ライフサイエンスコーパス: distal region

1 urrounding region ~1 kb away from the break (distal region).

2 of pancreas and lighter inflammation in the distal region.

3 which is necessary for the formation of the distal region.

4 ification frequency (12.5%) observed for the distal region.

5 binding site was identified in the membrane-distal region.

6 s while the membrane-free cytb 5 also uses a distal region.

7 from the central region of the synapse to a distal region.

8 186R induces large chemical shift changes at distal regions.

9 control elements, divided into proximal and distal regions.

10 neurons without contribution of inputs from distal regions.

11 s from its centromere-proximal to centromere-distal regions.

12 ults in increased splicing noise, even in CB-distal regions.

13 ost of these loci being localized toward the distal regions.

14 omeric regions and tended to increase in the distal regions.

15 amens, the strongest defects are seen in the distal regions.

16 ntromeric regions and marker clusters in the distal regions.

17 nterference were present in interstitial and distal regions.

18 Nr, we found no evidence of neuronal loss in distal regions.

19 ctions involving 15,905 promoters and 71,984 distal regions.

20 ivation properties from Na+ channels in more distal regions.

21 romatic DNA, which is predominately found in distal regions.

22 the promoter-proximal, but not the promoter-distal, region.

23 pithelium into molar (proximal) and incisor (distal) regions.

24 and that most Ly49 genes are clustered in a distal region -1 Mb distant.

25 (-1300/-7) of the UGT1A1 promoter, but also distal region (-6500/-4050) were responsible for the ind

26 ing soil and for 61% of its recovery for the distal region 8 d after rewetting.

27 The distal region (-830 to -720 bp) of the rat whey acidic p

28 -4 located another HNF-4-binding site in the distal region, -89 to -54.

29 ting axons were characterized by an enlarged distal region, a thin trailing remnant, and sinusoidal b

30 itiation of XCI, Xist initially transfers to distal regions across the X chromosome that are not defi

31 Wingless produced in the wing's prospective distal region activates target genes in a dose-dependent

32 ual cell types, and even projections between distal regions, allows us to investigate functional conn

33 movements, and identify dynamically coupled distal regions along the chromosomes.

34 This distal region also contains seven out of the eight intra

35 The resting membrane potential of distal regions also appeared to be slightly but consiste

36 and the coactivators SRC-1 and SRC-2 to the distal region and basal promoter.

37 ns with a high density of mapped ESTs in the distal region and bins of low density in the proximal re

38 naling accompanies apoptosis of cells in the distal region and gland involution after androgen withdr

39 nsgenic studies presented here focus on this distal region and narrow it to 1116 bp between -1866/-75

40 j1 transcript expression was restricted to a distal region and overlapped with that of sodium-chlorid

41 was expected to differ between proximal and distal regions and between age groups.

42 nucleotide-dependent dynamical couplings of distal regions and residues potentially important for th

43 se development whereby NA nerves die back in distal regions and undergo a compensatory sprouting resp

44 had similar waveforms as slow waves in more distal regions and were coupled to phasic contractions.

45 scribed genes (promoter-proximal compared to distal regions) and the phosphorylation status of its CT

46 hose proximal to gene promoters and those in distal regions, and developed a web resource called Prox

47 nd propagate both locally and into homotopic distal regions, and eventually invade all of visual cort

48 ifferences between cells of the proximal and distal regions, and has implications for prostatic disea

49 ture of autocrine ligand vis-a-vis escape to distal regions, and provide experimental test by constru

50 except 9 and 12, affected both proximal and distal regions, and was most severe on chromosome 10 (70

51 t gene conversion events at the proximal and distal regions are relatively independent of one another

52 Specification of the distal region as mitotic relies on induction by the soma

53 ite at -127 bound Sp1, Sp3, and Sp4, and the distal region at -143 bound E2F-4-DP-1-p107.

54 The -1602 to -1534 distal region (bcl-2j) of the promoter was E2-responsive

55 cus ASP analyses revealed locus trios in the distal region between D21S270 and D21S171, with excess a

56 g defined two minimum regions of deletion: a distal region between the markers D15S514 and D15S537 at

57 ession of Bmp4 and Msx2 was preserved in the distal region, but shifted ventrally.

58 tting, HgCl2 decreased LP and L(R, S) of the distal region by 23% and 32%, respectively, but LP and L

59 e facilitates displacement synthesis through distal regions by increasing RT processivity in the vici

60 oth theoretically and experimentally whether distal regions can influence the metal center in the dia

61 tructure of Izumo1, which reveals a membrane distal region composed of a four-helix bundle connected

62 The distal regions contain numerous, short (<2 kb) segments

63 urther revealed specific binding of Sp1 to a distal region containing a canonical Sp1 site.

64 ts of a proximal glutamate-rich region and a distal region containing multiple phosphorylation sites.

65 Deletion of a more distal region disrupts apical sorting, resulting in a no

66 vivo even though the binding of NF-kappaB to distal region DNA was unaffected in vitro.

67 of activated receptors, whereas those to the distal regions do not.

68 of the Golgi complex is redistributed to the distal region during hyphal formation.

69 5' distal regions were often enriched in 3' distal regions, etc.

70 ly regulated and, in the wing and leg discs, distal regions exhibit cytoplasmic extradenticle whereas

71 nal axons, mitochondrial damage may occur in distal regions, far from the soma where most lysosomal d

72 emes resulted in splaying of doublets in the distal region, followed by oscillatory bending between p

73 Complete distal regions generally account for a 4- to 100-fold st

74 xtra-embryonic mesoderm of the yolk sac; the distal region generates cardiac mesoderm and node-derive

75 constitutive histone H3 acetylation in this distal region in primary human NK cells, which is enhanc

76 A distal region in the D2R third intracellular loop harbor

77 cial function of the highly conserved stem I distal region in tRNA recognition and report its 2.65-A

78 PPNP, protects probes in the active site and distal regions in the large and small lobes of the kinas

79 BRG1 binding was found at promoters and distal regions, including both novel and previously vali

80 Distal regions influence magnitude and kinetics of expre

81 This chromatin configuration brings distal regions into close proximity to the gene.

82 rocircuitry as well as interconnections with distal regions involved in fear and anxiety.

83 limb development in flies and show that the distal region is actually patterned by a distal-to-proxi

84 This distal region is also preferentially acetylated on histo

85 m that a dynamic cluster of residues in this distal region is directly coupled to the active site.

86 d a highest core promoter activity while the distal region is suppressive.

87 on for the propagation of binding effects to distal regions is the presence of a significant fraction

88 1-23.2 (approximately 10 cM; 8 cases), and a distal region located at 6q25 (approximately 13 cM; 9 ca

89 ease in the number of cells with some origin-distal regions located in the forespore.

90 ase in TGF-beta signaling in the unprotected distal region (low Bcl-2 expression).

91 as the proximal region, indicating that the distal region may be looped to become positioned close t

92 teractions between hydrophobic groups in the distal regions may play a significant role in the format

93 ns rarely overlapped with motifs enriched in distal regions, motifs enriched in 5' distal regions wer

94 some repressive effects were detected in the distal region, mutations of the region proximal to the U

95 The results demonstrate that neither the distal region nor receptor tyrosines are essential for i

96 -insert clones that span 10.5 Mb of the most distal region of 1p36 to design a microarray.

97 A distal region of 2226 bp conferred a high level of expre

98 ntials that are initiated ectopically in the distal region of axons and propagate antidromically to t

99 found that BRSK activity is elevated in the distal region of axons in polarized hippocampal neurons

100 of BMP signaling with higher activity in the distal region of BA1, this gradient was disrupted and sh

101 The distal region of BA1, which gives rise to most of the ma

102 Thus, the distal region of betaL appears to function as a negative

103 n homozygous mice and has been mapped to the distal region of chromosome 10.

104 The distal region of chromosome 11 in B6 mice harbors a prev

105 deficient C57BL/6J mice with a QTL from the distal region of chromosome 13 from DBA/2J were able to

106 Ts65Dn) that possesses a triplication of the distal region of chromosome 16 has been developed as a p

107 This putative mouse Spo11 gene maps to the distal region of chromosome 2 (homologous to human chrom

108 l4), and have mapped its location to the mid-distal region of chromosome 4, close to the neurological

109 Phemx maps to the distal region of chromosome 7, a segment of the mouse ge

110 for chromosome 10; and amplification of the distal region of chromosomes 8 and 11.

111 utgrowth, accumulation of melanocytes in the distal region of each fin ray, loss of actinotrichia, an

112 of the anterior surface of the proximal and distal region of each leg was measured in the emergency

113 hippocampal neurons, with high levels in the distal region of extended axons.

114 dance of FOG-2 increases dramatically in the distal region of fbf-1 puf-8 double mutants.

115 r JAGGED (JAG), which promotes growth of the distal region of floral organs.

116 Chr 3, respectively, which correspond to the distal region of human chromosome 4q.

117 TL2.1 to Fir(s.p.)QTL2.5, and an effect on a distal region of IL 2-4 that was nonoverlapping with IL

118 yc(b16) and cyc(b229), have deletions in the distal region of LG 12.

119 ancing other lethal mutations located in the distal region of LG 12.

120 e addition of a single disulfide bond in the distal region of MnP resulted in an enzyme that maintain

121 rame may be in a single exon and maps to the distal region of mouse Chr 9 where the mouse macrophage

122 Cgnz1 and Agnz1 on the distal region of mouse chromosome 1 are associated with

123 unction, the gene for GC-G was mapped to the distal region of mouse chromosome 19 (syntenic with huma

124 Ldb1 maps to the distal region of mouse chromosome 19 that is syntenic wi

125 mapping allowed localization of Casp7 to the distal region of mouse chromosome 19, linked to Mxi1, Ad

126 ic backcross analysis to localize Bid to the distal region of mouse chromosome 6 near the Atp6e locus

127 MyD88 was localized to the distal region of mouse chromosome 9 by interspecific bac

128 Interstitial or terminal deletions of the distal region of one copy of chromosome 2 [del(2)] were

129 ll of RNO 5, MMU 11 to all of RNO 10 and the distal region of RNO 14 (14q21-q22), MMU 7 and MMU 19 bo

130 (FtsY) in complex with the tetraloop and the distal region of SRP-RNA, trapped in the activated state

131 support the long-entrenched notion that the distal region of tetrapod limbs, containing the wrist, a

132 is highly shielded from solvent, whereas the distal region of that same acyl chain is more accessible

133 Both of these HDACs associate with a distal region of the affected THI gene promoters that do

134 lium and chorio-adhesive cells begins in the distal region of the allantois, farthest from the streak

135 and an inner vascular network begins in the distal region of the allantois, which is most remote fro

136 maximal stimulated activity observed in the distal region of the axon.

137 (FISH-TSA), that this gene is located in the distal region of the B24 chromosome variant.

138 We propose that syndecans engage the distal region of the beta4 cytoplasmic domain and bring

139 us nuclear extracts that was specific to the distal region of the betaNRE sense strand (dbetaNRE-S; -

140 shift assay revealed that the binding at the distal region of the betaNRE sense strand was antigenica

141 n mediated by GRK4alpha is restricted to the distal region of the carboxyl terminus of the receptor,

142 binds to endogenous Ets binding sites in the distal region of the CCL5 promoter.

143 uction in Arl13b ciliary localization at the distal region of the cilium, consistent with the role of

144 e tabw2 effect under chow feeding map to the distal region of the congenic interval, whereas the diet

145 localized, although IFT88 accumulated in the distal region of the connecting cilium.

146 usly confirmed that UL25 occupies the vertex-distal region of the CVSC density by visualizing a large

147 xenobiotic-responsive enhancer module in the distal region of the CYP2B6 promoter (CYP2B6-XREM) toget

148 expansion alone or a CUG expansion plus the distal region of the DMPK 3'-UTR accumulate into RNA foc

149 The distal region of the Drosophila leg, the tarsus, is divi

150 hile the transit-amplifying cells occupy the distal region of the ducts.

151 hat all epitopes are located at the membrane-distal region of the E2/E1 spike.

152 s and ESRD and suggests that variants in the distal region of the ENPP1 gene may contribute to diabet

153 antimycin A inhibit electron transfer in the distal region of the ETC, but they did not abolish HPV.

154 Antimycin A and cyanide, which inhibit the distal region of the ETC, failed to abolish hypoxia-indu

155 the proximal rPDK4 promoter rather than the distal region of the gene that contains the T(3) respons

156 showed that transcription efficiency of the distal region of the gene was enhanced upon androgen ind

157 been generated that harbor mutations in the distal region of the gene, and a recent study suggests t

158 n affinity usually contain a tyrosine in the distal region of the heme.

159 Here we report that the distal region of the hepatoma type II hexokinase promote

160 tified an NKX6.1 recognition sequence in the distal region of the HNF1alpha promoter and demonstrated

161 culture fermentation model reflective of the distal region of the human large intestine.

162 d anaerobic batch cultures reflective of the distal region of the human large intestine.

163 We identified a distal region of the IL-6 promoter that contains 3 CCATT

164 n was still dependent on the presence of the distal region of the M2 cytoplasmic tail.

165 nt cis-sequences termed PAIR elements in the distal region of the mouse heavy chain immunoglobulin lo

166 At E9.5, the distal region of the mutant BA1 was prematurely and vari

167 d that DNA methylation was restricted to the distal region of the NEK2 promoter.

168 ere localized to a 36 nt sequence in the mid-distal region of the NF-H 3'UTR and to a 45 nt sequence

169 eport that FGF9 is normally expressed in the distal region of the optic vesicle that is destined to b

170 al tail of the H4 histone and reveals that a distal region of the peptide substrate interacts with th

171 ed sPSGL-1 or 2-GSP-6 targeted to a membrane-distal region of the presumed glycocalyx rolled more lik

172 ratinocytes is regulated by sequences in the distal region of the promoter and requires transcription

173 ites of interaction were also evident in the distal region of the promoter.

174 Strongly directed TA/IC movement toward the distal region of the prostate duct combined with weakly

175 mplifying and/or differentiated cells of the distal region of the prostatic ducts.

176 mutation in the AP-1 binding site within the distal region of the relB promoter eliminated its activa

177 apospory-linked markers were located in the distal region of the short arm of a single chromosome.

178 mbination, tumors form preferentially in the distal region of the small intestine.

179 We also found that the distal region of the TAS1R3 promoter harbors a composite

180 accelerates telomeric repeat turnover in the distal region of the telomere.

181 e skeletal structure that regenerates is the distal region of the terminal phalangeal bone that is as

182 Amputation of the distal region of the terminal phalanx of mice causes an

183 On chow, a subcongenic line retaining the distal region of the TH donor congenic interval exhibite

184 ighly conserved "Asp-Arg-Tyr" triplet in the distal region of the third transmembrane region of most

185 e only structurally known Ig domain from the distal region of the titin I-band.

186 d by conserved viral nucleotides at the most distal region of the transcript.

187 n, suggesting general destabilization of the distal region of the trimer apex.

188 t the 14 kDa dynein light chain binds to the distal region of the TrkA juxtamembrane domain.

189 equence analysis shows that the proximal and distal regions of 15q share extensive ancient similarity

190 form the moenocinyl sidechain, with the more distal regions of 5 aligning with the distal glucose in

191 ation underscores its potential for bringing distal regions of a chromosome together.

192 hough UNC-16 is also sparsely distributed in distal regions of axons, including the synaptic region.

193 was dramatically reduced, especially in more distal regions of axons, with gE(-), gI(-), and US9-null

194 Localization of chiasma to the distal regions of barley chromosomes restricts the genet

195 that it plays a central role in defining the distal regions of both the antenna and leg.

196 Two peptides defined conserved but distal regions of Brf1 that participate in stable bindin

197 In the absence of Ofd1, distal regions of centrioles, but not procentrioles, elo

198 We find that distal regions of chromatin structure (e.g., +/-200 kb)

199 The distal regions of chromosome arms showed higher numbers

200 rates that in the absence of homology in the distal regions of chromosome arms, even if relatively sh

201 CEST have demonstrated recurrent deletion of distal regions of chromosomes 1p and 6q.

202 ut the distribution of variation at the most distal regions of chromosomes arms.

203 entred on the subset of genes located in the distal regions of chromosomes where recombination is hig

204 ite shaft, can make excursions into the most distal regions of dendritic spines.

205 is recruited to the actin-binding, membrane-distal regions of dense bodies via its C-terminal SH3 do

206 microtubule array and is enriched within the distal regions of developing processes.

207 f these groups to either the proximal or the distal regions of Df(3R)ea(5022rx1).

208 Distal regions of euchromatin and pericentromeric region

209 TOP2A CCRs are biased toward the distal regions of gene bodies, and TOP2 poisons cause a

210 tion with the membrane-proximal and membrane-distal regions of integrin cytoplasmic-transmembrane dom

211 unit mRNA and protein levels in proximal and distal regions of perilesional cortex and in homotopic a

212 ased in lesioned animals within proximal and distal regions of perilesional cortex compared with dist

213 ites clustered along the substrate cleft and distal regions of PR, respectively.

214 During development, the proximal and distal regions of respiratory tract undergo distinct pro

215 ed from intact nerves and from the wound and distal regions of severed nerves.

216 nonrandom with EST clusters occurring in the distal regions of short arms and middle regions of long

217 es, rather than being restricted to promoter-distal regions of snRNA genes.

218 on or near the growth cone, suggesting that distal regions of the axon are more responsive to FGF-2

219 All domains also perturbed more distal regions of the beta3 tail that appear to form the

220 ng is a highly branched network in which the distal regions of the bronchial tree transform during de

221 Schwannoma cells showed high Rac activity at distal regions of the cells and failed to align processe

222 y visible as chiasmata, is skewed toward the distal regions of the chromosomes.

223 tificial chromosome-based techniques to fuse distal regions of the contig to create transgene miniloc

224 toward the soma (and antidromically to more distal regions of the dendrite) at rapid rates (300-700

225 elerated trafficking of Ca(V)1.2 channels to distal regions of the dendritic arbor.

226 ates the invasive differentiation program in distal regions of the developing placental epithelium.

227 are transcriptomes from proximal, middle and distal regions of the embryonic chicken cochlea, and fou

228 formation of large cytoplasmic vesicles from distal regions of the fiber.

229 ted with both promoter proximal and promoter distal regions of the form I (cbb(I)) promoter operon sp

230 uroD1 maintains a DNA conformation such that distal regions of the gene are brought into proximity of

231 actions between unpaired loops of SL9266 and distal regions of the genome.

232 -4 transduced allografts in the proximal and distal regions of the graft.

233 tion of essential nutrients and drugs in the distal regions of the human gastrointestinal tract.

234 cells revealed some projecting to new, more distal regions of the inner plexiform layer.

235 Dll is required in the distal regions of the leg for the expression of tarsal-s

236 r loss of epidermal and dermal fibres in the distal regions of the leg than proximal regions.

237 regions of the long arms the most and in the distal regions of the long arms the least.

238 The proximal and distal regions of the lung contain epithelial cells spec

239 ed in bronchiolar epithelium, in contrast to distal regions of the lungs, which expressed lower or un

240 uts, those from the lagena are segregated to distal regions of the M-cell and synapse on the distal d

241 -1 recognition sequences within proximal and distal regions of the mouse pdx-1 promoter and demonstra

242 This study revealed that two distal regions of the p53 molecule contribute synergisti

243 e into large scale conformational changes in distal regions of the protein.

244 located exclusively on the smallest diameter distal regions of the Purkinje cell dendrites, whereas p

245 1 and enhance low affinity interactions with distal regions of the receptor.

246 f two synergistic mechanisms afforded by the distal regions of the ribosome.

247 peptide contains sequence homologies to two distal regions of the second extracellular loop of human

248 uplings that link the ligand-binding site to distal regions of the structure.

249 osyl linkages, and it is the topology of the distal regions of the substrate binding surface that con

250 synthesis occurring at the apex and discrete distal regions of the tip.

251 mpB could function either by stabilizing two distal regions of the tmRNA, or by facilitating an inter

252 The distal regions of the transposon-like sequences in promo

253 oregulators such as SRC1 are distinct and at distal regions of these receptors, cell-based and EMSA s

254 Frequent deletions of the distal region on the long arm of chromosome 6 have been

255 to assess cooperativity and coupling between distal regions on an enzyme, is used to interrogate subs

256 eveals the co-dependency of BRG1 and CHD7 at distal regions on regulating expression of their common

257 hat this is manifested by Dam moving between distal regions on the same DNA molecule, which is mediat

258 (3) is complex and mediated by at least five distal regions, one of which contains a specific element

259 Although distal regions pair at the time of bouquet formation, pa

260 vels of acetylation at promoter proximal and distal regions prior to transactivation.

261 binding site on the gp120 core, whereas more distal regions protrude toward the cell surface, likely

262 d receptor expression in three progressively distal regions: proximal and distal stratum radiatum (SR

263 which MPPs migrate from the proximal to the distal region relative to the endosteum of the bone marr

264 the membrane-proximal region to the membrane-distal region, relying on the coordination among multipl

265 h correspond to CpG island (CGI) proximal or distal regions, respectively.

266 These data led us to conclude that this distal region serves as both a target of chromatin remod

267 ubtelomeric region indicated that the 1.4-kb distal region showed elevated structural variation relat

268 ed for p65 binding to and acetylation of the distal region, suggesting communication between the two

269 nsity of functional Na(+) channels than more distal regions, suggesting that this region of dendrite

270 of Mg(2+) and TPP, the P1 helix, as well as distal regions surrounding the TPP-binding site, exhibit

271 puts from the utricle are also segregated to distal regions, synapsing on the ventral branch of the l

272 9 tolerance to single-base mismatches in PAM-distal region than to PAM-proximal region and the high s

273 gion that is controlled by FGF8, and a small distal region that depends on other signaling molecules

274 of the TNF-alpha promoter by TIF required a distal region that includes three NF-kappaB binding site

275 splicing domain (domain I) interacts with a distal region that is sufficient for high affinity bindi

276 here the identification of both proximal and distal regions that regulate murine Elf3 promoter activi

277 in response to TNF at both the proximal and distal regions that were dependent on the p65 subunit of

278 Here, we show that in the distal region the NR1 promoter has an active NF-kappaB s

279 ctivation loop can allosterically couple two distal regions, the dimerization and substrate recogniti

280 Within the proximal and distal regions, there are potential cis sites for known

281 pattern, progressing from the low-frequency (distal) region toward the high-frequency (proximal) regi

282 This broad tolerance for steric bulk in a distal region was not observed for dinucleoside tetrapho

283 Within this distal region we found a Stat5-like motif, and in vitro

284 reased rapidly at origin-proximal and origin-distal regions, well before a replication fork could pas

285 The distal regions were enriched for enhancer marks and tran

286 hed in distal regions, motifs enriched in 5' distal regions were often enriched in 3' distal regions,

287 Origin-distal regions were resegregated in a ParABS-independent

288 ons, which bridge the central region to each distal region, were also well protected with the excepti

289 reduced recombination rates relative to the distal regions, were significantly less variable than lo

290 ed under hypoxic conditions localizes to the distal region where the overlapping HIF-1/E-box sequence

291 he CA variants were most evident in membrane-distal regions, where apparent CTDs interconnect hexamer

292 requires both the fourth site (Ser539) and a distal region, which acts to recruit GSK3 to eIF2Bepsilo

293 ybridization revealed the physical size of a distal region, which is represented by six of the eight

294 tion assays demonstrated MTA1 binding to the distal region, which spans several regulatory cis elemen

295 ation, which is mostly relegated to the more distal regions, which are largely euchromatic.

296 structure was that of the I27 module of the distal region, whose mechanical properties have been rep

297 with a coated pit sequence for uptake, and a distal region with an EDE triad for the unusual deeper t

298 TATA element in the proximal region, plus a distal region with octamer (OCT) and SphI postoctamer ho

299 ructural capacity of N17 to fold back toward distal regions within huntingtin requires an interacting

300 recovery occurred as unbleached protein from distal regions within the 300 nm granule diffused into t