ライフサイエンスコーパス: domain

1 rotation is mostly uncoupled from the motor domain.

2 fold and a Holliday junction resolvase-like domain.

3 high-resolution structure exists for the TP domain.

4 a small peptide motif within its MT-binding domain.

5 ls, but not the DNA methylation, of the Peg3 domain.

6 tional Src inhibitors that target the kinase domain.

7 ces stem from the orientations of the apical domain.

8 iled-coil 2-leucine zipper ubiquitin binding domain.

9 , they become inapplicable in the low-energy domain.

10 and a beta-hairpin turn of the Phy-specific domain.

11 minal hydroxyphenylpyruvate dioxygenase-like domain.

12 Sso7d binding module and a cellulose-binding domain.

13 binding specificity of the overexpressed SH2 domain.

14 the hormone binding signal to the catalytic domain.

15 sequence similarity and different auxiliary domains.

16 omain and the HCN C terminus through the TPR domains.

17 phatidylinositol (4,5)-bisphosphate-enriched domains.

18 of mitochondria to maintain distinct Ca(2+) domains.

19 are notably more impactful within their own domains.

20 atic stripes and locally aligned focal conic domains.

21 structures reveals propagating polarization domains.

22 insically disordered regions and coiled coil domains.

23 ns with moderately hydrophobic transmembrane domains.

24 which connects the HIRAN and ATPase/helicase domains.

25 ted CARD8 protein lacking the FIIND and CARD domains.

26 zing auxin response between their expression domains.

27 acement between the VAMP721 SNARE and longin domains.

28 re leads to the formation of distinct margin domains.

29 on site; and 2 variants represented the head domain, 1 complete and 1 truncated.

30 e hypoxia-inducible factor prolylhydroxylase domain-1 (PHD-1) enzyme.

31 ortion of CD23, including the stalk and head domain; 1 variant was identical with the first, except f

32 18 (95% CI, 7-30), and St. George's Activity Domain = 12 (95% CI, 2-21).

33 eable, although the sequence and function of Domain 2 are highly conserved.

34 Domain 4 exhibited low-affinity binding to LRP6 in in vi

35 -catenin, inhibited the biologic activity of domain 4.

36 Recessive mutations in WD repeat domain 62 (WDR62) cause microcephaly and a wide spectrum

37 apply this method to study the cAMP binding domain A (CBD-A) of Protein kinase A.

38 llular matrix protein, the fibronectin extra domain A isoform (FnEDA), which is relatively restricted

39 The structure shows that POT1C contains two domains, a third OB fold and a Holliday junction resolva

40 lapse repeatability of about 2% in the model domain-a threshold that is low enough for observing subt

41 5 (SCA5) L253P mutation in the actin-binding domain (ABD) of beta-III-spectrin causes high-affinity a

42 Talin contains three actin-binding domains (ABDs).

43 membrane-binding defective mutant of the C2 domain abrogated these properties.

44 introduction of new rAb fragments and single-domain Abs have reinvigorated the concept of passive imm

45 It is based on domain adaptation principles and is a generalization of

46 SCCH domain alternation is accompanied by conformational chan

47 FtsZ comprises a polymerizing GTPase domain, an intrinsically disordered C-terminal linker (C

48 structure revealed that DddY contains a cap domain and a catalytic domain with a Zn(2+) bound at its

49 terminal extension containing a proline-rich domain and an actin-binding Wiskott-Aldrich syndrome pro

50 s that bind to the interface between TAM Ig1 domain and Gas6 Lg1 domain can inhibit TAM activation, a

51 ng domain immediately precedes the catalytic domain and has tight associations with it.

52 his study, we identified pleckstrin homology domain and leucine-rich repeat protein phosphatase 1 (PH

53 cleotide-binding domain through a 37-residue domain and the HCN C terminus through the TPR domains.

54 ion causes structural perturbation in the A2 domain and thereby destabilizes the domain by approximat

55 oss to impaired performance across cognitive domains and increased risk for dementia diagnosis.

56 static forces on individual atoms, residues, domains and molecules, and generates an output that can

57 proach to control the buckling of individual domains and thus the outcome configurations of planar-pa

58 hesis) and StoA (apical sterol-rich membrane domains), and its essentiality in polar deposition of ch

59 s, such as AR-V7, at their conserved SET/NAP domain, and exacerbate and repress the transactivation o

60 NLS and the neighboring microtubule-binding domain, and RhoA-GTP binding may relieve this inhibition

61 ng insertion of its N-proximal transmembrane domain, and subsequently, COX18 transiently interacts wi

62 r correlation describing the size of genetic domains; and (3) a dimensionless constant quantifying th

63 utations in the N-terminal end of the kinase domain are more disruptive of protein function.

64 The polyglutamine-proximal portions of these domains are immobilized and clustered, limiting access t

65 FNIII domains are one of the most common protein folds and are

66 During cooling, toric focal conic domains arise through a sequence of morphological transf

67 as exclusively hydrolyzed, confirming the TE domain as a key catalytic bottleneck.

68 an N-terminal sugar phosphate isomerase-like domain associated with DSD activity and a novel C-termin

69 ns while enhancing network-based analyses of domain associations, subcellular localization, and co-co

70 s developed to show that a unique, conserved domain at the C-terminus of Swc5, called Bucentaur (BCNT

71 The zf-MYND-like domain at the N terminus of rice CCR4 and the PXLXP moti

72 First, the motor domain attains the poststroke conformation without direc

73 ion of photopigment and puc expression) BLUF domain before and following photoexcitation.

74 te following exposure of the BAK BH3 and BH4 domains before BAK homodimerization.

75 P) sequencing (ChIP-Seq) data shows that the domain boundaries identified by ClusterTAD have a high e

76 at the dimer interface of the catalytic core domain but at the same time markedly impair HIV-1 replic

77 n the A2 domain and thereby destabilizes the domain by approximately 10 kJ/mol, promoting its unfoldi

78 nterface between TAM Ig1 domain and Gas6 Lg1 domain can inhibit TAM activation, and support the furth

79 N-terminal fragment comprising the catalytic domain can interact both with itself and with a C-termin

80 very of phylogenetically-informative protein domains can be up to 55%.

81 rt from trivial 180(o) commensurate magnetic domains, can be described by ferromagnetic and ferroelec

82 The C-terminal homology domain (CHD) of Af4 was sufficient to confer this linkag

83 ssociate with the coiled-coil and marked-box domains (CMs) of E2Fs.

84 how that there is a rearrangement in the eag domain-CNBHD interaction with the kinetics, voltage-depe

85 ry mediate de novo formation of a 3D contact domain comprising IGF2 and a lineage-specific super-enha

86 zation domain, leucine rich repeat and pyrin domain containing 1 (NLRP1), NLRP3, and nucleotide-bindi

87 Alpha-beta Hydrolase Domain Containing 5 (ABHD5) is a key regulator of intrac

88 y protein nucleotide-binding oligomerization domain-containing 2 (NOD2); however, the reported effect

89 Alpha-beta hydrolase domain-containing 5 (ABHD5), the defective gene in human

90 ndent mechanism involving Toll-IL-1-receptor domain-containing adapter-inducing IFN-alpha (TRIF) and

91 rine/threonine-protein kinase 3 (RIPK3), TIR-domain-containing adapter-inducing interferon-beta (TRIF

92 essor genes, including Src homology region 2 domain-containing phosphatase-1 (SHP-1) and TXNIP (thior

93 The EH-domain-containing protein 2 (EHD2) is a dynamin-related

94 Neither patatin-like phospholipase domain-containing protein 3 rs738409 nor transmembrane 6

95 We show that upon citrate binding, the PAS domain contracts, resulting in a shortening of the C-ter

96 conjugated unimNPs with the cholera toxin B domain (CTB) for RGC-targeting and with Cy5.5 for unimNP

97 ifferences in how the Rb and p107 C-terminal domains (CTDs) associate with the coiled-coil and marked

98 pha), and phosphorylation of the DNA-binding domain (DBD) at Thr-38 in CAR regulates this conversion.

99 a serine-rich motif immediately after the PH domain decreases both PtdIns(4)P binding and ceramide tr

100 Moreover, the domains disappear above a distinct miscibility transitio

101 usative point mutations upstream of the JmjC domain do not disrupt UTX demethylation.

102 identified single-point mutations in the Fc domain (e.g., E345K or E430G) enhancing Fc:Fc interactio

103 s model, a loop defined by the SCI's B and C domains encircles the C-terminal segment of the IR alpha

104 ein VP3 folds into a globular protruding (P) domain, exposed on the virion surface.

105 H changes in order to mimic properly IgGs Fc domain/FcRn receptor interaction.

106 ifferent regions in the Notch1 extracellular domain for activation or inhibition.

107 atic hydroxylation reactions represent a new domain for high-valent bis(mu-oxido)dimetal reactivity.

108 tide that reconstitutes the collagen-binding domain for integrins GFOGER reverted the assembly of FN

109 tive research was used to identify important domains for the Population, Intervention, Comparison, Ou

110 opeller-shaped structure, where the two Cas2 domains form a central hub (twofold axis of symmetry) fl

111 "Loop domains" form because of tethering between two loci-almo

112 In this study, we demonstrate that binding domains from autolysins and lysins can be fused to the F

113 h located distant to the active site, the C2 domain greatly enhances catalytic turnover.

114 We now reveal that mature domains harbor their own independent targeting signals (

115 Notably, two domains harbored by beta-1,3 galactosyltransferase, an e

116 The second domain has a known SWIB/MDM2 fold, which was not observe

117 play key residues of the p53 transactivation domain have emerged as bona fide clinical candidates for

118 ked to palmitoylation of the cysteine-string domain, however the regions of the mutant proteins that

119 The pseudosubstrate and C1a domains, however, are minimally essential for maintainin

120 nd loaded with plasmid DNA encoding perlecan domain I and VEGF189 and analyzed in vivo for their abil

121 ng plasmid DNA encoding VEGF189 and perlecan domain I have the potential to induce angiogenesis and w

122 separase (also known as Esp1) contains four domains (I-IV), and a substrate-binding domain immediate

123 eractions of rProtein uL23 and its tail with Domain III and with DIII(core) rRNA.

124 However, most evidence suggests that the domain immediately downstream of the S2' cleavage site i

125 four domains (I-IV), and a substrate-binding domain immediately precedes the catalytic domain and has

126 omain from the C-terminal growth factor (GF) domain in each monomer, pro-TGF-beta is secreted and sto

127 found that the RING B-box coiled-coil (RBCC) domain in KAP1 and the proximal coupling of ubiquitin co

128 biquitin conjugation to ER degradation (CUE) domain in SMARCAD1 mediate their direct interaction.

129 (RNAP) beta subunit is a part of RNA binding domain in transcription complex.

130 We identified 19 rotor domains in 10 patients (1.8+/-1.1 per patient; 7 in the

131 slocation could be restored by alpha-helical domains in a position- and organism-dependent manner.

132 Here we study the multiferroic domains in ferromagnetic ferroelectric Mn2GeO4 using neu

133 Recent observations of switching of magnetic domains in ferromagnetic metals by circularly polarized

134 viours of heterochromatin, and how chromatin domains in general regulate essential nuclear functions.

135 Here, the authors identify two pseudoGTPase domains in p190RhoGAP, characterize them biochemically a

136 examined associations between the 12 symptom domains in the Neuropsychiatric Inventory (NPI) and rela

137 These data argue that many distant domains in the rRNA can assemble simultaneously during e

138 advancements in a number of crucial sensing domains, including biomolecules, environmental toxins, e

139 The C-terminal DSP domain induced phosphorylation of occludin Ser(490) and

140 Bromodomain and extraterminal domain inhibitors (BETi) represent promising therapeutic

141 ne protein with a single immunoglobulin (Ig) domain, instructs the distinct, neuron-type-specific ela

142 lular protein, and it suggests that the SLII domain is a potential target for antiviral therapy.

143 show here that while the central DNA binding domain is essential for anchoring at parS, this interact

144 So far, it has been assumed that the pilin domain is essential for the allosteric propagation withi

145 Conformational freedom of the FMN domain is thought to be essential for the electron trans

146 ediately upstream of the SNARE heptad-repeat domain, is required for normal fusion activity with HOPS

147 vertebrate thalamus, pretectum, and midbrain domains jointly correspond to a single amphioxus region,

148 indicates how tension between the two motor domains keeps their cycles out of phase in order to stim

149 cs are regulated by kinases, such as the LIM domain kinase (LIMK), which regulates actin activity thr

150 fic residues in the PPARdelta ligand-binding domain (LBD).

151 tween GK and the nearby Src homology 3 (SH3) domain, leading to a closed conformation, whereas a non-

152 proteins nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing

153 sis, is executed by the mixed lineage kinase domain-like (MLKL) protein, which is triggered by recept

154 PK3) phosphorylation of mixed-lineage kinase domain-like protein (MLKL), which results in disruption

155 The matrix domain (MA) of HIV-1 Gag protein is N-myristoylated and

156 eIF4G plus an adjacent probable RNA-binding domain mediate translation initiation.

157 Domain migration is observed on the surface of ternary g

158 Expression of the PTEN C2 domain mimicked effects of full-length PTEN but a membra

159 ted by its conserved mitochondrial targeting domain (MTD), which, in unstressed conditions, is inhibi

160 NQO1 is a FAD-dependent, two-domain multifunctional stress protein acting as a Phase

161 We also identified POLE proofreading domain mutations in three endometrioid ovarian tumors.

162 king and undocking of its nucleotide-binding domain (NBD) and substrate-binding domain (SBD).

163 cted that a region in the nucleotide-binding domain (NBD) of DnaK interacted with a region in the mid

164 inding site of NRP1 and the NRP1 cytoplasmic domain (NCD), but not the known NCD interactor GIPC1.

165 LRP3, and nucleotide-binding oligomerization domain (NOD)-like receptor C4 (NLRC4) were associated wi

166 Here, we show that Cet1's N-terminal domain (NTD) promotes the recruitment of FACT (facilitat

167 Spectral-domain OCT is useful in identifying various imaging find

168 This variable domain of an H chain-only Ab (VHH or nanobody) significa

169 e, we report that the hydrophilic N-terminal domain of Brassica napus DGAT1 (BnaDGAT11-113) regulates

170 n the Ca(2+) binding loops particularly at C-domain of CaM, enabling Ca(2+) release.

171 with a novel binding motif in the N-terminal domain of CaV1 LTCC alpha1 subunits that is not conserve

172 ver, replacement of TM2 by the transmembrane domain of CD4, the asialoglycoprotein receptor, or the t

173 Replacement of the transmembrane domain of CD74 or the asialoglycoprotein receptor with A

174 milarities to the cysteine-rich zinc-binding domain of DnaJ chaperones.

175 ranslation and show that the functional core domain of eIF4G plus an adjacent probable RNA-binding do

176 The receiver domain of ETR1 is involved in this function in germinati

177 inding of the S339D/S340D mutant to the FERM domain of Ezrin is sensitive to buffer salt concentratio

178 the specific interaction with the N-terminal domain of Hsp90 required for catalysis.

179 DnaK interacted with a region in the middle domain of Hsp90Ec.

180 gh the signaling function of the cytoplasmic domain of ICAM-1.

181 We also found that the extracellular domain of IL1RAPL1 is required for this effect, independ

182 bind to the plexin-semaphorin-integrin (PSI) domain of inactive, beta3 integrins.

183 Conversely, receptors with the intracellular domain of IR display higher IRS-1 phosphorylation, stron

184 NA is found throughout much of the bacterial domain of life, where it commonly controls the expressio

185 show that TIGIT bound to the immunoglobulin domain of nectin-2 that is most distal from the membrane

186 nt polypeptide chains, also binds to the TPR domain of Sec72, even though it lacks the TPR-binding C-

187 tab and HAP1-DeltaOSCP, lacking the membrane domain of subunit b or the OSCP, respectively, in which

188 ed probes consisting of the PtdIns4P-binding domain of the bacterial effector SidM.

189 ha13 protein from binding to the cytoplasmic domain of the beta3 integrin prevents outside-in signali

190 s identified in the intracellular C-terminal domain of the GluN2B NMDAR subunit.

191 system, the phosphorylation of the receiver domain of the histidine kinase CYTOKININ-INDEPENDENT 1 (

192 ts were conferred by changes in the constant domain of the light chain.

193 otaxis protein CheY, the N-terminal receiver domain of the nitrogen regulation protein NT-NtrC, and t

194 the unfolded protein stress-sensing luminal domain of the UPR transducers PERK and IRE1alpha does no

195 uences outside of-but adjacent to-the kinase domain of TrkA.

196 and similar to the active state of receiver domains of bacterial response regulators.

197 (alpha2AAR) that occurs at the intracellular domains of both proteins.

198 tive cost-benefit valuation across different domains of effort and provide insight into the multidime

199 was utilized to demonstrate that isolated TM domains of Hendra virus F protein associate in a monomer

200 The ligand-binding betaI and alphaI domains of integrin are the best-studied von Willebrand

201 for ten core proteins, nearly all essential domains of its RNA, and five stably associated auxiliary

202 mes have been discovered in all evolutionary domains of life.

203 ame unimodal core coalignment but form local domains of microtubules polymerizing in the same directi

204 lve the crystal structures of the N-terminal domains of PHF1 and MTF2 with bound CpG-containing DNAs

205 localized to the canalicular and basolateral domains of polarized hepatic cells, respectively.

206 Cerebellar systems are implicated in diverse domains of sex-biased behavior and pathology, but we lac

207 t mobile small RNAs generate sharply defined domains of target gene expression through an intrinsic a

208 physical-impairment and everyday-activities domains of the Migraine Physical Function Impact Diary (

209 We find that both the N- and C-terminal domains of TTP are involved in an interaction with CNOT9

210 study the influence of a cytoplasmic protein domain on the clustering behaviour.

211 pair and which is framed by extensive ZMYND8 domains on the flanking chromatin.

212 described by ferromagnetic and ferroelectric domains only.

213 study identified LMO1, which encodes an LIM-domain-only transcriptional cofactor, as a neuroblastoma

214 eld fluorescein angiography (UWFA), spectral-domain optical coherence tomography (SD-OCT), and optica

215 erent redox states have a profound effect on domain orientation in the enzyme and we analyse the data

216 y, we demonstrate that only three of the six domain orientations are present in solution, where Dcp2

217 exchange between the TCR alpha/beta constant domain pair and the IgG1 CH3 homodimer was evidenced by

218 tramers composed of a stable oligomerization domain (Pcore) flanked by large intrinsically disordered

219 -NW directed input from the high-attenuation domain, possibly a dyke emplacement.

220 of sporozoite factors reveals the 6-cysteine domain protein P36 as a major parasite determinant of ho

221 lated enhancer controls expression of an SAM domain protein that confers survival in anemia.

222 members of a small family of immunoglobulin domain proteins, we found that OIG-8, a previously uncha

223 Overall cognition, individual cognitive domains, psychosocial function, and activities of daily

224 rcome such limitations, protein transduction domains (PTDs) have been used as protein carriers, howev

225 pathway, including RNA POLYMERASE V (POL V), DOMAINS REARRANGED METHYLTRANSFERASE 2 (DRM2) and SAWADE

226 her-order form that adopts carboxyl-terminal domain rearrangements.

227 as pRNA acceptors indicated that the PRNTase domain recognizes the C-2-amino group, but not the C-6-o

228 onnection to extensive annotation of several domain-relevant semantic classes, and connection to comp

229 The function and regulation of these domains remain largely unknown.

230 We found that the minimal domains required for efficient Ede1 localization at CME

231 obular, cofactor-containing extracytoplasmic domains requiring the dual action of the co-translationa

232 al cysteine pairs in the CSF3R extracellular domain resulted in either gain- or loss-of-function chan

233 PFM hysteresis loops for the bubble domains reveal that they undergo an irreversible phase t

234 of 40 CBMs, in fusion with an N-terminal GFP domain, revealed that type A CBMs possess the ability to

235 e-binding domain (NBD) and substrate-binding domain (SBD).

236 M) complex thickness as measured by spectral-domain (SD) optical coherence tomography (OCT).

237 n are independently folded into well-defined domains separated by a flexible linker.

238 compounds that allow a tailoring of magnetic domain shapes and sizes are essential.

239 ants that do not have the 10th transmembrane domain show very poor activity.

240 als, suggesting its emergence as a result of domain shuffling.

241 of learned eye-movement plans represented in domain-specific areas of the brain.

242 ing to account for the separation of the two domains starting from a homogeneous array of cells, and

243 The domain structures were then docked in silico to provide

244 , which comprise vast, highly differentiated domains such as the axon and dendrites.

245 Fkh1- and Fkh2-domain-swap-minus (dsm) mutations are functional as tran

246 be associated with topologically associating domain (TAD) borders, while dCP enhancers are more often

247 ir own independent targeting signals (mature domain targeting signals [MTSs]).

248 n through transcriptional enhancer associate domain (TEAD) and runt-related transcription factor 2 (R

249 n mice with a mutation in the TR DNA-binding domain that abrogates binding to DNA and leads to comple

250 i by targeting cellular ligases through a sT domain that also inhibits MCV large T oncoprotein turnov

251 fication of cysteine residues within the RGS domain that are located distal to the Galpha-binding int

252 NEMO (residues 112-150) in its coiled-coil 1 domain that impedes the binding of linear (M1-linked) di

253 We also showed that YeeJ contains a LysM domain that interacts with peptidoglycan and thus assist

254 tt-Aldrich syndrome protein homology 2 (WH2) domain that is absent in Tmods.

255 e Xist locus is coated with a broad H3K27me3 domain that is established during oocyte growth and pers

256 pecific NLS sequence in the N-terminal lyase domain that promotes transport of the protein independen

257 the allosteric propagation within the lectin domain that would otherwise be conformationally rigid.

258 mber of redox-inactive ketoreductase (KR(0)) domains that are implicated in the generation of C2-epim

259 mational changes within the Uba1 adenylation domains that effectively disassemble the adenylation act

260 ditors containing mutated cytidine deaminase domains that narrow the width of the editing window from

261 a membrane, respectively, to create membrane domains that partition upstream regulators of the TORC1

262 organs of the inner ear and the non-sensory domains that separate them are still unclear.

263 Lon to bind DNA is determined by its ATPase domain, that this binding is required for processing pro

264 1 localization at CME sites are the third EH domain, the proline-rich region, and the coiled-coil reg

265 Although EPFR formation occurs on the metal domains, these differences were correlated with the alte

266 ment with an absence of predicted structural domains, these were characterized as intrinsically disor

267 surface uniformity and conserved fold of SH3 domains, they display different binding mechanisms and a

268 IP8b binds the HCN cyclic nucleotide-binding domain through a 37-residue domain and the HCN C terminu

269 e linker dictates the rotation of the lectin domain, thus modulating the GalNAc-Ts' long-range prefer

270 eterodimers further dimerize through SAV1 WW domains to form a heterotetramer, in which MST2 undergoe

271 Unoccupied WH2 domains transiently associate with free filament ends, p

272 This resulted from both N-domain twisting and rotation of the C domain (up to 30 d

273 One domain type shows extremely weak superstructure phenomen

274 irreversible phase transition to cylindrical domains under the electric field, accompanied by a trans

275 are the best-studied von Willebrand factor A domains undergoing significant conformational changes fo

276 both N-domain twisting and rotation of the C domain (up to 30 degrees ) at the end of the relatively

277 racts also demarcate seven columnar neuropil domains (ventromedial, ventro-lateral, centromedial, cen

278 We report bi-directional domain wall (DW) motion along and against current flow d

279 otentially related to the controllability of domain wall electronic properties.The electronic states

280 Our results introduce a concept for the domain wall electronic property, the walls own internal

281 which provide a better understanding of the domain wall motion.

282 eversal curve measurements indicate a strong domain wall pinning along the direction orthogonal to th

283 eal that the higher coercive field is due to domain wall pinning in deeper defects and hence a higher

284 y to present phase co-existence separated by domain walls (DWs) above room temperature provides immen

285 energy in well-defined train of polarization domain walls allows undistorted propagation of polarizat

286 Moreover, since domain walls are generally writable, erasable and mobile

287 onic properties.The electronic states within domain walls in an interacting electronic system remain

288 Magnetic domain walls in magnetic tracks produce strong localized

289 The possibility of controlling magnetic domain walls using voltages offers an energy efficient r

290 P-D, containing homotrimeric neck and lectin domains, was expressed in Escherichia coli BL21(lambdaDE

291 Outcomes (outcome domains) were then compared separately for each disease.

292 Anillin contains a RhoA-GTP binding domain, which autoinhibits the NLS and the neighboring m

293 al changes in the tailpiece and the adjacent domain, which drive further polymerization.

294 This domain, which was only found in bacterial proteasomal AT

295 Effective target sites fall within two domains, which are conserved in sequence/structure indic

296 The amino-terminal domain with a fold distinct among known TRP structures,

297 possesses an ubiquitin (Ub) E2 variant (UEV) domain with a pocket that can bind PT/SAP motifs and ano

298 t DddY contains a cap domain and a catalytic domain with a Zn(2+) bound at its active site.

299 We find that a non-catalytic domain within Cas9, REC3, recognizes target complementar

300 nalysis, highly conserved protein motifs and domains within each of the AARS loci were identified and

301 we define the Xist RNA Polycomb Interaction Domain (XR-PID), a 600 nt sequence encompassing the Xist