ライフサイエンスコーパス: divalent cation

1 r Mg(2+) or Mn(2+) capable of serving as the divalent cation.

2 d dephosphorylation in reactions requiring a divalent cation.

3 uclease depending on the nature of the added divalent cation.

4 d sequesters a single PKR in the presence of divalent cation.

5 influence calcium diffusion because it is a divalent cation.

6 g three acidic side chains that coordinate a divalent cation.

7 PhoQ indicate distinct mechanisms of binding divalent cation.

8 rom crystals grown in the presence of either divalent cation.

9 ed in binding of the catalytically essential divalent cation.

10 ementing medium with zinc but not with other divalent cations.

11 tein ZnuA binds zinc but does not bind other divalent cations.

12 re decreased by treatment with a chelator of divalent cations.

13 that their fusion efficiency is increased by divalent cations.

14 identical with that previously observed for divalent cations.

15 when performing RED using streams containing divalent cations.

16 the presence of Zn(2+) than in water free of divalent cations.

17 oop complexes in the presence and absence of divalent cations.

18 nce that is relaxed by chelation of residual divalent cations.

19 erved CAP tetrad and is incapable of binding divalent cations.

20 ically stable in solution in the presence of divalent cations.

21 by reoccupying the buried site with various divalent cations.

22 nt carried by a wide range of monovalent and divalent cations.

23 domains of calreticulin that are impacted by divalent cations.

24 verse transcription requires the presence of divalent cations.

25 otetrameric enzyme activated by a variety of divalent cations.

26 family K+ channels is sensitive to external divalent cations.

27 eptide, mastoparan X, was engineered to bind divalent cations.

28 lent cations up to 5 times more rapidly than divalent cations.

29 hosphate and has an absolute requirement for divalent cations.

30 , CD-MPR binding affinities are modulated by divalent cations.

31 hat has been implicated in direct binding to divalent cations.

32 duct is found symmetrically bridging the two divalent cations.

33 cuing bsd2Delta/rer1Delta yeast by exporting divalent cations.

34 .7 muM), and selective for Fe(2+) over other divalent cations.

35 -347) downstream of S6 reduces inhibition by divalent cations.

36 was also activated by Na(+)and inhibited by divalent cations.

37 ly important for cell adhesion in niche with divalent cations.

38 f this mode of detachment in the presence of divalent cations.

39 s ) with to near-zero contact angles without divalent cations.

40 out the effects of environmentally important divalent cations.

41 As for the ability of the divalent cations (1-17.5mM) to induce the precipitation

42 ene family known to import Mn, Zn, and other divalent cations across the plasma membrane.

43 ntrations of Ca(2+) and Mg(2+), showing that divalent cations act as crosslinkers.

44 the entry of Ca(2+) because Sr(2+) and other divalent cations also permeate and support degranulation

45 KO mice are more sensitive to inhibition by divalent cations, although they respond normally to cyto

46 Both structures reveal that the divalent cation and cholesterol binding sites are connec

47 0-catalyzed reaction occurs independently of divalent cation and proceeds via a Schiff base intermedi

48 mammalian enzymes also require a structural divalent cation and surface positively charged residues

49 a phosphodiesterase mechanism, in which the divalent cation and the general base Glu-209 activate a

50 is repressed by millimolar concentrations of divalent cations and activated by antimicrobial peptides

51 ponent system, which detects and responds to divalent cations and antimicrobial peptides and can trig

52 Co-crystals with divalent cations and ATP reveal the molecular mechanism

53 m that was dependent on the presence of both divalent cations and ATP.

54 Divalent cations and heavy chain 2 are essential co-fact

55 PhoQ activity is repressed by divalent cations and induced in environments of acidic p

56 t mitochondrial iPLA(2)gamma is activated by divalent cations and inhibited by acyl-CoA modulating th

57 ulation of integrin-binding affinity by both divalent cations and intracellular signal inhibition.

58 CcLpxI is stimulated by divalent cations and is inhibited by EDTA.

59 from the beta(2)-integrin CR3 that requires divalent cations and polyvalent ligands for activation o

60 loss that is not dependent upon H(2)O(2) and divalent cations and requires Bak in a Bax-independent f

61 cific binding of AMP to Lpp was resistant to divalent cations and salts, which were able to inhibit t

62 els with integrin activation in solutions of divalent cations and shift dramatically upward to hypera

63 basal levels with activation in solutions of divalent cations and shift dramatically upward to hypera

64 of conformational changes, and the impact of divalent cations and tensile forces.

65 CAX1, that can transport both monovalent and divalent cations and that appears to play a role in cell

66 water molecules mediate contacts between the divalent cations and the C-tetrad, allowing Ba(2+) ions

67 steric sites on CHRMs respond differently to divalent cations and the effects of allosteric modulatio

68 sion assays demonstrated parallel effects of divalent cations and the FAK inhibitor on cell adhesion.

69 ponent system, which detects and responds to divalent cations and to antimicrobial peptides, and can

70 Like other 5'-nucleotidases, S5nA requires divalent cations and was active in the presence of Mg(2+

71 gly inhibited in the formulations containing divalent cations and/or CMCS as excipients, although spe

72 ionality in a reaction that is stimulated by divalent cations, and both nucleases are inhibited by th

73 trate that PA-PhoQ binds and is repressed by divalent cations, and can functionally complement a S. t

74 nduced in environments of acidic pH, limited divalent cations, and cationic antimicrobial peptides (C

75 t, channel activations by capsaicin, low pH, divalent cations, and even heat are mostly intact in mut

76 Reactions do not require divalent cations, and have limited dependence on monoval

77 Overall, pH, divalent cations, and NOM can play complex roles in the

78 ability to dock with other proteins or bind divalent cations, and/or its localization.

79 The role of different divalent cations are discussed in relation to these two

80 pproximately 1.5 mm Our results suggest that divalent cations are not SLO2 pore blockers, but rather

81 of the ion atmosphere content indicates that divalent cations are preferentially lost over monovalent

82 Divalent cations are required for activity, whereas mono

83 e in the preQ1 class I (preQ1-I) riboswitch, divalent cations are required for high-affinity binding.

84 Divalent cations are shown here to crossbridge polyanion

85 Divalent cations are used by protein kinases to both sta

86 In addition, NMCCs do not permeate divalent cations, are inhibited by calcium ions, and dem

87 pplied stress using a theory that treats the divalent cations as crosslinkers: at low stress, the beh

88 inate can form gel particles in contact with divalent cations as found in seawater.

89 (MIDAS) motifs required for coordination of divalent cations, as well as a specific tyrosine residue

90 Divalent cations associate preferentially over monovalen

91 n betaA domain of the beta-subunit through a divalent cation at the metal ion-dependent adhesion site

92 h reveals the presence of a binding site for divalent cations at a crystal contact.

93 stances might represent peculiar features of divalent cations at the ferroxidase site.

94 ve electrostatic trap, with a preference for divalent cations, at the luminal entrance.

95 This includes signature sequences for divalent cation binding and an alpha-helical barrel.

96 These results show that targeting a divalent cation binding residue can enable selective inh

97 inding cavity; the other is close to a known divalent cation binding site in other pentameric ligand-

98 magnesium ion bound in a similar manner to a divalent cation binding site of the group II intron.

99 A common divalent cation binding site, distinct from the position

100 egrees C, suggesting that readily accessible divalent cation binding sites in the particle are critic

101 he remote site in solution is specific for a divalent cation, binding both calcium and magnesium with

102 eals the molecular details of three distinct divalent cation-binding sites identified through electro

103 us-ms time scale and deactivates both of the divalent cation-binding sites of the cTnC C-domain.

104 RSV transcription system suggested that the divalent-cation-binding domain of actin is critically ne

105 Divalent cations (both ion channel and intracage binding

106 at interacts with the inner membrane through divalent cation bridges.

107 roup concentration and resultant reduced NOM-divalent cation bridging.

108 ange County Groundwater Basin sediments, the divalent cations Ca(2+) and Mg(2+) are critical for limi

109 dipeptides, and their interactions with the divalent cations Ca(2+), Ba(2+), Sr(2+), Cd(2+), Pb(2+),

110 the presence of millimolar concentrations of divalent cations Ca(2+), Ba(2+), Sr(2+), or Mg(2+) or 30

111 critical deposition concentration (CDC) for divalent cation (Ca(2+) and Mg(2+)) were more than 31-fo

112 , the NSP4 VPD showed similar conductance of divalent cations (Ca(2+) and Ba(2+)) as monovalent catio

113 nts demonstrated the importance of including divalent cations (Ca(2+) and Mg(2+)) in the suspension m

114 cs in the presence of monovalent (Na(+)) and divalent cations (Ca(2+)) show that attachment efficienc

115 In the presence NOM and divalent cations (Ca(2+), Mg(2+)), GO aggregates settle

116 ylmaleimide, propranolol, phenylglyoxal, and divalent cations (Ca(2+), Mn(2+), and Zn(2+)).

117 he alkali metal cations, Na(+) and K(+), the divalent cations, Ca(2+) and Mg(2+), and the trace metal

118 t immobilized alphaLbeta2 in environments of divalent cations (Ca2+, Mg2+, and Mn2+) and demonstrate

119 2 on microspheres in millimolar solutions of divalent cations (Ca2+, Mg2+, Mn2+).

120 ermination by DPA with its associated Ca(2+) divalent cation (CaDPA) but germinated better than wild-

121 Here we show that the divalent cations calcium, strontium, and magnesium can p

122 A divalent cation (calcium), a polyion (protamine), and an

123 * conformer is stabilized by a high-affinity divalent cation capable of inner-sphere coordination, su

124 ir of dimer-related tyrosines, together with divalent cations, catalyse G-segment cleavage.

125 asing salt concentration and introduction of divalent cations caused aggregation of SWNT clusters by

126 otoxin, as well as Ca(2+) free solutions and divalent cation Cav channel blockers, eliminate the outw

127 riotoxin (10 mum), Ca(2+) free solutions and divalent cation Cav channel blockers.

128 in member 7 (TRPM7) and member 6 (TRPM6) are divalent cation channel kinases essential for magnesium

129 The divalent cation chelator EDTA, which disrupts heterodime

130 can be recapitulated by acute treatment with divalent cation chelators, including those specific for

131 Ligases react with ATP or NAD(+) and a divalent cation cofactor to form a covalent enzyme-(lysi

132 MaPT activity was not dependent on a divalent cation cofactor, although it was reversibly ina

133 ditions were identified where monovalent and divalent cations compete and their stability effects are

134 This study suggested that divalent cation complexation with carboxylate groups in

135 Changing divalent cation composition affects these coefficients,

136 olutions containing 20 mg C/L increased with divalent cation concentration until reaching a critical

137 re lower than in CaCl(2) solution at a given divalent cation concentration.

138 folding times and calibrated monovalent and divalent cation concentrations.

139 ing Hg uptake pathways; we propose that base divalent cations contribute to hamper net Hg(II) accumul

140 tate stabilization (Arg308, Arg648, Gln275), divalent cation coordination (Glu236), or activation of

141 The LPS layer is rigid and stabilized by divalent cation cross-links between phosphate groups on

142 e presence of Ca (and most probably of other divalent cations), Cs accessibility to exchange position

143 This interaction is divalent cation-dependent and overlaps with the binding

144 This interaction was divalent cation-dependent and required sialylation of EG

145 ate at position Asp-50 was indispensable for divalent cation-dependent gating of Cx30 hemichannels, s

146 dinic endonuclease 1 (APE1), a member of the divalent cation-dependent phosphoesterase superfamily of

147 Cell interactions were divalent cation-dependent, indicating integrin dependenc

148 -T3 and beta4GalNAc-T4 to terminal GlcNAc is divalent cation-dependent.

149 ssical transcription factor for the virus by divalent-cation-dependent binding to the viral template

150 We investigated the role of reverse divalent cation diffusion in forward osmosis (FO) biofou

151 airing with template and mapped movements of divalent cations during preinitiation.

152 that allow for influx or efflux of mono- or divalent cations (e.g., Ca(2+)) important for synaptic t

153 ters can destabilize the nanoparticles, with divalent cations (e.g., Ca(2+), Mg(2+)) being more influ

154 +) binding sites are collapsed and devoid of divalent cations (E2-PLB).

155 n demonstrating that both ionic strength and divalent cations effect a decrease in the Fe(II)-binding

156 Third, divalent cation effects on the 5'-exonuclease and the en

157 we found that ranolazine and elevated serum divalent cations eliminate myotonia by inhibiting AfD an

158 Consequently, at neutral pH the presence of divalent cations enhanced the aggregation of HAdV as wel

159 content of calreticulin are impacted by the divalent cation environment, with the ER range of calciu

160 riencing low cytosolic magnesium (Mg(2+)), a divalent cation essential for ribosome stabilization and

161 Cytidylyltransferases require a divalent cation for catalysis, and the cation preference

162 s a DNA exonuclease that did not require any divalent cations for activity.

163 ed a variant of ANGPTL4 that is dependent on divalent cations for its ability to inhibit LPL.

164 If the currents observed in divalent cation-free Ringer's solution were due to Cx46

165 Chelating divalent cations from the culture medium abolished these

166 in alpha1 I domain induced by the binding of divalent cations, full-length type IV collagen, or a fun

167 In contrast, in the presence of a divalent cation, GTPgammaS adopts an extended conformati

168 Divalent cations have long been known to neutralize and

169 ration, suggesting that Cdc1p might regulate divalent cation homeostasis.

170 We show that LTA is needed for divalent cation homoeostasis and that its absence has se

171 Voltage sensitivity is not influenced by divalent cations; however, it is Na+-dependent with a 63

172 action, explain the role of the noncatalytic divalent cation in 6 RdRp, and pinpoint the previously u

173 Magnesium (Mg(2+)), the most common divalent cation in living cells, plays crucial roles in

174 the present study, we have investigated how divalent cations in concert with the chondroitin sulfate

175 m by which monovalent cations substitute for divalent cations in hammerhead catalysis remains unclear

176 250) in spacegroup I41 and the other without divalent cations in spacegroup P6122.

177 e from solvent that normally bridges the two divalent cations in structures determined in the presenc

178 The protein does not require divalent cations in the active site for catalytic activi

179 s distorted (beta/alpha)(8)-barrels with two divalent cations in the active site.

180 +) directly and specifically substitutes for divalent cations in the hammerhead active site.

181 gluconolactone showed a k(cat) preference of divalent cations in the order Zn(2+) > Mn(2+) > Ca(2+) >

182 ic linker DNA bending by linker histones and divalent cations in vivo may mediate the transition betw

183 ated metalloprotein with the ability to bind divalent cations including Co(2+), Zn(2+), Fe(2+), and N

184 F-SCAN channels permeate both monovalent and divalent cations, including Ca(2+), and exhibit synergis

185 ions was not re-established, indicating that divalent cations increase the energy barrier between tra

186 In the presence of divalent cations, incremental heating between 45 degrees

187 4 and/or i,i+7 intervals, which by chelating divalent cations induce and stabilize helical conformati

188 0 (KOCx50) mouse lenses, removal of external divalent cations induced a macroscopic current composed

189 al of the Mg(2+) found in plasma and because divalent cations influence the conformation and affect f

190 Divalent cations inhibit R-3-OHC14-ACP-dependent acylati

191 , POPC only interacts weakly with Ca(2+); 5) divalent cations interact with lipids in a lipid- and io

192 te linkage, monodentate or bidendate, to the divalent cation is a useful parameter for tuning the tra

193 physiological levels of Mg(2+) because this divalent cation is critical for the stabilization of mem

194 To investigate whether inhibition by divalent cations is conserved in an invertebrate SLO2 ch

195 The affinity of the remote site for divalent cations is in the low millimolar range and rema

196 Improvement in bioavailability of divalent cations is needed.

197 lectrostatic interactions with intracellular divalent cations is tested here using lipid monolayer an

198 els, with few showing the ability to conduct divalent cations, like calcium (Ca(2+)).

199 is inhibited for activation by acidic pH and divalent cation limitation.

200 Three divalent cations (M(++)=Zn(++), Co(++), Ni(++)) were eva

201 significantly lower binding affinity for the divalent cations magnesium and strontium.

202 The sensitivity toward divalent cation-mediated gating differed between small a

203 complexes in chloroform, especially for the divalent cation Mg(2+).

204 Moreover, we demonstrate that the divalent cations Mg(2+) and Ca(2+) can replace the role

205 In this study, we investigate the effects of divalent cations (Mg(2+) and Ca(2+)) on RED and demonstr

206 On an aqueous subphase containing divalent cations (Mg(2+), Ca(2+), Zn(2+), Sr(2+), or Cd(

207 CD spectroscopic studies of apo (absence of divalent cations)-, Mg(2+)-, and Ca(2+)/Mg(2+)-bound sta

208 The presence of the divalent cation, Mg(2+), essential for chromatin compact

209 sponse to manipulations to the extracellular divalent cation milieu.

210 results and those of reactions that employed divalent cation mixtures, we propose that topoisomerase

211 identified the fractional surface density of divalent cations (n(s2))as the parameter which best expl

212 Divalent cations neutralized/shielded virus surface char

213 t of selectivity differences among different divalent cations observed for each Ca(2+)-binding site.

214 romatin to a greater extent than the natural divalent cation of the cell, magnesium ion (Mg(2+)).

215 Divalent cations of larger ionic radius than Sr(2+) are

216 and high conductance for both monovalent and divalent cations of these channels.

217 Divalent cations of two alkaline earth metals Ca(2+) and

218 reviously investigated, beneficial effect of divalent cations on the activity of CDH was also present

219 en the influent water was at pH 5, contained divalent cations or 50 mM NaNO3, silver concentrations w

220 er able to self-associate in the presence of divalent cations or under heat shock.

221 was increased to favor the permeation of one divalent cation over the other, a similar increase in ce

222 TRPM7's kinase activity and selectivity for divalent cations over monovalent cations were dispensabl

223 nity is strongly affected by the presence of divalent cations, owing to their complexation with the f

224 Aided by divalent cations, P4 is poised to act as a "screw cap" o

225 Zinc, a divalent cation packaged in synaptic vesicles along with

226 Divalent cations play critical structural and functional

227 DNA duplexes and highlights the unique role divalent cations play in differential stabilization of c

228 ional change induced in Delta50 lamin A with divalent cations plays a regulatory role in the posttran

229 We show that: counterions, especially divalent cations, predominantly condense around the nucl

230 results suggest that gp32 and UvsY may alter divalent cation preference and facilitate the formation

231 Divalent cations present in SP had little effect on the

232 that surprisingly, MdfA catalyses efflux of divalent cations, provided that they have a unique archi

233 ward current activated by withdrawal of bath divalent cations, representing SOCE.

234 eports that CT296 has properties shared with divalent cation repressors such as Fur.

235 0.03 and -0.52 +/- 0.01 with monovalent and divalent cations, respectively, and these results help c

236 c LTAs have fundamentally important roles in divalent cation retention within the Gram-positive cell

237 e tip into a solution containing a dissolved divalent cation salt to form a solid gel; (ii) the resul

238 The effect of addition of divalent cation salts CaCl(2), MnCl(2) as well as carbox

239 nticity of the ligand Asp/Glu can modify the divalent cation selectivity at MIDAS and hence integrin

240 ulated by the intracellular concentration of divalent cations sensed by a large structure in the BK c

241 ulent in mice, indicating that acidic pH and divalent cation sensing by PhoQ are dispensable for viru

242 The interaction was affected in a pH- and divalent cation-sensitive manner.

243 fic properties in mind, we characterized the divalent cation-sensitive permeation pathway in primary

244 s as a partial agonist for the high-affinity divalent cation sensor in the RCK1 domain of the Slo1 BK

245 Mg(2+) unbinding at the divalent cation sensor triggers a conformational change

246 frigidimarina cultured in 1/2 MB and LB with divalent cations shows that a maximum current output can

247 We show here that divalent cations slow the activation rate of two EAG fam

248 Mephenesin or high divalent cation solutions were used to limit oligosynapt

249 FrvA functions in vitro as a divalent cation specific ATPase most strongly activated

250 hich PQ is transported by DAT: In its native divalent cation state, PQ(2+) is not a substrate for DAT

251 spatially distinct site for reabsorption of divalent cations such as Ca(2+) and Mg(2).

252 Divalent cations such as calcium can cause clustering of

253 In immune cells, divalent cations such as calcium, magnesium, and zinc ha

254 zinc ions is readily exchangeable with other divalent cations such as manganese, which strongly stimu

255 molar concentrations of monovalent cations, divalent cations such as Mg(2+) are required for efficie

256 Electrochemical storage systems that utilize divalent cations such as Mg2+ can improve the volumetric

257 vated by low extracellular concentrations of divalent cations such as Mg2+, and subsequently the resp

258 Interestingly, other divalent cations such as Zn(2+), Fe(2+), Co(2+), and Mn(

259 The presence of cholesterol or divalent cations, such as Ca(2+) and Mg(2+), lead to dec

260 oQ/PhoP two-component system is repressed by divalent cations, such as Mg(2+) and Ca(2+), in the grow

261 Divalent cations, such as zinc and copper, have alloster

262 nhances its activity, which was inhibited by divalent cations, such as Zn2+ and Mn2+.

263 nd dendritic cells (DCs) is known to require divalent cations, suggesting involvement of C-type lecti

264 ed by the gate electrode are impacted by the divalent cation-surface interactions, limiting modulatio

265 e only after the ES complex captures a third divalent cation that is not coordinated by the enzyme.

266 gh, we found that SLO2.2 is inhibited by all divalent cations that activate SLO1, with Zn(2+)being th

267 han dsDNA, is precipitated by alkaline-earth divalent cations that are unable to condense dsDNA.

268 of SLO2 channels in mammals andDrosophilaby divalent cations that have second messenger functions ma

269 e for radial shear assays in the presence of divalent cations that increase integrin-ECM affinity.

270 Our results imply that it is the removal of divalent cations that makes reservoir rocks more hydroph

271 Upon complexation with a divalent cation, the accessible conformational space shr

272 electivity for Ca(2+), but in the absence of divalent cations they also conduct monovalent ions.

273 ore sensitive to the inactivating effects of divalent cations, thus, in the presence of Mg(2+) , ATP

274 on in which the addition of small amounts of divalent cations to a buffered monovalent ionic solution

275 t these sites alter the ability of different divalent cations to activate the channel.

276 can be induced by the addition of mono- and divalent cations to aqueous U60 solutions.

277 Issues such as the effect of mono- and divalent cations to hybridization and the mechanism of t

278 he analysis of selected assemblies requiring divalent cations to preserve their structural integrity

279 ported to exhibit functional properties of a divalent cation transcription repressor (DcrA), with sim

280 It remains unclear how TRPM6 affects divalent cation transport and whether this involves func

281 ent-selective Neosepta CMS is known to block divalent cations transport and can therefore mitigate re

282 ly 11 member 1 (SLC11A1; formerly NRAMP1), a divalent cation transporter crucial to host defense agai

283 nexin SNX3, and a recycling signal from the divalent cation transporter DMT1-II.

284 K/RR03 and the transcriptional regulators of divalent cation transporters MerR and PsaR in vitro and

285 permeation properties to both monovalent and divalent cations under perfused two-electrode voltage cl

286 site of RIG-I cannot efficiently accommodate divalent cations under the RNA-free repressed conformati

287 these vesicles are a distributed system for divalent cation uptake and release, but in this case the

288 Manganese (Mn) and zinc (Zn) are essential divalent cations used by cells as protein cofactors; var

289 To enable dynamic sensing of divalent cations via PAI, we have engineered a new rever

290 ligohistidine-appended proteins for chelated divalent cations was exploited to facilitate this intera

291 ally, exposure to elevated concentrations of divalent cations was found to restore touch-evoked behav

292 Upon addition of EDTA and EGTA, the divalent cations were sequestered from the stabilized ap

293 ced Gla residues allow binding of functional divalent cations, which induces end-to-end alpha-helices

294 owever, SLO1 is activated by Ca(2+)and other divalent cations, while SLO2 (Slack or SLO2.2 from rat)

295 organelles rich in polyphosphate chains and divalent cations whose significance in these parasites r

296 f this state is influenced by interaction of divalent cations with both activating and inhibitory cyt

297 calcium can be easily displaced by mono- and divalent cations with no effect on activity, whereas rem

298 alent-permeable Fuji T1 is able to transport divalent cations without a major increase in resistance.

299 to hypothesize that a non-neurotrophin, the divalent cation zinc, can transactivate TrkB.

300 pproximately 16 muM), using an extracellular divalent cation, zinc (Zn(++)), as a nonspecific positiv