ライフサイエンスコーパス: distant

1 le pS1493 binds an unanticipated pocket 70 A distant.

2 ailure were categorized as local/regional or distant.

3 .3% per year for regional, 2.4% per year for distant, 1.8% per year for unknown).

4 equence and structural similarities with the distant Acidobacteria LexA protein.

5 eling of tRNA(Cys) between SepRS and SepCysS distant active sites.

6 nce interval) of highly expressed genes with distant alternative exons exhibit coordination, showcasi

7 The metastatic spread of malignant cells to distant anatomical locations is a prominent cause of can

8 10 years of follow-up and include cancers at distant anatomical sites.

9 We found that the two active sites are distant and do not show evidence of direct communication

10 Distant and local relapses can occur, and in studies rep

11 -ie, those that might lead to death, such as distant and locoregional relapses outside the preserved

12 ative rate increases were seen for regional, distant, and ulcerated disease, especially among males l

13 ence in domestic poultry with two temporally distant, and yet geographically consistent, HFMG isolate

14 long-distance information between spatially distant areas of the nervous system and in controlling m

15 MYB33/65 homologs of species as evolutionary distant as gymnosperms.

16 hydrogen absorption lines on the spectra of distant background quasars known as the Lyman-alpha fore

17 have focused on kappa-carrageenases from two distant bacterial phyla, which belong to glycoside hydro

18 Samples from four distant basins in Chile were genotyped for 13 microsatel

19 Distant biofilms can thus coordinate their behavior to r

20 okes approach responses in two taxonomically distant blood-seeking predators, Stable fly and Wolf, wh

21 ce also showed increased bacterial growth in distant body sites.

22 ional connectivity, both locally and between distant brain areas, and these long-range changes correl

23 hanism to coordinate memory processes across distant brain areas.

24 e and activity from multiple neurons both in distant brain regions (striatum and hippocampus) and wit

25 They suggest that distant brain regions might coordinate their activity in

26 w long-range cross-frequency coupling across distant brain regions subserves working memory.

27 monomeric Tau, followed by its spreading to distant brain regions.

28 ies in the ACC and the DLPFC, two relatively distant but reciprocally connected regions, are coherent

29 expression in species more phylogenetically distant, but sharing a need for common interspecific emo

30 gates between two high-dimensional atoms in distant cavities coupled by an optical fiber.

31 t code quasilinearly for its position, while distant cells remain largely invariant to the object's p

32 Axons convey information to nearby and distant cells, and the time it takes for action potentia

33 the biofilm alters the membrane potential of distant cells, thereby directing their motility.

34 d by a Bacillus subtilis biofilm can attract distant cells.

35 r communication between both neighboring and distant cells.

36 y of cues such as the Shh signal can pattern distant cellular responses to assure functional integrit

37 ge electron transfer to ultimately oxidize a distant co-anchored proxy catalyst before charge recombi

38 dditional models including a theory based on distant cytotoxic log-kill effects were unable to fit th

39 ion to coordinate GABA release at relatively distant dendrodendritic synapses formed throughout the d

40 points were local-recurrence interval (LRI), distant disease-free interval (DDFI), and overall surviv

41 [HR], 1.00; 95% CI, 0.78 to 1.28; P = 1.00), distant disease-free survival (HR, 1.12; 95% CI, 0.86 to

42 eported toxicity, overall survival (OS), and distant disease-free survival.

43 rsus men with poor response to SRT (nodes or distant-disease PSMA).

44 ring-shaped cohesin complex brings together distant DNA domains to maintain, express, and segregate

45 These data argue that many distant domains in the rRNA can assemble simultaneously

46 ent the experimental characterization of two distant double-slit masks illuminated by chaotic light,

47 over multiple stages of embryogenesis in two distant Drosophila species (with 1.4 substitutions per n

48 stillation on a quantum network primitive of distant electron-nuclear two-qubit nodes.

49 ny of these cryptogenic strokes arise from a distant embolism rather than in situ cerebrovascular dis

50 Distant eQTL formed 125 significant distant eQTL hotspot

51 Distant eQTL formed 125 significant distant eQTL hotspots with their targets significantly e

52 In this work, we describe a distant evolutionary branch within genotype D4.

53 similar cortical architecture despite their distant evolutionary divergence.

54 n-specific noise correlations with local and distant excitatory neurons.

55 Freedom from distant failure rates were 96% and 95% in apex LD and HD

56 Main outcome measures were time to distant failure, local failure, death, enucleation, radi

57 eceptors have been limited because mutations distant from an agonist-binding site can alter agonist s

58 same agro-ecosystem, but several kilometers distant from any oilseed rape fields.

59 nsor imaging (DTI) to identify axonal injury distant from contusions.

60 s and juveniles) when their territories were distant from feeding stations.

61 ith disease risk, yet many of these loci are distant from protein coding genes.

62 es in close proximity, also positioning them distant from the active site pocket.

63 restricted to clones that were anatomically distant from the biopsy site.

64 lves the structural rearrangement of regions distant from the capsid pores.

65 gene(s) for biosynthesis of the latter were distant from the core dynemicin cluster.

66 eQTLs is now routine, trans-eQTLs, which are distant from the genes of origin, are far more difficult

67 on site, but is transmissible to normal skin distant from the infection site and to skin from co-hous

68 isease to studies of multiple specimen types distant from the lung that are tested for multiple patho

69 s and patents typically stand 2 to 4 degrees distant from the other domain.

70 serologically distinct and phylogenetically distant from VSV.

71 regions might be effectively coordinated by distant frontal brain regions through synchronized activ

72 ulated by modulating theta phase coupling of distant frontal cortical areas and can contribute to the

73 ion pathways between the OM binding site and distant functional regions.

74 teric communication of mutational effects to distant functional sites leading to loss-of-function rem

75 Lewis pairs may be achievable in the not-too-distant future.

76 nder TU; savings under AU emerge in the more distant future.

77 veys that are sensitive enough to detect the distant galaxies that act as signposts for these structu

78 ially to the star-formation rate observed in distant galaxies.

79 140 years ago to depend on innervation from distant ganglion neurons, but the underlying mechanism h

80 to identify effects of genetic variation on distant genes (trans-eQTLs) and understand their biologi

81 that some trans-eQTLs regulate expression of distant genes by altering the expression of nearby genes

82 0,000 years ago) divergence between the most distant genetic lineages.

83 y in theory lead to larger improvements when distant high-fitness genotypes more readily evolve from

84 hia coli F element-encoded protein TraR is a distant homolog of the chromosome-encoded transcription

85 in Enterobacteria and Pseudomonas phage, and distant homologs in other phage and bacterial genomes, s

86 only on experimental characterization of its distant homologue CorA magnesium channel.

87 YonO shares very distant homology with msRNAPs, but no homology with sing

88 Ligands bearing distant hydroxycoumarin-derived antennae attached throug

89 ecules upon other subsequent, and temporally distant, immunostimulatory challenges.

90 d-directly coevolving residue pairs that are distant in protein structures-to determine the origins o

91 eptides, i.e. peptides composed of fragments distant in the parental protein.

92 Since amino acids that are distant in the sequence can be close in the 3-dimensiona

93 s facilitate neighbours while competing with distant individuals, can reproduce various regular patte

94 ound by MLL4 correlated with MLL4 binding at distant interacting regions.

95 y and historical biogeography resulting in a distant intercontinental disjunction are poorly understo

96 nts (59.8%), and local recurrence as well as distant lesions in 25 of 107 patients (23.4%).

97 al recurrence in 68 of 107 patients (63.5%), distant lesions in 64 of 107 patients (59.8%), and local

98 t with metabolic tumor volume at regional or distant levels, suggests that cfDNA may better reflect t

99 etically close isolates colocalize in space, distant lineages with distinct phenotypes separated by a

100 hat branching events are synchronized across distant locations within the lung, and are preceded by l

101 rrelations of evolutionary histories of even distant loci.

102 cose metabolism between the primary PDTX and distant lymph node metastases.

103 ostate, seminal vesicles, local lymph nodes, distant lymph nodes, bone, and others) at both time poin

104 approach was developed using 19 genetically distant maize (Zea mays) lines from Europe and America.

105 factor 15 (GDF15), also known as MIC-1, is a distant member of the transforming growth factor-beta (T

106 te of its photo-release and its arrival at a distant membrane patch at different temperatures.

107 essment of locoregional recurrences (LR) and distant metastases (DM) in head-and-neck cancer.

108 , loss of KLF10 in PDAC is shown to increase distant metastases and cancer stemness through activatio

109 ormed in 40 hormone-refractory patients with distant metastases and progressive disease (mean age, 71

110 An assessment of associations between distant metastases and tumor characteristics was a secon

111 We found that in 65% of cases, lymphatic and distant metastases arose from independent subclones in t

112 xpression were associated with lower risk of distant metastases at follow-up in univariate analysis (

113 e intention-to-treat population (3 had overt distant metastases at the time of randomization; 2 withd

114 Remarkably, distant metastases co-evolved a dependence on the oxidat

115 ulted in complete regression of pre-existing distant metastases in 65% of the animals and a significa

116 tic cell viability - leads to elimination of distant metastases in a mouse model of metastatic breast

117 nship between primary tumor, lymph node, and distant metastases in human colorectal cancer.

118 Whether ITPP protects from distant metastases in primary colon cancer is unknown.

119 lity to induce immune-mediated regression of distant metastases is still poorly documented.

120 Distant metastases occur in half of patients and are res

121 , but no models exist to readily investigate distant metastases that are mainly responsible for morta

122 iate models were built for overall survival, distant metastases, and local recurrence using only clin

123 correction for sex, age at the diagnosis of distant metastases, metastases site, and metastases exte

124 For overall survival and distant metastases, pretreatment compactness improved th

125 erogeneity between primary tumours and their distant metastases.

126 d growth, tumor invasion, and development of distant metastases.

127 imary tumors from colon cancer patients with distant metastases.

128 e baseline still corresponded with a lack of distant metastases.

129 and the mediastinal lymphadenopathy without distant metastases.

130 Conversely, distant-metastases and deaths were lower for BCS but not

131 was 22% (95% CI, 12%-32%); 5-year actuarial distant metastasis and locoregional recurrence were 54%

132 nificantly correlated with increased risk of distant metastasis and reduced relapse-free and overall

133 The true detection rate of distant metastasis and synchronous cancer was assessed f

134 umulative incidences of local recurrence and distant metastasis for radical versus conservative group

135 f a basal-like or TNBC phenotype and reduced distant metastasis free survival.

136 rates high specificity and PPV for detecting distant metastasis in cervical and endometrial cancer an

137 dered the main cause of local recurrence and distant metastasis in lung cancer.

138 KPNA4 significantly reduces PCa invasion and distant metastasis in mouse models.

139 association of one 3q driver gene FXR1 with distant metastasis in TNBC (P = 0.01) was further valida

140 The C-index for 10-year distant metastasis of the clinical model alone was 0.76;

141 ted a significantly higher detection rate of distant metastasis or synchronous cancer than strategies

142 The true detection rate of distant metastasis or synchronous cancer with PET/CT was

143 was to test this hypothesis by comparing the distant metastasis rate (DMR) on initial (18)F-FDG PET/C

144 for patients in the training cohort, 10-year distant metastasis rates for National Comprehensive Canc

145 ier clinical-genomic risk groups had 10-year distant metastasis rates of 3.5%, 29.4%, and 54.6%, for

146 Overall prevalence of distant metastasis was 13.7% (21 of 153) for cervical ca

147 , progression-free survival (PFS), actuarial distant metastasis, and locoregional recurrence.

148 ), progression-free survival, local failure, distant metastasis, and selected Common Terminology Crit

149 imilarly poor survival as patients with more distant metastasis, and thus may not benefit from surger

150 /MRI correctly detected 3 (1%) patients with distant metastasis, CHCT/MRI detected 11 (4%) patients,

151 outcome (local recurrence, nodal metastasis, distant metastasis, or disease-specific death) of CSCCs

152 TNBC) has high rates of local recurrence and distant metastasis, partially due to its high invasivene

153 also promoted hematogenous dissemination and distant metastasis, which was linked to neuroblastoma ce

154 l (OS), progression-free survival (PFS), and distant metastasis-free survival (DMFS) (Hazard Ratios [

155 emical recurrence-free survival [bRFS], 29%; distant metastasis-free survival [DMFS], 53%; prostate c

156 Rates of distant metastasis-free survival and freedom from relaps

157 rogression-free survival, local failure, and distant metastasis-free survival were not different betw

158 ondary end points included overall survival, distant metastasis-free survival, freedom from relapse,

159 ed overall survival, local and regional PFS, distant metastasis-free survival, quality of life, adver

160 w Foxa1 expressions are associated with poor distant metastasis-free survival.

161 odifications during the natural evolution of distant metastasis.

162 re recorded, and all patients were free from distant metastasis.

163 ference standard, reviewed PET/CT images for distant metastasis.

164 subtype, CREB3L1 expression is predictive of distant metastasis.

165 liac node metastasis, and 44 (9.9%) had more distant metastasis.

166 th no such metastasis and patients with more distant metastasis.

167 ks analysis was used to estimate the risk of distant metastasis.

168 tumorigenic fitness during the evolution of distant metastasis.

169 had locoregional recurrence and one (2%) had distant metastasis; 2-year progression-free survival was

170 In the Erasmus Breast Cancer Cohort, 5-year distant-metastasis-free survival was longer in patients

171 nitial tumour staging and had no evidence of distant metastates.

172 tients, locoregional lymph nodes in 39%, and distant metastatic disease in 16%.

173 e of cancer-related deaths, primarily due to distant metastatic disease.

174 to safely eradicate both primary tumors and distant metastatic foci.

175 lete surgical resection is often followed by distant metastatic relapse for reasons that remain uncle

176 from its origin in the pancreas to colonize distant metastatic sites.

177 like system coupled to a 1D waveguide with a distant mirror, where guided photons represent the qubit

178 ion by ATP to perform C-C bond ligation at a distant Mn center.

179 ations of attitudes and values by exerting a distant modulatory influence on cortical areas and their

180 ns comprise a fundamental mechanism by which distant neural structures establish and express function

181 lume conduction, FPs may reflect activity in distant neurons superimposed upon that of neurons close

182 infecting fungal pathogen in a taxonomically distant nonhost plant species presumably by cell surface

183 appear larger and to move more quickly than distant objects.

184 dly favors local (short-range) contacts over distant ones.

185 ONALE: Acute kidney injury may contribute to distant organ dysfunction.

186 orthotopic SCLC tumor xenografts as well as distant organ metastases with high sensitivity.

187 ngested M. canettii organisms to relocate to distant organs and lungs.

188 a role of Akt2 in CRC cell dissemination to distant organs in vivo.

189 Metastatic tumor cell growth and survival in distant organs is facilitated by the formation of a pre-

190 establish pre-metastatic microenvironment in distant organs is unclear.

191 r cells infiltrate in the primary tumour and distant organs with different time kinetics and regulate

192 e followed by growth of secondary tumours at distant organs, is the primary cause of cancer-related d

193 utonomous autophagy in neighboring cells and distant organs, thus fueling tumor growth and metastasis

194 roenvironment to metastasize successfully to distant organs.

195 he blood, extravasation, and colonization of distant organs.

196 istinct cancer-microenvironment crosstalk in distant organs.

197 ascular growth, to disseminate and invade to distant organs.

198 rrelations between the fitness landscapes of distant orthologues implicate both sequence and structur

199 h measures the entanglement between multiple distant pairs of simulated spins, as well as the block e

200 mice infected acutely or chronically with 6 distant parasite strains, we integrated simultaneously 6

201 tal globules,' and even the most genomically-distant parts of the chromosome can be physically connec

202 of individuals will detect many errors where distant parts of the genome are erroneously joined toget

203 DNA in these lineages often occurred in the distant past, and the selective pressures underlying the

204 er a proxy of the NAO conditions in the more distant past, helping assess its predictability.

205 re fundamentally different from those in the distant past.

206 ide binding footprint encompassing spatially distant peptide residues.

207 The disparate biosynthetic origins and distant phylogenetic distribution implies these loops ev

208 of action between SVP genes of taxonomically distant plant species.

209 nt vascular systemic dissemination of Xcc in distant plant tissues.

210 genetic differentiation among geographically distant populations (fixation index = 0.026), suggesting

211 ween genetically distinct and geographically distant populations.

212 o during a period of successive conquests by distant populations.

213 cidiphilum Y(T) variants from geographically distant populations.

214 rved both in the normal position and in more distant positions from the vein.

215 Homology between two distant protein families can be determined by comparing

216 ation of the evolutionary relationship among distant protein families.

217 ediated via long-range communication between distant protein sites.

218 no doses was lower among students with more distant receipt of the second vaccine dose.

219 ize and optimize response sensitivity across distant receptive fields and preclude any bias toward lo

220 in to be stretched sufficiently to reach the distant receptor target, and a restriction on chain conf

221 iod from 5 to 20 years, the absolute risk of distant recurrence among patients with T1N0 breast cance

222 ning data on the absolute risk of subsequent distant recurrence if therapy stops at 5 years could hel

223 The risk of distant recurrence was strongly correlated with the orig

224 e-survival, breast cancer-free interval, and distant recurrence-free interval.

225 The 3-year estimated distant recurrence-free survival was 90.3% (95% CI, 0.79

226 pproaches, possibly contributing to local or distant recurrence.

227 There were 1,046 distant recurrences.

228 the recording electrode, due to the use of a distant reference electrode, they often reflect those of

229 o GDNF family receptor alpha-like (GFRAL), a distant relative of receptors for a distinct class of th

230 the free-living nematode Oscheius tipulae, a distant relative of the model Caenorhabditis elegans We

231 ian great apes and phylogenetically our most distant relatives among extant hominids [1].

232 Social insects are distant relatives of vertebrate social learners, but the

233 EoE as evidenced by increased risk of EoE in distant relatives.

234 rigins of evolutionary pressure on spatially distant residues and to understand the sources of error

235 heir wild counterparts in two geographically distant rivers.

236 Thermalized elastic membranes without distant self-avoidance are believed to undergo a crumpli

237 e results confirm the close proximity of two distant sequence sections of TatC proposed to concertedl

238 erimental characterization of evolutionarily distant sequences reveals that sequence variation at sec

239 AAV serotypes, including the evolutionarily distant serotypes AAV2 and AAV5.

240 ts effects when the ants were displaced to a distant site from the feeder.

241 mong patients with metastatic disease to any distant site) and triple-negative (0.7% among entire coh

242 mong patients with metastatic disease to any distant site) subtypes.

243 to structural and/or dynamical changes at a distant site.

244 useful reactions, because it can reach more distant sites and be applied to substrates that do not c

245 PAH-contaminated samples from geographically distant sites and detected 232 azaarene congeners distri

246 lect those of synaptic activity occurring in distant sites as well.

247 management, can explain future demography at distant sites connected through dispersal.

248 ir olfactory sense before being displaced to distant sites have impaired homing ability but it is unk

249 metastatic, migrating through lymph nodes to distant sites of the body, especially to lungs, liver an

250 YCP3 would result from its ability to bridge distant sites on a DNA molecule with the DNA-binding dom

251 s to fulfill their many tasks and migrate to distant sites to either direct developmental patterning

252 tributes to premetastatic niche formation at distant sites, but they also provide comprehensive insig

253 warts in a subset of patients, including at distant sites, suggesting that this effect may be mediat

254 During metastasis to distant sites, tumor cells migrate to blood vessels.

255 tion of immune responses both locally and at distant sites.

256 nderlie the dissemination of cancer cells to distant sites.

257 activates Cas9 for DNA cleavage at spatially distant sites.

258 ells in the tumors and was effective against distant solid tumors and lung metastases.

259 lensing-the formation of multiple images of distant sources due to the deflection of their light by

260 Previous estimates of the linkage from distant sources rely on the sensitivity approach (i.e.,

261 F-3s) tRNA loops in these three evolutionary distant species showed that they are conserved and their

262 r-prey predicted manner across taxonomically distant species, as well as the first known chemosignal

263 guishing saponin profiles from taxonomically distant species, it can unravel plant adulteration issue

264 x loci from different populations, even from distant species, which led to the acquisition by domesti

265 thaliana CENH3 is replaced with CENH3s from distant species.

266 acids, transport these cargos to adjacent or distant specific recipient cells, and thereby regulate g

267 waves allow a pulse to radiate power into a distant spectral region.

268 No evidence for distant spread of disease was identified.

269 d 2.9% per year (95% CI, 1.1%-4.7%) for SEER distant stage papillary thyroid cancer.

270 es in OS between these periods were noted in distant-stage gastrointestinal NETs (HR, 0.71; 95% CI, 0

271 NETs has improved over time, especially for distant-stage gastrointestinal NETs and pancreatic NETs

272 ort as well as specific subgroups, including distant-stage gastrointestinal NETs and pancreatic NETs.

273 tinal NETs (HR, 0.71; 95% CI, 0.62-0.81) and distant-stage pancreatic NETs (HR, 0.56; 95% CI, 0.44-0.

274 te + nitrite concentrations compared to more distant stations.

275 studied populations into two geographically distant subpopulations.

276 polysome granules before their transport to distant synaptic locales.

277 dues for the propagation of input signals to distant target binding sites.

278 n sensory systems has been documented across distant taxa, fewer studies have investigated how change

279 dentify novel activities toward insects from distant taxonomic Orders and establish this technology b

280 3 gene, enabling functional interaction with distant TCF4/beta-catenin-binding sites in the intron of

281 ted in murine infection and dissemination to distant tissues after needle inoculation.

282 tumour microenvironment and systemically in distant tissues.

283 mote the spreading of primary tumor cells to distant tissues.

284 Although located distant to the active site, the C2 domain greatly enhanc

285 hin coiled or beta-sheet regions in domain B distant to the active site.

286 y, clinicians and researchers test specimens distant to the site of infection.

287 and their role in driving the stimulation of distant tumor growth and (b) use adjuvant drug therapies

288 Combined RFA plus S3I-201 reduced systemic distant tumor growth at 7 days (end diameter: 11.8 mm +/

289 also suppressed postablation stimulation of distant tumor growth, proliferation, and microvascular d

290 ence (P = 0.716 and 0.900, respectively), or distant tumor relapse (P = 0.303 and 0.471, respectively

291 tion STAT3 activation is linked to increased distant tumor stimulation and can be suppressed with adj

292 activated T cells in both virus-injected and distant tumours, and leads to effective rejection of bot

293 d that MLL4 catalyzed methylation of H3K4 at distant unbound enhancers via chromatin looping, which i

294 of antiviral signals from infection sites to distant uninfected tissues.

295 te eradication of primary treated tumors and distant untreated tumors in some mice implanted with the

296 Sequential immunization with mutationally distant variants is shown to robustly induce bnAbs that

297 To validate these findings in a distant vertebrate species, we used single-cell RNA sequ

298 s showed markedly different affiliation with distant visually responsive areas and fell coarsely into

299 nt failures were largely (31 [48%] patients) distant, with low rates of crude local (10 [16%]) and re

300 through intestinal barriers, a fundamentally distant yet important clinical phenomenon.