ライフサイエンスコーパス: distribution volume

1 t brain uptake can be robustly calculated as distribution volume.

2 ypoxia (k3), perfusion (K1), and (18)F-FMISO distribution volume.

3 odeling was used to estimate the radioligand distribution volume.

4 binding) to cerebellum (nonspecific binding) distribution volume.

5 of tumor hypoxia, perfusion, and radiotracer distribution volume.

6 ith regional tracer binding quantified using distribution volume.

7 y, corresponding to changes in [(11) C]PBR28 distribution volume.

8 del to derive reliable estimates of regional distribution volumes.

9 n volume, 0.182 vs 0.244; median whole liver distribution volume, 0.175 vs 0.207; P = .008).

10 ntly increased after treatment (median tumor distribution volume, 0.182 vs 0.244; median whole liver

11 Distribution volume (130 min) was lower by 30%-35% in th

12 atistical analysis examined changes in total distribution volume after treatment with AZD3241 compare

13 sion and Hamilton Anxiety Rating scales, and distribution volume also was assessed.

14 y optimal methods for derivation of regional distribution volume and binding potential and to determi

15 l analysis yielded reliable estimates of the distribution volume and could separate newly diagnosed h

16 ector by constraining the binding potential, distribution volume and dissociation rate constant to im

17 umors liver metastases; a lower pretreatment distribution volume and high arterial flow fraction was

18 No relationship between [(11)C]NOP-1A distribution volume and other clinical measures (includi

19 pretreatment did not affect cerebellar total distribution volume and reduced total distribution volum

20 d to compute parameters including fractional distribution volume and the arterial flow fraction.

21 [(123)I]5-IA SPECT images were converted to distribution volume and were analyzed using regions of i

22 Regional distribution volumes and binding potentials were calcula

23 Kinetic models were used to estimate distribution volumes and binding potentials, for which t

24 Total distribution volumes and nondisplaceable binding potenti

25 A SPECT images were converted to equilibrium distribution volumes and were analyzed using regions of

26 and k3-surrogates for perfusion, (18)F-FMISO distribution volume, and hypoxia-mediated entrapment, re

27 on, and arterial flow but lower portal flow, distribution volume, and mean transit time than did the

28 rterial flow, portal flow, total blood flow, distribution volume, and mean transit time) parameters w

29 er transport rate constant k(1), equilibrium distribution volumes, and influx rate constant K than di

30 e benzodiazepine receptor binding measure of distribution volume are consistent with fewer benzodiaze

31 hought to be small (<10%), because values of distribution volume are stable during 60-120 min and var

32 (trans-4-fluorocyclohexanecarboxylic acid), distribution volumes attributed to the parent radioligan

33 ference tissue-based methods to estimate the distribution volume, binding potential (BPND), and SUVR.

34 The cerebellum had the lowest distribution volume, but the time-activity curve data co

35 nitoring, correlation of infused volume with distribution volume, clearance of infused liposome conta

36 The relationships between (123)I-iomazenil distribution volume, clinical features of alcohol depend

37 (18)F-FMISO distribution volume deviated from the expected value of

38 The mean anterior cingulate cortex distribution volume differed across groups (F55 = 3.4; P

39 availability was quantified as VT/fP (total distribution volume divided by free plasma concentration

40 but statistically significant reductions in distribution volume (DV) of both (R)- and (S)-[11C]nicot

41 By comparing the distribution volume (DV) of different regions to the cer

42 ficantly reduced FMZ ligand influx (K1), FMZ distribution volume (DV), and 1CMRg1c bilaterally in the

43 fraction (ART), portal venous fraction (PV), distribution volume (DV), and mean transit time (MTT) of

44 Distribution volume (DV), mean transit time (MTT), and p

45 analysis was used to calculate (18)F-FEAnGA distribution volumes (DV(Logan)) in various brain areas.

46 (DV) of different regions to the cerebellum distribution volume, DV(ratio)-1, which is proportional

47 binding site density (tissue-to-plasma DTBZ distribution volume, DV) from the cerebral and plasma DT

48 an index of nigrostriatal terminal density (distribution volume; DV), also provide a measure of tran

49 The ratio of striatal-to-occipital distribution volume (DVR) was calculated directly by usi

50 ressure), and brain DA [reduced decreases in distribution volumes (DVs) of [(11)C]raclopride, althoug

51 analyzed using graphic analysis to give the distribution volumes (DVs) of different brain regions.

52 2-compartment model for estimation of tracer distribution volumes (DVs).

53 ma to brain transfer constant (K1), striatal distribution volume (DVstr) and DA D2 receptor availabil

54 ) and Logan plot slopes, a measure of tracer distribution volume (equilibrium tissue-to-plasma ratio)

55 The outcome measure was the total distribution volume, estimated with the invasive Logan g

56 The ratio of the distribution volume for [11C]d-threo-methylphenidate in

57 ) x 10(-1) ml/g; n = 5] agreed well with the distribution volume for compartment 1 of the 3-compartme

58 se of peripheral and splanchnic interstitial distribution volumes for [(14)C]inulin.

59 The total distribution volumes for multiple cortical regions and t

60 ided good fits to the PET data, and regional distribution volumes from the latter correlated well wit

61 Distribution volume image data were analyzed by means of

62 cipants, the NFL players showed higher total distribution volume in 8 of the 12 brain regions examine

63 Regional [(11)C]NOP-1A distribution volume in alcohol dependence was not signif

64 g revealed two large excursions in which the distribution volume in alcoholic patients was significan

65 s by examining the stability of the apparent distribution volume in DAT-rich (striatum) and DAT-poor

66 total distribution volume and reduced total distribution volume in other regions to a level comparab

67 [(11)C]NOP-1A distribution volume in regions of interest (including th

68 Main Outcome Measure Relative distribution volume in regions of interest was used as t

69 The distribution volume in the cerebellum increased up to 1.

70 onsistent with the rodent data, the apparent distribution volume in the cerebellum of both humans and

71 uantifying the following for 5-FU in tumors: distribution volume in the extracellular space, cell tra

72 There was no overall change in total distribution volume in the placebo group (n = 6).

73 lability was measured using the ratio of the distribution volume in the putamen to that in the cerebe

74 ning times required to derive time-invariant distribution volumes in all regions were comparable for

75 Bmax/Kd (ratio of the distribution volumes in striatum to that in cerebellum m

76 Total distribution volumes in the cerebellum were 6.91 +/- 0.6

77 The distribution volumes in the thalamus were measured in th

78 (18)F-FDG distribution volume increased with infiltrating neutroph

79 Benzodiazepine receptor distribution volume is significantly lower in several co

80 ire duration of imaging, in which delay, K1, distribution volume, k3, and k4 were optimized using a n

81 ron emission tomography measured MAO-A total distribution volume (MAO-A VT), an index of MAO-A densit

82 aging scans) and by a pixel-by-pixel method (distribution volume maps were analyzed with statistical

83 he AD3241 treatment group (n = 18) the total distribution volume of (11)C-PBR28 binding to translocat

84 f the ratio of (111)In/(18)F to the apparent distribution volume of (99m)Tc-DTPA.

85 ic modeling of binding potentials revealed a distribution volume of 334 in cerebral blood that droppe

86 resulted in an increase in the nanoparticle distribution volume of 51% and 123%, respectively.

87 They measured the distribution volume of benzodiazepine receptors in 11 re

88 with the [11C]raclopride data to derive the distribution volume of D2 receptors.

89 ance [ANOVA]), indicating an increase in the distribution volume of Gd-DTPA-BMA in postischemic myoca

90 cement of myocardial necrosis is the greater distribution volume of injured myocardium compared with

91 lood-to-brain transfer constant, Ki, and the distribution volume of mobile protons, Vp) of 15 out of

92 ution volume of the region of interest minus distribution volume of the cerebellum.

93 d a volume-of-interest basis using the total distribution volume of the radioligand (18)F-3-fluoro-5-

94 ulated with the formula: binding potential = distribution volume of the region of interest minus dist

95 This would reduce distribution volume of therapeutics, and consequently mi

96 There was no significant correlation between distribution volumes of (11)C-tariquidar or (11)C-elacri

97 s of (11)C-tariquidar or (11)C-elacridar and distribution volumes of (R)-(11)C-verapamil in different

98 -euglycemic clamps, transport parameters and distribution volumes of [(14)C]inulin were determined in

99 The fractional distribution volumes of gadopentetate dimeglumine and 99

100 nucleoid, and (ii) localization patterns and distribution volumes of sRNAs can differ from some large

101 F-FDG phosphorylation rate (P < 0.05) and to distribution volume (P < 0.01).

102 The median initial distribution volume predicted by the model was consisten

103 roaches yielded more stable estimates of the distribution volume ratio (1 + BPND), with coefficients

104 r characteristic analysis identified optimal distribution volume ratio (1.06) and standard uptake val

105 ng the specific distribution volume (VS) and distribution volume ratio (DVR [2TCM]) and a multilinear

106 quantification were explored including Logan distribution volume ratio (DVR) and static SUV ratio (SU

107 (18)F-NOS uptake was quantified as the distribution volume ratio (DVR) determined by Logan plot

108 ed using various SUVR approaches, as well as distribution volume ratio (DVR) estimated with (blDVR) o

109 reduction (20.6%; P < 0.0001) in the mGluR5 distribution volume ratio (DVR) in the gray matter of 14

110 The SUVRs were compared with Logan graphical distribution volume ratio (DVR) measurements (35-90 min)

111 CAR90 best agreed with ART90 distribution volume ratio (DVR) measures across brain re

112 Microglial activation was evaluated as the distribution volume ratio (DVR) of (11)C-PK11195 from dy

113 reference tissue method was used to generate distribution volume ratio (DVR) parametric maps for a su

114 Regional TSPO availability was measured as a distribution volume ratio (DVR) relative to the caudate

115 egion, was used to estimate various regional distribution volume ratio (DVR) values in the brain befo

116 RTM) and SRTM2; the Logan graphical analysis distribution volume ratio (DVR) was calculated for 30-15

117 n-of-interest analysis was performed and the distribution volume ratio (DVR) was computed for striatu

118 C-PBR28 PET total volume of distribution and distribution volume ratio (DVR) were estimated using 2-t

119 In vivo binding was evaluated using the distribution volume ratio (DVR) with respect to a refere

120 tention that included compartmental modeling distribution volume ratio (DVR), arterial- and reference

121 eta) in vivo is often accomplished using the distribution volume ratio (DVR), based on a simplified r

122 Plasma-input Logan distribution volume ratio (DVR)-1 values agreed well wit

123 lar amyloid measured by global mean cortical distribution volume ratio (P=0.075) and within the precu

124 ormal-tissue ratio (tau = 0.07, P = 0.56) or distribution volume ratio (tau = 0.26, P = 0.14).

125 etention was significantly increased in CAA (distribution volume ratio 1.18 +/- 0.06) relative to hea

126 retest variability was less than 15% for the distribution volume ratio and 12% for the radioactivity

127 ratio (r = 0.89; P = 0.001) but not between distribution volume ratio and either PR status or standa

128 We quantified the [11C]PiB distribution volume ratio and standardized uptake value

129 there was a significant correlation between distribution volume ratio and T/N ratio (r = 0.89; P = 0

130 The distribution volume ratio and the standardized uptake va

131 Normal-appearing white matter distribution volume ratio at baseline was correlated wit

132 Good agreement was found between the distribution volume ratio calculated using the graphic t

133 The resulting distribution volume ratio correlated with a low bias tow

134 on of (18)F-FEOBV correlated highly with the distribution volume ratio estimates from reference tissu

135 Distribution volume ratio estimates obtained using compa

136 The distribution volume ratio for the basal ganglia was then

137 At 12 mo, the Logan distribution volume ratio for the FC was 1.03 and 0.93 (

138 the amyloid-positive group with cortical PiB distribution volume ratio greater than 1.2.

139 A and AD subjects were PiB-positive, both by distribution volume ratio measurements and by visual ins

140 PET data analysis employed the distribution volume ratio method (DVR) in which the cere

141 implified reference tissue model (SRTM) with distribution volume ratio minus 1 (DVR - 1) for 60- and

142 Microglial activation was evaluated as distribution volume ratio of (11)C-(R)-PK11195.

143 ta level was measured according to a summary distribution volume ratio of frontal, lateral temporal a

144 S had an increased hippocampal [(18)F]PBR111 distribution volume ratio relative to healthy control su

145 (11)C-d-Methamphetamine distribution volume ratio was not substantially affected

146 rol subjects (p = .024), and the hippocampal distribution volume ratio was strongly correlated with t

147 al-appearing white matter was estimated as a distribution volume ratio with respect to a caudate pseu

148 ar monoaminergic transporter type 2 binding (distribution volume ratio) and thalamic and cortical ace

149 ominent contributor to this group (mean [SD] distribution volume ratio, 1.08 [0.05] for the SNAP grou

150 Voxel-wise maps of [(11) C]PIB distribution volume ratio, reflecting myelin content, we

151 g the baseline normal-appearing white matter distribution volume ratio, T2 lesion volume and normal-a

152 mal tissue and tumor to muscle, and relative distribution volume ratio.

153 ptake value ratio, and 11C-PiB were given as distribution volume ratio.

154 correlated with BDI scores and [(18)F]PBR111 distribution volume ratio.

155 81.0%, standard uptake value ratiolow 83.3%; distribution volume ratiohigh 61.9%, standard uptake val

156 lds (standard uptake value ratiohigh = 1.40, distribution volume ratiohigh = 1.20) that are more cons

157 compound-B positivity (typically at or above distribution volume ratiohigh and standard uptake value

158 iolow 95.8%; standard uptake value ratiolow, distribution volume ratiohigh and standard uptake value

159 nsitive than high thresholds (sensitivities: distribution volume ratiolow 81.0%, standard uptake valu

160 neuritic plaques, with similar specificity (distribution volume ratiolow 95.8%; standard uptake valu

161 olds (standard uptake value ratiolow = 1.21, distribution volume ratiolow = 1.08) that represent the

162 s that were nearly identical to the a priori distribution volume ratiolow and standard uptake value r

163 Distribution volume ratios (DVR) of [(18) F]Nifene in wh

164 o (SUVR) and the Logan plot result in biased distribution volume ratios (DVRs) in ligand-receptor dyn

165 urgh compound B positron emission tomography distribution volume ratios (DVRs).

166 TSPO tracer (18)F-GE180, we then calculated distribution volume ratios after establishing a suitable

167 n of (18)F-GE180, which correlated well with distribution volume ratios calculated from the entire re

168 ke value ratios calculated at late times and distribution volume ratios estimated with the reference

169 Distribution volume ratios for maternal and fetal brain

170 TBI showed significantly increased [11C]PiB distribution volume ratios in cortical gray matter and t

171 Increases in [11C]PiB distribution volume ratios in patients with TBI were see

172 (11)C-PIB distribution volume ratios of regions of interest were e

173 The distribution volume ratios of the maternal striatum were

174 ional (11)C-PIB retention was quantitated as distribution volume ratios using Logan graphical analysi

175 Distribution volume ratios were calculated to quantify b

176 [11C]PIB distribution volume ratios were calculated using Logan g

177 TRODAT-1 distribution volume ratios, a reflection of DAT availabi

178 On the basis of mean cortical distribution volume ratios, participants were divided in

179 erize and compare cerebral-to-cerebellar PIB distribution volume ratios, reflecting fibrillar Abeta b

180 The distribution volume reduction across nigrostriatal regio

181 omographic images were converted to units of distribution volume (regional activity/free (123)I-iomaz

182 the uptake in the brain can be quantified as distribution volume relative to concentrations of (18)F-

183 In responders, tumor and whole liver distribution volume significantly increased after treatm

184 enil revealed normal benzodiazepine receptor distribution volumes, similar to those seen in sporadic

185 this effect depends on the magnitude of the distribution volume, so that the bias is more pronounced

186 ients had significantly lower benzodiazepine distribution volume than comparison subjects in the fron

187 ection and residuals and resulted in greater distribution volumes than did no damping with the first

188 raphic method enables derivation of regional distribution volumes that are free from assumptions abou

189 Translocator protein density measured by distribution volume (TSPO VT) is increased in activated

190 is technique was first optimized to maximize distribution volume, using tissue-simulating phantoms.

191 cer were found for transport k(1), influx K, distribution volume V(d), as well as early (6-10 min) an

192 ts in the 42 healthy subjects (average Logan-distribution volume (V T) was 13.3+/-3.8 mL/cm(3) for fu

193 Total distribution volume (V(T)) and binding potentials (k3'/k

194 d that receptor density can be quantified as distribution volume (V(T)) using the gold standard of co

195 Brain uptake was measured as total distribution volume (V(T)) using the Logan plot and meta

196 ility) were assessed for 3 outcome measures: distribution volume (V(T)), binding potential (BP), and

197 edures were used for calculation of regional distribution volume (V(T)), nondisplaceable binding pote

198 equate time for more accurate measurement of distribution volume (V(T)), which is the summation of re

199 Distribution volume (V(T); a measure of receptor density

200 Distribution volume (V(T); a measure of receptor density

201 terial input function, we measured the total distribution volume (V; specific plus nondisplaceable),

202 The estimated MIBG distribution volumes (V(d)) for transduced Jurkat, C6, a

203 (specific plus nondisplaceable compartments) distribution volumes (V(T)') agreed between bolus and B/

204 ood data were used to calculate steady-state distribution volumes (V(T)) during the baseline conditio

205 Regional distribution volumes (V(T)) were derived for 16 brain re

206 Total distribution volumes (V(T)) were derived using kinetic 2

207 ta and more robust derivations of the tissue distribution volumes (V(T), in mL/g) than a 2-tissue com

208 was injected into Compartment 1, the initial distribution volume (Vd) of the antibody, which included

209 rmed in living brain (kloss); and the tracer distribution volume (Vd), which is an index of dopamine

210 9-yl)acetamide) to determine nondisplaceable distribution volume (VND) via Lassen occupancy plotting

211 rom the estimated Kd and the nondisplaceable distribution volume (VND).

212 orrected plasma data estimating the specific distribution volume (VS) and distribution volume ratio (

213 -compartment model fitted the data well, and distribution volume (VT) (mLcm(-3)) values ranged from 1

214 to arrive at reliable estimates of regional distribution volume (VT) and binding potential (BPND) wi

215 Parametric distribution volume (VT) and influx rate (K1) were compa

216 The [11C]PBR28 distribution volume (VT) corrected for free fraction (fP

217 the absence of group differences in SUV and distribution volume (VT) estimated with an arterial inpu

218 The distribution volume (Vt) for (18)F-UCB-H was calculated

219 ivated during neuroinflammation and the TSPO distribution volume (VT) is an index of TSPO density.

220 The total distribution volume (VT) of the tracer was significantly

221 Intersubject variation in the cerebellar distribution volume (VT) was clearly related to the TSPO

222 With the lowest steady-state distribution volume (VT), determined in the corpus callo

223 late 5 outcome measures in 14 brain regions: distribution volume (VT), VT normalized by fP (VT/fP), a

224 2T) models were evaluated to calculate total distribution volume (VT).

225 d as an increase in [(11)C]flumazenil tissue distribution volume (VT).

226 in a priori volumes of interest, with total distribution volume (VT/fP) being the measure of nAChR a

227 gs of each parametric method were optimized, distribution volumes (VT) obtained with Logan graphic an

228 gs of each parametric method were optimized, distribution volumes (VT) obtained with Logan graphic an

229 ssue-compartment modeling for calculation of distribution volumes (VT).

230 er across the BRB (K1, k2) and total retinal distribution volume VTDuring ABCB1 inhibition, retinal V

231 er across the BRB (K1, k2) and total retinal distribution volume VTResults: During ABCB1 inhibition,

232 The pretreatment whole liver distribution volume was significantly lower in responder

233 Distribution volume was well identified ( approximately

234 related to benzodiazepine receptor binding (distribution volume) was obtained with single photon emi

235 equate time for more accurate measurement of distribution volume, we selected a scan duration (i.e.,

236 (18)F-FDG phosphorylation rate and distribution volume were calculated with a 4-compartment

237 The values of distribution volume were well identified and had relativ

238 Regional total distribution volumes were derived using the arterial inp

239 Distribution volumes were derived using the Logan graphi

240 Lower distribution volumes were found in the prefrontal cortex

241 The fractional distribution volumes were greater in infarcted myocardiu

242 noise is associated with underestimation of distribution volumes when data are analyzed with graphic

243 primary outcome parameter was [(18)F]FP-TZTP distribution volume, which is proportional to the produc