ライフサイエンスコーパス: dogma

1 s, energy metabolism, regulation and central dogma.

2 etical analysis that starts with the Central Dogma.

3 zation beyond the dark level, now a textbook dogma.

4 a striking observation that challenges this dogma.

5 language of genes, mutants, and the central dogma.

6 he study of the main machines of the central dogma.

7 tive immunity, which led us to question this dogma.

8 n intracellular compartments challenges this dogma.

9 lling into question this long-standing lunar dogma.

10 eins; however, recent studies challenge this dogma.

11 or gene silencing, contrary to long accepted dogma.

12 revising the mammalian rod/cone bipolar cell dogma.

13 on, in particular what he called the central dogma.

14 rch, as well as the need to reassess current dogma.

15 d recent investigations have questioned this dogma.

16 ated enzyme chemistry underlying the central dogma.

17 ological molecules, representing the central dogma.

18 y and bystander effects have challenged this dogma.

19 speak for themselves is fast becoming a new dogma.

20 unity ecology and speciation challenges this dogma.

21 bsence of Foxp3(+) Tregs, countering current dogma.

22 Here we challenge this dogma.

23 ivax and Plasmodium ovale malaria has become dogma.

24 ylotrophy and the challenge of long-standing dogmas.

25 radigm shift mandated revisions of cherished dogmas.

26 ioperative management may have changed these dogmas.

27 n more complex requiring a rethinking of the dogma?

28 In contrast to the current dogma, a longitudinal study of conditional Ift88 cilia m

29 We show that, contrary to current dogma, a significant part of the dermal lymphatic vascul

30 ate analysis of small globular proteins; and DOGMA, a web-server that allows comparative analysis of

31 l yeasts, a recent study also challenged the dogma about the absence of DNA methylation in yeast spec

32 ntial immune-neural interactions is revising dogmas about their insular actions and revealing that im

33 The dogma according to which alpha-catenin bridges cadherin.

34 onstrate that, in contrast to the prevailing dogma, acetylation of H3 K56 does not directly affect th

35 Here we review current dogma and argue that it is time to delineate novel immun

36 Our data challenge prevailing dogma and have implications for how the sizes of the CD8

37 neration in acute stress has challenged this dogma and led to the proposition that myocyte renewal is

38 treatment for FXS have been challenging the dogma and principle of the national NBS program: screen

39 dult "two-tier" hierarchy challenges current dogma and provides a revised framework to understand nor

40 te an essential underlying assumption of the dogma and question the specificity of FoxP3-based Treg d

41 h three key findings that challenge existing dogma and suggest new paths.

42 challenge the "one toxin for one antitoxin" dogma and suggest that M. tuberculosis may enlist a soph

43 he recent past, which challenges traditional dogma and ushers in a new era of understanding with pote

44 biology of genomes have overturned long-held dogmas and have led to new models for many essential cel

45 The results have challenged established dogmas and it is therefore timely to integrate new data

46 rs ago, going against a number of entrenched dogmas, and yet succeeding against many odds and obstacl

47 Contrary to accepted dogma, APD and I(to) in a mouse model of hypertrophy and

48 Current dogma asserts that ubiquitin is typically covalently att

49 ction is well established in plants, current dogma assumes that in animals, intact fertile sperm with

50 indings show that contrary to the prevailing dogma, astrocyte scar formation aids rather than prevent

51 han that of Smad4(CKO) mice, challenging the dogma, at least in chondrocytes, that Smad4 is required

52 The Dual Organellar GenoMe Annotator (DOGMA) automates the annotation of organellar (plant chl

53 e strains of Agrobacterium, with the current dogma being that no functional VirF is encoded by nopali

54 We have deliberately violated this dogma by constructing a recombinant influenza virus stra

55 005 study by Stewart et al. [5] reversed the dogma by demonstrating that Escherichia coli were suscep

56 is issue by Joshi and colleagues upsets this dogma by identifying several bacterial species that do n

57 We challenge this dogma by mathematical modeling and with experimental evi

58 Here, we challenge this dogma by showing that yeast laboratory strains and strai

59 NA expressivity, are challenging a series of dogmas concerning the nature of the genome and the relat

60 Existing dogma defines mucous phenotypes in asthma and chronic ob

61 Until recently, dogma dictated that the immune system and the central ne

62 Dogma dictates that adipocytes are 'passive' cells that

63 Based on previous T-cell studies, current dogma dictates that LAT1 is required for plasma membrane

64 Dogma dictates that the lethal blow is delivered to micr

65 exit sites in deeper lymph node venules, as dogma dictates, has a dominant function in antiviral CD8

66 According to three widely held dogmas, DNA is the unchanging template of heredity, is i

67 However, contrary to current dogma, electrogenic transport is not rate-limiting for w

68 Contrary to dogma, FHL-1 and FH exhibited equal regulatory activity,

69 vo findings significantly impact the current dogma for assessing the therapeutic potential of interna

70 The current dogma for cell wall polysaccharide biosynthesis is that

71 A dogma for DNA polymerase catalysis is that the enzyme bi

72 ylated retinoblastoma (RB) is the prevailing dogma for E2F transcriptional activation of target genes

73 A similar central dogma for guiding and unifying nanoscience has been miss

74 direct evidence that, in contrast to current dogma, GRKs can (at least in some instances) constitutiv

75 However, in the last decade this dogma has been challenged by new findings on non-coding

76 ood pressure circadian rhythm; however, this dogma has been challenged by the discovery that each of

77 The common dogma has been that phosphorylation of the hydrophobic m

78 The dogma has been that prions lack nucleic acids and are co

79 Dogma has held that lamins B1 and B2 play unique and ess

80 Alphavirus dogma has long dictated the production of a discrete set

81 Conventional dogma has regarded E-cad as a metastasis-suppressor gene

82 Contrary to this accepted dogma, here it is shown that IFNGR1 with a mutant (Y440F

83 Current dogma holds that active ion transport sets up local osmo

84 Prevailing dogma holds that cell-cell communication through Notch l

85 lycogen is stored in the muscle, the current dogma holds that Glc-6-Pase (now named Glc-6-Pase-alpha)

86 Current dogma holds that the Rpt(1-6) unfolding ring of the 19S

87 e suprachiasmatic nucleus (SCN), and current dogma holds that the SCN is required for the expression

88 The current dogma implicating RelA as the sole enzyme controlling (p

89 cription factor has become a widely accepted dogma in biology.

90 The accepted dogma in circadian biology is that the transcription fac

91 However, the broad applicability of this dogma in clinical disease is only partially understood.

92 amyloid hypothesis has long been the central dogma in drug discovery for Alzheimer's disease (AD), le

93 A dogma in ecology and evolution holds that the environmen

94 A central dogma in immunology is that antibody specificity is a fu

95 A central dogma in immunology is that antibody specificity is sole

96 A prevailing dogma in sedimentation analysis is that the weight-avera

97 This finding goes against firmly entrenched dogma in showing that HKT proteins can function as both

98 een found that there is an exception to this dogma in that a porcine isolate of the paramyxovirus par

99 These findings depart from current dogma in the field by identifying a unique effect of TLR

100 Thus, the prevailing dogma in the field is that Cos2 functions solely as a sc

101 such a widespread belief that it approaches dogma in the field of drug discovery and optimization an

102 Contrary to the current dogma in the field that Pseudomonas aeruginosa is the do

103 This binding selectivity revises the dogma in the field.

104 he aim of the current study was to test this dogma in the least shrew model of vomiting.

105 These results overturn a long-standing dogma in the study of sensorineural hearing loss and hig

106 To what extent is the prevailing dogma incorrect, and how can the recent findings be reco

107 Current dogma indicates that stress granules function as inert s

108 According to dogma, initiator caspases are activated through proximit

109 suggest that it is necessary to rethink the dogma involving GAS pathogenesis, and that the most prod

110 Additionally, dogma is being challenged by data showing very low and e

111 lated data are used to demonstrate that this dogma is false, especially for low affinity systems, ass

112 ong-standing problems in science or refuting dogma is not necessarily the best strategy for a young i

113 Prevailing dogma is that cadherins are linked to the actin cytoskel

114 Nonetheless, the prevailing dogma is that endosomal membrane trafficking ceases duri

115 The inevitable derivative of this dogma is that every invasive carcinoma is in fact a miss

116 oth nanoparticulates and matrix; the popular dogma is that long-lived, high-affinity bonds to both sp

117 The current dogma is that obesity-associated hepatic inflammation is

118 The current dogma is that stress-induced phosphorylation activates t

119 A well accepted dogma is that TCF7l2 inhibits oligodendrocyte differenti

120 The dogma is that the mitotic spindle governs the assembly a

121 Current dogma is that these effects reflect a role for LH neuron

122 fragment crystallizable (Fc) region, and the dogma is that this protects the bacteria against phagocy

123 One such dogma is the adenoma-carcinoma sequence and that a multi

124 The 'dogma' is that IgE molecules merely sensitise mast cells

125 proteins, a network known as life's central dogma, is now marvellously complex, and the progressive

126 lexes only with one 12-RSS and one 23-RSS, a dogma known as the 12/23 rule that governs the recombina

127 esults indicate that, in contrast to current dogma, Mdm2 expression is required for cell survival eve

128 Thus, contrary to current dogma, memory CD8(+) T cells require CD28 costimulation

129 Here, we show that, contrary to dogma, MMTV-Wnt1 mammary tumors with mutant p53 exhibite

130 hus, the generally accepted neurotransmitter dogma needs to be updated since more recent neurochemica

131 Contrary to dogma, no correlation between the GR monomeric/dimeric s

132 The established dogma of 'horror autotoxicus' was overturned 50 years ag

133 This blurs the existing dogma of a clear distinction between stationary nups and

134 e is perceived, and represent a shift in the dogma of allergic disease development.

135 hese data have led to a reexamination of the dogma of brain immunologic privilege and to new studies

136 The dogma of coupled transcription and translation in bacter

137 The central dogma of gene expression (DNA to RNA to protein) is univ

138 The central dogma of gene expression is that DNA is transcribed into

139 autosomal imprinting in mammals violate this dogma of genetic equality.

140 ecomes prevalent with age and highlights the dogma of HSC regulation by their progeny.

141 uccinct evidence to refute the long-standing dogma of interplastid connectivity.

142 The central dogma of mammalian brain sexual differentiation has cont

143 According to the accepted dogma of mammalian sex determination, the Y-linked gene

144 ing quantitative descriptions of the central dogma of molecular biology and the demonstration that a

145 The central dogma of molecular biology describes the translation of

146 A classical dogma of molecular biology dictates that the 3D structur

147 A central dogma of molecular biology is that the sequence of a pro

148 The central dogma of molecular biology states that DNA makes RNA mak

149 The central dogma of molecular biology states that the flow of genet

150 s of new proteins, a key step in the central dogma of molecular biology, has been a major biological

151 tant aspects to understanding of the central dogma of molecular biology.

152 , providing a new way to look at the central dogma of molecular biology.

153 tion of thiamin metabolism is not the simple dogma of negative feedback control.

154 is observed, in the latter case breaking the dogma of ortho metalation.

155 ole for p23, contrasting with the historical dogma of restricted cytosolic activities for molecular c

156 AIDS in an African monkey suggests that the dogma of SIV nonpathogenicity in African NHP hosts shoul

157 into mammals is a relatively rare event, the dogma of the B allele being especially restricted is mis

158 The prevailing dogma of the role of astrogliosis in inhibition of axona

159 nal organ has a direct impact on the current dogma of vascular integration during organ development a

160 Together, our findings challenge current dogmas of both normal spine development as well as spine

161 s can exist, uniting the often contradictory dogmas of DNA overstretching.

162 his observation underlies one of the central dogmas of T cell biology: because thymocytes are seeming

163 rter than control myelin, vitiating accepted dogmas of what constitutes regenerated myelin.

164 work, we suggest that the so-called "central dogma" of amyloid formation, where aggregation takes pla

165 anding phylogenetic controversies, to refine dogma on how chromosomes evolve and to guide annotation

166 ecent revelations is challenging the current dogma on how ubiquitin-dependent processes culminate in

167 hether the "Wigglesworthia-Sodalis-Wolbachia dogma" operates across species and populations.

168 In stark contrast with previous dogma, our study suggests that dolichodial and iridomyrm

169 at panel, e.g. subsystems within the central dogma panel include transcription, translation and prote

170 Current dogma posits that CRLs first catalyze UB transfer from a

171 A long-held dogma posits that strong presentation to the immune syst

172 Although dogma predicts that under normal circumstances, potentia

173 tJ, rho, and rpsQ help protect these central dogma processes in the presence of ethanol.

174 Long-standing dogma proposes a profound contribution of membrane bindi

175 DOGMA provides a graphical user interface for viewing an

176 rogenesis in the adult brain have overturned dogma, provoked reevaluation of cellular plasticity in t

177 esearch, where the aim is to affirm existing dogmas rather than to pioneer efforts involving unconven

178 These findings do not adhere to the present dogma regarding memory T cell generation and provide a m

179 nitor cells has challenged the long-standing dogma regarding the inability to repair or regenerate te

180 acterized, leading to the revision of former dogma regarding the processes of platelet aggregation, c

181 According to current dogma, regulation of the Egr1 expression takes place pri

182 tissue macrophages in the steady state, the dogma remains that tissue macrophages derive from monocy

183 A dogma set forth by early anatomical studies is that bipo

184 like for other enteric viruses, the current dogma states that astroviruses infect in a species-speci

185 This is important because dogma states that HIV-1 mutates to evade host recognitio

186 Current dogma states that the fibroblast makes up the largest ce

187 Current dogma suggests risk is greatest in seropositive recipien

188 Current dogma suggests that chronically demyelinated axons are a

189 Current dogma suggests that high-energy-consuming photoreceptors

190 Current dogma suggests that most, if not all, Tmem responses are

191 Current dogma suggests that oligomeric alphaSyn intermediates ma

192 Current dogma suggests that salivary gland homeostasis is stem c

193 Current dogma suggests that the murine fetal intestinal epitheli

194 Current dogma suggests that the positive correlation between obe

195 In contrast to the dogma surrounding allosteric modulators, the results ind

196 ory roles for C3a and challenges the general dogma surrounding C3a, which, historically, has ubiquito

197 These studies challenge the long-standing dogma that "a calorie is just a calorie" and suggest tha

198 ying virion morphogenesis and challenges the dogma that "capsid maturation," and therefore the capsid

199 tissues in established MCs, contrary to the dogma that activated T cells inevitably traffic to nonly

200 by autoinhibition and challenge the current dogma that all class I-III Fic domain proteins are inhib

201 findings challenge the currently prevailing dogma that all initiator procaspases require homodimeriz

202 y autonomous photoreceptors, overturning the dogma that all visual information originates with rods a

203 Our results challenge the dogma that AMs are short lived and suggest that these di

204 Therefore, the dogma that an asymptomatic primary tumor never should be

205 Contrary to the accepted dogma that ATP is the canonical phosphate donor in amino

206 Taken together, these results question the dogma that autocrine HH signaling plays no role in HH-de

207 ings suggest that in contrast to the current dogma that Ca(2+) release via IP3R does not participate

208 In contrast to the conventional dogma that carbohydrates are poorly immunogenic T-cell-i

209 The longstanding dogma that cholesterol (chol) autoxidation gives chol 7-

210 The old dogma that CNS neurons cannot be regenerated in the adul

211 er with other recent examples, challenge the dogma that codon optimization primarily increases transl

212 This phenomenon not only challenges the dogma that Cox-1 is only developmentally regulated, but

213 fferentiated donor cells has refuted the old dogma that development is an irreversible process.

214 he lack of published evidence supporting the dogma that ex vivo culture generates artifactual genetic

215 This hypothesis differs from the current dogma that excessive activity of T cells mediates delaye

216 tors act as GPCRs in plants, challenging the dogma that GPCRs are exclusively 7TM proteins.

217 l and colleagues challenged the Watson-Crick dogma that hydrogen bonds between complementary bases ar

218 Our study challenges the dogma that IFN-gamma suppresses Th17 and enhances Th1 de

219 Our data challenge the dogma that IL-23 and Th17 plasticity are universally req

220 ctively neutralize virus alters the existing dogma that influenza virus neutralization is mediated so

221 bgroup of patients with T2D, we question the dogma that IR is primarily harmful to the body and shoul

222 Recent studies have overthrown the dogma that irritable bowel syndrome is characterized by

223 shotgun sequencing, clearly challenging the dogma that mid-depth shotgun recovers more diversity tha

224 These materials break the dogma that MOFs must be prepared from small, rigid ligan

225 This case goes against dogma that mothers of severely affected sons are asympto

226 We reexamined the dogma that mouse cytomegalovirus cannot productively rep

227 Does the dogma that multiple myeloma is incurable still hold?.

228 These data challenge the conventional dogma that MuRF1 is controlling the degradation of only

229 The dogma that muscle responses seen when the investigator s

230 Despite long-standing dogma that Na(+)/H(+) antiport regulates pH during the p

231 sed and active in the brain, challenging the dogma that neuronal genomes are static and revealing tha

232 gnaling and significantly expand the current dogma that NIK is predominantly cytosolic and exclusivel

233 acellular chloride, challenging decades' old dogma that NLC reports on eM steady-state behavior.

234 Taken together, these findings challenge the dogma that nuclear accumulation of SAPKs is a pre-requis

235 Our findings challenge the current dogma that only liver, kidney, and intestine can contrib

236 ased protein unfoldedness and challenges the dogma that only specific protein-protein interactions ca

237 Shattering the long-held dogma that organolithium chemistry needs to be performed

238 It is now dogma that osteoclasts (OCs) arise from cells of the mon

239 In contrast to the current dogma that overcoming apoptosis is an important step tow

240 ning during infancy, challenging the current dogma that PFC is an underdeveloped brain system until a

241 Kim et al. challenge the dogma that phosphatidylinositol synthesis is restricted

242 Thus, the dogma that procollagen I and procollagen III N-proteinas

243 However, the long-standing dogma that reticulate evolutionary processes are likewis

244 within the retina, a notion that refutes the dogma that RGCs only provide physiological signals to th

245 In vivo studies have now overturned the dogma that robust plasticity is limited to an early crit

246 nction in experimental models challenges the dogma that RV failure is irreversible without regression

247 Emerging evidence has challenged the dogma that sensing of viral DNA occurs exclusively in su

248 nt in diverse bacteria, thus challenging the dogma that such organisms do not use copper in this loca

249 al aortic aneurysms have led to the emerging dogma that Th2-dominant immune responses result in expan

250 mmary the present study offers weight to the dogma that the adult ovary is populated by a fixed numbe

251 However, the dogma that the apoptotic nuclear morphology depends on D

252 Our results agree with established dogma that the initial endowment of ovarian follicles is

253 enes in germinal initials challenges current dogma that the mitotic to meiotic transition occurs late

254 urons and glia, a concept that shattered the dogma that the nervous system lacked regenerative power.

255 last decade, new evidence has challenged the dogma that the ovary is the main source of this cancer.

256 Recent studies have questioned the accepted dogma that the regenerative capacity of the heart follow

257 Dogma that the regulatory T cell (Treg) prevents catastr

258 We believe that our findings challenge the dogma that the standard P-cluster is the only cluster sp

259 rent approaches, resulting in more or less a dogma that the two branches progress almost independentl

260 udies are generally predicated on Anfinsen's dogma that there is a unique native state of a protein.

261 deficient in LCs have begun to challenge the dogma that there is a universal requirement for these ce

262 This has led to the long-held dogma that these characteristic protein inclusions, whic

263 Contrary to the dogma that these enzymes use ATP as the source of phosph

264 Pase-activating proteins also challenged the dogma that these negative Rac regulators solely act as t

265 These results challenge the current dogma that thymocytes cannot self-renew, and indicate a

266 s surprising considering that it is accepted dogma that TPR proteins do not undergo large conformatio

267 These findings directly refute the dogma that TSPO is indispensable for steroid hormone bio

268 dogenous bioregulators and break the current dogma that vitamin D is solely activated through the seq

269 To examine the widely accepted dogmas that corneal grafts lack passenger leukocytes or

270 Recent reports have overturned a series of dogmas that have been well entrenched in the neuroscienc

271 e two directions, so neither the imperialism dogma (that Eurasian species are exceptionally successfu

272 ur data demonstrate, contrary to established dogma, that loss of haematopoietic-derived focal adhesio

273 ose, the greater the response, following the dogma "the dose makes the poison".

274 Contrary to prevailing dogma, the formed human epicardium is not a simple squam

275 In contrast to the current dogma, the mTOR pathway was not activated in all TSC2(+/

276 In contrast to dogma, the pRb protein is not essential to maintain cell

277 ference of New Ideas in Cancer - Challenging Dogmas." The aim of the conference was to take an honest

278 Science is marked by the death of dogmas; the discovery that adipocytes are more than just

279 According to current dogma, there is little or no ongoing neurogenesis in the

280 Thus, in contrast to current dogma, these data demonstrate that increased transcripti

281 According to the current dogma, they are involved in eliminating bacteria, after

282 Opposing this conventional dogma, this study reveals a much higher level of WSX1 ex

283 We previously challenged this dogma to demonstrate a second non-ES(E/D)V PSD-95-bindin

284 The current "dogma" views the Tag-p53 complexes as a way of sequester

285 This dogma was challenged by recent findings of rotavirus in

286 Recently, dogma was challenged in a report demonstrating oral insu

287 a stochastic two-state model of the central dogma was constructed and verified using joint mRNA/prot

288 This dogma was recently challenged by stable isotope labeling

289 hogenesis of several diseases, the 1980s-90s dogma was that contraction-induced radical production wa

290 Contrary to the current dogma, we demonstrate that nucleosome disassembly is not

291 Additionally, in contrast to the dogma, we find that the major Crohn's disease-associated

292 Contrary to dogma, we report here that injection of anti-CD25 mAb re

293 Contrary to current dogma, we show that both efficient DNA cross-linking and

294 Contrary to dogma, we show that these "macrophageless" mice are able

295 radigm complements the current mitochondrial dogma, whereby molecules endogenously present on or insi

296 Contrary to current dogma, which avers that this is a T-cell defect, we demo

297 pecifics, promise to replace one ideological dogma with another.

298 Li et al. challenge this dogma with evidence that all three of these programs are

299 s have seen a revolution in these prevailing dogmas, with a significant contribution made by the auth

300 Thus, contrary to the prevailing dogma, wrapping by the erythrocyte combined with parasit