ライフサイエンスコーパス: distal tubule

1 progenitors, and then subsequently marks the distal tubule.

2 e of inclusions from epithelial cells of the distal tubule.

3 sorption and potassium secretion in the late distal tubule.

4 for FGF23-dependent FGFR activation, in the distal tubule.

5 at this regulation likely takes place in the distal tubule.

6 e sodium chloride cotransporter (NCC) in the distal tubule.

7 )(-) reabsorption in the proximal tubule and distal tubule.

8 orption through sodium channels in the renal distal tubule.

9 idin-encoding Hamp1 and hepcidin staining in distal tubules.

10 ximal tubules and represses the formation of distal tubules.

11 fic for the collecting ducts and a subset of distal tubules.

12 alized to tricellular tight junctions of the distal tubules.

13 e collecting ducts and both the proximal and distal tubules.

14 e in a more oxidized state than those in the distal tubules.

15 TPase, was lower in proximal tubules than in distal tubules.

16 ules, but potential was better maintained in distal tubules.

17 (3)(-) reabsorption in both the proximal and distal tubules.

18 d bicarbonate transport by both proximal and distal tubules.

19 disappeared except for a small population of distal tubules.

20 ne or more of the sodium transporters of the distal tubule (a site for fine tuning of sodium balance)

21 genous endothelins as mediators of increased distal tubule acidification induced by dietary acid.

22 ace epithelium and is induced throughout the distal tubule after administration of LPS.

23 In the amphibian early distal tubule aldosterone activates the Na(+)-H+ exchang

24 ntrolling Na(+) reabsorption along the renal distal tubule and collecting duct (CD).

25 secretion of buffered protons (mainly in the distal tubule and collecting duct).

26 we show that mecom is necessary to form the distal tubule and to restrict both proximal tubule forma

27 ats: lithium reabsorption in the superficial distal tubules and amiloride-sensitive lithium reabsorpt

28 t E12.5 and epithelial cells of proximal and distal tubules and collecting ducts at E17.5 and P0 mous

29 3 widened in I/R-injured kidneys from normal distal tubules and collecting ducts to dilated proximal

30 d expression of 24p3R in apical membranes of distal tubules and collecting ducts, but not of proximal

31 Histology revealed cystogenesis in distal tubules and collecting ducts, decreased ciliogene

32 ult mouse kidney, NPN protein was located in distal tubules and collecting ducts.

33 uired at high levels during nephrogenesis in distal tubules and later exclusively in thick ascending

34 protein expression in the renal proximal and distal tubules and significantly increased PGI2, not PGE

35 injury, HB-EGF is produced predominantly in distal tubules and that endogenous HB-EGF may be an impo

36 the renal cortex (specifically proximal and distal tubules) and sustained beyond 2 months post injec

37 ssion in the proximal tubule, loop of Henle, distal tubule, and collecting duct and suggest that unde

38 tributes importantly to acidification in the distal tubule, and that it plays a major role in limitin

39 intense staining of crescents, proximal and distal tubules, and interstitial mononuclear cells.

40 gments, including cortical collecting ducts, distal tubules, and loop of Henle.

41 the epithelial layers of the loops of Henle, distal tubules, and the collecting ducts of the kidney a

42 The insulin receptor in the distal tubule appears to modulate BP, but the role of th

43 sal medium, differentiated into proximal and distal tubules as well as endothelium, as highlighted by

44 ts derived from either collecting tubules or distal tubules but not from proximal tubules, which corr

45 lls, mesangial cells, endothelial cells, and distal tubules but not proximal tubules.

46 way, lending support to the novel finding of distal tubule cell apoptosis in patients with FSGS.

47 bules of Drosophila, we show that a specific distal tubule cell regulates both tissue architecture an

48 ptors on the luminal surface of proximal and distal tubule cells and on afferent and efferent arterio

49 cently tagged PTH1Rs, we show that in kidney distal tubule cells and rat osteosarcoma cells, which la

50 l tubule progenitors express cadherin-6, the distal tubule cells express E-cadherin, whereas the glom

51 cells transiently transfected with 24p3R or distal tubule cells internalized submicromolar concentra

52 noreactivity in the descending thin limb and distal tubule cells was located in the Golgi apparatus a

53 member of the WNK kinase family expressed by distal tubule cells, interacts with WNK4 and WNK1 to reg

54 confirmed an abnormality of proximal but not distal tubule cells, marked in sustained ARF but not in

55 , apoptosis was evident in both proximal and distal tubule cells.

56 crease the fluid and electrolyte load to the distal tubule, consistent with a role of MD nNOS in tubu

57 es in both the proximal (proximal SNGFR) and distal tubules (distal SNGFR).

58 xpression of WNK1-S and WNK4 is strongest in distal tubule, dropping sharply in collecting duct and w

59 luding FGFR1, and alpha-Klotho in the kidney distal tubule (DT), leading to increased sodium retentio

60 rominent expression by maturing proximal and distal tubules during development, but with a more prono

61 ical membrane of the diluting segment (early distal tubule, EDT) of the frog are involved in the regu

62 The Xenopus laevis distal tubule epithelial cell line A6 was used as a mode

63 5 (TRPV5) channel on the apical membrane of distal tubule epithelial cells.

64 preciable hypertrophy and hyperplasia of the distal tubule epithelium of the nephron, resembling salt

65 oliferating cells were found in proximal and distal tubule epithelium throughout the cortex, and the

66 Notably, S1 and distal tubules exhibited similar metabolic profiles desp

67 re the concentration of bicarbonate in early distal tubule fluid and to measure distal bicarbonate re

68 In collections of distal tubule fluid, TF/P were 2.8 +/- 0.3 [-/-] and 4.4

69 Bosentan had no effect on distal tubule HCO3 or H+ secretion in control animals.

70 In the distal tubule, however, calcium is reabsorbed by channel

71 Fractional lithium delivery to the early distal tubule in low-K+ rats (0.31 +/- 0.01) was similar

72 ed that HB-EGF was produced predominantly in distal tubules in kidneys injured either by ischemia/rep

73 basolateral plasma membrane of proximal and distal tubules in rat kidney, where many G protein-coupl

74 ximal tubules and represses the formation of distal tubules in the mammalian nephron, we show that in

75 +/+, during free-flow collections from early distal tubules (influence of MD intact, 7 +/- 0.7 versus

76 ion of the collecting duct, proximal tubule, distal tubule, interstitial cells, and rarely glomerular

77 egulated, and those in the loop of Henle and distal tubule lineages were downregulated.

78 olocalization experiments using proximal and distal tubule markers confirmed that EBV DNA and the CD2

79 zation of FGFR1 and Klotho suggests that the distal tubule may be an effector site of FGF23.

80 approaches were used to evaluate the role of distal tubule NHE2 in compensating for the proximal defe

81 secretion and increased H+ secretion in the distal tubule of animals given dietary acid.

82 The epithelium of the distal tubule of the nephron shows striking hypertrophy

83 red for terminal differentiation of the late distal tubule of the Xenopus pronephros and regulates re

84 analyses demonstrated jagged-1 expression in distal tubules of kidneys from normal mice or contralate

85 ally distinct WNK bodies were evident in the distal tubules of mice subjected to dietary potassium lo

86 d increased H+ secretion in in vivo-perfused distal tubules of rats fed dietary acid as (NH4)2SO4.

87 rter (NCC) mediated salt reabsorption in the distal tubules of the kidney.

88 Microperfusion of live renal distal tubules reveals that they are impermeable to wate

89 ere, we generated mice lacking mTORC2 in the distal tubule (Rictorfl/fl Ksp-Cre mice), which were via

90 responsible for differentiation of the first distal tubule segment.

91 alance between K secretion and absorption in distal tubule segments such as the connecting tubule and

92 i was measured in single microperfused early distal tubule segments using the fluorescent probe 2',7'

93 egions that include a series of proximal and distal tubule segments, which are comprised of intercala

94 he low NaCl diet, fenoldopam decreased renal distal tubule sodium transport but did not cause natriur

95 ed with the inhibition of renal proximal and distal tubule sodium transport.

96 ced in structure and/or coiling whereas more distal tubule structure was unaffected.

97 luminal bicarbonate load is presented to the distal tubule, such as in NHE3 null mice.

98 In vivo microperfusion of rat distal tubules suggests that a significant fraction of b

99 natriuresis by inhibiting renal proximal and distal tubule transport, but on a low NaCl diet the incr

100 rolling sodium excretion at the level of the distal tubules via activation of the apical epithelial s

101 ractional lithium delivery to the end of the distal tubule was increased slightly (to 0.15 +/- 0.02;

102 orption of fluid or chloride up to the early distal tubule was not different between nNOS -/- and +/+

103 lcium channel TRPV5, normally present in the distal tubule, was expressed in Xenopus oocytes.

104 r markers specifically expressed in the late distal tubule were absent in xBic-C-MO-injected embryos.

105 segment, whereas concentrations in the early distal tubule were markedly lower.

106 Distal tubules were present but in reduced numbers, and

107 d in all nephron segments, especially in the distal tubule, where it correlated with an increase in s

108 his study, the cortical thick ascending limb-distal tubule, with attached glomerulus, was isolated an