ライフサイエンスコーパス: docking protein

1 y within virions in the presence of Vpr as a docking protein.

2 both as an ion channel and as an adaptor or docking protein.

3 cell receptor and functions as a multidomain docking protein.

4 effector proteins that are recruited by this docking protein.

5 ation of genes encoding for integrins and FA docking proteins.

6 tial binding sites for SH2 domain-containing docking proteins.

7 om axonemes contained LC8 and putative spoke-docking proteins.

8 is a member of the Cas family of cytoplasmic docking proteins.

9 AB1-3), insulin receptor substrate 2 (IRS2), docking protein 1 (DOK1), Src homology 2 domain containi

10 ellular binding of PRAS40 to the cytoplasmic docking protein 14-3-3.

11 (active), which required a platform protein, docking protein 4 (DOK4), on the inner membrane.

12 Phosphorylated MuSK recruits docking protein-7 (Dok-7), an adaptor protein that is ex

13 report here that c-Cbl, which is a Gab1-like docking protein, also becomes tyrosine-phosphorylated in

14 ation of the Grb2-associated binder-1 (Gab1) docking protein and induced the association of several S

15 se observations suggest that Cbl serves as a docking protein and may transduce signals to downstream

16 se observations suggest that Cas serves as a docking protein and may transduce signals to downstream

17 the GAP-associated p62 acts as an SH2 domain docking protein and mediates the interaction between Nck

18 nal transduction kinase, also functions as a docking protein and participates in the activation of Fy

19 n a unique complement of interacting vesicle docking proteins and PSP, a putative regulator of vesicl

20 ts through intracellular cleavage of vesicle docking proteins and subsequent organism-wide autonomic

21 osphorylation sites of the Disabled 1 (Dab1) docking protein are essential for the transmission of th

22 ement of the Grb2-associated binder-1 (Gab1) docking protein because it interacts with both EGFR and

23 nguish between chaperone oligomerization and docking protein-chaperone interactions and to calculate

24 on of PI 3-kinase and Akt, we use a chimeric docking protein composed of the membrane targeting signa

25 b2-associated binder-1 (Gab1) is a multisite docking protein containing a pleckstrin homology (PH) do

26 The Src substrate p130(Cas) is a docking protein containing an SH3 domain, a substrate do

27 of Reln correlates with up-regulation of the docking protein Dab1 and decreased Dab1 tyrosine phospho

28 syl protein, is thought to act as a multiple docking protein downstream of receptor or non-receptor t

29 nhancer of filamentation 1) is a member of a docking protein family that includes p130(Cas) and Efs.

30 We report that the docking protein fibroblast growth factor receptor substr

31 diated by an indirect mechanism in which the docking protein fibroblast receptor substrate 2alpha (FR

32 emented for algorithms demonstrating protein docking, protein folding, loop modeling and design.

33 er, p59 Fyn functions as an Ang II-activated docking protein for both JAK2 and STAT1, a docking inter

34 the insulin receptor substrate-1 (IRS-1), a docking protein for both the insulin and the IGF-1 recep

35 The insulin receptor substrate-1 (IRS-1), a docking protein for both the type 1 insulin-like growth

36 PTRF acts as a docking protein for MG53 during membrane repair potentia

37 adhesions in host cells and that p130Cas, a docking protein for multiple SH2 domains, is a direct su

38 Pex3 is classically a docking protein for other proteins that affect peroxisom

39 ults show that alpha(3)beta(1) integrin is a docking protein for seprase to form functional invadopod

40 EGF and insulin receptors, and can act as a docking protein for several SH2-containing proteins.

41 treatment, IRS-1 functions selectively as a docking protein for the SH2 domains of the p85 subunit o

42 We found that Gab1, a docking protein for the SHP2 protein-tyrosine phosphatas

43 factor receptors and cytokines by acting as docking proteins for the SH2 domains of signaling elemen

44 Grb2-associated binder 1 (GAB1) is a docking protein found to associate with the activated c-

45 The docking protein FRS2 alpha has been implicated as a medi

46 The docking protein FRS2 is a major downstream effector that

47 nt mutations in Fgfr2's binding site for the docking protein Frs2alpha (Fgfr2(LR/LR)), however, have

48 pathways by selective uncoupling between the docking protein Frs2alpha and activated Fgfr2c, resultin

49 The docking protein FRS2alpha functions as a major mediator

50 The docking protein FRS2alpha is a major mediator of FGF sig

51 The docking protein FRS2alpha is a major mediator of fibrobl

52 enables simple and stable immobilization of docking protein-fused bioactive proteins in the hydrogel

53 g with phosphorylation of the multisubstrate docking protein Gab1 and its binding to SHP-2.

54 to Grb2-mediated complex formation with the docking protein Gab1 and its tyrosine phosphorylation, r

55 Sos1 and the docking protein Gab1 are brought into the MT complex thr

56 The docking protein Gab1 has been implicated as a mediator o

57 Here we observe that the docking protein GAB1 is hyper-phosphorylated in carcinom

58 these functional changes, we focused on the docking protein Gab1 that assembles signaling complexes.

59 proteins, or via the phosphorylation of the docking protein Gab1, and the subsequent interaction of

60 Met associates with, and phosphorylates, the docking protein Gab1, which in turn binds to the src hom

61 g and suggest that Met utilizes at least two docking proteins, Gab1 and Cbl, to activate downstream s

62 The docking protein Gab2 may link SFK to PI3-kinase.

63 olgin-related proteins including the vesicle docking protein GM130.

64 tein 2-associated binding protein 2 (Gab2)-a docking protein-governs the development of fatty liver d

65 We tested the hypothesis that the albumin-docking protein gp60, which is localized in caveolae, co

66 ed into the assembling coated bud, and novel docking proteins have been suggested to be partners with

67 IRS-2, but not of IRS-1, suggests that these docking proteins have different roles in hormone-induced

68 The focal adhesion-associated docking protein HEF1 is cleaved by caspases during both

69 receptor substrate-2 (IRS-2) is a multisite docking protein implicated in mitogenic signaling after

70 Calsyntenin-1 is a transmembrane cargo-docking protein important for kinesin-1-mediated fast tr

71 of the transcription machinery, acting as a docking protein in between the complexes Rad6-Bre1, COMP

72 responses, while expression of the chimeric docking protein in FRS2alpha(-/-) MEFs rescues stimulati

73 demonstrate that expression of the chimeric docking protein in Gab1(-/-) MEFs rescues PI 3-kinase an

74 jor fibroblast growth factor receptor (Fgfr) docking protein in mouse nephron progenitors results in

75 this study, we analyzed the role of the Gab2 docking protein in regulation of the Erk MAP kinase in B

76 ck-mediated phosphorylation of Gab1 and Gab2 docking proteins in IL-6-induced proliferation and survi

77 Similarly, the docking protein insulin receptor substrate 1 (IRS-1) was

78 downstream of the TrkB receptor and involves docking proteins insulin receptor substrate-1 and Shc, w

79 orylation and proteosomal degradation of the docking protein, insulin receptor substrate, and enhance

80 r tyrosine kinase to phosphorylate its major docking protein, insulin receptor substrate-1, in MCF-7

81 tyrosine residues on both of its downstream docking proteins, insulin receptor substrate 1 and insul

82 by exogenous EGF, we examined recruitment of docking proteins, internalization of EGFR, and migration

83 Paxillin, a multifunctional docking protein involved in cell adhesion, was phosphory

84 port a functional role for nephrocystin as a docking protein involved in organizing a protein complex

85 erent growth factors and cytokines, the Gab1 docking protein is tyrosine phosphorylated and in turn a

86 tified pleckstrin homology domain-containing docking protein, is a major binding protein of SHP-2 tyr

87 of filamentation-1 (HEF1), a multifunctional docking protein, is involved in integrin-based signaling

88 ostimulation and found that Cas-L, a 105-kDa docking protein, is marginally expressed in Jurkat T cel

89 phorylation of proximal tyrosine kinases and docking proteins like linker for activation of T cells i

90 e apparent ability of Gbetagamma to act as a docking protein may also serve to provide an interface f

91 (NF-kappaB), occur through the intracellular docking proteins MyD88 and Trif.

92 he insulin receptor substrate-1 (IRS-1) is a docking protein of the insulin-like growth factor-1 (IGF

93 we use functional replacement of the vesicle docking protein p115 to separate its essential from its

94 nd that this complex can bind to the vesicle docking protein p115.

95 formation via the direct association of the docking protein p130(Cas) (Cas) with diverse molecules.

96 1-P), which prevents Crk from binding to the docking protein p130(CAS) (CAS).

97 rs (GEFs), which bound to the focal adhesion docking protein p130(Cas).

98 strated that a complex formation between the docking protein p130Cas (Cas) and the adapter protein Cr

99 e phosphatase 1B (PTP1B) associates with the docking protein p130Cas in 3Y1 rat fibroblasts.

100 The docking protein p130Cas is a major Src substrate involve

101 exchange factor domain to the focal adhesion docking protein p130Cas.

102 n-associated proteins HEF1 (a p130(Cas)-like docking protein), paxillin, and focal adhesion kinase an

103 d NLS, docking interactions between PRAK and docking proteins, phosphorylation of PRAK, and cellular

104 studies suggest that c-cbl may function as a docking protein, possibly linking distinct signal transd

105 of Tyr(P) IRS-2, hormonal activation of this docking protein probably occurs through the IGF-1R.

106 A simple and reliable method for docking protein-protein complexes using (1)H(N)/(15)N ch

107 type 1 had revealed nephrocystin as a novel docking protein, providing new insights into mechanisms

108 in conjunction with deletion of the vesicle-docking protein Rab3A greatly enhances the efficacy of c

109 hnan and Baltimore identify Sam68 as a TNFR1 docking protein required for proper activation of TNF-al

110 2-associated binder 1 (GAB1) is an important docking protein responsible for intracellular signaling

111 fected by knockdown of the mitochondrial JNK docking protein, Sh3 homology 3 binding protein 5 (Sab).

112 The docking protein SNT1/FRS2 (fibroblast growth factor rece

113 inant Tub4p complex to the spindle pole body docking protein Spc110p affects its nucleating activity.

114 d protein (C11orf84), which we renamed SPIN1 docking protein (SPIN.DOC), that directly binds SPIN1 an

115 diacylglycerol but is inhibited by cytosolic docking proteins such as 14-3-3.

116 The axon-specific mitochondrial docking protein (syntaphilin) and phosphorylated neurofi

117 HEF1 is a recently described p130(Cas)-like docking protein that contains one SH3 domain and multipl

118 that Pax-5 functions as a cell type-specific docking protein that facilitates binding of the early B-

119 structure to pl30cas, a recently identified docking protein that is a substrate for phosphorylation

120 substrate (Cas) is a tyrosine-phosphorylated docking protein that is indispensable for the regulation

121 p130(cas) (Crk-associated substrate) is a docking protein that is involved in assembly of focal ad

122 Grb2-associated binder 1 (Gab1) is a docking protein that is tyrosine phosphorylated followin

123 Thus, lipotransin is a novel docking protein that may direct the hormonally regulated

124 FRS2 is a lipid-anchored docking protein that plays an important role in linking

125 se to various growth factors and serves as a docking protein that recruits a number of downstream sig

126 Paxillin is a prominent focal adhesion docking protein that regulates cell adhesion and migrati

127 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the

128 receptor substrate 2alpha (Frs2alpha), a key docking protein that transmits fibroblast growth factor

129 d Efs/Sin constitute a family of multidomain docking proteins that have been implicated in coordinati

130 IRS-1 (and their relatives) are cytoplasmic docking proteins that possess phosphotyrosine-binding (P

131 ought to involve tyrosine phosphorylation of docking proteins that serve as scaffolds for the plasma

132 tion of many adaptor proteins, including the docking protein TNF receptor-associated factor-2 (TRAF-2

133 d by Cdk1/cyclin B at prophase and acts as a docking protein to bring Plk1 into proximity with SA2, r

134 (IRS-1) by the insulin receptor permits this docking protein to interact with signaling proteins that

135 Thus paxillin itself serves as a docking protein to recruit signaling molecules to a spec

136 factors (karyopherin alpha) and nuclear pore-docking proteins to facilitate the transport of the NP a

137 e tetratricopeptide repeat domain-containing docking proteins Toc64, OM64, and AtTPR7 reside in the c

138 biochemical analysis of peroxisomal membrane docking proteins, we cloned and expressed the previously

139 a target recognition subcomplex and the RBX1 docking protein, which delivers the activated ubiquitin

140 to the molecular interplay between motor and docking proteins, which arrests axonal mitochondrial tra

141 Among these is IRS-1, a docking protein with tyrosine phosphorylation sites that