ライフサイエンスコーパス: dissect

1 virus (KSHV) as a model system, we sought to dissect a putative allosteric network linking a cryptic

2 oach AD in a more differentiated way (ie, to dissect and stratify the complex clinical phenotype into

3 Sixty-eight embalmed feet were dissected and anatomically classified to define the rela

4 After sterile washing steps, sand flies were dissected and guts were separated.

5 nts were included, with a total of 57 groins dissected and histologically evaluated.

6 sed to Sox10-CreER(T2) or Wnt1-Cre mice were dissected and the 6 populations of cells were isolated b

7 We also discuss the challenges of dissecting and interpreting the phenotypic effect of reg

8 Plaques were dissected, and the culprit lesions used for histology an

9 Ophthalmoplegia secondary to a traumatic dissecting aneurysm in the cavernous segment of internal

10 nternal carotid artery (ICA) together with a dissecting aneurysm in the cavernous segment.

11 rrowed and dissected segment of ICA, and the dissecting aneurysm of the cavernous segment was success

12 mediate diagnosis and appropriate therapy of dissecting aneurysms is necessary for good clinical outc

13 We apply fine-mapping analysis to dissect associations in the human leukocyte antigen regi

14 Mouse mammary buds dissected at E14 and cultured for 5 days showed that est

15 m in which these computations may be further dissected at the circuit level.

16 using TNF-alpha and IL-17A were conducted to dissect basement membrane remodeling.

17 e, using cell-biological approaches, we have dissected basic principles that underlie the biogenesis

18 The PIMOC was dissected bilaterally in all cadavers and there were no

19 This allowed for dissecting bona fide caveolar functions from those suppo

20 e estimates, thereby enabling researchers to dissect both the shared and distinct genetic architectur

21 ult in varying phenotypes are challenging to dissect, but can be delineated through focused internati

22 ng, cellular barcoding, molecular recording, dissecting cancer biology, and connectome mapping.

23 Here we dissect cell fate transitions during colonic regeneratio

24 To dissect cell-specific Smad3 actions in myocardial infarc

25 o, aubergine, strawberry and apple - we have dissected cell wall matrix polysaccharide contents using

26 ingle cell could be of significant value for dissecting cellular heterogeneity in tumors and analyzin

27 foot-and-mouth disease virus (FMDV) in micro-dissected compartments of the bovine nasopharynx by micr

28 tiplex genome editing can be used to rapidly dissect complex biological systems and genetic redundanc

29 (GWAS) have represented a major approach to dissect complex human genetic diseases.

30 k recording are overcoming the challenges of dissecting complex circuits that underlie this integrati

31 atility and open new avenues of research for dissecting complex gene regulatory dynamics.

32 raits, our findings provide a foundation for dissecting complex relationships between gene-regulatory

33 ness requires sophisticated force protocols, dissecting contributions from altered Ca(2+) homeostasis

34 it our ability to live image and genetically dissect de novo BM formation during Drosophila developme

35 Finally, to dissect early and late events following interspecific hy

36 ed whole-exome sequencing (WES) on 111 micro-dissected EBV-positive NPCs, with 15 cases subjected to

37 ent provides an in vivo model to genetically dissect EGFR signaling.

38 entiation, we isolated transcripts from cryo-dissected endosperm specimens enriched with BETL, AL, or

39 ng computational methods in combination with dissecting enhancer features and TF cistromes, we implic

40 We aimed to dissect equine immune responses after experimental NPHV

41 we demonstrate how the approach allows us to dissect experimental data into a number of dynamic proce

42 The mPFC was dissected, extracted with ethanol and metabolite (13)C e

43 of mouse eyes and fluorescence microscopy of dissected eye tissues from the conjunctiva, cornea, reti

44 n individual-based non-parametric method for dissecting fine population structure.

45 sed EM and crosslinking mass spectrometry to dissect five conformational substates of the complex, in

46 be used to identify rate-limiting steps and dissect folding and assembly pathways for complex RNAs.

47 functions in enhancer activation that can be dissected from cooperative binding.

48 found that the majority of SCs in the nerves dissected from embryonic and neonatal mice of both sexes

49 nificantly lower oxidative stress than those dissected from the embryo.

50 complete signaling system can be genetically dissected, from the enzymes producing pheromones, percep

51 n high-throughput and a CRISPR-based tool to dissect functional GI networks.

52 Maps of genetic interactions can dissect functional redundancies in cellular networks.

53 The structure provides a foundation to dissect further how Piezo channels are regulated by mech

54 o control differentiation and the ability to dissect gene function in a temporal manner.

55 mplications of these results for attempts to dissect genetic architectures and to predict individual

56 A powerful approach for dissecting GPCRs is to use light-controlled pharmacologi

57 The success of marker-based approaches for dissecting haematopoiesis in mouse and human is reliant

58 hock protocol to analyze the HSR in mice and dissected heat shock factor 1 (HSF1)-dependent and -inde

59 recent approaches that have been employed to dissect heterogeneity to give a flavour of the current d

60 roid (PSTVd) infecting tomato as a system to dissect host interactions with pathogenic ncRNAs, using

61 This integrated approach was applied to dissect how an ensemble of premotor neurons in the larva

62 architectures, allowing us to systematically dissect how brains learn.

63 We apply our approach to dissect how Erk activity is decoded by immediate early g

64 Here, via a deep mutational scan, we dissect how mutations at all positions of the variable d

65 To dissect how the microbiota contributes to tumor distribu

66 lymphomas, but few models are available for dissecting how EBV causes lymphomas in vivo in the conte

67 uencing (scRNA-seq) of developing neurons to dissect/identify NPC subtypes and critical developmental

68 Recent efforts to dissect immunological responses to ZIKV have provided si

69 (for gammadelta27(-)) cell counterparts, we dissect in this study similarities and differences in th

70 To genetically dissect in vivo the requirement of different signal tran

71 Further, we have dissected in greater detail the changes in transcript le

72 of the innate immune system has not yet been dissected in P0106-125-induced murine experimental autoi

73 Berries were collected during ripening and dissected in skins and seeds.

74 Tocochromanol biosynthesis has been dissected in the dicot Arabidopsis thaliana, which has g

75 These stress responses have generally been dissected in vitro at 30 degrees C on artificial growth

76 these pigs can serve as a powerful tool for dissecting in vivo gene functions and biological process

77 Here, we dissect individual mechanisms of sugar uptake during the

78 The unequaled ability to dissect infection dynamics at a high spatiotemporal reso

79 nerally, our approach provides an avenue for dissecting interactions of individual protomers in homo-

80 this study, we engineered the transporter to dissect interdomain communication paths.

81 CAVD valves (n = 52) dissected into noncalcified and calcified portions were

82 known whether this clustering process can be dissected into steps differentially regulated by indepen

83 on detergent treatments, the holo complex is dissected into subcomplexes that are analyzed by a three

84 re to guide site-directed mutagenesis and to dissect its function.

85 Here, we functionally dissected its four predicted transmembrane (TM) segments

86 The OPL and its surrounding structures were dissected; its morphology was carefully observed, analyz

87 he power of the chemical-genetic approach in dissecting kinase catalytic functions from the protein's

88 In this work, we dissected language-related (arcuate, uncinate, inferior-

89 aining of Drosophila whole-mount embryos and dissected larvae.

90 takes longer than typical antibody stains of dissected larval tissues-12 or 16 d, depending on the si

91 We molecularly dissected leptomeningeal metastasis, or spread of cancer

92 Photoaffinity labels are powerful tools for dissecting ligand-protein interactions, and they have a

93 ates these multiple events by systematically dissecting LKB1 protein domain function in combination w

94 ross the mammalian spindle in space-time and dissect local anchorage mechanics and mechanism.

95 The six dissected lymph nodes were negative for malignancy.

96 A major hurdle has been dissecting macrophage-specific functions from those in o

97 We sought to dissect mast cell responses at the single-cell level and

98 pproaches that have recently been applied to dissect mechanisms of regeneration.

99 rom both differentiated TS cell cultures and dissected mouse placentae resulted in proliferating colo

100 tools and drug-inducible gene expression to dissect Msp1 function.

101 pharmacological and optical intervention for dissecting neural circuitry during behavior.

102 Thus our model provides a means of dissecting out the role of physical forces in controllin

103 ex (P < 0.0001), and greater number of nodes dissected (P = 0.0324) were associated with increased ly

104 However, molecular tools to dissect pathways depending on either mono- or poly-SUMOy

105 virus-induced AAD exacerbations were used to dissect pDC function in vivo and unwind the potential me

106 l transformation (MuGENT), we systematically dissect PTS transport in V. cholerae.

107 easy interpretation of attempts to directly dissect Rap1 structure-function relationships.

108 Small RNA sequencing of dissected regions of immature seed coats demonstrated th

109 the K1 locus, we compared RNA-seq data from dissected regions of two Clark isolines having similar s

110 ified through gas chromatography analysis of dissected seeds.

111 A stent was placed in the narrowed and dissected segment of ICA, and the dissecting aneurysm of

112 iven off by the fruit, which is critical for dissecting sensory properties and quality traits.

113 They are excellent tools for dissecting SFK functions in normal development and signa

114 -based paracrine factor library screening to dissect signaling pathways that govern progenitor cell a

115 gner drugs (DREADDs) has made it possible to dissect specific GPCR signaling pathways in various cell

116 d demonstrate how time-course EM can further dissect stoichiometric states of complexes that are not

117 ed modern phylogenomic methods to accurately dissect subclones and their phylogenies from noisy and i

118 e as case studies, we demonstrate NetDecoder dissects subnetworks to identify key players significant

119 la egg chamber provides a tractable model to dissect such contributions during morphogenesis.

120 33 loci, suggesting these cells' utility to dissect T2D molecular genetics in these regions.

121 We dissected T3S substrate targeting and hierarchical switc

122 and cycling patterns of gene expression and dissect temporally ordered gene expression changes in re

123 ne neurons by mu opioid receptors and to (2) dissect the anatomy and neurochemistry of these neurons,

124 odeling, and provides a general framework to dissect the biological functions of DNA methylation read

125 selective, efficient, and convenient tool to dissect the biological processes controlled by a GPCR-in

126 r, we contribute a cellular disease model to dissect the biology of AL PCs.

127 eurons that mediate appetitive behaviors and dissect the BLA-to-CeA circuit for appetitive behaviors.

128 We used ShootingStar to dissect the cellular basis of development, morphogenesis

129 unctions of the BBS proteins is key to fully dissect the cellular basis of the syndrome.

130 To dissect the circuit in detail, we developed methods to i

131 ver, recent sequencing efforts have begun to dissect the complex genomic landscape of MIBC, revealing

132 RNA-disease associations would contribute to dissect the complex mechanisms of disease pathogenesis.

133 model could prove a powerful tool to further dissect the complex pathophysiological mechanisms that u

134 mic technologies have enabled researchers to dissect the complex roles of phospholipases in lipid met

135 ncer, this link represents an opportunity to dissect the complexity and heterogeneity of tumours and

136 ecome one of the most powerful approaches to dissect the complicated misfolding pathways of protein a

137 This method allowed us to dissect the concerted process of E1-E2-catalyzed Ub conj

138 study, we used bacterial and host mutants to dissect the contribution of autophagic processes respons

139 Our BMI paradigm can dissect the contribution of different elements in the se

140 Here, we systematically dissect the contribution of each gene to growth on chiti

141 ut in vivo binding assays, to systematically dissect the contribution of each of these features to th

142 Our results provide a general framework to dissect the coupling of synthesis and folding essential

143 Here, we dissect the different functionality of these sites in vi

144 Here we dissect the distinct roles of YAP/TAZ in endodermal epit

145 fluid provide unprecedented opportunities to dissect the earliest phases of stem/progenitor clonal (a

146 d randomised controlled trials are needed to dissect the effects of ayahuasca on these outcomes.

147 Herein, we use single-cell mass cytometry to dissect the effects of graphene oxide (GO) and GO functi

148 reinforce the need for systematic trials to dissect the efficiency and safety of new treatments for

149 sion in order to modulate cell phenotypes or dissect the epigenetic mechanisms involved in their cont

150 To dissect the establishment of heterochromatin, we investi

151 of DSBs with multilayered transcriptomics to dissect the events shaping gene expression after DSB ind

152 Here we dissect the events that specify ectodermal cells as plac

153 Gervais & Fessler dissect the folk concept of "contempt" to argue for a fu

154 Xs as a surrogate model of cold allodynia to dissect the framework of cold allodynia-activated centra

155 We identify several markers to help dissect the functional distinctions among gustatory neur

156 saturation mutagenesis has the potential to dissect the functional landscape of noncoding regions, b

157 To dissect the functional mechanism of ERV-9 lncRNAs, we pe

158 ged in functional (epi)genomic approaches to dissect the genetic and molecular factors controlling is

159 and accurate phenotyping methods required to dissect the genetic architecture of complex traits.

160 kers and phenotyped in multi-environments to dissect the genetic architectures of WSPC and protein co

161 nge to gather sufficiently large datasets to dissect the genetic basis of complex traits such as beha

162 and labor-intensive limiting the ability to dissect the genetic basis of quantitative traits.

163 studies (GWAS) have been used extensively to dissect the genetic regulation of complex traits in plan

164 n [Glycine max (L.) Merr.] were leveraged to dissect the genetics of Sclerotinia stem rot (SSR) [caus

165 ed from 374 pedigree and mixed-breed dogs to dissect the genetics of skull form.

166 mini-metagenomics make it a powerful tool to dissect the genomic structure of microbial communities w

167 uclear cells and collagen-alginate matrix to dissect the host-pathogen interaction.

168 good screening tools, but allergen molecules dissect the IgE response on a molecular level and put al

169 er mice and gene-deficient mice were used to dissect the immunologic mechanisms.

170 is issue of Neuron, Ben-Yaacov et al. (2017) dissect the interaction between AMPA receptors and auxil

171 Here, we dissect the interaction between circadian regulation and

172 ill exploit these genetic tools to precisely dissect the isoform- and tissue-specific requirements of

173 We used single-molecule fluorescence to dissect the kinetic and thermodynamic properties of a se

174 Here, we dissect the long-term dynamic behaviour of the gut micro

175 To dissect the mechanism of pathogenesis of I2771R, we crea

176 We used blockade of IL-21 to dissect the mechanisms by which this cytokine promotes a

177 d nonhuman primate models are widely used to dissect the mechanisms of viral pathogenesis in the CNS.

178 re, we use several biochemical techniques to dissect the molecular characteristics of native tau prot

179 and (epi)genome editing] will be critical to dissect the molecular genetics of T2DM pathogenesis, to

180 Here we report and dissect the molecular mechanism of action of three class

181 This model has enabled us to dissect the molecular mechanisms of MFS, identify novel

182 reat biological and clinical significance to dissect the molecular mechanisms that tune NF-kappaB act

183 n this issue of Cancer Cell, Nagaraja et al. dissect the molecular mechanisms underlying therapeutic

184 ok the advantages of the Drosophila model to dissect the molecular pathways that can be affected by D

185 teomics with HK-2 cells and animal models to dissect the molecular pathways underlying nephropathy ca

186 spontanea) is an excellent model to dissect the molecular processes underlying de-domesticat

187 Our work provides a novel means to dissect the motile mechanisms of these pathogens.

188 etworks (TRNs) has been increasingly used to dissect the nature of gene regulation.

189 point to the rodents as promising models to dissect the neuronal circuitry underlying transformation

190 to process noise, and use this framework to dissect the noise-processing ability of signaling networ

191 of feedback in the PKA signaling network and dissect the nonintuitive dynamic effects that ensue from

192 Results from a variety of assays used to dissect the poxvirus life cycle demonstrate that bisbenz

193 ells in AD inflamed skin, it is difficult to dissect the precise and multiple roles of upregulated KL

194 believe that our work not only allows us to dissect the process of protein folding, but will also he

195 Genetic tools help to dissect the relationship between aerobic glycolysis and

196 estigate these contradictory findings and to dissect the relative contribution of pRGCs and rods/cone

197 To dissect the relative contributions of the paracrine effe

198 llography and DFT calculations, can reliably dissect the response of small GTPases to site-specific m

199 Here, we dissect the RNA code recognized by RBM10 and relate it t

200 nd in vivo (mice) models of BBB were used to dissect the role of alpha7 nAChR in up-regulation of Abe

201 live-cell imaging in Drosophila embryos, we dissect the role of condensin I in the maintenance of mi

202 To further dissect the role of IL-23 in the expression of autoimmun

203 To dissect the role of neutrophils during mucosal candidias

204 lerance for BmbD and BmbE and systematically dissect the role of the follower peptide, which we show

205 To dissect the role of this channel in detail, we generated

206 Blocking antibodies were used to dissect the role of Toll-like receptor 2 (TLR2) and prog

207 Here, we mechanistically dissect the role of Tregs in HF and HFSC biology.

208 Here we use a variety of techniques to dissect the roles of individual protein kinase Calpha (P

209 aims to depict the structure of TFIIH and to dissect the roles of its subunits in different cellular

210 siology in acute mouse hippocampal slices to dissect the roles of P/Q- and N-type VGCCs.

211 ants; thus, additional studies are needed to dissect the roles of rare and structural variations.

212 ying BPL-1 function in C. elegans could help dissect the roles of this important metabolic enzyme und

213 Drosophila represents an excellent model to dissect the roles played by the evolutionary conserved f

214 uscle development in a mouse model of BWS to dissect the separate and shared roles for misexpression

215 to measure CDI and computational modeling to dissect the sequence of events that underlies it.

216 e revisit these and other related studies to dissect the step-by-step intricacies of this complex pro

217 To dissect the structural architecture of dysferlin, we hav

218 ecular dynamics and FRET-based approaches to dissect the structural basis of selective G protein inte

219 rotein localization and genetic epistasis to dissect the structure of this network in Drosophila We f

220 y2(+/-) (Hey2 heterozygous knockout) mice to dissect the underpinnings of the 6q22.31 association wit

221 Our study is the first to dissect the viable microbiota of the human stomach by me

222 We have now dissected the antiinflammatory mechanism of action of th

223 Here we have dissected the contribution of regulatory TRAIL receptors

224 Here, we dissected the directionality and magnitude of subunit co

225 Using a mutagenesis approach, we dissected the energetic basis for the TIGIT/nectin-2 int

226 utagenesis and structure-guided analyses, we dissected the function of individual N-glycan sites in b

227 In this study, we dissected the host response to EBOV and RESTV infection

228 In this study, we dissected the kinetics of heme binding to Rev-erbbeta an

229 Here we dissected the lysosomal HOPS complex as a tethering comp

230 ls for multiple sclerosis for comparison and dissected the MHC-III-mediated mechanisms of importance

231 Here, we have dissected the molecular characteristics of seed-competen

232 Here, we dissected the monocyte gene expression profile in childh

233 In the current study, we dissected the QTL2 region using an expression- and micro

234 Here we genetically dissected the relative contributions of APC-regulated be

235 Here, we dissected the roles of TGFbeta receptor II (TGFBR2) and

236 We further dissected the sequence of mechanical and morphological e

237 factor binding from ChIP-seq data are key to dissecting the allelic effects of non-coding variants an

238 By dissecting the cellular composition of dorsal-horn netwo

239 A challenge for dissecting the communication mechanisms in homo-oligomer

240 nd genetic mechanisms of PRR activation, and dissecting the complex signaling networks that orchestra

241 proaches, Bayesian and Deep Neural networks, dissecting the confounding effects of datasets and targe

242 H-mutant gliomas and a general framework for dissecting the differences among human tumor subclasses.

243 t into the mechanism of dynein regulation by dissecting the distinct functional contributions of the

244 g than cells from HIV progressors.IMPORTANCE Dissecting the factors that are involved in B cell matur

245 These results provide a new framework for dissecting the functional impact of amygdalar mGluR-plas

246 esky et al. (2017) tackles this challenge by dissecting the genetic architecture of parental care in

247 stics has generated substantial dividends in dissecting the genetic basis of myeloid neoplasms with e

248 in complex traits, has proven effective for dissecting the genetics and biology of such traits.

249 ur findings provide an important step toward dissecting the host genetic architecture of response to

250 Dissecting the immunology of Acanthamoeba infections has

251 icros model, it provides an ideal system for dissecting the intricacies of how the UPR evaluates and

252 described here provides a valuable tool for dissecting the mechanism of toxin pore formation and tra

253 To begin dissecting the molecular changes that led to the evoluti

254 ted by subtomogram analysis form a basis for dissecting the molecular organization of the TRAP comple

255 The recent advances in dissecting the molecular regulation and targeting histon

256 mission studies and played a pivotal role in dissecting the mosquito immune response against infectio

257 the complex composition of the HSC niche and dissecting the niche remodeling processes that appear to

258 R mutations and provide a powerful model for dissecting the pathogenesis of CALR-mutant ET and PMF.

259 his review will summarize recent advances in dissecting the relative contributions of mTORC1 versus m

260 We aimed at dissecting the relevant intracellular pathways through w

261 t conflict can be resolved by systematically dissecting the role of all of the relevant interactions

262 ein-coupled receptors are valuable tools for dissecting the roles of G protein-dependent and independ

263 Dissecting the roles of individual NSPs in humans is pro

264 ation are tightly coupled to metabolism, and dissecting the signaling molecules which link these proc

265 area neurons and a valuable entry point for dissecting the sleep control circuit.

266 Lim et al. provide refined genetic tools for dissecting the spatial organization and temporal dynamic

267 DSSR (Dissecting the Spatial Structure of RNA) is an integrate

268 channel has served as a powerful system for dissecting the structural changes that are related to fo

269 New research, dissecting the swim motor networks in two related nudibr

270 Dissecting the underlying mechanism, we show that actomy

271 Identifying the genetic causes and dissecting the underlying mechanisms are critical to und

272 her classical concepts and new evidence that dissects the influence of its different neuronal subtype

273 This review dissects the mechanisms of action of two families of end

274 mall-molecule inhibitors are useful tools to dissect their distinct biological functions.

275 and will allow rational design of mutants to dissect their function at a mechanistic level.

276 cytoskeletal networks makes it difficult to dissect their individual effects on the nucleus.

277 ore efforts will be needed to systematically dissect their roles on non-histone proteins, especially

278 direct protein target for berberine but also dissects their binding mode and validates that berberine

279 athways, alongside studies that attempted to dissect these activities through structural and biochemi

280 ture system that will enhance our ability to dissect these interactions.

281 We dissected these influences in isocitrate dehydrogenase (

282 numerous aspects of health and disease, but dissecting these connections is challenging because gene

283 implicated in human deafness, in addition to dissecting these interactions using domain mapping and m

284 Here, we dissect this adenoma-carcinoma sequence in vivo by using

285 To fully dissect this data requires the development of stochastic

286 e role of IKKalpha in cellular signaling, to dissect this from IKKbeta and to validate it in its own

287 By dissecting this loop, we show that Syk is a direct targe

288 cent structure-based models and functionally dissect three elements of Cdc20 inhibition: (1) sequestr

289 tron microscopy/single particle analyses, we dissected three molecular mechanisms underlying the inhe

290 neral positions within the complex have been dissected through a combination of genetic analyses, sup

291 the CCL1-CCR8 axis in Treg cells was further dissected through adoptive transfer studies using CCR8(-

292 XDH2 gene expression was observed in tissues dissected throughout a time course.

293 e larvae, compared with 2-3 d for embryos or dissected tissue stains-but time is saved by eliminating

294 ter the final PET scan, and radioactivity in dissected tissues was measured with a gamma-counter.

295 We used these binding signatures to dissect two properties of developmental enhancers: (1) p

296 ferior-longitudinal fasciculi were virtually dissected using manual and automatic deterministic fiber

297 the motor-sensory homunculus were virtually dissected using TrackVis, and diffusion properties were

298 technology have prevented its application to dissect variability in RNA processing events such as spl

299 Before foraging's functions can be further dissected, we need a precise genetic null mutant to defi

300 as and renal cell carcinomas can be reliably dissected with mass cytometry.