ライフサイエンスコーパス: dissociation rate

1 ing kinetics is characterized by a very slow dissociation rate.

2 ate phosphorylation through increases in ADP dissociation rate.

3 triplex stability by decreasing the triplex dissociation rate.

4 72K) decreased DNA binding by increasing the dissociation rate.

5 al transporter EAAT3 as a result of a slower dissociation rate.

6 ntial occupation was observed despite a high dissociation rate.

7 urement of the dissociation constant and the dissociation rate.

8 1 nm primarily because of a decrease in the dissociation rate.

9 T1-TPP1 bound to the primer decreased primer dissociation rate.

10 iciency with which IkappaBalpha enhances the dissociation rate.

11 e mutations produce changes primarily in the dissociation rate.

12 is consistent with a 4-fold increase in its dissociation rate.

13 stability to autoxidation and similar oxygen dissociation rate.

14 g by a greater-than-sixfold reduction of the dissociation rate.

15 effects of SRI-compounds on cocaine-mediated dissociation rate.

16 association rate with no major change in the dissociation rate.

17 lecular interactions and increases GPIbalpha dissociation rate.

18 aM with an associated increase in the Ca(2+) dissociation rate.

19 cal parameters such as enzymatic binding and dissociation rates.

20 NPs, they can exhibit different association/dissociation rates.

21 A-protein binding through increasing protein dissociation rates.

22 binding within the nucleosome by decreasing dissociation rates.

23 iation (approaching the diffusion limit) and dissociation rates.

24 primarily derives from large differences in dissociation rates.

25 ates to be used for examining solute-protein dissociation rates.

26 luable for the determination of drug-protein dissociation rates.

27 gonists displayed a range of association and dissociation rates.

28 ctions have low binding affinities and rapid dissociation rates.

29 n through alteration of both association and dissociation rates.

30 hanical feedback between MyoII advection and dissociation rates.

31 al parameters that determine association and dissociation rates.

32 nce-specific changes in both association and dissociation rates.

33 he 38 lead compounds altered the radioligand dissociation rate, a hallmark of allosteric behavior.

34 residue in the enzyme seems to increase the dissociation rate, although the drug retains its inhibit

35 hus leverages the wide variation in membrane dissociation rates among different gamma-subunit types t

36 The CD44s-fibrin pair has a lower unstressed dissociation rate and a higher tensile strength than CD4

37 Guided by a kinetic model, the oligomer dissociation rate and equilibrium constants were seen to

38 the proximal heme pocket, restored normal O2 dissociation rate and equilibrium constants, and reduced

39 both isomeric forms resulting in a slower NO dissociation rate and much higher stability than Hb(III)

40 , W50Pra]Ts1 for Nav with high affinity, low dissociation rate and reduced toxicity while retaining t

41 ons is achieved with both an increase in the dissociation rates and a decrease in the rate of peptide

42 CI in vitro, including affinity, association/dissociation rates and binding ratio.

43 saccharide chains of peptidoglycan, reducing dissociation rates and increasing binding affinity.

44 Our extensive measurements of dissociation rates and specific-nonspecific relative bin

45 t-translocation state by decreasing the dNTP dissociation rate, and increased the affinity for pyroph

46 haracterizing their apparent association and dissociation rates, and for determining their relative i

47 , while the stability of the complex and its dissociation rate appear to be influenced by the chemist

48 rate approximately 2-fold and increasing the dissociation rate approximately 10-fold, implicating thi

49 The association and dissociation rates are 81 microM(-1) s(-1) and 32 s(-1),

50 exponential decay model, from which relative dissociation rates are determined for all peptides with

51 Dissociation rates are determined from interfacial resid

52 ilarly affected by pH at both ends, although dissociation rates are differentially affected.

53 The initial SF and subsequent triplet pair dissociation rates are found to be more rapid in the mon

54 Yet, the dissociation rates are nearly the same for both iRBC-rec

55 The requisite microcanonical dissociation rates are obtained from ab initio transitio

56 tional state, greatly increasing the product dissociation rate as compared to the intrinsic pathway t

57 in filaments, Aip1 also augments the monomer dissociation rate at both the barbed and pointed ends of

58 This model explains the faster dissociation rate at higher ionic strengths that may ass

59 hrough mutation reduces both association and dissociation rates by factors of ~10(4), while minimally

60 g the possibility of deliberately increasing dissociation rates by incorporating hairpins into single

61 at regulate TF dynamics in vivo and increase dissociation rates by orders of magnitude are not known.

62 to VLA-4 integrin, modulation of the ligand dissociation rate can be observed for different LFA-1 af

63 mass-action model, in which association and dissociation rate coefficients are concentration-depende

64 ng molecule, but with a significantly faster dissociation rate compared to the tetraintercalators.

65 and by contrast, the 15-fold decrease of the dissociation rate concurs to stabilize the pentameric co

66 onic phospholipid reduced the myo1c(IQ-tail) dissociation rate constant >50-fold but marginally chang

67 ensity (Bavail) and the apparent equilibrium dissociation rate constant (1/appKD) under in vivo condi

68 The reduction in K(d) results from a reduced dissociation rate constant (from 16 s(-1) to 0.3 s(-1) i

69 in reduced values for ATP-induced actomyosin dissociation rate constant (K(1)k(+2)) and ADP affinity

70 The association rate constant (k(on)) and dissociation rate constant (k(off)) for eIF4F binding to

71 ecovery after photobleach indicated that the dissociation rate constant (k(off)) for f-PPE was signif

72 study the association rate constant (k(on)), dissociation rate constant (k(off)), and equilibrium dis

73 The dissociation rate constant (k(off), s(-1)) of each multi

74 g both the association rate constant and the dissociation rate constant at the necessary ratio to cre

75 ons of fenofibrate were able to increase the dissociation rate constant for [(3)H]-CP55940 at the CB1

76 low membrane dissociation and an increase of dissociation rate constant for a construct lacking the a

77 = 6.1 x 10(-7) cm(-1) s(-1)), along with the dissociation rate constant for the [Re]-Y-betaC19-alpha2

78 ferent DNA concentrations, we determined the dissociation rate constant for the specific complex and

79 /- 0.2 as [O(2)] --> infinity suggesting the dissociation rate constant from the PHM x BIAA complex d

80 om the reaction medium and the fact that its dissociation rate constant is non-significantly differen

81 The dissociation rate constant kd (off-rate) is the componen

82 onstant kon and no significant effect on the dissociation rate constant koff.

83 nstant of k(+) = 5 x 10(5) M(-1) s(-1) and a dissociation rate constant of <3s(-1).

84 A dissociation rate constant of 2.7 (+/-0.2) s(-1) was obt

85 P-perturbed M230 resonance, and enhances the dissociation rate constant of the NVP, resulting in an i

86 The rate-limiting dissociation rate constant of the tetra-intercalator com

87 The dissociation rate constant of the TWEAK-Fn14 interaction

88 was increased from 50 to 300 mm, whereas the dissociation rate constant was increased 2-fold.

89 ions, such as the association rate constant, dissociation rate constant, affinity constant, as well a

90 ffinity was mainly due to an increase in the dissociation rate constant, but a significant decrease i

91 When efficacy was compared with the dissociation rate constant, however, the two were highly

92 ffinity was largely due to a lowering of the dissociation rate constant, Koff.

93 esis of allosteric residues affects only the dissociation rate constant, suggesting that binding foll

94 (1)), compensated by a correspondingly small dissociation rate constant.

95 iron, high oxygen affinity, and slow oxygen dissociation rate constant.

96 ygen affinity, and a relatively rapid oxygen dissociation rate constant.

97 al model, we are able to extract the dimer's dissociation rate constant.

98 Carbon monoxide dissociation rate constants (k(-CO)) and corresponding a

99 , DeltaH degrees , DeltaS degrees ) and O(2) dissociation rate constants (k(-O(2)), DeltaH(double dag

100 direct determination of the association and dissociation rate constants (k(a) and k(d), respectively

101 4 and 15 were similar to those for ID 1, but dissociation rate constants (k(d)) were 4- to 10-fold hi

102 um binding constants (K(eq)) and association/dissociation rate constants (k(on) and k(off)).

103 nstants (Ka) or global affinities (nKa') and dissociation rate constants (kd) for testosterone with s

104 ) approximately 10(4)-10(5) M(-1) s(-1), and dissociation rate constants (koff) approximately 10(-4)-

105 st affinity extraction to determine both the dissociation rate constants and equilibrium constants fo

106 ns of thrombin, and provides association and dissociation rate constants and equilibrium dissociation

107 SPR allows for analysis of association and dissociation rate constants and modeling of biomolecular

108 ular interaction (namely the association and dissociation rate constants and the association constant

109 Because the dissociation rate constants are 3-10 times faster than t

110 been able to show that both association and dissociation rate constants are decreased when a partner

111 tudies yield the values of hybridization and dissociation rate constants as 9.6 x 10(4) M(-1) s(-1) a

112 Ferric heme association and dissociation rate constants at 10 degrees C were as foll

113 ws weaker salt dependence of the binding and dissociation rate constants compared with AmPrbetaCD.

114 The measured dissociation rate constants for BLIP-II and various beta

115 d that they all have similar association and dissociation rate constants for complex formation, despi

116 sive collection of published equilibrium and dissociation rate constants for CuFS and NiFS complexes,

117 or rapid association rate constants and slow dissociation rate constants for ligand binding.

118 embranes to measure both the association and dissociation rate constants for O1 and O4 antibodies bin

119 Both association and dissociation rate constants for these ligands are obtain

120 t molecules, and the agonist association and dissociation rate constants from both the closed- and op

121 veral YFP variants and detect slow kinetics (dissociation rate constants in the range of 0.1-1 s(-1))

122 confirmed these results by showing increased dissociation rate constants induced by Pepcan-12.

123 M(-1) s(-1) for monomers and heterodimer and dissociation rate constants k(-1) of approximately 9 x 1

124 Association and dissociation rate constants obtained for a reversible pr

125 The dissociation rate constants obtained for soluble HSA wit

126 In the absence of competitive ligands, the dissociation rate constants of ABA-X-BY630 from A(1) and

127 nging from 2 x 10(-6) M to 2 x 10(-9) M, and dissociation rate constants of approximately 6 s(-1) to

128 t separation and purification by determining dissociation rate constants of compounds in crude reacti

129 The association and dissociation rate constants of the agonists were determi

130 Lower limits for the very high formation and dissociation rate constants of the model 1:1 pyridine-he

131 Conversely, the dissociation rate constants of the ternary complexes var

132 tes, there were hardly any variations in the dissociation rate constants of these molecules with resi

133 In sharp contrast, however, dissociation rate constants prove to be exponentially se

134 ower for the W51H mutants, while the cyanide dissociation rate constants range from 3 times slower to

135 xes in a DGT system was used to estimate the dissociation rate constants that provided the best agree

136 (Phi), and the acetylcholine association and dissociation rate constants were approximately temperatu

137 The antibody-antigen association and dissociation rate constants were determined for the anti

138 Calcium dissociation rate constants were determined for the visi

139 tant alphaG153S, the choline association and dissociation rate constants were temperature-dependent (

140 The measured spontaneous dissociation rate constants were validated with SPR usin

141 ly quantify antibody-antigen association and dissociation rate constants, kon and koff, in a single e

142 ly measures antibody-antigen association and dissociation rate constants, kon and koff.

143 es with variation in affinity due to altered dissociation rate constants, suggesting that changes in

144 ly longer than predictions based on chemical dissociation rate constants, suggesting that SH2 modules

145 ach other only in oxygen affinity and oxygen dissociation rate constants, two factors key to their di

146 ence spectroscopy to measure association and dissociation rate constants, we show that hydrophobic in

147 nding kinetic constants, the association and dissociation rate constants, yields k(a) of (7.21 +/- 0.

148 whereas mutation of charged residues affects dissociation rate constants.

149 nce, was fast, with high association and low dissociation rate constants.

150 ten fold), with no effect on the microscopic dissociation rate constants.

151 association rates to the D2 receptor, while dissociation rates correlate with prolactin elevation.

152 Here we show that association rates, but not dissociation rates, correlate with EPS.

153 activation, such as effector activation and dissociation rates, correspondingly affected the time to

154 Our results suggest that dissociation rates could account for the recently descri

155 It is also observed that the dissociation rate decreases after heat shock, whereas th

156 concentrations that SRP-RNC association and dissociation rates depend on nascent chain length and th

157 dissociation with two distinct regimes: the dissociation rate depends weakly on the applied force at

158 tions that dramatically altered the ligand's dissociation rate despite only marginally influencing it

159 alization experiments can accurately measure dissociation rates despite their limited spatiotemporal

160 The dNTP association and dissociation rates do not vary as a function of voltage,

161 nd its selectivity manifests in differential dissociation rates; e.g., the protein releases a 2-Amino

162 Pulsatility emerges at intermediate dissociation rates, enabling convergent advection of Myo

163 ding two PIP molecules as evident by a lower dissociation rate for Atg18 in comparison with its PIP b

164 Second, we determined a very slow dissociation rate for ilicicolin (k = 1.2 x 10(-3) s(-1)

165 D-1 is principally due to the 3-fold smaller dissociation rate for PD-L2 binding.

166 We observe both a remarkably low dissociation rate for wild type HCV NS5B, and a highly d

167 The apparent dissociation rates for cTn were 5 x 10(-3) min(-1), 150

168 ha-thio elemental effect of 1.5, varying DNA dissociation rates for the binary complex (0.043 s(-1))

169 Microscopic dissociation rates for the chimeric mutants (~10 s(-1))

170 nt frequencies and corresponding binding and dissociation rates for the different Rev-RRE stoichiomet

171 resonance analyses revealed 33 times faster dissociation rates for the LVXEF ligand when compared wi

172 measuring THRX-198321-evoked changes in the dissociation rates for the orthosteric radioligands, [N-

173 ata, we derived estimates of association and dissociation rates for the test set of antagonists, iden

174 solution, provides evidence that the subunit dissociation rate from a microtubule tip increases as th

175 le assembly kinetics assume that the subunit dissociation rate from a microtubule tip is independent

176 containing one specific binding site to the dissociation rate from DNA fragments containing two spec

177 r trimer nucleus formation, faster phosphate dissociation rate from polymerized actin, and faster nuc

178 not cytotoxic, and showed substantially long dissociation rates from PLA2.

179 in rigor myofibrils was used to estimate Tn dissociation rates from the nonoverlap and overlap regio

180 the corona proteins based on their relative dissociation rates from the NPs was developed, employing

181 Normalization of the apparent dissociation rates gives 1:30:50 for cTn compared with 1

182 xtracted for a wide range of association and dissociation rates, gradient slopes, and curvatures, and

183 y weakly dependent on sequence; however, the dissociation rate greatly increases from <0.006 s(-1) to

184 determination of association rate constants, dissociation rates have received less attention.

185 of the salt concentration dependence of the dissociation rate, however, shows that the predictions f

186 binders had subnanomolar affinities with low dissociation rates (i.e., kd values around 1 x 10(-3) s(

187 be observed for compounds with modestly slow dissociation rates (i.e., residence times >0min but </=2

188 -Boltzmann effects can influence the overall dissociation rate in the gas.

189 The higher cTn dissociation rate in the nonoverlap region and ATPase ac

190 ombined with measurements of in vitro Ca(2+) dissociation rates in fully reconstituted WT and cardiac

191 T) can provide direct information on complex dissociation rates in natural waters.

192 a bonds that show high dynamicity (high bond dissociation rate), in the form of either linear polymer

193 The Y390F dissociation rate increase is suppressed when complexes

194 nd that because both the association and the dissociation rates increase at higher free subunit conce

195 pidly bind PAC-1 from 2-90 min, although the dissociation rate increased at later times, indicative o

196 Dissociation rates increased linearly with constant forc

197 tions (millimolar MgATP), not only the dimer dissociation rate increases, but also the dimerization r

198 e characterized by fast association and slow dissociation rates, indicating formation of stable compl

199 slocation rates and the dNTP association and dissociation rates, individually at each dNTP concentrat

200 Thus, the slower SQ(-) dissociation rate is a direct physical consequence of th

201 relationship between hotregion size and the dissociation rate is also investigated and, using hotspo

202 ting, but at approximately 90 s(-1), the ADP dissociation rate is comparable to the 30 s(-1) k(cat).

203 accessible to nuclease digestion and RAD-51 dissociation rate is reduced.

204 However, a relatively slow dissociation rate is required for the proposed deaminase

205 and dissociation constant (Kd), but not the dissociation rate (k off) from the target, by concentrat

206 s decreased from 4 to 1 nucleotide (nt), the dissociation rate (k(off) ) for P-site tRNA increases by

207 mmaretroviral enzyme has a remarkably higher dissociation rate (k(off)) from DNA, which also results

208 y, the effects of ribosomal mutations on the dissociation rate (k(off)) of various tRNAs from the P s

209 epend not only on monovalent association and dissociation rates (k(off) and k(on)), but also on a mul

210 Slower dissociation rates (koff) of the lead compounds were obs

211 timer technology, we quantified the TCR:pMHC dissociation rates (koff) of tumor-specific vaccine-indu

212 , still allow formation of a stable complex (dissociation rate <0.006 s(-1)), suggesting that extreme

213 ces sometimes exceeds the enhancement of the dissociation rate measured in pulling experiments, indic

214 alysis of relaxation dispersion data and THF dissociation rates measured by stopped-flow spectroscopy

215 ich represent the fastest Xe association and dissociation rates measured for a high-affinity, water-s

216 ate of 0.0016 +/- 0.0001 muM(-1) s(-1) and a dissociation rate of 0.00020 +/- 0.00005 s(-1) at 37 deg

217 ued motor integrity, and calculated a stator dissociation rate of 0.038 s(-1).

218 The dissociation rate of 3 nM BODIPY-TMR-CGP was 0.09 +/- 0.

219 41 or SRI-30827 following cocaine slowed the dissociation rate of [(3)H]WIN35,428 binding in WT hDAT

220 A dependence of the dissociation rate of a DNA-protein complex on competitor

221 Here, assessment of the dissociation rate of a fluorescent analog of CGP 12177 [

222 We further observed a strong increase in the dissociation rate of adsorbed CO upon exposure to hydrog

223 Loss of spliceosome subunits increases the dissociation rate of cohesin from chromatin and abrogate

224 ut through short-range effects that slow the dissociation rate of ColE9 TBE from its complex with Tol

225 rbed end, causing a 300-fold increase in the dissociation rate of CP from the end (i.e. uncapping).

226 ted that IkappaBalpha markedly increases the dissociation rate of DNA from NF-kappaB.

227 A low dissociation rate of DNAJB6 from Abeta42 aggregates lead

228 We find that the dissociation rate of EcoRI-DNA-specific complexes at 80

229 tidine, His27, which may increase the proton-dissociation rate of His19.

230 Because of the exceptionally slow dissociation rate of IgE-FcepsilonRI complexes, such all

231 We determined that the product dissociation rate of MPG at the hotspot codons was appro

232 emonstrating that IkappaBalpha increases the dissociation rate of NF-kappaB from the DNA in a highly

233 constant >50-fold but marginally changed the dissociation rate of phospholipase C-delta, suggesting t

234 n binding but by dramatically increasing the dissociation rate of protein complexes from their DNA-bi

235 iffusion along DNA based on the ratio of the dissociation rate of protein from DNA fragments containi

236 Using steady-state approximations, the dissociation rate of PS in cavitating bubble systems was

237 These Ca(2+)-induced events decrease the dissociation rate of synaptotagmin-1 membrane binding wh

238 is probably due to a significant increase in dissociation rate of the antagonist in the presence of B

239 Because FBI-GS significantly reduced the dissociation rate of the GlnR-DNA complexes, the stabili

240 ional diffusion during active unwinding, the dissociation rate of the helicase also exhibits sequence

241 xtent of Hsc70 association with CFTR nor the dissociation rate of the Hsc70-CFTR complex.

242 The dissociation rate of the met-alpha.AHSP complex (k(AHSP)

243 , causing reduced stability and an increased dissociation rate of the mutant complex as compared with

244 lly decreased that for GDP by increasing the dissociation rate of the nucleotide.

245 We measured the overall dissociation rate of the polymerase-DNA complex and the

246 tion system is kinetically controlled by the dissociation rate of the stabilized N-RNAP complex.

247 Here we examine the subunit dissociation rate of the trimeric membrane enzyme, diacy

248 s and revealed alphaIIbbeta3 association and dissociation rates of 4500+/-100s(-1) and 2.1+/-0.1s(-1)

249 o1 current kinetics provided association and dissociation rates of 7.0 x 10(5) M(-1) s(-1) and 0.11 s

250 The dissociation rates of Cas and two other adhesion molecul

251 ong timescales despite the rapid binding and dissociation rates of Dps.

252 tion of the channel by increasing the proton dissociation rates of His-19.

253 These measurements reveal the microscopic dissociation rates of HMGB from DNA.

254 ric-based measurements of monomeric TCR-pMHC dissociation rates of living CD8(+) T cells on a wide av

255 and between predicted IC(50) values and true dissociation rates of peptide-MHC class II complexes.

256 aminoacyl-tRNA substrate, a study measuring dissociation rates of several misacylated tRNAs containi

257 ta yield reliable values for the spontaneous dissociation rates of single-molecule specific bonds, an

258 We show that the arrival and dissociation rates of SRP binding to RNCs vary according

259 rmined equilibrium constants and association/dissociation rates of the chromophores with free tryptop

260 the SPIONs were collected regardless of the dissociation rates of the complexes.

261 This was accomplished by measuring the DNA dissociation rates of wild-type AraC and heterodimeric A

262 The dependence of the dissociation rate on applied force was obtained using pr

263 ated an exponential dependence of the unit's dissociation rate on the force delivered to the rotor.

264 advances in kinetic models to predict alkane dissociation rates on solid surfaces.

265 e bound complex of pKID:KIX via altering the dissociation rate, phosphorylation can facilitate effect

266 3 + 1) hybrid structure is controlled by the dissociation rate, rather than the association rate of l

267 ) and Mn(2+) substantially decrease the dNTP dissociation rate relative to Mg(2+), while Ca(2+) also

268 DDX1 and adenylyl-imidophosphate, while the dissociation rates remained unchanged.

269 tablishes two stable regimes of high and low dissociation rates, resulting in MyoII planar polarity.

270 Transient complexes with fast association/dissociation rates showed distinct mobility change from

271 DRaCALA yielded a dissociation constant and dissociation rate similar to previously reported values.

272 s highly specific, with both association and dissociation rates strongly affected by epitope mutation

273 bicans cell surface (~2 nN) and showed a low dissociation rate, suggesting a highly stable bond.

274 site mutations caused a decrease in the dNTP dissociation rate, suggesting that they perturb Phi29 DN

275 s also provide estimates for force-dependent dissociation rates, suggesting that kinesin-1 and the mi

276 and in vivo We report in vitro PNP-inhibitor dissociation rates (t(1/2)) from 3 to 31 min for seven I

277 hese precomplexes are weak, with much larger dissociation rates than suggested elsewhere.

278 Direct transfer is characterized by a dissociation rate that depends on total DNA concentratio

279 ic and steric factors result in an effective dissociation rate that is approximately sevenfold slower

280 rimarily ascribed to the increase in exciton dissociation rates through the PCBDR/DNA interface and t

281 D2 receptors and integrates association and dissociation rates to calculate the net rate of reversal

282 a novel approach by relating the changes in dissociation rates upon mutation to the energetics and a

283 istance to 7 mol/L urea) and slower antibody dissociation rates using surface plasmon resonance.

284 resistance, respectively) and lower antibody dissociation rates using surface plasmon resonance.

285 saturation of fH binding to fHbp, even when dissociation rates varied over 10-fold.

286 At 20 muM Ca(2+), the dissociation rate was substantially lower, indicating in

287 e AB2 interaction had slower association and dissociation rates, was not saturable, and did not requi

288 B1 interaction had very fast association and dissociation rates, was saturable, and required an intac

289 t 37 degrees C, which represents the slowest dissociation rate we have observed for any beta2 adrenoc

290 These effects on the BODIPY-TMR-CGP dissociation rate were markedly enhanced in beta1-adreno

291 that for binding of fH to fHbp, and the MAb dissociation rates were >500-fold lower than that for fH

292 ments, and receptor-scaffold association and dissociation rates were adjusted to fit single-molecule

293 The apparent cTn dissociation rates were approximately 2-10-fold faster t

294 We found that 1), two-dimensional dissociation rates were comparable to three-dimensional

295 ith picomolar, whole blood activity and slow dissociation rates were discovered by incorporating an a

296 de interaction kinetics and showed that slow dissociation rates were mediated by large hydrophobic co

297 responsible for the cooperativity, while the dissociation rates were responsible for the anticooperat

298 ontrol the diffusional encounter but not the dissociation rate, which is critical for the establishme

299 SHIP1 SH2 domain having fast association and dissociation rates while the SHIP2 domain showing appare

300 ondition, only the proteins with slow enough dissociation rates would be collected with the NPs in th