ライフサイエンスコーパス: distal

1 one membrane-proximal and the other membrane-distal.

2 n and reciprocal duplication carriers of the distal 16p11.2 220 kb BP2-BP3 interval showed that these

3 ve disorders observed in human patients with distal 18q deletions, including the Tshz1 locus.

4 crystal structure of the complex between the distal (2B) helices of K1 and K10 to better understand h

5 heters (jugular vein, peritoneal cavity, and distal abdominal aorta).

6 ions are distinctly targeted by local versus distal acupuncture electrostimulation, acupuncture at lo

7 tial differential mechanisms of local versus distal acupuncture using diffusion tensor imaging of whi

8 s reduced symptom severity, verum (local and distal) acupuncture was superior to sham in producing im

9 Corresponding with this, proximal and distal ADCs were highest in patients with sDPN compared

10 ecorded for each patient (treated and mesial/distal adjacent teeth) at baseline (T0), 6 months after

11 hoalveolar lavage, large proximal, and small distal airway brushings were collected from patients wit

12 cells, and NK cells were found in the small distal airways in BOS compared with stable patients and

13 in proinflammatory proteins and IFN-alpha in distal airways.

14 sinophils into paratracheal lymph nodes from distal alveolar lung was diminished in leukotriene C4 sy

15 n one such approach, an understanding of the distal and geometric relationships between the functiona

16 st and second molars consistently lacked the distal and lingual cusps; this resulted in only a single

17 These findings show that distal and proximal disruptions of glycolysis have oppos

18 X10 and MITF and for chromatin remodeling at distal and proximal regulatory sites.

19 ucts), and outcomes (proximal, intermediate, distal) and applied retrospectively to NTP's research on

20 ain is either tightly packed at the membrane-distal apex or rotated into a receptor-accessible confor

21 collateral and temporoammonic inputs at the distal apical dendrites.

22 vity, which also triggers the acquisition of distal appendage markers on daughter centrioles and the

23 ue imaging and 3-dimensional analysis of the distal aqueous drainage tract (DT) in transgenic mice in

24 aspect, and 32.1%, 50.0%, and 17.9% on their distal aspect, respectively.

25 In addition to being expressed in the distal aspects of the nephron, where ENaCs couple the ab

26 acrestal in 46.9% of cases, whereas on their distal aspects, the same categorical positions were foun

27 nism of skeletal patterning along a proximal-distal axis has been an area of intense inquiry.

28 occurs in enterocytes along the proximal-to-distal axis of the small intestine.

29 isms of skeletal patterning along a proximal-distal axis.

30 cuole-associated BACE1 is accumulated in the distal axon of Alzheimer's disease-related mutant human

31 s established that nascent autophagosomes in distal axons move predominantly in the retrograde direct

32 imary isoform underlying TTX-r conduction in distal axons of somatosensory C-fibers.

33 rting nascent autophagic vacuoles (AVs) from distal axons toward the soma, where mature lysosomes are

34 microfluidic chambers to separate and injure distal axons, we show that axotomy causes retrograde den

35 ecificity wherein gRNA-DNA mismatches at PAM-distal bases modulate different biophysical parameters t

36 in relationship to the pathogenesis of human distal bile duct cancer (DBDC).

37 t how local PV interneurons communicate with distal brain regions to regulate NSCs and hippocampal ne

38 f AKAP350A, whereas Cep68 interacts with the distal C-terminal AKAP350A region.

39 An Ala mutation of the distal C-terminal Arg-354 or Ser-357, which forms a cons

40 ta-arrestin 1, and phosphorylated central or distal C-terminal peptides competed for association with

41 otein complexes demonstrated that central or distal C-terminal peptides competed for the CB1R associa

42 g the TAD alpha-helix but retaining the most distal C-terminal residues exhibited robust rhythms duri

43 prevented uptake of tau species, whereas the distal C-terminal-specific antibody (Tau46) had little e

44 t phosphorylation at threonine-468 of a CB1R distal C-terminus 14-mer peptide reduced CB1R-CRIP1a ass

45 ant tumors was more strongly associated with distal cancers.

46 nd C(sp(3) )-H bond cleavage gives access to distal carbon radicals that undergo SH 2 functionalisati

47 with intestinal-type duodenal, ampullary, or distal CBD adenocarcinomas had longer median overall sur

48 ients with cancers of the duodenum, ampulla, distal CBD, or pancreas, respectively (P = .01), indicat

49 and PD >/=4 mm were recorded, and mesial and distal CBL was measured on standardized digital radiogra

50 s can largely recapitulate TLR activation in distal cells in vitro.

51 tentially due to aberrant hypomethylation of distal CGIs, despite methylation at proximal promoters.

52 tes phosphatidylinositol 4,5-bisphosphate in distal cilia.

53 erence was more pronounced for cancer of the distal colon and rectum and for physicians with higher P

54 nd TNF-alpha expression were examined in the distal colon of 3, 12, 18 and 24-month old mice and faec

55 tnatal mouse bowel and transplanted into the distal colon of 3- to 4-week-old wild-type recipient mic

56 y-state short circuit current (Isc) in mouse distal colon tissue relative to controls.

57 ted significant spasmolytic activity (on rat distal colon), with PhPeITC being almost 100 times more

58 ilable, we observed 1264 proximal colon, 866 distal colon, and 670 rectal tumors.

59 Its role in the distal colon, which also absorbs salt and fluid and expr

60 ith proximal colon cancer and 690 cases with distal colorectal cancer matched by age and sex.

61 rk (total number of edges, n = 173) than the distal colorectal cancer network (n = 95) (P < 0.0001 in

62 roximal colon cancer network and 0.30 in the distal colorectal cancer network, indicating the greater

63 network of proximal colon cancer, but not in distal colorectal cancer.

64 involved in establishing the identity of the distal compartment before the initiation of branching mo

65 xert a "glycan remodelling" process, even at distal compartments.

66 uding hexasomes that lack either proximal or distal contacts.

67 e sodium-chloride cotransporter (NCC) in the distal convoluted tubule (DCT) is solely responsible.

68 the ROMK K(+) channel did not change in the distal convoluted tubule and decreased slightly in the c

69 e thick ascending limb of Henle (TAL) and in distal convoluted tubules (DCTs): Ksp-cre;Pth1r(fl/fl) M

70 rast, native cyt c is six-coordinate, as the distal coordination site is occupied by Met80.

71 Throughout exercise, distal coronary pressure and flow velocity and central a

72 erative phase, only axons that fuse to their distal counterparts contribute to functional recovery.

73 Deletion of the distal CTCF-binding site results in loss of Ramp3 expres

74 M2 distal cytoplasmic domain sequences were still required

75 Mutations in the distal cytoplasmic tail region of M2, and in particular

76 orally synchronized excitatory inputs at the distal dendrites could trigger plateau potentials in SPN

77 plasma membrane, although their presence at distal dendrites is controversial.

78 ing to a loss of a cytoskeletal mechanism in distal dendrites required for dendrite stabilization and

79 n the most lateral neuropil corresponding to distal dendrites while gephyrin puncta are enriched on n

80 rect input from entorhinal cortex onto their distal dendrites, these inputs produce a 5- to 6-fold la

81 ortical inputs onto CA2 compared with CA1 PN distal dendrites.

82 e the GNM to identify novel cross-correlated distal domains (CCDDs) representing pairs of regions dis

83 edian villous height to crypt depth ratio in distal duodenal biopsies was not significantly different

84 The distal early stripe element (DESE) mediates both activat

85 rns of tissue specificity, compare local and distal effects, and evaluate the functional properties o

86 l thalamic lesions in humans have widespread distal effects, disrupting the modular organization of c

87 the repression of hTERT gene was dictated by distal elements and its chromatin environment.

88 Our findings demonstrate that the distal end of the antithrombin A-sheet is crucial for th

89 The distal end of the eukaryotic flagellum/cilium is importa

90 ibosomes translating a U6A shift site at the distal end of the gag gene performing a programmed -1 ri

91 eric communication pathway that connects the distal end of the motor domain with the active site.

92 The importance of the 4'-phosphate at the distal end of the pantetheine arm is demonstrated to bot

93 optically absorbing coating deposited at the distal end.

94 e by DUB is faster if this linkage is at the distal end.

95 oplasmic continuity between the proximal and distal ends declines with age.

96 curs when a contact is predicted between the distal ends of a pair of adjacent stemloops but even wit

97 y to be disrupted by a mutation close to the distal ends.

98 A large number of distal enhancers and proximal promoters form enhancer-pr

99 ethod identifies three previously identified distal enhancers in maize, validating the new set of enh

100 lly determined accessibility was enriched at distal enhancers, but random monoallelically accessible

101 c regulation by GR preferentially occurs via distal enhancers, whose chromatin accessibility is typic

102 aled a highly unconventional H2O2-activating distal environment with the reactive propionic acids (2

103 expression remain unclear, particularly for distal eQTLs, which these studies are not well powered t

104 ves did not differ significantly between the distal esophageal mucosa of controls (median, 25.5 cell

105 trast swallow following total gastrectomy or distal esophagectomy cannot be recommended.

106 < 1 cm segment of columnar metaplasia in the distal esophagus, also called an irregular Z line, are e

107 Remarkably, the thermally active distal-exo adduct becomes inert under tension due to poo

108 Given that other painful conditions of the distal extremities (ie, neuropathy related to human immu

109 g a common biologic origin, likely to be the distal fallopian tube among all cases.High-grade serous

110 tensor imaging (DTI) and tractography in the distal femur and proximal tibia related to age, sex, and

111 se domain can then access a site 40 residues distal from the consensus sequence that collectively dir

112 munoglobulin domain of nectin-2 that is most distal from the membrane with an affinity of 6 mum, whic

113 e hinge region dynamics, which propagates to distal functional regions of the protein and modifies Ap

114 an endo or exo configuration and proximal or distal geometry, were activated in solution by ultrasoun

115 ove the graft longevity and patency rates at distal graft anastomoses.

116 am from cyclic GMP-gated cation channels and distal guanylate cyclases.

117 stigate the alterations of microbiota in the distal gut of pigs fed E. faecalis UC-100 substituting a

118 felt bigger, one oriented with the proximal-distal hand axis (Along orientation) and one oriented wi

119 se reaching to different locations can alter distal hand kinematics and grasping different objects ca

120 h the Gn of a genetically and geographically distal hantavirus, Puumala virus, indicating that the ob

121 umption was associated with a higher risk of distal (hazard ratio (HR) = 1.45; P = 0.02) but not prox

122 y provides mechanistic insights into how the distal heme ligand in neuroglobin caps its reactivity to

123 opathies such as Charcot-Marie-Tooth type-2, distal hereditary motor neuropathies, spinal muscular at

124 harcot Marie Tooth Disease type 2 (CMT-2) or distal hereditary motor neuropathy (dHMN).

125 cognised, including spinal muscular atrophy, distal hereditary motor neuropathy and LMN variants of f

126 cases from Australian, European, and Korean distal hereditary motor neuropathy families identified t

127 ferent ancestries and one additional Belgian distal hereditary motor neuropathy family of Caucasian o

128 Distal hereditary motor neuropathy is a heterogeneous gr

129 ified the same mutation in another Taiwanese distal hereditary motor neuropathy pedigree with differe

130 gh at least 15 genes have been implicated in distal hereditary motor neuropathy, the genetic causes r

131 more M2-like macrophages in the proximal and distal hind-limb muscles.

132 Mutation of the distal His(64) residue to alanine promotes rapid binding

133 different reaction options influenced by the distal histidine ligand.

134 Distal ileum tissues from patients with CD had lower lev

135 Distal ileum tissues were collected from mice; IECs and

136 ssive and active flexion of the proximal and distal interphalangeal joints were compromised, without

137 ndary coordination sphere of the outermost, "distal", iron-sulfur cluster.

138 (n = 6), and transcriptomic profiling of the distal (ischemia-affected) and proximal (non-affected) a

139 chains containing differential proximal and distal isotopic labels and measuring USP7 binding by nuc

140 ng entry point for Na(+) reabsorption in the distal kidney nephron and is regulated by numerous hormo

141 in the regulation of Na(+) transport in the distal kidney nephron.

142 nduced accumulation of Pip in inoculated and distal leaf tissue.

143 In the telencephalon, members of the distal-less (Dlx) homeobox gene family are expressed in,

144 7-oxidized/carbonylated protein has a vacant distal ligation site, and it represents the true peroxid

145 Their slender distal limb bones resemble those of Asiatic asses, such

146 in interaction profiles between proximal and distal limb bud cells isolated from mutant stocks where

147 In this unified TAD, both proximal and distal limb enhancers nevertheless continued to work ind

148 oised, but inactive state broadly across the distal limb mesenchyme.

149 p of inherited neuropathies characterized by distal limb muscle weakness and atrophy.

150 oblast growth factor (FGF) signalling in the distal limb primes the ZRS at early embryonic stages mai

151 ces between the 2 measurement approaches for distal, lingual, and buccal sites but not mesial.

152 nkers, associating more closely with the CTD-distal linker.

153 nd extends a newly-formed alpha helix to the distal loop where it forms protein interactions.

154 it can also trigger increased flexibility in distal loops in response to allosteric conformational ch

155 and migration in vitro and intrahepatic and distal lung metastasis in vivo of HCC cells.

156 that RBC-induced microvascular injury in the distal lung plays a central role in the development of l

157 esonance imaging that provide measurement of distal lung ventilation reflecting small-airway disease.

158 icial in mucosa from patients with NERD-both distal (median, 9.5 cell layers to surface; IQR, 1.5-13.

159 particular, a one-electron redox change at a distal metal site leads to a change in oxygen atom trans

160 nas, and Prevotella species-is maintained in distal metastases, demonstrating microbiome stability be

161 ound repression of prostate tumor growth and distal metastasis and substantially prolonged overall su

162 Distal metastasis of luminal breast cancer is frequent a

163 ritic membrane potential (DMP) from putative distal-most dendrites using tetrodes in freely behaving

164 on and with recovery of conduction block and distal motor amplitude suggesting a nodo-paranodopathy.

165 nt is required for HPRT1 expression and that distal mutations are unlikely to contribute substantiall

166 The scope and limitations of the distal N-group were investigated.

167 Deletion of the distal N-terminus (Delta2-135) accelerated off-gating cu

168 ctionally interact in the second part of the distal nephron (DCT2).

169 in the proximal tubule but decreased in the distal nephron because of diminished Na(+) delivery.

170 egments, including the aldosterone-sensitive distal nephron where the epithelial Na(+) channel (ENaC)

171 ending limb and in the aldosterone-sensitive distal nephron.

172 h encodes a prostaglandin transporter in the distal nephron.

173 The distal nephrons of females had a higher abundance of tot

174 We find that over 5000 distal noncoding regions exhibit dynamic changes in chro

175 et nucleotides, both in the seed and in more distal nucleotides, plus disruption of the protospacer a

176 Thus, patients with distal oesophageal cancer with coeliac node metastasis s

177 f the mutant allele, which disrupts the most distal of two polyadenylation sites.

178 sion of the articles' specific subjects, and distal ones, such as national Twitter conversation in br

179 ranscription start sites are associated with distal or inter-chromosomal caRNAs.

180 ir effects on secondary exosome secretion by distal organs have not been explored.

181 te of stimulus perception are transmitted to distal organs to elicit plant-wide responses.

182 wn to initiate at 2 alternative promoters, a distal P1 and a proximal P2 promoter.

183 ase selection factors for minimally invasive distal pancreatectomy (MIDP) and identify actual risk fa

184 tors for adverse outcomes compared with open distal pancreatectomy (ODP).

185 tients undergoing pancreaticoduodenectomy or distal pancreatectomy [POPF: pasireotide (n = 152), 9% v

186 n lead to injury and dysfunction of the most distal part of small sensory fibres in a length-dependen

187 on of the NHE3 at a single amino acid in the distal part of the C-terminus affects multiple aspects o

188 ximal part of the hearing organ while in the distal part of the organ, small organ and cap cell size

189 be achieved by varying the asymmetry of the distal part of the ovipositor by protracting one valve s

190 PAS, and others using both the proximal and distal PAS to differing degrees.

191 R based on use of either the proximal or the distal PAS, which differ in length by 100 bp.

192 s varied in the usage of the proximal versus distal PAS, with some alleles using only the proximal PA

193 to-adult transition is delayed, and proximal distal-patterning is abnormal in this mutant.

194 ud to direct outgrowth along the proximal to distal (PD) axis.

195 d action potentials (C-CAPs) of proximal and distal peripheral nerve segments and dorsal roots from m

196 ated de novo protein synthesis occurs within distal, perisynaptic astrocyte processes.

197 is, microphthalmia, short stature, and short distal phalanges.

198 e conventional Shc adaptors, ShcD suppresses distal phosphorylation of the Erk MAPK.

199 s primarily through the first, most membrane-distal, PKD domain (PKD1) of AAVR to promote transductio

200 imode optical fibres, each terminated with a distal polariser that ensures pre-determined output pola

201 Whether injury to the most distal portion of sensory small fibres due to a primary

202 ality characterized by absence of a variable distal portion of the hindlimbs.

203 ce, Sonic hedgehog (Shh) is expressed in the distal posterior mesenchyme, where it acts as a mediator

204 This strategy revealed early induction of distal pre-metastatic niches uncoupled from lymphangioge

205 paucity of mouse models for live imaging of distal pre-metastatic niches.

206 ODS AND cFFR, instantaneous wave-free ratio, distal pressure/aortic pressure at rest, and FFR were me

207 te slices demonstrates robust translation in distal processes.

208 The identification of mRNAs in distal projections of model organisms has led to the dis

209 ested whether genetic variants in the IL1RL1 distal promoter are involved in UC and affect glucocorti

210 g (n=48), BA and stenting (n=52), or DA with distal protection and bailout stenting (n=55).

211 The aim of this study was to compare the distal pulmonary vasculature of <2 mm in diameter in Sys

212 inputs to hippocampus, which target the very distal pyramidal neuron dendrites, provide an unusually

213 retic-induced sodium release did not undergo distal reabsorption.

214 of a DNA triplex and a repressor protein to distal recognition sites on supercoiled DNA minicircles

215 rectum resulting in a better exposure of the distal rectum and presumed better outcome.

216 The concomitant distal redistribution of FGF14 together with Nav and Kv7

217 we resolve active Hh/Smo output to a narrow distal regenerate zone comprising pObs and adjacent moti

218 n was still dependent on the presence of the distal region of the M2 cytoplasmic tail.

219 movements, and identify dynamically coupled distal regions along the chromosomes.

220 ed from intact nerves and from the wound and distal regions of severed nerves.

221 The proximal and distal regions of the lung contain epithelial cells spec

222 nd propagate both locally and into homotopic distal regions, and eventually invade all of visual cort

223 on is largely shared across tissues but that distal regulation is highly tissue specific.

224 Our results suggest that no singular distal regulatory element is required for HPRT1 expressi

225 In this study, we hypothesized that distal regulatory elements (DREs) are involved in optima

226 ction, and the physical interactions between distal regulatory elements and promoters.

227 in the nucleus involving gene promoters and distal regulatory elements are currently considered majo

228 s of enrichment filters in order to identify distal regulatory elements harboring putative driver mut

229 between transcriptional promoters and their distal regulatory elements play an important role in tra

230 with early-onset sensorineural deafness and distal renal tubular acidosis.

231 Whereas the infiltration of the proximal or distal resection margin is associated with poor survival

232 ons (CSPs) of each mutant reveal clusters of distal residues affected by acid loop mutation.

233 ns also hydrolyze derivative linkages on the distal ribose ring.

234 e and at follow-up examination 6 weeks after distal right internal mammary artery device closure.

235 lammation, malaria, and body mass index) and distal risk factors (e.g., education status, household s

236 l outside metropolitan boundaries and impact distal river ecosystems.

237 NCX1 palmitoylation is governed by a distal secondary structure element rather than by local

238 n in the proximal tubule and increased it in distal segments with lower energetic efficiency.

239 ased in the proximal tubule but increased in distal segments with lower transport efficiency with res

240 on of the unconventional myosin Dachs on the distal side of cells (nearest the center of the disc).

241 nts of grafted bone height at the mesial and distal side of each implant were taken, and the sinus fl

242 ctrostimulation, acupuncture at local versus distal sites may improve median nerve function at the wr

243 facilitating cancer invasion and seeding to distal sites.

244 y directly cleaves the 5' strand DNA at more distal sites.

245 ).Macronutrient delivery to the proximal and distal small intestine elicits different outcomes.

246 about the primary site of injury, namely the distal small intestine.

247 Distal sodium transport is a final step in the regulatio

248 ukotriene A4 hydrolase (LTA4H) catalyses the distal step in LTB4 synthesis and hence inhibitors of th

249 of either of an omphalocele, ectopia cordis, distal sternal defect, pericardial defect, anterior diap

250 evelopmental transitions that must occur for distal structures to arise from cells with proximal iden

251 of repair cells from chronically denervated distal stumps.

252 ous studies had implicated only the membrane-distal subdomain in ligand recognition.

253 mbrane-proximal ATPase domain and a membrane-distal substrate-recognition assembly.

254 lly interlock with soft tissues by selective distal swelling after skin insertion.

255 We report that, in the absence of distal target organs, molecular guidance cues can mediat

256 The inability to reach the distal target zone (n=48/100) or to reenter (n=43/100) m

257 f frequent systematic and narrative reviews, distal technologies have received scant attention.

258 Distal technologies refer to electronic systems designed

259 issues of global adoption, knowledge gaps in distal technology, and recommendations for future direct

260 ynamics in the GC with more MT growth in the distal than the proximal region of the GC during repulsi

261 The best treatment for fractures of the distal tibia remains controversial.

262 , displaced, extra-articular fracture of the distal tibia, neither nail fixation nor locking plate fi

263 DTI-MRN covered proximal (sciatic nerve) and distal (tibial nerve) nerve segments of the lower extrem

264 ristae and ridges on the plantar side of the distal tibiotarsus and proximal tarsometatarsus, as in e

265 ation of wild-type (WT) JE virus isolates at distal time points after vaccination.

266 -1/TGFbetaR signaling cascade in the gonadal distal tip cell (DTC), the germline stem cell niche, whe

267 We hypothesized that the human distal tip epithelium is an analogous progenitor populat

268 by the apical ectodermal ridge (AER) at the distal tip of the limb bud to direct outgrowth along the

269 ng of the joints occur simultaneously at the distal tip, implying that an integrated model is require

270 contributes to a traction peak near the FA's distal tip.

271 ll vessels, and this vaso-occlusion leads to distal tissue ischaemia and inflammation, with symptoms

272 ession of multiple HSR genes in proximal and distal tissues.

273 al cell-specific chromatin structure located distal to Cyp27b1 that mediates unique basal and parathy

274 ed according to whether they are proximal or distal to known promoters.

275 reatly reduced accumulation of Pip in leaves distal to P. syringae inoculation, they display a consid

276 There is consensus that, distal to peripheral nerve injury, myelin and Remak cell

277 t regulatory T-cell proliferation in tissues distal to site of lymphatic injury contributes to impair

278 positively charged nucleic acid binding site distal to the active center that plays a key role in sub

279 identified a kidney-specific control module distal to the Cyp27b1 gene that mediates the basal activ

280 idues within the RGS domain that are located distal to the Galpha-binding interface.

281 distribution, particularly within structures distal to the hindfoot.

282 changes in local metabolites, but not those distal to the infection site, by acting directly on host

283 l nerves, the myelin and Remak Schwann cells distal to the injury site reorganize and modify their pr

284 named because this pathotype infects tissues distal to the intestinal tract, is a frequent cause of s

285 ects and stress responses at unexposed sites distal to the irradiated tissue.

286 , isolated dilatation of the ascending aorta distal to the sinotubular junction, or diffuse dilatatio

287 new miRNAs that target these mRNAs at sites distal to the stop codon.

288 Blastemas only generate structures distal to their origin unless treated with retinoic acid

289 ial cytokeratin 8.18, proximal tubular CD10, distal tubular cytokeratin 7, and endothelial von Willeb

290 PLD4 to be overexpressed in the proximal and distal tubular epithelial cells of murine and human kidn

291 Mice lacking distal tubular expression of CLDN10, the gene encoding t

292 oop diuretics develop DR due to compensatory distal tubular sodium reabsorption, but whether this tra

293 egulated, and those in the loop of Henle and distal tubule lineages were downregulated.

294 ion of the collecting duct, proximal tubule, distal tubule, interstitial cells, and rarely glomerular

295 sal medium, differentiated into proximal and distal tubules as well as endothelium, as highlighted by

296 ally distinct WNK bodies were evident in the distal tubules of mice subjected to dietary potassium lo

297 Microperfusion of live renal distal tubules reveals that they are impermeable to wate

298 alized to tricellular tight junctions of the distal tubules.

299 tin structure that likely hindered effective distal V-DJ recombination.

300 The distal vagina also showed increased vascularization and