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1 non-covalently to the same AT-rich sites as distamycin.
2 P analog, when compared with the parent drug distamycin.
3 ased on the N-methyl pyrrole carboxamides of distamycin.
4 MGA1 proteins) by both monomeric and dimeric distamycin.
5 s of the sequence-specific binding molecule, distamycin.
6 which can be distinguished by sensitivity to distamycin.
7 beyond the initial studies on netropsin and distamycin.
8 hods and using the minor groove-binding drug distamycin.
9 -specific alkylating antitumor derivative of distamycin.
11 cognate DNA than either the parent analogue, distamycin A (10-fold), or the structural isomer, f-PyIm
13 rmed that f-ImPyIm is a stronger binder than distamycin A and f-PyImIm and that f-ImPyIm preferential
16 nor groove-binding drugs such as netropesin, distamycin A and Hoechst33258 and may be a reflection of
17 ove-binders, chromomycin A(3) (GC-specific), distamycin A and netropsin (both AT-specific), have been
20 Minor groove binding compounds related to distamycin A bind DNA with high sequence selectivity, re
25 quence appears to be weaker than that of the distamycin A homodimer to A/T sequences, most likely due
26 ith guanine tetrads of quadruplex DNA, while distamycin A interacts by binding to quadruplex grooves.
30 erminations of the binding mode of Tel01 and distamycin A to quadruplex oligonucleotides indicate tha
31 aled that binding of f-ImPyIm, f-PyImIm, and distamycin A to their respective hairpin cognate sequenc
32 ST-NP6 protein competes for DNA binding with distamycin A, an antibiotic that chelates DNA within the
33 stoichiometry, and mode of binding of Tel01, distamycin A, and diethylthiocarbocyanine iodide (DTC) t
35 groove-binding drug chromomycin A3, but not distamycin A, disrupted Tax-enhanced CREB binding to the
38 ing selectivity for several agents including distamycin A, netropsin, DAPI, Hoechst 33258, and bereni
39 ies of these agents were compared to that of distamycin A, using a fluorescence intercalator displace
45 AT-selective minor-groove binders, including distamycin and bisdistamycins, bisnetropsins, novel lexi
46 In addition, DAPI was more effective than distamycin and Hoechst 33258 at inhibiting the assembly
48 ase I footprinting to examine the ability of distamycin and Hoechst 33258 to discriminate between dif
49 d only the AT bp in the binding sites, while distamycin and Hoechst protected these bp as well as fla
50 he basis for inhibition of vaccinia virus by distamycin and indicate that DNA minor-groove ligands ho
51 hree orders of magnitude more effective than distamycin and inhibited complexes between E2F1 and the
52 oove-binding ligands berenil, netropsin, and distamycin and the intercalating ligand acridine orange
55 nteraction of DNA binding drugs mithramycin, distamycin, and berenil with an intermolecular triplex f
56 NA-binding agents, such as ethidium bromide, distamycin, and doxorubicin, inhibit the formation of sl
57 equence specific ligands, such as netropsin, distamycin, and GLX, prefer uniform, narrow minor groove
58 nucleosome assembly only in the presence of distamycin, and increasing the number of 33-bp repeats i
61 These results demonstrate the utility of distamycin as a probe of G4 DNA-protein interactions and
62 tude more effective than the natural product distamycin at inhibiting formation of complexes between
71 related to the linked bis-netropsins and bis-distamycins, but here, only one amino-pyrrole-carboxamid
73 rug concentrations of either mitoxantrone or distamycin completely blocked transcription, while low d
74 ared to the previous 2:1 all-IC d(ICICICIC)2-distamycin complex, the substitutions of the I x C base-
76 and poly(dIdC)2 and competitive binding with distamycin demonstrate that complex II is bound in the m
79 k alters distamycin binding by weakening the distamycin:DNA complex, while slowing monomeric distamyc
83 groove binders (netropsin, Hoechst 33258 and distamycin) has shown the suitability of FSCE as a metho
84 s-linked lexitropsins based on netropsin and distamycin have been screened for their effectiveness in
85 two consensus sequences, either the expected distamycin hexamer binding sites followed by a CG base p
86 er for the I1L gene was partially reduced by distamycin; however, transcription from the intermediate
87 ber of 33-bp repeats increases the effect of distamycin in the destabilization of the nucleosome form
88 AT-rich repeating DNAs derived from the rare distamycin-inducible site, FRA16B, was examined for its
95 tructures of the side-by-side binding of two distamycin molecules to the DNA octamers d(ICITACIC)2 an
96 minor groove binding ligands (Hoechst 33258, distamycin, netropsin and berenil) with DNA fragments wh
100 n expression, we have examined the effect of distamycin on the cytokine-induced E-selectin expression
102 on, and, furthermore, the addition of either distamycin or berenil to the pre-formed triplex structur
104 to single-strand oligonucleotide ions, while distamycin/quadruplex complexes fragment into single-str
105 d by Me-lex are 3-MeA; 2) the co-addition of distamycin quantitatively inhibited methylation at all m
108 GA1a is displaced from the DNA by 1 equiv of distamycin, suggesting the ability to develop therapeuti
109 quadruplex complexes are similar to those of distamycin; therefore, it is concluded that DTC interact
111 likely to be due to preferential binding of distamycin to the minor groove of the DNA duplex as oppo
113 nscription was observed when mitoxantrone or distamycin was added either before or after assembly of
114 ustard and imidazole-containing analogues of distamycin was determined using modified sequencing tech
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