ライフサイエンスコーパス: divergent

1 of genetic loci with alleles that are highly divergent (15.1 megabases of the total genome size of 61

2 escent analysis and included isolates with a divergent 23B capsule locus.

3 lized using electrophilic reagents, enabling divergent access to varied substitution.

4 clathrin-coated structures can be remarkably divergent across different cell types, cells within the

5 This should lead to divergent activation patterns and, if disregarded, inter

6 These results show a mechanism by which divergent adaptation can have knock-on effects on host-m

7 Building on the divergent allele advantage hypothesis, we show that func

8 st population with low nucleotide diversity, divergent allele frequencies and the most private allele

9 Divergent alleles may be involved in adaptation to envir

10 These divergent alleles were differentially expressed across e

11 o map phosphorylation sites to the otherwise divergent amino-terminal extensions on these pollen sPPa

12 ukaryotes, but surprisingly, ISG15 is highly divergent among animals.

13 rd on poverty-related behaviors is much more divergent and broad than such constellations suggest.

14 xually and socially experienced adult males, divergent and characteristic neural ensembles represente

15 Recently published projections appear widely divergent and highly sensitive to non-trivial model choi

16 ortunately, many protein families are highly divergent and not suitable for sequence-based reconstruc

17 This divergent and restricted expression likely reflects diff

18 NP assembly that explains how evolutionarily divergent and seemingly antagonistic proteins cooperate

19 ct that the original models can show stable, divergent, and metastable (fragile) dynamics.

20 seeds of extinct and extant members of early divergent angiosperm lineages, the embryo to seed ratio

21 CR beta-chain bias, consistent with possible divergent antigen subspecificities between these bacteri

22 This strategy yielded highly divergent antigenic footprints that do not exist in natu

23 tional polarity because of strongly enhanced divergent antisense transcription at promoters.

24 lergists and dermatologists have similar and divergent approaches to the management of AD.

25 HCV JFH-1.IMPORTANCE Genotypes of HCV are as divergent as different types of flavivirus, and yet mech

26 atic groups, with implications for fields as divergent as medicine, biodiversity conservation, agricu

27 Our finding of divergent associations between health and segregation by

28 rgeoning transfer hydrogen methodology gives divergent asymmetric access to anti,syn and syn,syn poly

29 e broadly active antibodies against sequence-divergent atypically neutralization-sensitive (tier-1) v

30 The evidence reviewed here suggests that divergent auxin transport routes contributed to the dive

31 or the BBI inhibitory loop discovered highly divergent BBI-like sequences in the seedless, vascular s

32 an its aminomethylation displaying again the divergent behavior of isoelectronic Mn(I) and Fe(II) PNP

33 nergic inputs to striatum and PFC can elicit divergent behavioral effects.

34 tant role for supergenes in the evolution of divergent behavioral phenotypes.

35 Parallel study of degraders with divergent BRD9-binding chemotypes in models of acute mye

36 are encoded on the chromosome typically as a divergent but contiguous operon.

37 We examined two geochemically divergent but putatively methanogenic regions of Yellows

38 isms such as kinetoplastids are built from a divergent, but not ancestrally distinct, set of componen

39 Divergent, but not mutually exclusive, theories have bee

40 ated by alternative 3'-end processing, whose divergent C terminus shares the CBD common to all isofor

41 This divergent Cas9 protein was found in little-studied nanoa

42 ss, sex-biased CRF1 coupling translates into divergent cell signaling that is expressed as different

43 morphogenesis and suggest that Ntn1 may play divergent cellular roles despite its conserved expressio

44 he primary force to shape the convergent and divergent changes between Chinese domestic pigs (CHD) an

45 ice but decreased in PrP KO mice, indicating divergent changes in hippocampal synaptic responsiveness

46 nsequently be interpreted cautiously because divergent changes occurring simultaneously could potenti

47 ponents are structurally different and their divergent character suggests a lower spatial resolution.

48 neutralizing antibodies against infection by divergent circulating human and camel MERS-CoV strains.

49 We show that X-cells group in two highly divergent clades, robustly sister to the bivalve parasit

50 he mechanical forces to support motility are divergent class XIV myosins (MyoA) coordinated by access

51 climate (genetic differentiation due to past divergent climatic selection vs. plastic responses to on

52 receptor (NMDAR) channel-blocking drugs with divergent clinical effects.

53 ing has suggested that rTPJ is implicated in divergent cognitive domains, the demonstration of an inv

54 aled that the Sicilian population was fairly divergent compared to other Italian populations.

55 Divergent connections between MCs and GCs make minimal d

56 Changes in ambient temperature elicit divergent control of metabolic and cardiovascular action

57 used as the starting building block for the divergent, convergent, and double-stage convergent-diver

58 d the correlation functions that exhibit the divergent correlation length are universal in nature and

59 At the spinodal point, there exists a divergent correlation length that is associated with the

60 rature, nutrients) from each site, revealing divergent correlations depending on which data are used.

61 ency of biparental inheritance is greater in divergent crosses and in the presence of cytonuclear inc

62 plast inheritance in genetically similar and divergent crosses, and then associate inheritance with h

63 Highly selective divergent cycloaddition reactions of enoldiazo compounds

64 tral neurogenesis mode prefigures the highly divergent cytoarchitectures that are seen in extant spec

65 s has evolved by testing its activity in the divergent D. melanogaster genome.

66 d transcriptional motifs associated with the divergent DC programs.

67 have contrasting priorities that can lead to divergent decisions and delays in patient access to new

68 es to support cellular processes with widely divergent demands in regard to force production, capacit

69 g from 11 eastern U.S. states to address how divergent demographic histories influence geographic pat

70 Furthermore, PSCs showed divergent developmental associations, with PSCs in highe

71 This divergent developmental program is sufficient to induce

72 ion but also prevents aberrant activation of divergent developmental programmes.

73 f Drosophila pseudoobscura were subjected to divergent dietary selection and evolved significant posi

74 erated primitive neuroectodermal tumors with divergent differentiation including osteosarcoma.

75 1 or D2 receptors and in turn interface with divergent downstream structures such as the basolateral

76 Two divergent dynamin-related proteins found in Entamoeba ar

77 ein (GP) has limited their use against other divergent ebolaviruses associated with human disease.

78 ling of assortative mating with traits under divergent ecological selection helps maintain species in

79 nderlying assortative mating and those under divergent ecological selection.

80 ve functions, we demonstrated that PD-L1 has divergent effects depending on its location in donor ver

81 status, the same social experience can have divergent effects on brain function and cocaine self-adm

82 ese findings indicate that H- and K-Ras have divergent effects on cardiac hypertrophy and heart failu

83 different types of dietary fatty acids have divergent effects on CVD risk, and the effects also depe

84 cellular localization of Clusterin leads to divergent effects on epithelial cell regeneration and lu

85 ivory is one external variable that can have divergent effects on the individual and the population l

86 NG2/CSPG4 depletion has divergent effects, depending on the developmental stage

87 nd had distinct underlying DNA sequences and divergent enhancer activity as marked by histone 3 conta

88 presence or absence of tamoxifen, indicating divergent enhancer activity for tumors that develop in d

89 We cloned genetically divergent env genes from the plasma of two wild-infected

90 cantly reduced Pi accumulation and growth in divergent environments.

91 despite a polygenic basis for adaptation to divergent environments.

92 ed antibody affinity maturation pathways and divergent epitope targeting.

93 e studies provide insights into how a highly divergent eukaryote has re-wired protein N-glycosylation

94 nctional links between the two pathways in a divergent eukaryotic lineage.

95 ecent studies have also revealed patterns of divergent evolution in functional pitcher morphology wit

96 we review recent research on convergent and divergent evolution in pitcher plant traps, with a focus

97 t potentially attractive starting points for divergent evolution in the laboratory.

98 Our findings show divergent evolution of the ankB allele in exploiting eit

99 f selection for protein folding stability in divergent evolution.

100 Subjects selectively bred for divergent extinction phenotypes were fear conditioned to

101 etween PSC and PBC and is characterized by a divergent fate commitment and different signaling pathwa

102 is first application of WES in AI bulls with divergent fertility phenotypes has identified a novel ro

103 s model has been mixed, in particular due to divergent findings in human versus nonhuman primates.

104 L2-CRM with orthologous sequences from other divergent fly species.

105 es of the glue-forming aggregate glands were divergent from fiber-forming glands.

106 icated that segment 1 of this virus was more divergent from its homologues in other Picobirnaviridae

107 sequences of all of these enzymes are highly divergent from sequences found in other organisms, sugge

108 Source water microbiology was most divergent from tap water, and each step of treatment bro

109 A management strategy guided by FFR, divergent from that suggested by angiography, including

110 ently discovered astrovirus genotype that is divergent from the classic human astroviruses (mamastrov

111 l challenge when the novel species is highly divergent from the closest known species.

112 genomes and show that they are significantly divergent from the few modern nonintegrated HHV-6 strain

113 The Boodlea chloroplast genes are highly divergent from their corresponding orthologs, and displa

114 ossess a respiratory metabolic profile fully divergent from those obtained in the other patient group

115 ing showed overlapping yet also consistently divergent functional connectivity profiles for the BNST

116 y in the brain, where it may be endowed with divergent functions beyond microtubule nucleation.

117 em for defining evolutionarily conserved and divergent functions of LANA homologs in Rhadinovirus inf

118 cell signaling, but how cells control these divergent functions of TF remains incompletely understoo

119 G crystallizable fragment (Fc) dictate these divergent functions.

120 microbiologists will be to predict how these divergent future responses of marine microorganisms to c

121 genically relevant when recurrent, producing divergent gene expression (outlier analysis), or as func

122 And the divergent genetic changes reflect distinct breeding goal

123 urs instantly following the hybridization of divergent genomes and significantly increases over gener

124 oor-prognosis M3-UM divide into subsets with divergent genomic aberrations, transcriptional features,

125 We show that these two states acquire highly divergent genomic distributions with substantial disrupt

126 Within the 3 RV species, multiple divergent genotypes encode diverse 2A(pro) sequences tha

127 ome soluble gp120s and gp140s exhibit highly divergent glycosylation profiles compared to trimeric En

128 imers, and we investigated the impact on the divergent glycosylation profiles of changing the genotyp

129 ct Env's glycosylation profile at sites with divergent glycosylation.

130 Phylogenetic analysis shows two divergent groups for G. hirsutum and G. barbadense, sugg

131 The highly divergent HST branch is indicative of greater mtDNA dive

132 In malaria pathophysiology, divergent hypotheses on the inhibition of hematin crysta

133 ed ice-upper ocean coupled model reveal that divergent ice motion in the early melt season triggers l

134 of point mutations in three phylogenetically divergent IGPS proteins during adaptation to temperature

135 nt isoforms of the same gene tend to be more divergent in biological function, tissue expression, and

136 Double flowers in cultivated camellias are divergent in floral patterns which present a rich resour

137 c populations were always significantly more divergent in floral traits and the capacity to self auto

138 conserved nucleotide binding motifs, but is divergent in sequence ( 35% identity) and size ( 40% lar

139 protease and cell wall gene families, while divergent infection strategies are linked to radiations

140 pamine (OA) neurons exhibit courtship toward divergent interspecies D. virilis and D. yakuba females

141 it is unknown what, if any, role the highly divergent intracellular N and C termini contribute to th

142 The Lmod subfamily comprises three somewhat divergent isoforms expressed predominantly in muscle cel

143 that c. 51.4% of homoeologous genes produce divergent isoforms in each subgenome.

144 ent, convergent, and double-stage convergent-divergent iterative methods for the synthesis of dendrim

145 d for synaptic plasticity conspire to effect divergent learning outcomes.

146 g oxidative stress that are characterized by divergent levels of GSH, Cys, and Hcy.

147 ers were both required for the generation of divergent life histories.

148 We show that the anciently divergent lineage that comprises the primary ancestry of

149 n lineages existed in this region, with some divergent lineages contributing DNA to living humans and

150 e demonstrate that hybridization between two divergent lineages facilitated this process by providing

151 We conclude that hybridization between divergent lineages, when coincident with ecological oppo

152 mus in mammals and teleosts has evolved in a divergent manner: placental mammals have lost the monoam

153 These divergent mechanisms explain why the combination of mate

154 erfere with skeletal muscle function through divergent mechanisms that impair excitation-contraction

155 odels, all of which may influence AF through divergent mechanisms.

156 dine ring and thiazole heterocycle for which divergent members of the YcaO superfamily have been bios

157 body escape mutants, cross-neutralization of divergent MERS-CoV strains by RBD-induced antibodies rem

158 hal plus two representatives of climatically divergent MH populations (southwestern Europeans and nor

159 , which consists of two opposing slopes with divergent microclimates.

160 Divergent migration behaviours among individuals or amon

161 und to contain a high level of intraspecific divergent migration, including partial migration with th

162 genome studies have identified recurrent but divergent missense mutations affecting the substrate-rec

163 However, the control mechanisms for this divergent mode of replication are unknown.

164 HST carries the deepest divergent mtDNA lineage that splits from other Neanderth

165 m: how are associations between traits under divergent natural selection and traits that contribute t

166 of migration and undermining the efficacy of divergent natural selection to drive population differen

167 ses are evolutionarily conserved despite the divergent nature of host-symbiont interactions in these

168 lated processes that might be implemented by divergent neural networks.

169 vely, we attempt to shed light on shared and divergent neuroimaging effects across disorders with the

170 Together our findings define divergent neuropathological outcomes arising from differ

171 ngi, which are known to assemble by sequence-divergent non-catalytic dockerin domains (NCDDs)(4).

172 as the only compound that was described with divergent odor attributes, namely musty, rotten and coco

173 coworkers, and friends developed strong and divergent opinions of him.

174 hat SM gene clusters are often either highly divergent or uniquely present in one or a handful of spe

175 ften without recombination among genetically divergent organelles.

176 e of the native translocon in evolutionarily divergent organisms and disease-linked TRAP mutant fibro

177 The divergent outcome observed during the Hofmann rearrangem

178 ally impact HSV-1 and HSV-2 so as to produce divergent outcomes of infection.

179 he T cell antigen receptor (TCR) can produce divergent outcomes, but the mechanism of this remains ob

180 Divergent paralogs of ITS sequences, including putative

181 erived from near-isogenic but epigenetically divergent parents.

182 tions can be used to treat coinfections with divergent pathogens, demonstrating that the Tc bovine pl

183 iologists with a deeper understanding of the divergent pathways via which neighborhood affects health

184 structure-based optimization along multiple divergent pathways.

185 In addition to correctly predicting the divergent pattern of cell sizes, this model reveals allo

186 Bioethicists give voice to those divergent perspectives and provide a framework to facili

187 hetic clusters and experimentally validate a divergent phenazine cluster with potential new chemical

188 ity and is most evident when contrasting the divergent phenotypes that result after undertaking eithe

189 ifferential expression between families with divergent phenotypes, and their expression was strongly

190 RNAs were sequenced from 22 families showing divergent phenotypes.

191 potency against Cryptosporidium but display divergent PK properties.

192 crobial communities in 41 urban parks of (i) divergent plant functional types (evergreen trees, decid

193 by mediating initiation of IFS formation in divergent plant fungal pathogens in response to ROS sign

194 is the class XIV myosin motor, PfMyoA, and a divergent Plasmodium actin (PfAct1).

195 variation in initial conditions may explain divergent population responses to infection that range f

196 bryogenesis, which presumptively derive from divergent pre-zygotic transcriptional states established

197 ences between the models lead to potentially divergent predictions for the potential impacts of curre

198 These divergent processes seem to converge in mitochondrial dy

199 onent analysis of the full data set revealed divergent profiles for all five agonists.

200 thritic cartilage revealed the presence of a divergent progenitor subpopulation characterised by an e

201 Subsequently, the models made divergent projections about the fate of these soil carbo

202 proteins and are frequently located between divergent promoters.

203 ther clonal cysts and spiky masses possessed divergent properties, individual colonies of each morpho

204 We also reveal how these divergent protein mixtures are separately stored in the

205 e examined the motions of three evolutionary divergent proteins in the Escherichia coli cytoplasm by

206 host cells displaying chemically-controlled, divergent proteostasis environments.

207 t higher generations, in both convergent and divergent protocols because of the multistep constructio

208 ng flow UV photolysis and their first use in divergent protodeboronative and oxidative C(sp(2) )-C(sp

209 predominate in eukaryotes, microtubules with divergent protofilament numbers and higher-order microtu

210 neutralizing antibodies against infection by divergent pseudotyped and live MERS-CoV strains, as well

211 t(II) complexes and metalloligands with four divergent pyridyl groups.

212 a powerful tool to elucidate the process of divergent radiations, colonization and speciation in sym

213 Concerning divergent rankings reported in the literature, the great

214 T cells comprise subpopulations with highly divergent rates of turnover, and show that inflows of ne

215 RG-fusion organoid models showed evidence of divergent, rather than common, transcriptional programs.

216 probabilities reminiscent of traveler's and divergent ratios.

217 Three catalyst-dependent divergent reaction pathways for reactions of propargyl a

218 e embryonic stem cells (ESCs) and EpiSCs are divergent, reflecting the shift in the major acting TFs

219 ur results suggest that these evolutionarily divergent regions have undergone significant turnover of

220 re more likely to occur in climate sink and 'divergent' regions (areas where many rapid and diverging

221 respiration led to increased cell lysis via divergent regulation of two processes: increased express

222 cis-acting elements is responsible for these divergent regulations.

223 RARE-EGFP reporter axolotls showed divergent reporter activity in limbs undergoing PD dupli

224 IOC terminals in the retina are exclusively divergent, resembling the terminals from "ectopic" centr

225 In contrast, a 2 degrees C rise produced divergent responses across species growth, resulting in

226 warm temperatures without FTCs could lead to divergent responses in soil bacteria and their microinve

227 Ecosystem models show divergent responses of the terrestrial carbon cycle to g

228 ncompasses varied, co-occurring symptoms and divergent responses to treatment.

229 (HT) and chronic disease risk appear to have divergent results for cardiovascular disease.

230 tors also varied regionally, helping explain divergent results from previous studies at local scales;

231 n the ApoEe3/e4 subgroup showed individually divergent results with an MMSE rate of change of -3.2 po

232 were expanded, suggesting a failure to prune divergent retinal inputs.

233 We found a divergent risk pattern in the risk of 4 common infectiou

234 onas pyrrhocoris ostravirus 1) with a highly divergent RNA-dependent RNA polymerase missed by convent

235 Finally, WntA acquired a divergent role in the patterning of interveinous pattern

236 RNA-seq analysis reveals a divergent role of PI3K/AKT/mTORC signalling, specificall

237 In the present study, we demonstrate divergent roles for IL-10 depending on the site of infec

238 Studies of these mice revealed divergent roles for the C termini in morphine-induced be

239 onses downstream of these receptors and play divergent roles in breast cancer.

240 Macrophages undertook crucial but divergent roles in homeostasis and fibrosis: depleting m

241 In this Perspective, we discuss the divergent roles of the glial scar during CNS regeneratio

242 of cmr transcription and an activator of the divergent rv1676 gene.

243 Focusing on the three most divergent segments, we constructed pairs of viruses that

244 The interplay of divergent selection and gene flow is key to understandin

245 We model how divergent selection leads to a genome-wide negative corr

246 Divergent selection occurs when different environments f

247 The only signal of divergent selection was a tendency for foreign fish to h

248 ions were identified with a strong signal of divergent selection, including an odorant binding protei

249 their historical function or if the intense divergent selective pressures and geographical barriers

250 cause they should engage and activate a more divergent set of germlines than fully glycosylated Env.

251 We found that although TP53 elicits vastly divergent signaling cascades across cell lines, it direc

252 ers for the BATF-IRF4 complex might underlie divergent signaling outcomes in response to various stre

253 an activate these receptor pairs but lead to divergent signaling outcomes through mechanisms that rem

254 es 95:5 er, and the reactions can occur with divergent site selectivity.

255 MVA pathways remained unchanged, suggesting divergent sites of synthesis for dominating and long-cha

256 hemicals converge and interact to coordinate divergent social behaviors.

257 t problem, aligners are heuristics providing divergent solutions and no consensus exists on a gold st

258 Divergent somatic and presynaptic engagement in both pro

259 th the nonrisk alleles across evolutionarily divergent species is consistent with an impairment of co

260 pecies research to genomes of evolutionarily divergent species, and examination of responses to compl

261 Ca(2+) imaging approaches in evolutionarily divergent species, we demonstrate that Ca(2+)-permeable

262 (+) T cells from young and old mice from two divergent species.

263 s-associated gene set identified clones with divergent stemness pathway activation within the same tu

264 mmon functional groups and provide access to divergent stereoisomers and constitutional structures.

265 Ecosystem modeling suggests that divergent stomatal conductance, leaf sizes and stem life

266 This divergent strategy features the oxidative generation of

267 A divergent strategy for the synthesis of the tricyclic 6,

268 We report an efficient divergent strategy for their synthesis based on the Sono

269 luoranthene monomers was carried out using a divergent strategy that allows for systematic structural

270 Divergent sub-populations displayed increased senescence

271 expected dynamics and extent to which these divergent subclonal expansions occur.

272 rstanding of the drivers of the evolution of divergent substrate specificity in enzymes with identica

273 ptomics could be divided into subgroups with divergent survival probability by using single-cell sign

274 Divergent synaptic connections did not contribute direct

275 he pyrimidine and purine ribonucleotides; no divergent synthesis from common precursors has been prop

276 The divergent synthesis of two series of borazino-doped poly

277 A divergent synthetic approach furthermore provided a stra

278 A divergent synthetic strategy allowed access to several m

279 ng increasingly clear that gene flow between divergent taxa can generate new phenotypic diversity, al

280 ne (5hmC) and gene expression changes in two divergent terminal myeloid differentiation processes, na

281 Its supercooled liquid has divergent thermodynamic response functions.

282 Given these divergent timescales, we addressed how cytokine-responsi

283 ct test for genetic coupling by mapping both divergent traits and female mate choice in a classic mod

284 ting traits largely affected generalists and divergent traits specialists; but the effect of escalati

285 Besides, the plants containing the divergent transcription cassettes tend to have more corr

286 ery of transcription factors that coordinate divergent transcription from a pair of tightly linked co

287 cription in both directions, indicating that divergent transcription is a mechanistic feature that do

288 on cassettes: uni-directional transcription, divergent transcription, and convergent transcription.

289 Engagement of divergent transcriptional programs results in phenotypic

290 We identified significant and divergent transcriptional responses to stimulation in ea

291 revealing a highly flexible and structurally divergent type IV pilin.

292 The tecto-IOC terminals are delicate and divergent, unlike the prominent convergent tecto-ION ter

293 ocal sediment heterogeneity supports/selects divergent VC degradation processes at the OAI and that h

294 by distinct transformation pathways and have divergent viral and host expression programs.

295 fficient to provide broad protection against divergent virus strains in vivo.

296 conserved function, UL37 homologs also have divergent virus-specific functions.

297 Herein, we show that IIId2 sub-domains from divergent viruses have different functions.

298 ulation of energy and glucose homeostasis in divergent ways.

299 We compared replication timing in divergent yeast species and identified genomic features

300 cross the glomerular layer to provide highly divergent yet selective output onto interneurons and pri