anatomical RC connectivity in SZ offspring

38 tigated when interpreting putative endocrine disruption in Arctic wildlife with potential population-

39 ng with contraction impairment and myofibril disruption in cardiomyocytes.

40 Acute genetic disruption in early development, during the integration

41 xposure period) contributing to reproductive disruption in fish.

42 trongly attenuated upon siRNA-mediated clock disruption in human primary myotubes.

43 ariants, showing a causative role for DONSON disruption in MMS.

44 led-coil dimers and thick filaments, causing disruption in ordered myofibrillogenesis and/or myofibri

45 ure at severe OA during gametogenesis caused disruption in oyster reproduction.

46 r data suggest that CRISPR/Cas9-mediated NRL disruption in rods may be a promising treatment option f

47 sulted in heightened initial exploration and disruption in subsequent habituation to a novel environm

48 -repressed levels of cellular IGF2R led to a disruption in the structure of the trans-Golgi network.

49 We suggest that the disruption in utilization of negative outcomes to adapti

50 these data indicate that sorafenib causes a disruption in viral egress by targeting VCP and the secr

51 ects on mitochondrial toxicity and endocrine disruption in vitro.

52 We tested synaptic disruption in vivo by analyzing motor defects and bindin

53 Our observations implicate disruption in ZnT2 function as a modifier of secretory c

54 Anxiety disorders are associated with disruptions in both emotional processing and decision ma

55 Disruptions in circadian timing impair spatial memory in

56 Disruptions in fear-extinction learning are centrally im

57 Indeed, disruptions in neuronal positioning lead to a variety of

58 rkinje cell abnormalities causing subsequent disruptions in postnatal cerebellar foliation and lamina

59 dicate that exploration is related to sudden disruptions in prefrontal sensorimotor control and rapid

60 findings show that CSDS produces persistent disruptions in sleep and circadian rhythmicity, mimickin

61 PPs and their biological substrates, and how disruptions in these relationships contributes to human

62 Disruptions in this barrier are associated with diseases

63 nt of PI3K, are not inhibited by microtubule disruption, indicating that IRS-2 requires the microtubu

64 Such a disruption induces a cascade of events which impacts gly

65 metabolism could be the primary biochemical disruption initiating neuropathogenesis in HD.

66 A new study finds that splicing disruption is a frequent consequence of mutations genera

67 As demonstrated here, targeted CRISPR disruption is a valuable tool for functional studies of

68 ibutes to the disease risk, circadian rhythm disruption is emerging as a new risk factor for CVD.

69 This disruption is independent of the initiation of apoptosis

70 tinction when the intensity of environmental disruption is intense.

71 creases glucose tolerance and that circadian disruption is linked to glucose tolerance in mice.

72 Overall, the phenotype resulting from dnaK disruption is more akin to that observed in Escherichia

73 n protein localization is linked to polarity disruption is not clear.

74 age- or disease-specific blood-brain barrier disruption is unclear, and this is an important future a

75 These results suggest that a step during G4 disruption limits the kcat value and that DHX36 binding

76 function (i.e., basal ES and tight junction disruption, making the barrier leaky), in the testis in

77 rging studies suggest that age-related sleep disruption may be one key factor that renders the aging

78 we generated a knock-in mouse model with NB disruption mediated by 2 point mutations (C62A/C65A) in

79 s have uncovered the contribution of barrier disruption, mediated in part by defective desmosomes and

80 We determined the effects of disruption Mir34a, Mir34b, and Mir34c in ApcMin/+ mice.

81 of alpha-synuclein, and subsequent synaptic disruption, occur in absence of dopaminergic neuron loss

82 Once gland disruption occurs, the quality and quantity of meibum is

83 The results suggest that disruption of 2-HG production with brain-penetrant inhib

84 iseases, it is conceivable that differential disruption of a common primordial neuropathological subs

85 In addition, disruption of a conserved structure proximal to A1 cause

86 consistent with the hypothesis of pathologic disruption of a striatopallidal-thalamo-cortical mesocir

87 ted by cigarette smoke extract via oxidative disruption of actin polymerization.

88 or formation and metastasis by promoting the disruption of adherens junctions, dedifferentiation, and

89 We generated a mouse model with conditional disruption of ANK3 in pyramidal neurons of the adult for

90 Here we demonstrate that targeted disruption of Ant2 in mouse liver enhances uncoupled res

91 ransporter did not affect S. aureus However, disruption of any two systems significantly reduced Pi a

92 Suboptimal recovery may be influenced by disruption of areas seemingly spared by the stroke due t

93 Consequently, disruption of ATP6AP2 is extremely poorly tolerated in t

94 lts suggest two potential mechanisms for the disruption of autolysis by TiO2 NPs in a concentration d

95 The disruption of autolysis in B. subtilis cultures by TiO2

96 impairment of lysosomal enzyme activity and disruption of autophagic processes.

97 chanisms by which these signals regulate the disruption of avascular privilege in photoreceptors are

98 re induces a signaling cascade that leads to disruption of axonal transport, a critical function for

99 Combinatorial disruption of B-cell receptor signalling and PI3K-AKT-mT

100 Quorum quenching (QQ) is the disruption of bacterial cell-to-cell communication (know

101 rgent genomic distributions with substantial disruption of bimodal, CpG density-dependent methylation

102 We show here that disruption of both CRTC2 and CRTC3 causes embryonic leth

103 Targeted disruption of both CRTC2 and CRTC3 in stromal cells with

104 Simultaneous functional disruption of both TpnC genes resulted in jump-defective

105 In conclusion, diabetes exacerbates the disruption of BSCB after SCI via inducing ER stress, and

106 In contrast, disruption of caveolae by MCD treatment or Cav-3 knockdo

107 Although disruption of cell polarity is a prerequisite in epithel

108 QcrB subunit of the cytochrome bc1 complex, disruption of cell-wall homeostasis, and DNA damage.

109 ity, and loss of Tim10 is accelerated by the disruption of conserved disulfide bonds within the subst

110 ommonalities have been proposed to stem from disruption of conserved regulatory mechanisms evolved du

111 Optogenetic disruption of cortical activity before and during tone p

112 Growing evidence points to a disruption of cortico-thalamo-cortical circuits in schiz

113 rdiomyocyte electrophysiology after targeted disruption of coupled myofibroblasts and by cessation of

114 We show that disruption of Cul9-p53 binding in mouse embryo fibroblas

115 Selective disruption of D1 or D2 modulation of separate PFC output

116 Here, we test the hypothesis that disruption of developmentally regulated RNA alternative

117 context-specific dysregulation, exacerbates disruption of dopaminergic neurons in vivo, resulting in

118 osis by the ECD predominantly comes from the disruption of DR5 oligomerization and not ligand sequest

119 otonergic neurons, also blocked KOR-mediated disruption of DRL performance.

120 mutation rates increased sevenfold upon the disruption of either BRCA1 or BRCA2, and the arising mut

121 Loss of dysbindin-1A was not associated with disruption of either long-term (olfactory) memory or spo

122 Disruption of either MHC class I or LILRB1 potentiated p

123 The current study determined whether disruption of endogenous glucocorticoid signaling in cho

124 Disruption of endothelial KLF2 results in dysregulation

125 ea of intraretinal (IR) cysts, and extent of disruption of external limiting membrane (ELM) and ellip

126 ylcarnitine profiles, consistent with severe disruption of fatty acid metabolism.

127 This caused a disruption of Fc-binding and phagocytosis.

128 We describe here that disruption of FH function on the cell surface can also l

129 or cells incubated with LGRFYAASG-pen showed disruption of filamentous actin, focal adhesions and cav

130 Specifically, the disruption of focal adhesion kinase (FAK) and paxillin i

131 How cells respond to pathogen-mediated disruption of gene expression to nevertheless initiate p

132 tand the phenotypic consequences of complete disruption of genes in humans.

133 h the natural microbiota is unperturbed, the disruption of glpG but not glpR significantly reduced Ex

134 In vitro, we found that the disruption of glpG had polar effects on the downstream g

135 nearly abolished following selective genetic disruption of glutamate release from SuM(vglut2) neurons

136 Formation and disruption of granules, as well as RNA selectivity in gr

137 Mice with hepatocyte-specific disruption of Hif1alpha developed less-severe liver inju

138 thracis to promote disease virulence through disruption of host signaling pathways.

139 support the idea that preventing early-life disruption of host-associated microbiota might confer pr

140 Rescue of A-1254-induced disruption of HUVEC-based tube formation by gamma-secret

141 The anthropogenic disruption of hydrological habitat connectivity by dams

142 -osteoblastic actions are mediated via local disruption of IGF1-signaling.

143 Moreover, disruption of IL-33 or IL-23 signaling attenuated cytoki

144 hange mass spectrometry, we show progressive disruption of individual orthosteric contacts in the lig

145 Disruption of integrin ligation with an RGD-containing p

146 ction via apical inoculation was overcome by disruption of intercellular junctions.

147 is an essential metal for all organisms, yet disruption of its homeostasis, particularly in labile fo

148 Disruption of JDP2 function therefore appears to cause e

149 Structural and functional disruption of JMCs underlies contractile dysfunction in

150 EMENT The present work demonstrates that TMS disruption of M1 activity impairs the consolidation of m

151 mmon in Parkinson's disease (PD) and include disruption of melatonin secretion, disturbances of gluco

152 ISC-specific disruption of Met (Lgr5(Creert2)/Met(fl/fl)/Apc(fl/fl) m

153 li, we uncover a mode of action for DTPs-the disruption of metal homeostasis.

154 trate that these processes are halted by the disruption of microtubules and inhibition of molecular m

155 Disruption of MIR1 binding sites in HBL1 showed an effec

156 ut not in the exposed groups, suggesting the disruption of miRNA activity due to chemical exposure.

157 erging genetic and pharmacologic (metformin) disruption of mitochondrial (mt) respiration increased a

158 d mitochondrial structure was accompanied by disruption of mitochondrial homeostasis, including decre

159 This indicates that disruption of MT dynamics interferes with neurite outgro

160 Selective disruption of Munc13 autoinhibition profoundly impacts n

161 a of T2D patients, which may result from the disruption of muscle BCAA management.

162 Perturbation of glucose metabolism or disruption of Myc function or sterol biosynthesis impair

163 Disruption of NAD synthesis caused a deficiency of NAD a

164 g predictor of the slower reaction times via disruption of neural synchrony in visual cortex.

165 Disruption of neuronal morphology contributes to the pat

166 Disruption of NMDARs causes dysfunction in predictive co

167 These data demonstrate that disruption of normal HA catabolism in Hyal2(-/-) mice ca

168 Collectively, disruption of normal Zap70 autoinhibition engaged negati

169 Furthermore, tumor-specific disruption of Notch signaling may overcome legitimate co

170 initially accumulates in nuclei, leading to disruption of nuclear envelope architecture, partial seq

171 One possible implication of this is that disruption of olivocerebellar signalling could play a ma

172 LTM can be induced by partial training after disruption of original consolidation by protein synthesi

173 We further showed that disruption of original cysteine pairs in the CSF3R extra

174 only by genetic but also by pharmacological disruption of oxidative phosphorylation (OXPHOS).

175 Oral adhesions can result from a disruption of periderm formation.

176 We previously showed that the disruption of PHOSPHATIDIC ACID PHOSPHOHYDROLASE (PAH) a

177 Disruption of pntA resulted in phenotypic growth defects

178 on: a defect in matrix degradation, due to a disruption of podosome rosettes caused by myosin-IIA ove

179 Finally, disruption of PP1c-Gbeta1 complexes with myristoylated G

180 Alternatively, disruption of procollagen I ER export could activate the

181 Disruption of proteostasis can lead to the accumulation

182 depends on the activities of P4-ATPases, and disruption of PS distribution can lead to various diseas

183 Conditional disruption of Pten in the mouse prostate leads to tumori

184 We generated mice with disruption of Pten specifically in ductal cells (Sox9Cre

185 lopment of liver cancer in mice with hepatic disruption of Pten.

186 increased phosphorylation of PTK6 Y342, and disruption of Ptk6 impairs tumorigenesis.

187 Disruption of reconsolidation, the process by which reac

188 Dhrs3, and Ccr9 The beta-carotene-inducible disruption of retinoid homeostasis affected gut-homing a

189 nd rhythmic peaks of anxiety in BD suggest a disruption of rhythmic expression of SST in this disorde

190 Disruption of Sall1-NuRD in vivo in knock-in mice (Delta

191 This work provides evidence that MRV disruption of SGs may be facilitated by association of t

192 We performed studies of mice with disruption of Sirt1 specifically in the intestinal epith

193 Thus, disruption of sMAC provides a foundation for rejuvenatin

194 rm observed in our gas-phase data set to the disruption of specific domains within the protein.

195 Conclusion A disruption of structural connections between brain areas

196 ear organization of laminopathies, featuring disruption of the actin cap.

197 Overall, our results show that disruption of the afferent taste signal to sodium salts

198 obese mice with cardiac and skeletal muscle disruption of the Autophagy related 7 gene (Atg7(h&mKO))

199 roinflammatory diseases are characterized by disruption of the BBB and increased leukocyte infiltrati

200 Disruption of the BBB may contribute to various CNS dise

201 antibiotics on antimicrobial resistance and disruption of the beneficial microbiome compels the urge

202 Disruption of the Beta-2 Microglobulin (B2M) gene elimin

203 Peri-implantitis represents a disruption of the biocompatible interface between the ti

204 mice demonstrated reduced survival, greater disruption of the blood-brain barrier (BBB), higher brai

205 re and release of contents that complete the disruption of the blood-brain barrier.

206 d cell death that results from MLKL-mediated disruption of the cell membrane.

207 A hallmark of AD is disruption of the critical barrier function of upper epi

208 ure of lead molecule 7 and hypothesized that disruption of the crystal packing would improve solubili

209 ring development and disease to propose that disruption of the cytoskeleton, nodal architecture, and

210 acquired glomerular pathologies converge on disruption of the cytoskeleton, suggesting that this sub

211 n be overcome by mechanical force as well as disruption of the cytoskeleton.

212 Disruption of the drebrin/EB3 pathway using BTP2, a smal

213 Genetic and pharmacological disruption of the EDN3 receptor EDNRB in vivo significan

214 th SND correlates with greater CT, more HRS, disruption of the ELM, and significant macular functiona

215 y fungal membrane disruption, but instead by disruption of the ergosterol biosynthetic pathway via in

216 f and exploit this information to prove that disruption of the FBXW7-DISC1 complex results in a stabi

217 Specific disruption of the gene expressions of TNFalpha downstrea

218 Further disruption of the gene for dDia2 restores cells' ability

219 Disruption of the interaction between C-terminal helices

220 m, and we will discuss how a dietary-induced disruption of the intestinal environment may influence t

221 Disruption of the Krebs cycle is a hallmark of cancer, a

222 stimulation and demonstrated that temporary disruption of the left angular gyrus leads to impairment

223 Furthermore, disruption of the LXXLL nuclear receptor-interacting mot

224 cultured mammalian cells to demonstrate that disruption of the methylation pathway mediated by folate

225 he effects of HSP90 inhibitors on cells with disruption of the MIR21 gene, cells incubated with MIR21

226 , we generated a mouse model with a targeted disruption of the murine ortholog ClC-K2.

227 Disruption of the N-cadherin-LLGL1 interaction during co

228 Disruption of the N-terminal NMB0419 signal peptide, pre

229 Disruption of the NES consensus sequence relocalizes mut

230 rotein localization that are consistent with disruption of the nuclear envelope.

231 , results in dramatic nuclear pathology with disruption of the nuclear organization, bringing about t

232 Disruption of the pathway resulted in an impairment of s

233 Fourth, disruption of the permeability barrier induced similar e

234 domain-like protein (MLKL), which results in disruption of the plasma membrane.

235 Significantly, disruption of the Pumilio-binding sequence in chemotaxis

236 Here, we report that disruption of the Rasa1 gene in adult mice resulted in l

237 um in diameter, (2) a zone of attenuation or disruption of the RPE of at least 250 mum in diameter, (

238 Disruption of the SHANK3-encoding gene has been strongly

239 ear single quantum coherence spectra reveals disruption of the tertiary contacts among the regions cl

240 Temporal, dose-dependent and specific disruption of the TJ-associated ZO-1 and cytoskeletal-F-

241 Disruption of these features resulted in attenuation of

242 Conversely, disruption of these interactions by ALLINIs or mutations

243 early closed states of the channel, and that disruption of these interactions results in both faster

244 Disruption of these membrane-bound interactions (or enco

245 We also discuss how disruption of these PTP regulatory mechanisms can cause

246 However, the clinical consequences of disruption of this complex remain largely uncharacterize

247 ortical circuits to layer 4 are present, and disruption of this early sensory activity could be utili

248 Disruption of this histiotrophic pathway leads to advers

249 omote repair of DNA single strand breaks and disruption of this pathway by Poly(ADP-ribose) polymeras

250 lators of lOFC excitability and suggest that disruption of this process could contribute to various d

251 ale could persist for centuries, and why the disruption of this self-organizing system by the Green R

252 's cognitive nature is that the experimental disruption of this theta/beta-gamma transition pattern p

253 Disruption of ties through social exclusion has a marked

254 Selective disruption of trans engagement of E-cadherin in an other

255 In Arabidopsis thaliana, disruption of two subunits of the transcriptional regula

256 Although disruption of vessel normalization reduced T lymphocyte

257 al refinements in the mammalian cochlea, the disruption of which contributes to the deafness phenotyp

258 s a derivative MRI technique that can detect disruption of white matter tracts in the brain.

259 Disruption of ZBP1 function in vivo in mouse and chick r

260 lations that are thought to reflect profound disruptions of activity in neuronal circuits that mediat

261 These findings show that distal and proximal disruptions of glycolysis have opposite effects on proli

262 Given that prolonged disruptions of normal rhythms are highly detrimental to

263 Inconsistent evidence implicates disruptions of striatal dopaminergic indices in suicide

264 These results suggest that disruptions of temporal parietal and sub-cortical neurog

265 proteases in pathogenesis and how Giardia's disruptions of the mucous barrier facilitate bacterial t

266 ism for rejecting host RNA targets, and that disruptions of this selectivity filter give rise to auto

267 Genetic disruption or pharmacologic inhibition of glucagon signa

268 both in vitro and in vivo Moreover, genetic disruption or pharmacological inhibition of eNOS attenua

269 characteristic of PD.SIGNIFICANCE STATEMENT Disruptions or alterations in the activation of pathways

270 Individual disruption predicted the upregulation of semantic activi

271 verexpression exacerbates, whereas MIOX gene disruption protects against, cisplatin-induced AKI.

272 egative young men and suggest that endocrine disruption (PTH-FGF23) is a primary contributor to TDF-a

273 anges in pathway networks and the regulatory disruptions related to genomic aberrations in cancers.

274 This disruption renders the proximal flagellum inflexible and

275 ension requiring vasoactive support, conduit disruption requiring covered stent (n=2), and acute RV d

276 In this study, we determined that IL-12 disruption rescued angiogenesis and arteriogenesis in ty

277 lobules pathology in corticocerebellar loop disruption resulting in automation and cognitive optimis

278 Sleep and circadian rhythm disruption (SCRD) is a ubiquitous feature in today's 24/

279 that combine Wolbachia invasion with mating disruption tactics to enhance the pre-existing Allee eff

280 ) causes localized blood-brain barrier (BBB) disruption that is currently being advocated for increas

281 inhibitory component of PFC LFP responses, a disruption that resulted from local blockade of alpha7-n

282 to self-reported habitual sleep duration and disruption, these traits are heritable and identificatio

283 immune systems, with pathology resulting in disruption to neurotransmitter balance, increases in chr

284 rebral microinfarcts, which cause measurable disruption to structural brain connections, and are asso

285 e at key life stages or whilst foraging, and disruption to the acoustic habitat at these times could

286 ensors are capable of entering cells without disruption to the cellular environment and can report on

287 pathway components led to varying degrees of disruption to the normal differentiation phenotype indic

288 Eye blinks cause disruptions to visual input and are accompanied by rotat

289 gaze position during intrinsically generated disruptions to visual input.

290 down of GAPDH1 expression and catalytic site disruption validate the essentiality of GAPDH1 in intrac

291 ated with increased mitotic activity, axonal disruption, vascular neoplasia, and with several brain m

292 Postnatal circadian disruption was associated with reduced adult body mass,

293 d contribution of NMDAR hypofunction to this disruption, we examined the effects of the NMDAR antagon

294 nsformation, oxidative stress, and endocrine disruption were also measured using quantitative real-ti

295 Metabolite disruptions were not explained by altered expression of

296 markedly facilitate stretch-induced membrane disruptions while mechanically stiffening the associated

297 FID was defined as an intimal disruption with contrast material-filled outpouching fro

298 Conclusion Mechanical tumor tissue disruption with pulsed focused ultrasound-induced bubble

299 implicated in neurodevelopment and endocrine disruption, with expected metabolism perturbations, we p

300 ctivating Sleeping Beauty transposon to Pten disruption within the same genome.