ライフサイエンスコーパス: disruptive

1 ubstitutions of this aspartate are much less disruptive.

2 tracellular environment, where they could be disruptive.

3 O2 isotope signatures are time-consuming and disruptive.

4 k during piano performance can be profoundly disruptive.

5 hance patient-centredness and were minimally disruptive.

6 int stratigraphy before their effect becomes disruptive.

7 usive visual memories may be distressing and disruptive.

8 ar inflammation in a manner that is not host disruptive.

9 ary in silico modeling, gives insight to the disruptive ability and the molecular mechanism of action

10 the comprehensive mechanism for the membrane-disruptive action of this mammalian host-defense peptide

11 e linker, both resulted in improved membrane disruptive activity at the endosomal pH of 6.5.

12 hysical approaches we characterized membrane disruptive activity of the full-length PB1-F2 (90 amino

13 yplex size, stability, pH-dependent membrane disruptive activity, biocompatibility, and gene silencin

14 ctivity of Mph1 helicase, but not its D loop disruptive activity.

15 amilial; however, thus far no rare germ line disruptive alleles for CLL have been identified.

16 In stark contrast, disruptive alleles of Basket (Bsk), the Drosophila homol

17 association, the relative merits of testing disruptive alleles vs. missense alleles, frequency thres

18 roca's area and its right homologue, whereas disruptive alterations of pitch elevated activations in

19 Such disruptive analyses potentiate contamination, disrupt th

20 Dialysis was disruptive and demanding and served as a constant remind

21 gle-cell resolution yet in a label-free, non-disruptive and mechanism-specific manner can lead to man

22 agnetic implant that was developed as a less disruptive and more reproducible surgical option for pat

23 persistent pollutants found to be endocrine disruptive and neurotoxic in animals.

24 We found that gene-disruptive and putatively protein-damaging URVs (but not

25 o value in its own right, and considered too disruptive and time-consuming.

26 This rapid, robust, less disruptive, and cost-effective technology adds a valuabl

27 tion technology is facile, versatile and non-disruptive, and in addition to tissue oxygenation, it sh

28 clonal expansion of HSPCs carrying specific, disruptive, and recurrent genetic variants, in individua

29 naging infections and proposes 3 potentially disruptive applications for these data in the clinical w

30 e percentage of patients who respond to this disruptive approach remains modest to date.

31 d thermal gradients represents a potentially disruptive approach to create high-efficiency and high-h

32 ed the magnitude of vocal learning driven by disruptive auditory feedback in a negative reinforcement

33 nally, AIV neurons exhibit fast responses to disruptive auditory feedback presented during singing, b

34 Thus, compounds that can facilitate disruptive Bax insertion into mitochondrial membranes ha

35 ons ("ultrasensitive") and variants that are disruptive because of mechanistic effects on transcripti

36 antecedents of new adolescent-onset MDD, but disruptive behavior (beta = -0.08, P = .14) and low mood

37 Parents rated disruptive behavior and noncompliance on co-primary outc

38 o assessed 14 lifetime DSM-IV mood, anxiety, disruptive behavior and substance disorders before rando

39 Behavioral interventions are used to treat disruptive behavior but have not been evaluated in large

40 Children with early-onset disruptive behavior disorder (DBD), especially those wit

41 e most consistent dysfunction in youths with disruptive behavior disorder is in the rostro-dorsomedia

42 Across 24 studies, 338 youths with disruptive behavior disorder or conduct problems relativ

43 all whole-brain fMRI studies of youths with disruptive behavior disorder or conduct problems up to A

44 Youths with disruptive behavior disorder with psychopathic traits sh

45 tivity disorder (30.7% compared with 18.1%), disruptive behavior disorders (27.4% compared with 15.3%

46 Youths with disruptive behavior disorders (DBD) (conduct disorder an

47 depressive episodes (hazard ratio=1.99), and disruptive behavior disorders (hazard ratio=2.12) were a

48 mood (RhoG, 0.47), anxiety (RhoG, 0.35), and disruptive behavior disorders (RhoG, 0.48), may be accou

49 Major depressive episodes and disruptive behavior disorders are also indications for c

50 Youths with disruptive behavior disorders showed reduced use of expe

51 aim of this meta-analysis of fMRI studies in disruptive behavior disorders was to establish the most

52 Disruptive behavior disorders were associated with lower

53 were 38 community youths ages 10-18 (20 had disruptive behavior disorders, and 18 were healthy compa

54 t reward-related neurophysiologic feature in disruptive behavior disorders, findings generally suppor

55 Youths with disruptive behavior disorders, including conduct disorde

56 Disruptive behavior disorders, such as attention-deficie

57 y reflect reward insensitivity in youth with disruptive behavior disorders.

58 n the caudate during feedback in youths with disruptive behavior disorders.

59 ucted in pediatric office settings to reduce disruptive behavior in toddlers.

60 Disruptive behavior is common in children with autism sp

61 of evidence, the authors conclude that early disruptive behavior is neurodevelopmental in nature and

62 as superior to parent education for reducing disruptive behavior on parent-reported outcomes, althoug

63 urodevelopmental research on early childhood disruptive behavior within the historical context of the

64 age-of-onset reports) fear/anger, distress, disruptive behavior, and substance disorders significant

65 onent analysis yielded 3 composite measures (disruptive behavior, autism/mood, and caregiver strain)

66 ther disorders, including mood, anxiety, and disruptive behavior, each occurred in approximately 30%

67 epression and peer ratings of aggression and disruptive behavior.

68 sits) provided specific strategies to manage disruptive behavior.

69 lous behavior as two core exemplars of early disruptive behavior.

70 fered for parents of preschool children with disruptive behavioral problems screened from the whole p

71 dence-based early treatment of children with disruptive behavioral problems.

72 creening criteria indicating a high level of disruptive behavioral problems.

73 ipid-peptide interactions governing membrane-disruptive behaviors and establish a link between peptid

74 n between 2 and 4 years old who acknowledged disruptive behaviors on a 20-item checklist were include

75 mprovements in parenting practices and child disruptive behaviors that were attributable to participa

76 3-7 years) with autism spectrum disorder and disruptive behaviors were randomly assigned (86% white,

77 parenting strategies and reducing children's disruptive behaviors.

78 that might be found in nature, edge enhanced disruptive camouflage increases crypsis, even on substra

79 e enhancement increases the effectiveness of disruptive camouflage through mechanisms that may includ

80 Other patterns resemble disruptive camouflage, whereas the chin and jugal bosses

81 ucture, thus contributing to strong membrane disruptive capability and potent antimicrobial activity.

82 ) poor planning for medical setbacks; and 5) disruptive care transitions.

83 to environmental influences, and we discuss disruptive causes, preventative measures, and possible m

84 or-binding sequence and hydrophobic membrane-disruptive chains that are masked by acid-cleavable gala

85 An artificial, disruptive challenge; i.e., introduction of a novel obje

86 The approach has the potential to bring disruptive change to drug discovery; the many potential

87 These disruptive changes thus led to a dis-organization of F-a

88 A sequencing, have ushered in widespread and disruptive changes to biomedical research.

89 We identified 17 individuals with exon-disruptive CNVs (18.5%), including 13 different deletion

90 In addition, we provide evidence of gene-disruptive CNVs (in DISC1, WNT7A, RBFOX1, and MBD5), as

91 Probands carry more gene-disruptive CNVs and SNVs, resulting in severe missense m

92 mechanisms, of which background matching and disruptive coloration are likely the most common.

93 or properties, leading to camouflage through disruptive coloration.

94 Disruptive colouration is a visual camouflage composed o

95 This disruptive concept led to rapid treatment advances in ev

96 Both disruptive conditions increased activations in the suppl

97 lived, ecotypically specialized plants, with disruptive consequences for communities and ecosystems.

98 As endocrine disruptive contaminants in the environment, SSRIs affect

99 Disruptive, damaging ultra-rare variants in highly const

100 Disruptive, damaging ultra-rare variants in highly const

101 at sporadic cases of ASD/ID are enriched for disruptive de novo mutations.

102 ty has already been established by recurrent disruptive de novo protein-coding mutations (ARID1B, SCN

103 99.6% sequence identity, identify small gene-disruptive deletions, detect single-nucleotide variants,

104 This article proposes a disruptive device concept which meets both low power and

105 iently equip future leaders to make the next disruptive discoveries.

106 [HR], 2.02; 95% CI, 1.08-3.79; P = .03), any disruptive disorder (HR, 1.70; 95% CI, 1.05-2.75; P = .0

107 We hypothesized that the disruptive ecological changes triggered by the earthquak

108 of preventing such shifts to minimize their disruptive ecological, economic, and societal consequenc

109 twork positions, have a strong topologically disruptive effect and touch complexes with high function

110 tions, can have a constructive rather than a disruptive effect by allowing the emergence and maintena

111 g the SEF in the current trial rectified the disruptive effect caused by stimulation in the previous

112 This membrane-disruptive effect is enhanced for gel phase DMPC membran

113 ect on a vital Earth system process; (2) the disruptive effect is not discovered until it is a proble

114 This disruptive effect of competition is expected to be parti

115 Here, we aim to estimate the disruptive effect of mt-rRNA variations on the function

116 's tendency to attend to pain related to the disruptive effect of pain on his or her cognitive task p

117 The disruptive effect of radiofrequency electromagnetic fiel

118 This disruptive effect of stress on working memory has been l

119 ntrols, ie, impairment in sensitivity to the disruptive effect of such interference.

120 , and showed that STN inhibition reduced the disruptive effect of surprise.

121 sion oncoproteins is in part mediated by the disruptive effect of the E2F-ETS interaction on cell cyc

122 ills three conditions: (1) it has an unknown disruptive effect on a vital Earth system process; (2) t

123 nion aggregation, and the consequent reduced disruptive effect on the dynamic water structure.

124 ces, we test whether large inversions have a disruptive effect on widely applied population genetics

125 age mechanisms: pattern complexity matching, disruptive effects and background color matching.

126 at regulates unc-9 electrical signaling; its disruptive effects can be rescued by a constitutively ac

127 At the molecular level, we found that these disruptive effects did not require arrestin-dependent si

128 would have tended to minimize the otherwise disruptive effects of a changing thermal environment on

129 the first evidence in humans describing the disruptive effects of cocaine on the coordinated functio

130 at IL-10 deficiency predisposes to pregnancy disruptive effects of environmental toxicants.

131 The cytoskeleton-disruptive effects of excess PIP5KIgamma reflect its kin

132 imulation protocols capable of reversing the disruptive effects of focal cortical inhibition have dem

133 and was significantly less vulnerable to the disruptive effects of IFN, cellular restriction factors,

134 tasis in specific and distinct ways, and the disruptive effects of MsDef1 on Ca(2+) were mediated by

135 k for understanding sterol transport and the disruptive effects of mutations causing sitosterolaemia.

136 ant for developing lighting that reduces the disruptive effects of nocturnal light in humans, without

137 How cells in ectotherms cope with the myriad disruptive effects of temperature variation is poorly un

138 ur results suggest a novel mechanism for the disruptive effects of the absence or haploinsufficiency

139 with the flanking nucleotides buffering the disruptive effects of the isomeric linkage and resulting

140 Here, we investigated the disruptive effects of transcranial magnetic stimulation

141 found to induce Sertoli cell injury through disruptive effects on actin microfilaments and microtubu

142 ability (ID) patients that showed convergent disruptive effects on AMPAR recycling and glutamate unca

143 Therefore, we determined if MDPV exerts disruptive effects on brain functional connectivity, par

144 ese findings thus illustrate PFOS exerts its disruptive effects on Sertoli cell function downstream t

145 stis was shown to prevent F5-peptide induced disruptive effects on spermatogenesis.

146 CAPN14 induces disruptive effects on the esophageal epithelium by impai

147 These disruptive effects were relieved by either mutation of t

148 all the nuclear-receptor mediated endocrine disruptive effects, antiandrogenicity is frequently obse

149 luding severe aquatic toxicity and endocrine disruptive effects.

150 stem processes to identify currently unknown disruptive effects.

151 ent alterations can yield different types of disruptive effects.

152 .S. swine producers were confronted with the disruptive emergence of porcine epidemic diarrhoea (PED)

153 Foot-and-mouth disease (FMD) can cause large disruptive epidemics in livestock.

154 Evidence exists for synergistic as well as disruptive epistasis among loci.

155 ontrast, we found a single heterozygous exon-disruptive event in a BBS-associated gene (BBS9) in 229

156 brain volume can be altered, by either rare disruptive events causing hyperactivation of the pathway

157 idly emerging societal tensions arising from disruptive events like natural disasters.

158 idence of the importance of de novo and gene-disruptive events.

159 We will then address systems where the disruptive exchange of one metal for another leads to a

160 tisense oligonucleotides (PMO-AO) to exclude disruptive exons from the mutant DMD transcript and elic

161 Following these recommendations will be disruptive for both investigators and institutional revi

162 thy individuals tend to be neutral or weakly disruptive for protein molecular function.

163 es of MFE values and, therefore, may be more disruptive for the corresponding mRNA secondary structur

164 Our data suggest that PCBs impart pregnancy disruptive functions by activating the Notch/Dll pathway

165 It has been reported that unlike a disruptive G-protein-mediated PAR1 signaling by thrombin

166 ally, and by probing structurally predicted, disruptive, genetic variants from ciliary disease patien

167 We searched for disruptive, genic rare copy-number variants (CNVs) among

168 as hepatocyte growth factor (HGF) and hepato-disruptive GFs such as transforming growth factor (TGF)-

169 etabolism or by infiltrating the system with disruptive, heterologous pathways that overcome cellular

170 esponses in midlatitudes may be ecologically disruptive if interacting taxa respond oppositely to war

171 2_79 by approximately 100-fold and show that disruptive IgE inhibitors efficiently prevent passive cu

172 provides mechanistic insight into a class of disruptive IgE inhibitors that accelerate the dissociati

173 lective growth advantage over those carrying disruptive IL2RG mutations.

174 These findings support the disruptive impact of lights on moth activity, which is o

175 ence elements, recent studies have noted the disruptive impact of mutated generic spliceosome compone

176 heir sensitivity, selectivity, and minimally disruptive impact on biomaterials.

177 man exome is the first step in assessing the disruptive impacts of non-synonymous single nucleotide v

178 gh-performance nanomaterials that will cause disruptive improvements in the field of biosensing.

179 ses to identify which SCNA patterns are most disruptive in OV.

180 pecific amino acid change appears only to be disruptive in the ovary.

181 ical; this structure vividly illustrates the disruptive influence of MutM on the target base pair.

182 Together, these changes are disruptive influences on academic pathology research as

183 ed genomics therefore appears to represent a disruptive innovation in that it unveils a heterogeneity

184 Laser treatment of burn scars represents a disruptive innovation that can yield results not previou

185 ng innovations, punctuated by the occasional disruptive innovation.

186 infectious diseases may become untreatable, disruptive innovations are in the process of being disco

187 ly thin and transparent graphene may lead to disruptive innovations in such applications.

188 trometry for proteome analysis was driven by disruptive innovations that created a capability for lar

189 pINTK vectors use ura4+ selection to direct disruptive integration of leu1+ and lys1+ respectively,

190 in low resolution 2D pillar-based methods or disruptive intermediate steps of cell removal and substr

191 Vortex motion can be disruptive; it can cause phase transitions, glitches in

192 Recurrent de novo (DN) and likely gene-disruptive (LGD) mutations contribute significantly to a

193 ted that genes with de novo (DN) likely gene-disruptive (LGD) mutations in children with autism spect

194 Job loss is an involuntary disruptive life event with a far-reaching impact on work

195 kinetic stabilizing effect of fast ions on a disruptive magneto-hydrodynamic instability, known as a

196 rovides a simple and effective scheme of non-disruptive manipulation of the chemical landscape associ

197 hin minutes, the birds learned to avoid this disruptive masking (jamming) by adjusting the timing of

198 acterial activity against MRSA by a membrane-disruptive mechanism without detectable toxicity to mamm

199 ious, uncertain, and high-risk trajectory of disruptive medical innovation?

200 Non-disruptive methods avoiding critical steps, such as memb

201 This mutation (c.4166G>A;p.Arg1389His) is a disruptive missense mutation in the outer region of the

202 Disruptive mood dysregulation co-occurred with all commo

203 Bipolar disorder and disruptive mood dysregulation disorder (DMDD) are clinic

204 Disruptive mood dysregulation disorder (DMDD) is a new d

205 Disruptive mood dysregulation disorder (DMDD), a newcome

206 No empirical studies on the DSM-5 proposed disruptive mood dysregulation disorder have yet been pub

207 Disruptive mood dysregulation occurred with another diso

208 ages 8 to 17 years, 93 youths with anxiety, disruptive mood dysregulation, and/or attention-deficit/

209 nalyzed dimers wherein one subunit harbors a disruptive mutation and observed that ATP binding by bot

210 sequencing of spp3 identified an independent disruptive mutation in SvAUX1 (AUXIN1), one of the two g

211 A disruptive mutation in the Spt5 CTD-binding site of GTas

212 Disruptive mutations (L348R or Delta324-339) lowered the

213 The rarity of disruptive mutations among unaffected individuals (2/49,

214 2,519 cases of myeloid malignancies reveals disruptive mutations associated with poor survival, high

215 Gene-disruptive mutations contribute to the biology of neurod

216 y arising from rare (less than 1 in 10,000), disruptive mutations distributed across many genes.

217 th an excess of de novo mutations or private disruptive mutations in 5.7% of cases.

218 sequencing recently revealed that recurrent disruptive mutations in a few genes may account for 1% o

219 The latter are generally characterized by disruptive mutations in coding genes that have been esta

220 rum disorders (ASD) have high vulnerability: disruptive mutations in many of these genes, the vulnera

221 al and molecular data of 25 individuals with disruptive mutations in POGZ by diagnostic whole-exome,

222 A total of 8.7% of TGCT families carry rare disruptive mutations in the cilia-microtubule genes (CMG

223 We identify frequent disruptive mutations in the PRC1-like component and BCL6

224 Within this interval, we identified disruptive mutations in two genes.

225 in an explicit test by measuring the load of disruptive mutations in whole-exome sequence databases f

226 (p = 0.03) enrichment of de novo and private disruptive mutations within fetal CNS DNase I hypersensi

227 namics, while tolerating several potentially disruptive mutations.

228 The influence of disruptive natural selection on genetic variation is esp

229 heory, variation can persist at a gene under disruptive natural selection, but the process is little

230 only to re-emerge in adults, indicating that disruptive natural selection, rather than nonrandom mati

231 t as direct triggers of armed conflicts, the disruptive nature of these events seems to play out in e

232 tions to inform investigators of potentially disruptive NM technologies that have to be investigated

233 amaterials provide a platform for developing disruptive novel technologies, in which a combination of

234 progenitor cell assays, crenolanib was less disruptive of erythroid colony growth, which may result

235 tations in other genes could be specifically disruptive of ovarian or testicular function, while leav

236 N-terminal end of the kinase domain are more disruptive of protein function.

237 The predicted disruptive orientation is consistent with the amphiphili

238 This SNV, c.374A>G, causes a highly disruptive p.Tyr125Cys substitution just outside the sec

239 vo microdialysis experiments showed that the disruptive peptide selectively counteracted the ability

240 emonstrated that a cell-penetrating endosome-disruptive peptide we synthesized, termed 599, enhanced

241 s based on reversible inhibition of membrane disruptive polymers with protease-sensitive substrates.

242 targeting approach, we further improved the disruptive potency of E2_79 by approximately 100-fold an

243 ling separation of charge and spin currents, disruptive potential applications and the study of press

244 using HIA, we have been able to evaluate the disruptive potential for a subset of uncharacterized 12S

245 conservation of the rRNA fold to infer their disruptive potential.

246 human mitoribosome with different degrees of disruptive power.

247 chromatin remodeler to possess SWI/SNF-like disruptive properties.

248 Earlier work has shown that disruptive proteins, such as the non-hydrolytic non-oxid

249 mains an outstanding challenge for realizing disruptive quantum technology.

250 Our study provides insight into functionally disruptive, rare-variant mutations in human CaMKK2, whic

251 The high sensitivity and persistence of this disruptive response is surprising, given that the hummin

252 oteins often requires labeling approaches or disruptive sample preparation while it lacks chemical sp

253 prevalent neurological disorder resulting in disruptive seizures.

254 llion-year history of alternating periods of disruptive selection in contrasting environments and adm

255 sistence of the polymorphism is unknown, but disruptive selection is predicted to be frequency depend

256 ost genes are under purifying selection, but disruptive selection was inferred for a few genes/substi

257 pportunities for speciation during epochs of disruptive selection-a potential observable signature of

258 lternating between epochs of stabilizing and disruptive selection.

259 d by an intronic insertion of a loxP flanked disruptive sequence that can be deleted by Cre recombina

260 We find that disruptive sexual selection generates two fitness peaks

261 -regulation of thrombin-induced RhoA barrier disruptive signaling.

262 mber variant (CNV) or candidate de novo gene-disruptive single-nucleotide variant (SNV) had been dete

263 d in light of those stereotypes can elicit a disruptive state that undermines performance and aspirat

264 ch a mechanism [12-14], direct evidence from disruptive studies has hitherto been lacking.

265 Despite our intention to introduce highly disruptive substitutions, most had modest or no effect o

266 and circadian disturbances are particularly disruptive symptoms in patients with neurological disord

267 with the ability to compete toe-to-toe with disruptive technologies like organic light-emitting diod

268 Proteomics is the result of disruptive technologies, namely, mass spectrometry and d

269 , rather, they have the potential to lead to disruptive technologies.

270 -dimensional (3D) printing, is a potentially disruptive technology across multiple industries, includ

271 Nanopore sequencing may be the next disruptive technology in genomics, owing to its ability

272 Flow diversion is a disruptive technology that has changed the way many brai

273 ovskites have rapidly gained prominence as a disruptive technology.

274 objects capture more attention and are more disruptive than weakly salient distractors [7, 8].

275 only the privileged item was susceptible to disruptive TMS over MT+.

276 tems in WM are differentially susceptible to disruptive TMS, depending on their state, determined eit

277 This mutation is highly disruptive to ciliary assembly in other organs.

278 using membrane-permeable agonists is equally disruptive to growth.

279 ntain some dopaminergic tone and may be less disruptive to normal neuronal functions.

280 t the loss of betacyto-actin protein is more disruptive to primary fibroblast function than is the lo

281 s of widely used SDARs could be particularly disruptive to scientific research.

282 contain blue wavelengths may be particularly disruptive to the circadian system, potentially contribu

283 apy for hemophilia A that can potentially be disruptive to the way hemophilia is treated.

284 which is both life-sustaining and profoundly disruptive to their quality of life.

285 his open access movement will continue to be disruptive until a business model ensures continuity of

286 %) had a pathogenic SNV and six (0.1%) had a disruptive variant that was expected to be pathogenic, w

287 NV and six (0.3%) had an expected pathogenic disruptive variant, whereas 13 (0.6%) had likely pathoge

288 melanoma risk in the general population are disruptive variants (R alleles) in the melanocortin 1 re

289 s by showing that they are enriched for rare disruptive variants and de novo variants from schizophre

290 can cause severe immune deficiency, yet less disruptive variants are sometimes associated with immune

291 esistant schizophrenia had an excess of rare disruptive variants in gene targets of antipsychotics (3

292 The burden of singleton disruptive variants in the DISC1 Interactome was associa

293 WERacross), an increased burden of singleton disruptive variants in the Regulome was associated with

294 iants already known to cause a disease, rare disruptive variants predicted to be causal are not alway

295 prioritized genes with ultrarare and highly disruptive variants, in 11.3% of CDH patients.

296 utable to one or a few severely functionally disruptive variants.

297 Disruptive vocalisation may have been provoked by concen

298 hat could be avoided by using less circadian-disruptive wavelengths.

299 non-fire programs, and as the likelihood of disruptive within-season borrowing potentially increases

300 ber status in 2,988 cases of glioma revealed disruptive ZEB1 deletions associated with decreased surv