ライフサイエンスコーパス: disturb

1 e transport properties of these segments are disturbed.

2 early mesoderm when BMP and Wnt crosstalk is disturbed.

3 amino acid-related biological pathways were disturbed.

4 ng disposition, while the tip of motif VI is disturbed.

5 that the integrity of the protein HOS is not disturbed.

6 in these cells the mitochondrial network was disturbed.

7 Proteins significantly disturbed (214 out of 1906 detected, q < 0.05) were invo

8 st, as well as relocation to the open-ocean, disturb A. triostegus larvae transformation and grazing

9 About 4.6 billion years ago, some event disturbed a cloud of gas and dust, triggering the gravit

10 s of nicotinic acetylcholine receptors, they disturb acetylcholine receptor signaling leading to neur

11 use model that calcium homeostasis in PNs is disturbed across a broad range of physiological conditio

12 olin, leading to severed actin filaments and disturbed actin dynamics.

13 Ranging) to understand orangutan movement in disturbed and fragmented forests of Malaysian Borneo.

14 studies arguing that encoding operations are disturbed and others supporting deficits in memory maint

15 ental and spatial variables differed between disturbed and undisturbed forests (e.g., when Bray-Curti

16 different depths of evolutionary history in disturbed and undisturbed subtropical forests.

17 of IAA fluorescence signals in root tips was disturbed, and the IAA transportation from shoot base to

18 study provides a glimpse into how Aurein 1.2 disturbs anionic lipid-containing membranes without pore

19 e ideal properties to facilitate recovery of disturbed areas, thereby imparting a level of systemic r

20 habitat and force animals into degraded and disturbed areas.

21 Although the majority of C4 plants occupy disturbed, arid, and nutrient-poor habitats, some grow i

22 novel treatments for clinical conditions of disturbed arousal and sleep.

23 the specific expression of neuronal genes is disturbed as documented for MED12/p.R1295H mutation.

24 This environment is increasingly disturbed as human activity encroaches on previously une

25 oss of network efficiency, which could drive disturbed attentional and visual processing.

26 ignin perturbation, but rather the result of disturbing auxin homeostasis.

27 ular auxin transport, we concluded that MDCA disturbs auxin gradients by interfering with auxin efflu

28 The strongly disturbed BCR signaling of CD21(low) B cells is characte

29 When normal thyroid function is disturbed because of ionizing radiation (IR) exposure, d

30 energy metabolism, occur in normal aging and disturbed bioenergetics may be an important contributing

31 lops preferentially in vascular regions with disturbed blood flow (arches, branches, and bifurcations

32 Disturbed blood flow (d-flow) induces atherosclerosis by

33 n the AV are differentially expressed due to disturbed blood flow (oscillatory shear (OS)) experience

34 Atherosclerosis impacts arteries where disturbed blood flow renders the endothelium susceptible

35 We have demonstrated that acutely disturbed blood flow with increased retrograde shear str

36 ally develop in arterial regions experienced disturbed blood flow, which induces endothelial expressi

37 referentially in arterial regions exposed to disturbed blood flow.

38 obal IL-6 inhibition during the repair phase disturbed bone formation and remodeling.

39 Deletion of beta-catenin disturbed bone remodeling, as confirmed by increased bon

40 Seizures in temporal lobe epilepsy (TLE) disturb brain networks and lead to connectivity disturba

41 based assay in which mitosis is consistently disturbed by centrosome loss.

42 iving close to forest margins fragmented and disturbed by deforestation may be particularly exposed t

43 t can bring spin into a sample without being disturbed by electric energy.

44 hat over 60% of the riparian zones have been disturbed by human activities.

45 gulator for mitochondrial function, which is disturbed by maternal diabetes.

46 rge-scale chromatin reorganization, which is disturbed by MeCP2 Rett syndrome mutations.

47 When 2 Mha of Amazonian forests are disturbed by selective logging each year, more than 90 T

48 the E. coli population was only transiently disturbed by the introduction of new lineages before a n

49 This regulation of CD62L is disturbed by the presence of Tregs, because Tregs remove

50 Combined with the previous description of disturbed Ca(2+) signaling, the discovery of NF-kappaB s

51 inhibited lymphatic sprouting, presumably by disturbing calcium signaling.

52 Blocking KCa1.1 disturbs calcium homeostasis, leading to the sustained p

53 tive tricarboxylic acid cycle replenishment, disturbed carbohydrate metabolism, reduced phytosterol b

54 s enteric neuronal development and can, when disturbed, cause long-lasting abnormalities of GI functi

55 havior, including enhanced F-actin assembly, disturbed cell polarity, and increased cell motility.

56 ryl hydrocarbon receptor, the data suggest a disturbed cell-to-cell communication in this disease.

57 synthetic ion transporters have been used to disturb cellular ion homeostasis and thereby induce cell

58 sms with neurodegenerative diseases, such as disturbed cellular calcium and energy homeostasis and ac

59 amics and mitochondrial quality control, and disturbed cellular interorganellar communication.

60 evidence that this particular CISD2 mutation disturbs cellular Ca2+ homeostasis with enhanced Ca2+ fl

61 pregnancy leads to pseudo-MTHFR deficiency, disturbed choline/methyl metabolism, embryonic growth de

62 al biogenesis, increased ROS production, and disturbed circadian clock synchronization of glucose and

63 Major depressive disorder is associated with disturbed circadian rhythms.

64 uthern taiga), although mapping accuracy for disturbed classes was generally low (the highest of 31%

65 n of radiation from the RPT radionuclide may disturb coincidence detection and impair image resolutio

66 talpha reduces axonal filopodia dynamics and disturbs collateral branch formation.

67 robiota was still exhibiting a significantly disturbed composition whereas fecal microbiota recovered

68 More than 5,000 km separates the frequently disturbed coral reefs of the Eastern Tropical Pacific (E

69 gamma band (approximately 30-80 Hz), reflect disturbed cortical information processing in this patien

70 ion toward a proinflammatory signature and a disturbed crosstalk with trophoblasts.

71 es atherogenicity in inflamed macrophages by disturbing CWC22/EJC systems.

72 In line with the disturbed development of LSO circuitry, auditory process

73 leads to more proliferative keratinocytes in disturbed differentiation stages.

74 Increased Bax expression, a disturbed distribution of cytochrome c, and cleaved casp

75 A disturbed distribution pattern of mitochondria was predo

76 tudied extensively in various disorders with disturbed dopamine homeostasis.

77 When EI balance is disturbed during learning and memory in animal models, i

78 The disturbed eating behavior can be restored by substitutio

79 op severe diabetes and, additionally, show a disturbed eating behavior with reduced satiety.

80 redicted that blocking PFKFB3 normalizes the disturbed EC rearrangement in high VEGF conditions, as o

81 may alter carbon cycles in anthropogenically disturbed ecosystems at broad scales.

82 tant aspect of the non-linear restoration of disturbed ecosystems.

83 y tandem mass spectrometry, showed that they disturb either the assembly or the stability of the V-AT

84 at propagate up to the ionosphere generating disturbed electron densities in the E and F regions.

85 defects, indicating that the D-Tg transgenes disturbed enamel formation less than the A-Tg transgenes

86 st impairs endocytosis, we hypothesized that disturbed endocytosis might be a key cellular mechanism

87 ere with internalization of Yersinia without disturbing endocytosis.

88 results in increased vascular resistance and disturbed endothelial nitric oxide production.

89 tic flux analysis confirmed that mensacarcin disturbs energy production and mitochondrial function ra

90 ly to cells encountering surplus copper that disturbs envelope homeostasis, emulating the role of the

91 As disturbed epidermal differentiation is a main feature of

92 nocturnal secretion of melatonin, which may disturb estrogen regulation, leading to increased breast

93 radeoffs of the alternative schedule without disturbing existing clinical systems.

94 tional promoter activity of this element may disturb expression of neighboring genes.

95 s, family history of substance use disorder, disturbed family environment, childhood parental loss, l

96 Disturbed flow (DF) occurs in arterial bifurcations and

97 This study tested in vivo the involvement of disturbed flow and of neutrophils, hyaluronan, and Toll-

98 ance imaging, is a measure of energy loss in disturbed flow as it occurs, for instance, in aortic ste

99 In mice, disturbed flow as the result of partial carotid artery l

100 The maladaptation of endothelial cells to disturbed flow at arterial bifurcations increases permea

101 y bind to endothelial cells (ECs) exposed to disturbed flow condition in pro-atherogenic regions.

102 e known to maintain endothelial homeostasis, disturbed flow conditions including those the endotheliu

103 ritical role of the activation of YAP/TAZ by disturbed flow in promoting atheroprone phenotypes and a

104 P/TAZ knockdown significantly attenuated the disturbed flow induction of EC proliferative and proinfl

105 Together, our results demonstrate that disturbed flow influences endothelial function and induc

106 selectively bound to arterial ECs exposed to disturbed flow not only in the partially ligated carotid

107 -ICAM-1 specifically bound to endothelium in disturbed flow regions, reducing endothelial ICAM-1 expr

108 d endothelial cells (ECs) to the atheroprone disturbed flow resulted in YAP/TAZ activation and transl

109 tion of inflammatory signaling at regions of disturbed flow, and flow-dependent vascular remodeling.

110 dysfunction caused by the combined action of disturbed flow, inflammatory mediators and oxidants deri

111 inhibition in arterial wall ameliorates the disturbed flow-induced atherosclerosis through, at least

112 inhibited YAP/TAZ activities to diminish the disturbed flow-induced proliferation and inflammation.

113 ylation in vascular endothelium subjected to disturbed flow.

114 s in a flume in response to laminar flow and disturbed flow.

115 zation with a recovery state or time-lag for disturbed ("focal") patches, thus assuming that recoloni

116 Between paired units, the more recently disturbed ("focal") unit's beetle abundance was positive

117 gest that although orangutans do make use of disturbed forest, they select certain canopy attributes

118 d a significant effect on beta diversity for disturbed forests but had no effect on undisturbed fores

119 o a decline of 1/3 in the capacity of these disturbed forests to recover and recapture the C lost in

120 lture on PEOT/PBT and polysulfone profoundly disturbed function of islets, and induced severe tissue

121 (sIPSCs) in POMC neurons were unaffected by disturbing GABA release from AgRP neurons either by cell

122 a potential calpain autolytic site severely disturbs gametophore development.

123 t molecular signals due to NF1 mutations may disturb gene expressions, a subset of which defines cont

124 fferentiation and antibody responses without disturbing germinal center reactions.

125 ffects such as hyperphagia, hypermetabolism, disturbed glucose homeostasis, altered hematological par

126 her condition is necessarily associated with disturbed glucose metabolism.

127 e regulation, and long-QT syndrome may cause disturbed glucose regulation.

128 of illness-induced glucagon abundance in the disturbed glucose, lipid, and amino acid homeostasis and

129 Obesity, and the associated disturbed glycerolipid/fatty acid (GL/FA) cycle, contrib

130 y, we show that biallelic mutations in EXTL3 disturb glycosaminoglycan synthesis and thus lead to a r

131 A subgroup of CDGs can be attributed to disturbed Golgi homeostasis.

132 d reduced lifespan, reduced granularity, and disturbed granule morphology.

133 agents for weak electron doping without much disturbing graphene electronic pi-bands.

134 Although the value of disturbed habitats needs to be recognized in conservatio

135 imal species in this dataset are absent from disturbed habitats, even though most samples do still re

136 e both Ca(2+) transients and the tendency to disturb heart rhythm.

137 In this article, we show that, instead of disturbed heparin interactions, the impaired ability of

138 ws might also occur in healthy people due to disturbed hippocampal function arising during mental pro

139 trieval, exhibits characteristics indicating disturbed hippocampal function, and is predicted by redu

140 s and point out another deleterious trait of disturbed homocysteine levels that could participate in

141 pathogens have evolved various strategies to disturb hormonal homeostasis and facilitate infection.

142 n skin of AD patients, possibly leading to a disturbed host defense, which facilitates bacterial pers

143 ssociated with enhanced mortality and a more disturbed host response during sepsis independent of dis

144 in and establish the mechanism by which NSP4 disturbs host cell Ca(2+) homeostasis.

145 activation by AMPylation of its SBD does not disturb Hsp70 inter-domain allostery and preserves BiP s

146 Disturbed hypoxia sensing and signaling provides a mecha

147 Such changes can disturb immune system development.

148 Our results indicate a markedly disturbed immune signature in the cerebrospinal fluid of

149 Our study aims to investigate whether disturbed imprinting contributes to preeclampsia.

150 rovides evidence of a true association among disturbed imprinting, gene expression, and preeclampsia.

151 As a result of disturbed imprinting, the upregulated DLX5 affects troph

152 bolic pathway for ascorbate and aldarate was disturbed in all exposed spinach plants (nanopesticide a

153 eveals that host-microbiota interactions are disturbed in CD and thus provides mechanistic insights i

154 are essential for health and are frequently disturbed in disease.

155 We show that MT arrays are disturbed in gem3/aug6-1 during male meiosis and pollen

156 Cell-specific gene expression was widely disturbed in interferon- and IRF8-regulated transcripts.

157 effectors and ciliary proteins are severely disturbed in Npc1-deficient mice.

158 rgically stimulated adiponectin secretion is disturbed in obesity/type 2 diabetes as a result of the

159 This integration may be disturbed in patients with either hippocampal or vmPFC d

160 in the gamma frequency range (30-80 Hz) are disturbed in schizophrenic patients during cognitive pro

161 Chronotropic response was more disturbed in stage C3 than C1 and C2.

162 inetics of chemokine receptor signaling were disturbed, including chemokine- induced integrin activat

163 Using computational modeling, we demonstrate disturbed inference on alternative choice options in alc

164 Loss of this organization underlies disturbed insulin secretion kinetics in T2D.

165 thesized that clinical iron deficiency would disturb integrated human responses to hypoxia.

166 A disturbed integration of alternative choice options impl

167 cant decreased protein levels (P = 0.02) and disturbed interendothelial localization of the shear sen

168 the three substitutions promoting MxA escape disturbed intracellular trafficking of incoming viral ri

169 he normal microbiome population structure is disturbed, is a key feature in disorders of metabolism a

170 diversities of subtropical forests in human disturbed landscapes is still limited.

171 " patches can vary, especially in frequently disturbed landscapes such as fire-managed forests that h

172 Ablation of descending LPNs in mice disturbs left-right coordination at high speeds without

173 s of cellular lipid metabolism and implicate disturbed lipid biology in childhood-onset DYT1 dystonia

174 ne before significant heat is accumulated to disturb living tissues.

175 oxC clusters during differentiation not only disturbs local chromatin domain organization and regulat

176 yltransferase-deficient mice, manifesting as disturbed lymph node homeostasis and unresponsiveness to

177 le to common magnetic probes, insensitive to disturbing magnetic fields, and the antiferromagnetic el

178 on EC exposures had the most marked effects, disturbing maternal and fetal liver chemical profiles, m

179 We hypothesized that placental malaria may disturb maternofetal exchange of vitamins, lipids, and h

180 servations have been theoretically linked to disturbed mechanisms of inference, for example, to diffi

181 e immunologic treatments on pruritus and the disturbed microbiome in patients with AD has other poten

182 Moreover, disturbed mitochondrial function was ameliorated and the

183 Disturbed mitochondrial fusion and fission have been lin

184 cancer cells led to decreased NADPH levels, disturbed mitochondrial redox homeostasis, and increased

185 Here, we report that Ptpn11 GOF mutations disturb mitosis and cytokinesis, causing chromosomal ins

186 The extract disturbed more metabolic pathways than the three most ab

187 es across four restored and four unrestored, disturbed mountaintop communities.

188 gressive soft tissue cancer characterized by disturbed myogenic differentiation.

189 or Nek6 function in noncancer-derived cells disturbs neither spindle formation nor mitotic progressi

190 uently, deficits of ribosomal biogenesis may disturb neurodevelopment by reducing neuronal connectivi

191 lly impaired glucose tolerance, suggest that disturbed neuroenergetic regulation may be involved in t

192 ype mouse embryonic brains was sufficient to disturb neurogenesis and neuronal migration in a similar

193 Clinical iron deficiency disturbs normal responses to hypoxia, as evidenced by ex

194 t for closed forests (>83%), both intact and disturbed, of a range of tree heights (5->19 m).

195 yte progenitor cells following demyelination disturbs OL lineage cell expansion and survival, leading

196 ithin these forests, indicating that not all disturbed or degraded forest is of equal value for the l

197 USP28 function in parallel to select against disturbed or delayed mitosis, promoting mitotic efficien

198 Mitosis occurs efficiently, but when it is disturbed or delayed, p53-dependent cell death or senesc

199 uclear genes via retrograde signals from the disturbed organelles toward the nucleus.

200 strains exhibited impaired fracture healing, disturbed osteoclastogenesis and delayed cartilage-to-bo

201 To ensure the flow system does not disturb oxidative modification, Vero cells were labeled

202 ory can influence recolonization of recently disturbed patches and that these effects may persist ove

203 Most of these disturbed pathways are similar to our previous metabolom

204 gnaling individually in each tissue, without disturbing patterning elsewhere.

205 In contrast, disturbing peroxisome function by knockdown of peroxisom

206 m, pleiocotyly, abnormal leaf morphogenesis, disturbed phyllotaxis, fasciated stems, and variegation

207 re complex imbalance in lipid homeostasis by disturbing PI4P metabolism.

208 We found disturbed placental imprinting in preeclampsia and revea

209 CD74-knockout mice showed disturbed placental morphology, reduced junctional zone,

210 on of EN15 by the endogenous promoter caused disturbed pollen tube guidance and reduced fertility.

211 This, together with disturbed proportion of M1/M2 macrophages, accompanied b

212 IEZO2 protein in afferent neurons leading to disturbed proprioception causing aberrant muscle develop

213 oxia, nutrient deprivation and acidification disturb protein folding in the endoplasmic reticulum (ER

214 ily of potent and broad-spectrum antibiotics disturbing protein synthesis through binding to the A si

215 ce connecting cholesterol dysregulation with disturbed pulmonary homeostasis, we are wondering if die

216 ential for forest regeneration in previously disturbed regions.

217 Nino/Southern Oscillation and AGB stocks in disturbed regions.

218 We propose that this is due to a disturbed regulation of the latent-to-lytic switch, alte

219 ne of Rpl10 with testis-specific expression, disturbs ribosome biogenesis in late-prophase spermatocy

220 At present, it is unclear whether disturbed rRNA maturation is a primary or secondary defe

221 m and lend further support to the concept of disturbed selective autophagy pathways in neurodegenerat

222 x in depression is a neural correlate of the disturbed self-appraisal that is characteristic of the i

223 A disturbed sense of self is a core feature of depression.

224 indirect and direct basal ganglia pathways, disturbed sensory processing, and impaired plasticity in

225 ersistence of coral dominance at chronically disturbed shallow sites is likely due to an abundance of

226 Induction of disturbed shear stress in vivo and in vitro resulted in

227 The nature of these adaptations (disturbed signaling or compensation) is discussed.

228 e NVC, were enhanced under high ACh tone and disturbed significantly by ACh depletion.

229 conditions like depression and aging, where disturbed sleep coalesces with specific hormonal and imm

230 he resulting sickness behaviors (e.g., pain, disturbed sleep), depressive symptoms, and negative heal

231 e indicate that an impaired molecular clock, disturbed sleep, and shifting light-dark patterns influe

232 evere developmental delay and a dramatically disturbed sleep-wake cycle, with very long wake and slee

233 S mice showed impaired glucose tolerance and disturbed sleep.

234 ng excessive anxiety, antisocial traits, and disturbed sleep.

235 d P2X7R function in heterozygote individuals disturbs sleep and might increase the risk for developin

236 nucleosomes simultaneously with H1s without disturbing specific contacts between the H1 globular dom

237 Disturbed striatal activity dynamics relating to the slo

238 Involuntary movements arise from disturbed striatal resting activity through two differen

239 sing HaCaT cells as models that this variant disturbed subcellular localization, expression and solub

240 eceptor kinase 2 (GRK2) could counteract the disturbed substrate metabolism of late-stage heart failu

241 The development of disturbed substrate utilization of FASN transgenic cardi

242 Decompensated cirrhosis is characterized by disturbed systemic and splanchnic hemodynamics.

243 Colloidal particles disturb the alignment of rod-like molecules of liquid cr

244 plied that diminish rigidity of enzyme might disturb the catalytic conformation of tyrosinase.

245 evels and/or enhance intracellular ROS could disturb the cellular oxidative environment and induce ce

246 the addition of oil to the lipid phase could disturb the crystalline order and form lattice defects.

247 ndicate that Hdc deficiency in mice does not disturb the development of striatal and cortical interne

248 used reporter strategies can systematically disturb the dynamics they are intended to monitor, somet

249 enced by structural imperfections, which can disturb the flow and dynamics of exciton-polariton conde

250 ribacters and their metabolic activities may disturb the function of phloem, via disrupting osmotic g

251 induce large dynamic stress changes that may disturb the magma chamber of a volcano, thus acceleratin

252 Activation of CXCR3 signaling may disturb the maternal-fetal tolerance, and this may promo

253 e experimental procedures for separation may disturb the metabolic state of cells.

254 fically target S. mutans biofilms but do not disturb the overall oral microbiome are available.

255 t that these conformational changes can also disturb the protein's ability to interact with and adsor

256 high metabolic demand, and oxidative stress, disturb the protein-folding capacity of the endoplasmic

257 e-organizes catalytic residue Q61; mutations disturb the R789/Q61 organization, impairing GAP-mediate

258 SC therapies that promote differentiation or disturb the stem cell niche effectively reduced tumor in

259 ed via a rational approach and proved not to disturb the structure of the chaperonin, as demonstrated

260 errant alignment of endothelial cells, which disturbed the feto-maternal circulation.

261 The HFHS diet also disturbed the hormone and metabolite milieu and altered

262 functional evidence that epidermal Par3 loss disturbed the inside-out skin barrier, coinciding with a

263 N. caninum expressing TgGRA15 differentially disturbed the NF-kappaB pathway, inducing an increased I

264 ggested that D-galactose and its metabolites disturbed the spindle structure and chromosomal alignmen

265 r microstructure impact cognition in part by disturbing the ability of neural assemblies to synchroni

266 f (18)F-FAZA may be compromised, potentially disturbing the association between tissue hypoxia and (1

267 tidylcholine (PC) fatty acyl desaturation by disturbing the balance between FAD2 and FAD3 activities.

268 tends the length of the alpha5 helix without disturbing the beta6-alpha5 loop interactions.

269 maintaining long trap lifetimes and without disturbing the coherence of an ion quantum bit in an adj

270 g human lifestyles and medical practices are disturbing the content and diversity of the microbiota,

271 neumococcal disease can be conferred without disturbing the desirable preexisting commensal colonizat

272 hat DDX41 suppresses p21 translation without disturbing the function of p53 to directly induce p21 mR

273 iochemical analysis of site-directed mutants disturbing the interactions along the proposed path, sho

274 ar loops into the apposed membranes, locally disturbing the lipid bilayer and thereby lowering the en

275 rd glycine residue in the inner core without disturbing the poly-proline type II helical conformation

276 Results showed that disturbing the soil less (e.g. no-tillage and conservati

277 ations can be extracted and examined without disturbing the tissue structure.

278 The ER-located GPRC5A disturbs the assembly of the eIF4F-mediated translation

279 Thus, chronic HCV infection massively disturbs the B-cell compartment even in patients without

280 sheet A decreased heparin binding because it disturbs the basic cluster.

281 uctural analyses suggested that the mutation disturbs the integrity of macroglobulin domain 4 and ind

282 It is unclear how this urbanization disturbs the microbial ecology of soils and how the disr

283 Here, we report that Necdin deletion disturbs the migration of serotonin (5-HT) neuronal prec

284 This association disturbs the nuclear localization of CWC22, thereby supp

285 Inactivation of Rho proteins disturbs the organization of the cytoskeleton and affect

286 ), Phe(189), Phe(191), and Phe(336); it also disturbs the rotation of the alpha5 helix and the pi-pi

287 Low maternal iodine intake disturbs the thyroid function of neonates transiently or

288 s gambiae mosquitoes to malaria infection by disturbing their gut microbiota.

289 ted substantial endocrine defects, including disturbed tip/trunk patterning of the developing ductal

290 of autoimmunity as well as diseases in which disturbed tolerance is a common denominator.

291 s and opossum kidney (OK) cells demonstrated disturbed trafficking to the plasma membrane and loss of

292 tant that we designed based on the structure disturbed trimer formation, but didn't affect the auto-c

293 o understand which chloroplast processes are disturbed under heat stress.

294 stronger endothelial cell activation, a more disturbed vascular integrity, and evidence for enhanced

295 s an exocyst subunit and thereby potentially disturbs vesicle trafficking, a cellular process that is

296 ficiency; and mineral bone disease caused by disturbed vitamin D, calcium, and phosphate metabolism.

297 ation and point to a novel target to improve disturbed wakefulness and sleep.

298 nterpretation of aberrant pain processing as disturbed weighting of predictions and prediction errors

299 ts where bacteria are found are periodically disturbed, which can affect the spatial structure of the

300 sorder have produced preliminary evidence of disturbed white matter connectivity in these disorders,