ライフサイエンスコーパス: divalent

1 inal sulfide groups, and each sulfur atom is divalent.

2 e under-hydroxylation was shown to alter the divalent aldimine cross-link chemistry of mutant skin co

3 of sequence-dependent dsDNA condensation by divalent alkaline earth metal cations.

4 nic monovalent cation, ethidium, but not its divalent analog, propidium.

5 and indicated that affinity is increased for divalent analogues.

6 d three-site interaction model with explicit divalent and monovalent cations, that ion condensation i

7 g the large concentration difference between divalent and monovalent ions used in experiments, we dev

8 Divalent and tetravalent displays of M2pep ([M2pep]2-Bio

9 Through the use of organic branching points, divalent and trivalent DNA linkers were readily incorpor

10 DNA-based catalysts; they typically recruit divalent and trivalent metal ions for catalysis.

11 50 pM but only weak response to other common divalent and trivalent metal ions.

12 monovalent, divalent) and pH.

13 By screening an array of monovalent, divalent, and trivalent metal ions, we demonstrated that

14 The divalent anion sodium symporter (DASS) family (SLC13) pl

15 rboxylates are imported into the cell by the divalent anion sodium symporter (DASS) family of plasma

16 ransporter (TDT) family or the Na(+) coupled divalent anion-sodium symporter family.

17 Integral membrane proteins of the divalent anion/Na(+) symporter (DASS) family translocate

18 's main bridge, which comprises the reactive divalent C3 atom, is computed to be slow due to a high a

19 Ion-surface interactions between divalent Ca(2+) and Mg(2+) ions and the nanochannel wall

20 by ionically crosslinking in the presence of divalent Ca(2+) ions.

21 ying concentrations of monovalent (NaCl) and divalent (CaCl(2)) electrolytes.

22 udied under a wide range of mono- (NaCl) and divalent (CaCl2) electrolytes and using time-resolved dy

23 Interestingly, the presence of the divalent calcium cation facilitated multilayered SRHA ad

24 state at physiological temperatures and low divalent calcium ion concentrations.

25 ng them as solid hydrogel matrices by adding divalent calcium ions.

26 f esterification, HG can form complexes with divalent calcium ions.

27 The divalent carbene carbon centre in cyclic (alkyl)(amino)c

28 ctron-deficient transient species carrying a divalent carbon atom, carbenes have emerged as key react

29 critical deposition concentration (CDC) for divalent cation (Ca(2+) and Mg(2+)) were more than 31-fo

30 proof of concept, we show that SS-31 alters divalent cation (calcium) distribution within the interf

31 Both structures reveal that the divalent cation and cholesterol binding sites are connec

32 rospects for extending the method to predict divalent cation binding to nucleic acids.

33 otoxin, as well as Ca(2+) free solutions and divalent cation Cav channel blockers, eliminate the outw

34 riotoxin (10 mum), Ca(2+) free solutions and divalent cation Cav channel blockers.

35 ch NS1 monomer, and tubules are disrupted by divalent cation chelation and restored by cation additio

36 ulations also revealed the importance of the divalent cation cloud surrounding exposed phosphates on

37 Ligases react with ATP or NAD(+) and a divalent cation cofactor to form a covalent enzyme-(lysi

38 tion between DNA and RNA substrates based on divalent cation coordination and generates a positively

39 nsferases, essential for enzyme activity and divalent cation coordination, we found that a DxN motif

40 The LPS layer is rigid and stabilized by divalent cation cross-links between phosphate groups on

41 riencing low cytosolic magnesium (Mg(2+)), a divalent cation essential for ribosome stabilization and

42 A decrease in pH and the presence of a divalent cation improved the intramolecular electron tra

43 guing because magnesium is the most abundant divalent cation in all living cells.

44 Mg(2+) is the most abundant divalent cation in metazoans and an essential cofactor f

45 e primarily bound to the C-terminus, while a divalent cation is located at the catalytic site, acting

46 ex interacts significantly stronger with the divalent cation Mg(2+), despite their identical total ch

47 FrvA functions in vitro as a divalent cation specific ATPase most strongly activated

48 e only after the ES complex captures a third divalent cation that is not coordinated by the enzyme.

49 these vesicles are a distributed system for divalent cation uptake and release, but in this case the

50 ve sites, in the presence and absence of the divalent cation, Mg(2+).

51 eals the molecular details of three distinct divalent cation-binding sites identified through electro

52 us-ms time scale and deactivates both of the divalent cation-binding sites of the cTnC C-domain.

53 l Melastatin family of ion channels and is a divalent cation-conducting ion channel fused with a func

54 gulatory mechanism involved operates through divalent cation-dependent conversion between the non-tub

55 ate at position Asp-50 was indispensable for divalent cation-dependent gating of Cx30 hemichannels, s

56 The sensitivity toward divalent cation-mediated gating differed between small a

57 ed by the gate electrode are impacted by the divalent cation-surface interactions, limiting modulatio

58 roup was the microcapsules cross-linked with divalent cationic CaCl2 salt (MCS), and the third group

59 , the NSP4 VPD showed similar conductance of divalent cations (Ca(2+) and Ba(2+)) as monovalent catio

60 The co-occurrence of divalent cations (Ca(2+) and Mg(2+)) and Cr(VI) resulted

61 cs in the presence of monovalent (Na(+)) and divalent cations (Ca(2+)) show that attachment efficienc

62 ective ion removal, the selective removal of divalent cations (i.e., hardness) over monovalent cation

63 In this study, we investigate the effects of divalent cations (Mg(2+) and Ca(2+)) on RED and demonstr

64 ly upon addition of small amounts of certain divalent cations (Mg2+, Ca2+).

65 t pH 7 and at the presence of monovalent and divalent cations (Na(+), K(+), Mg(2+)(,) and Ca(+2)).

66 ould have been prevalent in early oceans) or divalent cations (which would have been required for RNA

67 a binding site for one of three betaI domain divalent cations and a unique beta6-alpha7 loop conforma

68 ing a common polyacrylic acid hydrogel, with divalent cations and acid as representative stimuli, we

69 ed up to 1,300-fold by low concentrations of divalent cations and the polyamine spermine.

70 ze DNA origami against low concentrations of divalent cations and the presence of nucleases.

71 otide-dependent RCK domains, indicating that divalent cations are a general cofactor in the regulator

72 In particular, divalent cations are coordinated by the gamma-phosphates

73 ination between the phosphate groups and the divalent cations are discernible even at very low Mg(2+)

74 The role of different divalent cations are discussed in relation to these two

75 For ribozymes, divalent cations are known to be more efficient than mon

76 ence, specific interactions between VIFs and divalent cations are likely to be an important mechanism

77 pproximately 1.5 mm Our results suggest that divalent cations are not SLO2 pore blockers, but rather

78 of the ion atmosphere content indicates that divalent cations are preferentially lost over monovalent

79 inate can form gel particles in contact with divalent cations as found in seawater.

80 Divalent cations behave as effective cross-linkers of in

81 Divalent cations Ca(2+) and Ba(2+) permeate TRPV6 pore a

82 dipeptides, and their interactions with the divalent cations Ca(2+), Ba(2+), Sr(2+), Cd(2+), Pb(2+),

83 we found that ranolazine and elevated serum divalent cations eliminate myotonia by inhibiting AfD an

84 site model (RISM), which allows us to treat divalent cations explicitly while keeping the implicit s

85 -1) using a preconditioning step to exchange divalent cations for monovalent ions, 0.2% carboxymethyl

86 addition, we discover an important role for divalent cations in determining the frequency and locati

87 250) in spacegroup I41 and the other without divalent cations in spacegroup P6122.

88 ding Zn(2+), suggesting a regulatory role of divalent cations in tubule formation.

89 We use "wash-in" experiments to show that divalent cations inhibit rescue during depolymerization,

90 -order in-line rate constant with respect to divalent cations is >200 times greater with Fe2+ than wi

91 To investigate whether inhibition by divalent cations is conserved in an invertebrate SLO2 ch

92 changes on MLOs, we studied the influence of divalent cations on the physical and chemical properties

93 Divalent cations preferentially bind to DNA over monoval

94 in aggregation and minor coalescence, while divalent cations resulted in extensive coalescence.

95 Divalent cations reversed this LCA-induced switch to cha

96 rge pH gradients, high salinity and abundant divalent cations should preclude vesicle formation.

97 spatially distinct site for reabsorption of divalent cations such as Ca(2+) and Mg(2).

98 gh, we found that SLO2.2 is inhibited by all divalent cations that activate SLO1, with Zn(2+)being th

99 inner shell and outer shell coordination of divalent cations to phosphate groups, which we demonstra

100 ent-selective Neosepta CMS is known to block divalent cations transport and can therefore mitigate re

101 lts depict that owing to the substitution of divalent cations with monovalent ones, asphaltene deposi

102 alent-permeable Fuji T1 is able to transport divalent cations without a major increase in resistance.

103 KO mice are more sensitive to inhibition by divalent cations, although they respond normally to cyto

104 C2A to 1.9 angstrom resolution bound to two divalent cations, and compare its three-dimensional stru

105 ve electrostatic trap, with a preference for divalent cations, at the luminal entrance.

106 els, with few showing the ability to conduct divalent cations, like calcium (Ca(2+)).

107 identified so far depend on the presence of divalent cations, LtpM is active in their absence.

108 ibosome is not exchangeable with surrounding divalent cations, presumably because those ions are tigh

109 0.03 and -0.52 +/- 0.01 with monovalent and divalent cations, respectively, and these results help c

110 e of the enzyme with Ca(2+), Zn(2+) or other divalent cations, thus providing greater catalytic power

111 ore sensitive to the inactivating effects of divalent cations, thus, in the presence of Mg(2+) , ATP

112 exhibit a significant structural response to divalent cations, which goes beyond generic electrostati

113 ic residues and lipid-selective targeting by divalent cations, which is relevant to the general signa

114 owever, SLO1 is activated by Ca(2+)and other divalent cations, while SLO2 (Slack or SLO2.2 from rat)

115 te the effects of two biologically important divalent cations, Zn(2+) and Ca(2+), on VIF network stru

116 modifications, target types, reporters, and divalent cations.

117 nce of very high concentrations of competing divalent cations.

118 performed in the presence of monovalent and divalent cations.

119 when performing RED using streams containing divalent cations.

120 erved CAP tetrad and is incapable of binding divalent cations.

121 lent cations up to 5 times more rapidly than divalent cations.

122 .7 muM), and selective for Fe(2+) over other divalent cations.

123 ically used opioid drugs, are monovalent and divalent cations.

124 esidues 55-60, and binds RNA oligos, but not divalent cations.

125 The system relaxes to the lowest manifold of divalent cobalt ((4) T 1) in 150-200 fs.

126 It is theoretically demonstrated that the divalent cobalt ion reaches 90% of the [Formula: see tex

127 t (Ka) was positive and greater than Keq for divalent complex formation.

128 Divalent copper ions when fully exchanged into high-sili

129 essence of this strategy involves the use of divalent counterions to temporarily perturb the packing

130 volved in ethylene polymerization are mainly divalent Cr ions in a 6-fold coordination, in interactio

131 y, and low cost due to the ability to employ divalent, dendrite-free, and earth-abundant magnesium me

132 Divalent dopants (Mn(2+), Fe(2+), Co(2+), Ca(2+) and Zn(

133 u click screens were used to develop potent, divalent enzymatic inhibitors.

134 CP coordinates a variety of divalent first-row transition metal ions, which is impli

135 rapid detection of environmental lead in its divalent form.

136 ching from a Ca(2+)-containing solution to a divalent-free Na(+) one, and fast Ca(2+)-dependent inact

137 s of MD simulations, we observe that loss of divalents from the core triggers local structural pertur

138 Finally, pharmacokinetic investigations of a divalent GLP-1 analogue demonstrated a promising gain in

139 Importantly, divalent GLP-1 analogues showed efficacy comparable to l

140 In lean mice, the divalent GLP-1 analogues were superior to monovalent ana

141 scattering measurements, we postulated that divalent guest molecules 4/5 cover the curved vesicular

142 We find that divalent interaction of SAv with biotinylated surfaces i

143 particularly encouraging considering that a divalent interferant was present in the feed.

144 receptor potential melastatin 7 (TRPM7) is a divalent ion channel with a C-terminally located alpha-k

145 Changes in monovalent and divalent ion concentrations drive an abrupt switch betwe

146 eriments over a wide range of monovalent and divalent ion concentrations.

147 ke and release, but in this case the primary divalent ion is Zn(2+) rather than Ca(2).

148 tructure, which retains many common sites of divalent ion occupation.

149 dence of competitive binding between the two divalent ion species.

150 carried out a series of experiments to test divalent ion usage and preferences.

151 Furthermore, divalent ion variations continuously tune the microenvir

152 e resultant peak potentials of the secondary divalent ion vary with its sample activity to yield an a

153 lular Ca(2+) , suggesting that influx of the divalent ion via more Ca(2+) -permeable normal MT channe

154 nnel of the trimeric Dut where it chelates a divalent ion.

155 ity of Gfh proteins depends on the nature of divalent ions (Mg(2+) or Mn(2+)) present in the reaction

156 vivo, colocalization of actin filaments and divalent ions are suppressed, and cells rely on linker p

157 Conversely, interactions with divalent ions can be used to tether headgroups in-plane,

158 However, RED using feed streams containing divalent ions experiences lower power densities because

159 Divalent ions fulfill essential cellular roles and are r

160 ge of the bilayer as well as the presence of divalent ions in the buffer play an important role.

161 nism, separate from fast adaptation, whereby divalent ions interacting with the local lipid environme

162 The inclusion of divalent ions leads to a reversal of the binding affinit

163 RNA domain, with one monovalent and several divalent ions located in specific sites within the struc

164 , we investigated the influence of different divalent ions on the activity of HtrA.

165 Necessity of the divalent ions to retain the suspension signified the ele

166 in and critically depends on the presence of divalent ions, consistent with results from small-angle

167 The presence of divalent ions, particularly calcium, appears to be an im

168 cules in a mixture containing monovalent and divalent ions.

169 ch contain not only monovalent ions but also divalent ions.

170 this transition was found to be enhanced by divalent ions.

171 ree of esterification and in the presence of divalent ions.

172 folds into its tertiary structure with bound divalent ions.

173 of defined concentrations of monovalent and divalent ions.

174 hysiological manganese substrate and similar divalents iron and cobalt, with several small amino acid

175 destabilized PbO(2) material and react with divalent lead [Pb(II)] at the surface of a basal litharg

176 Affinities of the divalent ligands were measured by ITC, and K(d)'s as low

177 Divalent ligands were prepared as inhibitors for the adh

178 Divalent lipid-conjugated siRNAs showed intermediate beh

179 e similar in shape and volume to that of the divalent local-moment antiferromagnet (AFM) EuRh(2)Si(2)

180 hatic endothelium by surface clustering with divalent LYVE-1 mAbs.

181 RIalpha mAbs are considerably less able than divalent mAbs are to induce anaphylaxis and deplete mast

182 ing by reducing agonist binding, whereas the divalent magnesium cation (Mg(2+)) has been shown to hav

183 agnesium-chloride bond and slow diffusion of divalent magnesium cations in cathodes.

184 Divalent manganese (Mn(2+)) exposure can stimulate neuro

185 supporting the transcellular trafficking of divalent manganese ions within the microvascular capilla

186 d diacylglycerol, and full activity required divalent manganese.

187 The transformations of aqueous inorganic divalent mercury (Hg(II)(i)) to volatile dissolved gaseo

188 be affected by the availability of inorganic divalent mercury (Hg(II)) and by the activities of Hg(II

189 es was used to assess the bioavailability of divalent mercury (Hg(II)) complexed in dissolved organic

190 Understanding the speciation of divalent mercury (Hg(II)) in aquatic systems containing

191 Cellular uptake of inorganic divalent mercury (Hg(II)) is a key step in microbial for

192 dentified as environments in which inorganic divalent mercury (Hg(II)) is transformed to methylmercur

193 ability in mercury concentrations (inorganic divalent mercury (IHg) and MeHg) and loads at four reser

194 environments, thermodynamics and kinetics of divalent mercury Hg(II) chemical speciation need to be u

195 Divalent mercury ion (Hg(2+)) is one of the most common

196 ically, we show that isostructural series of divalent metal amide complexes featuring extended hydrog

197 ction potentials and is inversely related to divalent metal binding affinity.

198 cules) on aluminum oxides in the presence of divalent metal cations (Ca(2+), Cu(2+), Mg(2+), Mn(2+),

199 Divalent metal cations are essential to the structure an

200 Replicative DNA polymerases (DNAPs) require divalent metal cations for phosphodiester bond formation

201 les of mineral-water interface processes and divalent metal cations on controlling polyphosphate spec

202 The interactions of divalent metal cations with PS lipids were further inves

203 that activity was driven by sequestration of divalent metal cations, a mechanism which was likely to

204 Our study indicates that the adsorption of divalent metal cations, particularly transition metals,

205 Additionally, essential and non-essential divalent metal content of human islets under normal envi

206 y terminus of hepcidin directly contacts the divalent metal in the ferroportin C domain.

207 alyte, a peptide, and/or an amino acid and a divalent metal ion (for 16 different monosaccharide isom

208 f-assembly of six dimers controlled by their divalent metal ion cofactors.

209 xperiment provides evidence for inner-sphere divalent metal ion coordination with a nucleobase.

210 efine the role of the newly discovered third divalent metal ion for DNA polymerase-catalyzed nucleoti

211 In C2A, a divalent metal ion in site 1 is sufficient to drive its

212 NMR experiments revealed that binding of one divalent metal ion per C2 domain results in loss of conf

213 SLC39A8 encodes ZIP8, a divalent metal ion transporter best known for zinc trans

214 In humans, the divalent metal ion transporter-1 (DMT1) mediates the tra

215 g., methylammonium (MA(+)), Cs(+)), B is the divalent metal ion(s) (e.g., Pb(2+), Sn(2+)), and X is t

216 This is an enzyme with divalent metal ion(s) (Mg(2+) or Mn(2+)) in its catalyti

217 sight into the local interactions underlying divalent metal ion-driven changes in the spectra of carb

218 le peptide, and each vertex is occupied by a divalent metal ion.

219 HNH nuclease domain, and identifying how the divalent metal ions affect the HNH domain conformational

220 strand transfer, and INSTIs tightly bind the divalent metal ions and viral DNA end after 3' processin

221 ly spun silk fibers; however, when and where divalent metal ions are incorporated into the metallofib

222 Divalent metal ions are responsible for the unique mecha

223 lyze phosphoryl transfer reactions using two divalent metal ions in the active site.

224 Other divalent metal ions including Ca(2+), Cd(2+), Zn(2+), Ni

225 When a large excess of divalent metal ions is absent, the charge is largely bal

226 he coupling of cellular levels of ligand and divalent metal ions to tightly control gene expression.

227 ngle-molecule junctions (M=Co, Ni, Cu, or Zn divalent metal ions), in which the current flows perpend

228 in the active site required the presence of divalent metal ions, a free 5'-flap (if present), a Wats

229 ility against pH changes and the presence of divalent metal ions, and their high homogeneity make the

230 nt probe, the silver ion, that, similarly to divalent metal ions, binds to monomeric Abeta peptide an

231 an organic solid, is highly amenable to host divalent metal ions, i.e., Mg(2+) and Ca(2+), in aqueous

232 is highly active at low pH in the absence of divalent metal ions, similar to eukaryotic DNase II.

233 into insoluble spherical nanoparticles with divalent metal ions.

234 ivity of aqueous silver nanoparticles toward divalent metal ions.

235 led on a membrane surface in the presence of divalent metal ions.

236 l formation within 30 min in the presence of divalent metal ions.

237 sed binding affinity toward a broad range of divalent metal ions.

238 Considering the potential role of the divalent metal manganese (Mn(2+)) in protein aggregation

239 Together, these results suggest that the divalent metal manganese acts as a key amplifier of NLRP

240 The effect of this variant on the divalent metal profile in human islets is unknown.

241 ake and the mRNA expression of iron importer divalent metal transporter 1 (DMT1) were significantly i

242 s implicated in iron uptake and storage, the divalent metal transporter 1 (DMT1), the ferritin heavy

243 E STATEMENT To determine the function of the divalent metal transporter 1, the transferrin receptor 1

244 on the promoter of the iron transporter gene divalent metal transporter-1 (DMT1).

245 Divalent Metal Transporter1, a major iron importer in ce

246 opsis thaliana member of the NRAMP family of divalent metal transporters, NRAMP2, which functions in

247 , human ZIP2 is predicted to harbor a single divalent metal-binding site, with the charged side chain

248 jor iron transporters in the small intestine divalent metal-ion transporter 1 (DMT1) and ferroportin

249 cal membrane of the intestinal enterocyte by divalent metal-ion transporter 1 (DMT1) and is exported

250 ile over-expression upregulates ferritin and divalent-metal-transporter-1 (DMT-1), indicating PrP(C)-

251 While many divalent metals bind to poly histidine sequences reversi

252 ssay, we find that the biologically relevant divalent metals copper and zinc inhibit intein splicing,

253 r detecting calcium as well as several other divalent metals in drinking water including copper, zinc

254 e examined the correlation of zinc and other divalent metals in human islets with rs13266634 genotype

255 tron-rich moieties are to be anticipated for divalent metals such as Ca(2+).

256 hat identify multiple biologically important divalent metals via metal-specific chemical shifts.

257 ing pH, temperature, and the requirement for divalent metals.

258 tions where phosphate is precipitated out by divalent metals.

259 During digestion, high concentrations of divalent minerals (DMs) can lead to insoluble lipid-soap

260 ly improved using a tetravalent instead of a divalent molecule, since the tetravalent molecule can fo

261 Usually divalent molecules show enhanced biological activities t

262 We observe that the divalent nature of Mg(2+) causes unique squeezing deform

263 The unique combination of a divalent organolanthanide fragment, Cp*2Yb, with bipyrim

264 U] (2), which contains uranium in the formal divalent oxidation state.

265 report the discovery of pressure-stabilized divalent ozonide CaO(3) crystal that exhibits intriguing

266 ibits selective fluorescence sensing towards divalent Pd ions with a very low detection limit (38 ppb

267 rcury (GEM, Hg) emissions are transformed to divalent reactive Hg (RM) forms throughout the troposphe

268 framework anions incurred by substitution of divalent S(2-) for monovalent Cl(-) play a major role in

269 Increased mono- and divalent salt concentrations counteracted this behavior.

270 xt, we also studied the effects of mono- and divalent salts on the flipping dynamics.

271 At pH 7.0, the divalent salts resulted in weaker gels formed by agglome

272 amine (DOPE), with the addition of mono- and divalent salts.

273 CorA, a divalent-selective channel in the metal ion transport su

274 tivated channels, eliminated the voltage and divalent sensitivity with minimal effects on adaptation.

275 y gap and Lewis acid-base bifunctionality of divalent Si centres.

276 a model system for understanding subsurface divalent silicate carbonation reactivity.

277 e dissolution and mass transport controls on divalent silicate reactivity in wet scCO(2) could be adv

278 The carbonation of divalent silicates exposed to humidified scCO(2) occurs

279 e facile degradation of P(4) mediated by two divalent silicon atoms in a bis(silylene) scaffold, resu

280 ygenative homocoupling of carbon monoxide by divalent silicon utilizing the (LSi:)(2)Xant 1a [Xant =

281 Here we describe an siRNA architecture, divalent siRNA (di-siRNA), that supports potent, sustain

282 rein, we investigated the effect of mono- or divalent small-molecule albumin binders for half-life ex

283 r than those elicited by Ca(2+) By combining divalent species interacting with unique sites, we demon

284 ibutes to the regulation of Zn(2+) and other divalent species of the central nervous system.

285 In contrast, divalent Sr(II) forms an ion-extractant complex with DHD

286 ehavior created by the onset of a metastable divalent state that starts at californium.

287 tor (CDF) proteins are a conserved family of divalent transition metal cation transporters.

288 ccomplished upon the complexation with seven divalent transition metal ions M(II) (M = Mn, Co, Ni, Cu

289 d no tau LLPS-promoting effect for any other divalent transition metal ions tested, including Mn(2+),

290 otobleaching (FRAP) assays, we show that the divalent transition metal zinc strongly promotes this pr

291 rapeutic approaches designed to exploit this divalent transition metal.

292 Divalent transition metals (TM = Mn(II) and Zn(II)) char

293 ly transporters catalyze uptake of essential divalent transition metals like iron and manganese.

294 acteria to humans-enable uptake of essential divalent transition metals via an alternating-access mec

295 try determined solely by the identity of the divalent transition-metal ion (Fe(2+) or Ni(2+)) in the

296 While we previously only considered divalent ureidopyrimidinone monomers we now present a mo

297 E-mediated anaphylaxis and food allergy than divalent variants of the same mAbs do.

298 rast to interactions of ions (monovalent and divalent) with rigid charged rods, in which ion condensa

299 ith relatively high drug content (6% w/w) if divalent zinc ions were used as an ionic "bridge" betwee

300 dings, combined with our previous results on divalent zinc ions, we propose a model that links the mi