ライフサイエンスコーパス: dissociation constant

1 ator pKa (the negative logarithm of the acid dissociation constant).

2 form a one-to-one complex with a micromolar dissociation constant.

3 n provided a lower limit of 100 mM for their dissociation constant.

4 yields KD=(2.1+/-1.1)muM as the single-site dissociation constant.

5 1-90), the weakest of which has a millimolar dissociation constant.

6 biology tools especially in determination of dissociation constants.

7 dent DNA intercalation rates and equilibrium dissociation constants.

8 acceptor fluorescence intensities, can yield dissociation constants.

9 llus kaustophilus with biologically relevant dissociation constants.

10 eral aptamers were discovered with nanomolar dissociation constants.

11 orms in distinct pockets with low millimolar dissociation constants.

12 (rho = -0.9) with experimentally determined dissociation constants.

13 allowing for capture of targets with higher dissociation constants.

14 state over alternatives and to fine-tune the dissociation constants.

15 r ligands with high micromolar to millimolar dissociation constants.

16 te analogues of PNP bind with picomolar (pm) dissociation constants.

17 l relationship between these two equilibrium dissociation constants.

18 ed high affinity to VLA-4, with a comparable dissociation constant (0.28 vs. 0.23 nM) and receptor co

19 autoantibodies were high affinity (antibody dissociation constant, 0.06-0.78 nmol) and predominantly

20 o binding characteristics of (213)Bi-IMP288 (dissociation constant, 0.45 +/- 0.20 nM) to TF2-pretarge

21 denosine (CPA; 0.25 mg/kg intraperitoneally; dissociation constant, 0.48 nM; n = 7); pretreated with

22 lls were similar to those of (177)Lu-IMP288 (dissociation constant, 0.53 +/- 0.12 nM).

23 Results:(111)In-DTPA-anti-PD-L1 (dissociation constant, 0.6 +/- 0.1 nM) demonstrated incr

24 ndrial, and E. coli helix69 revealed similar dissociation constants (1.3-1.7 and 4.0-5.4 muM, respect

25 M forms a tight complex with the PHD of Akt (dissociation constant = 100 nm).

26 ne A2A receptors; 4 mg/kg intraperitoneally; dissociation constant, 11 muM; n = 6); and pretreated wi

27 Dissociation constant, 3.3 nM (+/-0.58), and receptor de

28 ate with the trends of nonheme-metal-binding dissociation constants (35, 22, and 9 muM) closely, sugg

29 0.5 nmol T6P g(-1) fresh weight close to the dissociation constant (4 microm) of the T6P/ SnRK1 compl

30 ography showed high (11)C-donepezil binding (dissociation constant, 6-39 nM) in pig peripheral organs

31 e 3) binds alpha-syn PFF with high affinity (dissociation constant = 77 nanomolar), whereas the alpha

32 reactivity on both platforms had the highest dissociation constant among the tested antibodies, sugge

33 tions for different buffer parameters (e.g., dissociation constant and concentration).

34 ine starvation reduces SAM levels below this dissociation constant and promotes the association of SA

35 Here, we used ZX1, which has a 1 nM zinc dissociation constant and second-order rate constant for

36 otein complexes, allowing us to detect their dissociation constant and stoichiometry directly inside

37 Based on adsorption isotherms, we obtained dissociation constants and binding capacities of the mem

38 le-stranded RNAs bind to PKR with micromolar dissociation constants and can induce activation.

39 with surface plasmon resonance estimates of dissociation constants and FcRn affinity chromatography.

40 mal titration calorimetry, we determined the dissociation constants and ligand-to-protein stoichiomet

41 can be computed from macroscopic parameters (dissociation constants and promoter concentrations) and

42 multaneously to quantitate binding kinetics, dissociation constants and thermodynamic energies.

43 by the substrate/product concentrations and dissociation constants, and can follow either a ping-pon

44 c quantities of ionization reaction for acid dissociation constants as a function of temperature, and

45 ffinity bidentate reagents, with equilibrium dissociation constants as low as 97 pM: >200-fold better

46 receptor (hGH-R) which displays an invariant dissociation constant at KD = 9 muM.

47 orms a tetragonal complex with a 34 +/- 5 fm dissociation constant at pH 7.4.

48 ound at least one prosurvival protein with a dissociation constant between 1 and 500 nM; many peptide

49 The dissociation constant between CEA protein and anti-CEA w

50 icles had very good affinity to cocaine with dissociation constants between 0.6nM and 5.3nM.

51 mber of binding sites on an antibody and the dissociation constants between the antibody and the shor

52 mples for two ELISA assays with low and high dissociation constant: biotin/streptavidin (10 fM) and H

53 Dissociation constants calculated from RBNS data using a

54 ur approach combines pK(a) (logarithmic acid dissociation constant) calculations from all-atom consta

55 From the measured dissociation constants, CaM4 binds calcium with a threef

56 Equilibrium association and dissociation constants describing Con A-polysaccharides

57 (1)H NMR studies revealed that the dissociation constant determined for these complexes was

58 makes weak binding (micromolar to millimolar dissociation constants) difficult to quantify under biol

59 the same binding site, leading up to a first dissociation constant even in the hundred nanomolar rang

60 at transition-state analogues with picomolar dissociation constants exhibit long lifetimes on their t

61 The dissociation constant for (111)In-DOTA-Z09591 binding to

62 gold surface, the aptamer exhibited a lower dissociation constant for CYN than that observed in the

63 The dissociation constant for CysK:CdiA-CT (K d 11 nM) is

64 Compared with mexiletine, the dissociation constant for inactivated channels was ~600

65 n K44 is mutated to alanine, the equilibrium dissociation constant for small unilamellar vesicles inc

66 Additionally, the dissociation constant for the competitive inhibitor isop

67 used to successfully measure an equilibrium dissociation constant for Zn(2+) and human serum albumin

68 l transitions are well described by stepwise dissociation constants for [Mg(2+)] (K1 = 328 +/- 30 muM

69 ty (LA) and higher-affinity (HA) equilibrium dissociation constants for acetylcholine in adult-type m

70 concentrations (above the Kd for Na(+)) the dissociation constants for aspartate were in the nanomol

71 The equilibrium association and dissociation constants for Con A-glycogen and Con A-mann

72 , we have used the TIMES signals to find the dissociation constants for the affinity of reactions, th

73 The dissociation constants for the enzyme.L-serine and enzym

74 roscale thermophoresis to directly determine dissociation constants for the I-D subunits from Synecho

75 They bound with high affinity: equilibrium dissociation constants for the three MAbs were equal to

76 he substrate to kinetically characterize the dissociation constants for three-transition-state analog

77 te between ligands binding within a range of dissociation constants from K(d)=4 muM to K(d)=3.3 mM.

78 nding sites characterized by two equilibrium dissociation constants have been identified.

79 hibitory concentration (PSMA) of 15 nM and a dissociation constant (HSA) of 11.2 muM, cleared from th

80 .3 is calcium-dependent, with an equilibrium dissociation constant in the apo-state of 70 +/- 3 muM a

81 that zinc binds to this TDP-43 domain with a dissociation constant in the micromolar range and modifi

82 [(3)H]38 revealed a dissociation constant in the picomolar range (Kd 0.044 n

83 alidate, MWC model predictions for etomidate dissociation constants in both inactive and active recep

84 lls via low-affinity anti-human IgE Abs with dissociation constants in the 10(-6) to 10(-8) M range.

85 microfluidic chip that allows measurement of dissociation constants in the micromolar-range.

86 nd stability, E41A, E41G, and T57A displayed dissociation constants in the millimolar range.

87 by exponential enrichment (SELEX) exhibited dissociation constants in the nanomolar range.

88 Dissociation constants in the nanomolar regime were dete

89 n of M w with loading concentration revealed dissociation constants in the range 25-75 muM, commensur

90 cific binding to the target T4 lysozyme with dissociation constants in the sub-micromolar range.

91 yethylene glycol (PEG) chains with nanomolar dissociation constants in water.

92 nucleophiles (pKa < 25, where Ka is the acid dissociation constant) in palladium-catalysed asymmetric

93 proteins bound to Galcer liposomes with Kds (dissociation constants) in the nanomolar range.

94 acceptors, local protein concentrations, and dissociation constants, in each image pixel.

95 pairs in liquid ammonia, but the equilibrium dissociation constants indicate favorable interactions b

96 Crystallographically determined, apparent dissociation constants indicated approximately 10-fold s

97 Given this low dissociation constant, initiation and sustainability of

98 The result shows that the dissociation constant is 5.56 x 10(-10) M(-1).

99 impact is only noticeable if the multivalent dissociation constant is far below the virus concentrati

100 current is used to determine the PSA-aptamer dissociation constant K(D), of ca. 2.6 nM.

101 ocol also yielded an accurate measure of the dissociation constant (K(d) value) for the binding of N,

102 tion rate constant (k(off)), and equilibrium dissociation constant (K(D)) of chemically distinct SERT

103 a selected fluorinated reporter ligand, the dissociation constant (K(D)) of other ligands of interes

104 log, binds to the enzyme with an equilibrium dissociation constant (K(d)) of ~400 nM.

105 ycan:bacterial-glycan pairs with equilibrium dissociation constants (K(D)) ranging between 100 nM and

106 okine occupancy, we determined intramembrane dissociation constants (K(d,2D)) of 180 and 480 receptor

107 A high inhibition potency (equilibrium dissociation constant [K(i)] = 2.34 +/- 2.94 nM on LNCaP

108 We probe the importance of the dissociation constant, K(D), and the concentration of DN

109 cedure was used for the determination of the dissociation constant, K(d), of the OxLDL binding to the

110 Herein, the apparent equilibrium dissociation constant, K(Dapp), between Cu(2+) and 1-pal

111 The apparent equilibrium dissociation constant, K(DApp), for the Cu(2+)-PE comple

112 for short) allows the estimation of the acid dissociation constant Ka(LAC) of diamagnetic transition

113 ), which correspond to acid-base equilibrium dissociation constants (Ka) in excellent agreement with

114 uantitative measurement of the submicromolar dissociation constant Kd (0.2 muM) of the complex betwee

115 y1Ac variants bind TnCAD with high affinity (dissociation constant Kd = 11-41 nM), kill TnCAD-express

116 ased fluorescent indicator, which displays a dissociation constant Kd = 3.1 mM suitable for the detec

117 ectively inhibit TNIK kinase activity with a dissociation constant Kd = ~1 muM.

118 a limiting rate constant of 5.3 s(-1) and a dissociation constant Kd of 525 muM; both kred and kred/

119 ed specific affinity to a BPA aptamer with a dissociation constant Kd of 54 nM, and provided a dose-d

120 periment is realized with human transferrin (dissociation constant Kd~10(-8) M(-1)).

121 loited to search for weak binders with large dissociation constants KD > 1 mM that are important for

122 s and fluorescence correlation spectroscopy (dissociation constants KD = 236 +/- 66 nM and KD = 282 +

123 We obtained the dissociation constants Kd for TAT binding to POPC and PO

124 es on ERK2, and we obtain an estimate of the dissociation constant (Kd ) for this interaction of 8 mu

125 C binds to the inner rod protein YscI with a dissociation constant (Kd ) of 3.8 mum and with 1:1 stoi

126 the soluble beta-1,3-glucan laminarin with a dissociation constant (Kd ) of approximately 26 mum and

127 The measured subfemtomolar dissociation constant (Kd = 6.41 x 10(-16) M) of DJ-1 fo

128 rred interaction site close to heme 2 with a dissociation constant (Kd) = 490 muM, in good agreement

129 rmation of each heterooligomer has a similar dissociation constant (Kd) and free energy of associatio

130 Equilibrium dissociation constant (KD) and maximum binding capacity

131 by the new PDE model, with estimates of the dissociation constant (Kd) and receptor density close to

132 Sensitivity of biosensors is set by the dissociation constant (Kd) between analytes and probes.

133 as identified as its membrane target and the dissociation constant (Kd) between Src and isorhamnetin

134 diate exosome endocytosis - with an apparent dissociation constant (Kd) equal to about 1 nM, indicati

135 cs, as indicated by the measured equilibrium dissociation constant (Kd) for the binding of free SDF1

136 nt assay-type binding assay, the equilibrium dissociation constant (Kd) for the interaction was estab

137 binds to beta3 integrin with an equilibrium dissociation constant (KD) of 21 microM, measured by sur

138 o isolate a urea specific DNA aptamer with a dissociation constant (Kd) of 232 nM.

139 The dissociation constant (KD) of a ligand of interest can b

140 binding affinity - is quantified through the dissociation constant (KD) of each recombinant antibody

141 The apparent dissociation constant (Kd) of Man-SNPs with fluorescein

142 Furthermore, we determined the dissociation constant (Kd) of ORF3 interactions with the

143 The dissociation constant (KD) of the interaction between re

144 in the presence of p67(phox); the calculated dissociation constant (Kd) of the p67(phox): phosphoPrdx

145 The dissociation constant (Kd) of the target protein was als

146 binds c-di-GMP in a specific manner, with a dissociation constant (Kd) value of 1.73 muM, which is i

147 We compared the dissociation constant (Kd) values from these experiments

148 equally well to short ssDNA substrates, with dissociation constant (Kd) values of 2.2 x 10(-7)M and 1

149 observable was used to determine equilibrium dissociation constant (Kd) values.

150 The determined dissociation constant (Kd) was affected more than 50% wh

151 The dissociation constant (KD) was calculated using a two-si

152 y was assessed using the occupancy plot; the dissociation constant (Kd) was determined by fitting sel

153 observed kinetic association rate (k on) and dissociation constant (Kd), but not the dissociation rat

154 nable kinetics and a >150-fold change in the dissociation constant (Kd).

155 ed more than 20 synbodies with low nanomolar dissociation constants (KD < 10 nM) for GII.4 VLP.

156 ents revealed tight binding to McpX(PR) with dissociation constants (Kd ) in the nanomolar range for

157 entally measured bond lifetimes (1/koff) and dissociation constants (Kd = koff/kon), determined by me

158 n is a previously reported DNA aptamer, with dissociation constants (Kd values) of 0.6 muM.

159 ncentration, allowing determination of their dissociation constants (Kd's).

160 tely 10(-4)-10(-3) s(-1); giving equilibrium dissociation constants (Kd) = 8-50 nM.

161 es with over a four-log range of equilibrium dissociation constants (KD) and found that Simoa assay p

162 antibodies is small, yet surprisingly their dissociation constants (Kd) are low, between 10 and 200

163 resolution binding curves from which precise dissociation constants (Kd) for protein-peptide interact

164 ary of 1.8 x 10(15) oligonucleotides showing dissociation constants (KD) in the low nanomolar range.

165 finity protein interactions with equilibrium dissociation constants (KD) in the picomolar range is of

166 of R-LA in a biphasic binding isotherm with dissociation constants (Kd) of 0.9 and 7.4 mum.

167 GSK2801 binds to BAZ2 bromodomains with dissociation constants (KD) of 136 and 257 nM for BAZ2B

168 s 0.56mIU/ml and 2.93mIU/ml (at S/N=3), with dissociation constants (Kd) of 5.65+/-2.5mIU/ml and 7.28

169 tration devices were used to examine (i) the dissociation constants (Kd) of individual PFOS and PFOA

170 Aptamers with dissociation constants (Kd) of nanomolar range were isol

171 tailed study of specificity, interaction and dissociation constants (Kd) of the peptide-ligand Delta-

172 nd interactions, yet when applied to measure dissociation constants (KD) through ligand titration, th

173 eled Dynabeads exhibited similar equilibrium dissociation constants (Kd), approximately 2 nM.

174 hat specifically bind to TICs with excellent dissociation constants (Kd).

175 Thus, the dissociation constants (Kd, muM) of 4 (11.2) and 5 (0.16

176 ate-dependent affinity of rSodC (equilibrium dissociation constant [KD] = 0.862 muM) that was 20-fold

177 he concentration dependence of the effective dissociation constant, KD,eff, which varies from 100 pM

178 nce emission measurements of the equilibrium dissociation constants, Kd, of oxidized (hAR*NADP(+)) an

179 usable protein concentrations and accessible dissociation constants, KD.

180 The value of the equilibrium dissociation constant (KD1xKD2=1.64x10(-7) mol L(-1)) de

181 and specificity to both beta-LG A and B with dissociation constants (Kds) of 82 and 80nM, respectivel

182 The dissociation constants (Kds) of the selected DNA aptamer

183 ty was measured at pH 4.0 to 11.0 and its TA dissociation constant (Ki) at pH 7.0.

184 Association constant kon, dissociation constant koff, and binding potential (kon/k

185 Substrate dissociation constants (Ks) for four variants were 37-13

186 inhibitors 10 and chemical probe VH298, with dissociation constants <100 nM, which induced marked HIF

187 al to use a binding moiety whose equilibrium dissociation constant matches that of the average predic

188 Dimer dissociation constants measured by a FRET-based assay ra

189 Counterintuitively, dissociation constant measurements show a stabilization

190 -saturation to estimate the tracer's in vivo dissociation constant, nondisplaceable volume of distrib

191 l simulations demonstrate the reliability of dissociation constants obtained by the standard KinExA a

192 The dissociation constants obtained in the fluorescence anis

193 imum number of binding sites, as well as the dissociation constant of (3)H-prazosin and the inhibitio

194 d MIP sensor is characterized by an apparent dissociation constant of (3.3+/-0.5)x10(-9)M and has a b

195 bound to phosphorylated beta-catenin with a dissociation constant of 0.28 mum, and although both the

196 th a rate constant of 700 +/- 20 s(-1) and a dissociation constant of 0.51 +/- 0.04 mM.

197 igher affinity toward LDL biomolecules and a dissociation constant of 0.896 ms(-1).

198 ing fluorescence anisotropy, we determined a dissociation constant of 1.0 mum and a strict requiremen

199 microarray experiment predicted an apparent dissociation constant of 1.33 muM for the PPI.

200 +/- 3.6% radiochemical yield and exhibited a dissociation constant of 1.5 +/- 0.5 nM.

201 lized aptamer for thrombin was raised with a dissociation constant of 1.6 nM.

202 strongest binding to a hemagglutinin trimer (dissociation constant of 1.6 x 10(-7) M) and afforded th

203 Purified ELK1 and AR bound with a dissociation constant of 1.9 x 10(-8) m A purified mutan

204 ed using absorbance at 525 nm to determine a dissociation constant of 13 mum Steady-state oxygen cons

205 ith a simple kinetic mass action model, a 2D dissociation constant of 1753 +/- 243 mum(-2) (correspon

206 (18)F-FHNP had a dissociation constant of 2 nM and maximum binding capaci

207 alcium-dependent manner, with an equilibrium dissociation constant of 2-5 muM in the calcium-bound fo

208 stereoselective activity was revealed, and a dissociation constant of 2.7 nM was determined for the m

209 against Mcl-1, resulting in a peptide with a dissociation constant of 2.9nM for binding to KSBcl-2 an

210 R2 interaction by binding to Sestrin2 with a dissociation constant of 20 micromolar, which is the leu

211 ence correlation spectroscopy, we measured a dissociation constant of 20 nM between EGFP-labeled LcrV

212 a (64)Cu-DOTA-anti-periostin-F(ab')2 with a dissociation constant of 29.2 +/- 3.0 nM.

213 D5 bound to tubulin with a dissociation constant of 29.4 +/- 6 muM.

214 A dissociation constant of 3 mum was estimated for a putat

215 of 18 fmol/10(6) cells, and (18)F-FES had a dissociation constant of 3 nM and maximum binding capaci

216 ZAP-2012 has a dissociation constant of 30 nM against these cells.

217 NSAH binds to hRRM1 with an apparent dissociation constant of 37 microM, and steady-state kin

218 S, and we estimated an hsc-70/PS equilibrium dissociation constant of 4.7 +/- 0.1 mum.

219 It is characterized by a dissociation constant of 40 mum at pH 5.9 and is highly

220 he highest binding affinity to BTX-2, with a dissociation constant of 42nM.

221 ctin domain of LecRK-I.8 binds NAD(+) with a dissociation constant of 436.5 +/- 104.8 nM, although mu

222 DORN1 binds ATP with high affinity (dissociation constant of 45.7 +/- 3.1 nanomolar) and is

223 F-FPyKYNE-losartan bound with high affinity (dissociation constant of 49.4 +/- 18.0 nM and maximal bi

224 ditions used for biochemical analysis with a dissociation constant of 5 nM, but the pro-domain can be

225 ta-estradiol (E2) was isolated by SELEX with dissociation constant of 50 nM and tethered to the surfa

226 TPX2 bound to microtubules with an apparent dissociation constant of approximately 200 nm, and micro

227 The final aptamer has a dissociation constant of approximately 35 nM.

228 complex by binding directly to SAMTOR with a dissociation constant of approximately 7 muM.

229 ave substantial reduction in the equilibrium dissociation constant of binding (KD) of hMPG toward 1,N

230 The dissociation constant of carbonylated recombinant MyBPC

231 oichiometry, copper oxidation state, and the dissociation constant of human amylin-copper(II) complex

232 o hemagglutinin H5 of avian influenza with a dissociation constant of K(D) = 446 nM and an inhibitory

233 s a sequence-specific PNA-RNA triplex with a dissociation constant of less than 1 nm at physiological

234 2 bound to human and cynomolgus PD-L1 with a dissociation constant of less than 35 pM, as measured by

235 tionally, the data indicate that the kinetic dissociation constant of M-NTA complexes in the resin la

236 The dissociation constant of the best aptamer, designated as

237 A fit to the law of mass action reveals the dissociation constant of the binding reaction.

238 Energy consumption can indeed decrease the dissociation constant of the chaperone-substrate complex

239 The equilibrium dissociation constant of the dimeric clamp varies with s

240 The dissociation constant of the IFT46-ODA16 complex was 200

241 oncentration is significantly lower than the dissociation constant of the initially formed reversible

242 The dissociation constant of the ligand-aptamer complex was

243 Studies were conducted to determine the acid dissociation constant of TPT's phenolic -OH and intercon

244 rprisingly, these mutants did not affect the dissociation constant of ubiquinone or its analog HQNO (

245 We measured the dissociation constant of VSV polymerases from their whol

246 1753 +/- 243 mum(-2) (corresponding to a 3D dissociation constant of ~30 muM) was obtained for the b

247 -GATOR2 complex by binding to CASTOR1 with a dissociation constant of ~30 muM, and its arginine-bindi

248 followed a Hill-type function with apparent dissociation constants of 1-5 nM, and 4 Ca(2+) binding s

249 on disulfide monolayers yielded equilibrium dissociation constants of 1.4x10(-7)M.

250 from 3 to 31 min for seven Immucillins with dissociation constants of 115 to 6 pm Treatment of human

251 pair of Ca(2+) binding sites with identical dissociation constants of 5.03 muM, (ii) a Ca(2+)-depend

252 ition-state analogues of H. pylori MTAN with dissociation constants of 50 pM or below.

253 The dissociation constants of albumin-binding of our lipidat

254 B310-672) directly binds PNAG oligomers with dissociation constants of approximately 1-3 mM, and the

255 We have determined the dissociation constants of binding between the lipidated

256 Fos and c-Jun, which allowed us to determine dissociation constants of c-Fos homodimers (Kd = 6.7 +/-

257 tochastic analysis was used to determine the dissociation constants of CPR/CYP2C9 complexes in a lipi

258 Dissociation constants of GG-X-GG and X5 peptides (X = G

259 udy, the effect of the ionic strength on the dissociation constants of six different noncovalent comp

260 s could potentially be used to determine the dissociation constants of surface-bound biomolecules.

261 thoxy)cinnamoyl]-1,5-gamma-quinide), finding dissociation constants of the albumin-chlorogenic acids

262 Because the dissociation constants of the dimer and tetramer are ver

263 in the upstream regulator are far below the dissociation constants of the regulated genes, as with i

264 raction was selected taking into account the dissociation constants of these arsenic species in diffe

265 an be used for the accurate determination of dissociation constants of weak protein-ligand complexes.

266 with 1:1 stoichiometry at a KD (equilibrium dissociation constant) of 1.5 muM.

267 mon resonance (SPR) to determine the binding dissociation constant (off-rate, kd) for compounds bindi

268 tudies showed that all three antibodies have dissociation constants on the order of 10(-7).

269 The low value of equilibrium dissociation constant or affinity unit (KD) showed high

270 pH than His37 in AM2, indicating larger acid-dissociation constants or lower pKa's.

271 A hydrogen-bonded, pKa (where Ka is the acid dissociation constant)-perturbed pair of conserved aspar

272 asic covariates, like lipophilicity (log P), dissociation constant (pK(a)), and polar surface area (P

273 d by volume ratios, we use the apparent acid dissociation constant, pK', as a proxy for intersystem c

274 y, theoretical results indicate aqueous acid dissociation constant (pKa) values of 1.5 +/- 1 for NH3C

275 15)N intensities yielded two resolved proton dissociation constants (pKa's) of 7.1 and 5.4, which dif

276 protonation of carboxyl groups with low acid dissociation constants (pKa) as the main contributors to

277 ing is of high specificity and affinity with dissociation constants ranging between 22.1 and 32.2 nM.

278 d affinities for 19 individual peptides with dissociation constants ranging from 0.1 to 60nM.

279 zine fluorescent K(+) sensor (KNIR-1) with a dissociation constant suited for detecting changes in in

280 CPR(ox)/CYP2C9 complexes have a much higher dissociation constant than CPR(2-)/CYP2C9 or CPR(4-)/CYP

281 ble interaction, resulting in a subnanomolar dissociation constant that is similar to that observed b

282 ovel tandem tetramers bound with a nanomolar dissociation constant to 24 bp sequences made up of four

283 The Fab (BRG) binds with 20nM dissociation constant to a single-stranded RNA (ssRNA) s

284 igands and that it binds a fatty acid with a dissociation constant typical of lipid transporter prote

285 The corresponding dissociation constant value for the acetylated version o

286 For the peptide Tyr-Leu-Ala, the equilibrium dissociation constant value is 7.2 nM, whereas that of i

287 ero-3-phosphocholine) yielded an equilibrium dissociation constant value of Kd = 180 +/- 47 mum for t

288 The dissociation constant value was 387.7 +/- 97.9 nM for Cy

289 The dissociation constant values are 3-10 muM for MelB(St) a

290 series of affinity mutants was selected with dissociation constant values of 0.08 to 11 mm, which spa

291 d both human and bovine fibronectin with Kd (dissociation constant) values of 22 and 33 nM, respectiv

292 ARRDC3 PPXY-Nedd4 WW dissociation constants vary from unmeasurable to Kd = 3

293 raction was 0.2%; thus, the tracer's in vivo dissociation constant was estimated to be 55 pM.

294 ximum number of binding sites x affinity [(1/dissociation constant]) was determined using in vitro ho

295 tamers with high-nanomolar to low-micromolar dissociation constants were achieved after only three ro

296 ty of the method for subsequent analysis and dissociation constants were calculated as 3.24-5.24x10(-

297 ectrometry and a label-free assay from which dissociation constants were calculated.

298 in to 11CR and opsin has a 25-pM equilibrium dissociation constant, which corresponds to only 0.3 kca

299 t M1 (A213) exhibits an almost twofold lower dissociation constant with its primary target human neut

300 SK.Pg* and SK.Pm formation yielded rate and dissociation constants within 2-fold of those determined