ライフサイエンスコーパス: domain architecture

1 full-length sequence similarity with common domain architecture).

2 s of some of these insects and studied their domain architecture.

3 binding does not extend to the overall multi-domain architecture.

4 izosaccharomyces pombe Rhp23, has an unusual domain architecture.

5 ain was inserted interior to the existing NR domain architecture.

6 ith those in other CFs that contain the same domain architecture.

7 ith each subfamily sharing a common, modular-domain architecture.

8 despite not being part of the canonical BLUF domain architecture.

9 aprioi knowledge of family relationships or domain architecture.

10 n and does not require a priori knowledge of domain architecture.

11 new protein sequences into families based on domain architecture.

12 ilarities, and a graphical representation of domain architecture.

13 nt, Delta(187-243), to obtain information on domain architecture.

14 n the interfaces involved but also different domain architecture.

15 th the number of proteins involved and their domain architecture.

16 Light Chain, a membrane protein with a novel domain architecture.

17 rised according to taxonomic distribution or domain architecture.

18 CoA mutase (MCM), HCM has a highly conserved domain architecture.

19 13 (PBL13), a subfamily VII RLCK with unique domain architecture.

20 ood are WHAMM and JMY, two NPFs with similar domain architecture.

21 Each subunit shows a domain architecture.

22 C heterodimer and determine its higher-order domain architecture.

23 cture revision required us to reconsider the domain architecture.

24 nce alignments based on commonality of multi-domain architectures.

25 th an extraordinary diversification of their domain architectures.

26 nerates a dynamic 2D network of related Pfam domain architectures.

27 ompare heterodimers of chains with different domain architectures.

28 a bank (PDB) are grouped based on their PFAM domain architectures.

29 ies, were identified and classified by their domain architectures.

30 implifies the visual analysis of represented domain architectures.

31 ence motifs, shared structural features, and domain architectures.

32 d in the generation of many lineage-specific domain architectures.

33 allows a priori design of these hierarchical domain architectures.

34 ganismal complexity by the generation of new domain architectures.

35 provide highly comprehensive composite multi-domain architectures.

36 searching genomes to identify related multi-domain architectures.

37 by cyclodextrin disruption of PM lipid micro-domain architecture, a change that also retarded lateral

38 are represented by orthologs with conserved domain architecture across the three superkingdoms of li

39 other genomes or groups of genomes; compare domain architectures across selections of genomes and fi

40 The TraI domain architecture, although not previously described,

41 many RabGAPs share a Tre-2/Bub2/Cdc16 (TBC)-domain architecture, although the majority of TBC protei

42 Pases of ESX secretion systems have a unique domain architecture among proteins of the FtsK/SpoIIIE f

43 Genomic context and domain architecture analyses support a role for the GxGY

44 ng the relationships between related protein domain architectures, analyses of ligand binding cluster

45 sequence alignment, structure prediction and domain architecture analysis, we have identified a novel

46 ad options provide improved functionality to domain architecture analysis.

47 We observe an alphabeta-roll domain architecture and a dimeric assembly which are con

48 ribosomal peptide synthetase with an unusual domain architecture and an L-threonine:4-nitrophenylacet

49 ss II fusion proteins have a conserved three-domain architecture and are found in many important vira

50 The superfamily curation defines signature domain architecture and categorizes memberships to impro

51 The two-domain architecture and dimerization of MinC can be rati

52 The domain architecture and DNA recognition profile displaye

53 Our results show that VACV-A6 has a two-domain architecture and functions in both crescent forma

54 llography, we obtained new insights into the domain architecture and interaction network of the Cep10

55 cleoside contributions to the tRNA anticodon domain architecture and its decoding of the genome has a

56 Based on domain architecture and phylogenetic analyses grape home

57 Despite a domain architecture and positioning of catalytic residue

58 oscopy analysis demonstrate a highly dynamic domain architecture and provide the foundation for under

59 w families of transcription factors based on domain architecture and receive predictions for a protei

60 de query sequence the server will return the domain architecture and SCOP classification.

61 ture of the BT_1012 protein confirms its two-domain architecture and structural analysis of both doma

62 The web interface includes services such as domain architectures and alignment details for all prote

63 domains show a tendency to occur in diverse domain architectures and can be considered "promiscuous.

64 ein (MCP) homologs that have diverse sensing domain architectures and generate a potential for sensin

65 Comparison of domain architectures and multiple alignments resulted in

66 e of life, searches for functionally similar domain architectures and phylogenetic trees.

67 ies in our test set exhibit a broad range of domain architectures and sequence conservation, demonstr

68 s of phylogenetic profiles, genomic context, domain architectures and sequence identity reveal that s

69 nd MX2 are closely related and share similar domain architectures and structures.

70 The diversity of domain architectures and the abundance of alternative do

71 ats of Rad4(TopBP1), revealing a distinctive domain architecture, and characterized their phosphoryla

72 ces to other databases, graphical display of domain architecture, and links to multiple sequence alig

73 otein membership, parent-child relationship, domain architecture, and optional description and biblio

74 e analyses of protein families via conserved domain architectures, and a recent curation effort focus

75 oups of transcription factors have identical domain architectures, and this implies that roughly thre

76 embers of the protein phosphatases family by domain architecture as an ontology.

77 The structures have a three-domain architecture as observed previously for other gly

78 BtGH115A reveals that BtGH115A has the same domain architecture as the other structurally characteri

79 s provide a framework to rationalize the LOV domain architecture, as well as the signaling mechanisms

80 eveal not only a novel chemoreceptor sensing domain architecture but also, possibly, a different mech

81 TRIM proteins have conserved domain architecture but diverse cellular roles.

82 5/OTT1, and RBM15B/OTT3 share the structural domain architecture but show distinct functional propert

83 y from CCP tandems, suggesting that not only domain architectures but also cleavage location can be c

84 the widespread four-helix bundle cytoplasmic domain architecture can control VGIC responses, uncover

85 networks by which zoonotic receptor binding domain architecture can productively engage hACE2, but o

86 Search results are displayed as domain architecture cartoons and pairwise alignments bet

87 Knowledgebase (UniProtKB) by comparing their domain architectures, classifying proteins based on the

88 The hIKK2 domain architecture closely resembles that of Xenopus IK

89 lus Gfh1 at 2.4 A resolution revealing a two-domain architecture closely resembling that of GreA.

90 - and O-glycosylated catalytic domain (CD)-a domain architecture common to many biomass-degrading enz

91 The structure contains a bi-domain architecture composed of a GAF domain (commonly f

92 The minimal consensus domain architecture comprises a signal peptide, a 60-90-

93 Netrin G proteins share a common multi-domain architecture comprising a laminin N-terminal (LN)

94 uitinating enzymes exhibit a conserved three-domain architecture, comprising Fingers, Palm, and Thumb

95 P4 has a two-domain architecture consisting of a core alpha/beta doma

96 uginosa chemoreceptor, Aer-2, has an unusual domain architecture consisting of a PAS-sensing domain s

97 ata revealed MrkH to be a monomer with a two-domain architecture consisting of a PilZ C-domain connec

98 CheB has a two-domain architecture consisting of an N-terminal regulato

99 It has a modular domain architecture consisting of an Src homology 2 doma

100 study was to analyse the protein domain and domain architecture content of the 137 fungal proteomes

101 First, we compared the domain and domain architecture content of the human and fungal prot

102 how that, despite appreciable differences in domain architecture, Csk from Corallochytrium limacispor

103 ary sequence conservation, protein size, and domain architecture, deemed ELMOD and ELMO.

104 of the NCBI Entrez Protein Database based on domain architecture, defined as the sequential order of

105 The effector collection and network of domain architectures described here can serve as a roadm

106 her identify a chemoreceptor with an unusual domain architecture, DosM, which is essential for format

107 Some layered domain architectures (e.g. mainly-beta and alpha-beta sa

108 om a common ancestor and instead suggest the domain architecture evolved at least twice.

109 share core light-input and signaling-output domain architectures except for the loss of C-terminal r

110 PGTs that reveals a core structure with dual domain architecture featuring a C-terminal soluble globu

111 sigma(E)/ChrR complex reveal a modular, two-domain architecture for ChrR.

112 notated sequence regions to derive consensus domain architecture for each sequence and subsequently g

113 e, we propose a higher-resolution functional domain architecture for nsp3 that determines the interac

114 me encodes apparent orthologs with conserved domain architecture for the majority of the disease gene

115 Prediction and comparison of TLR protein domain architectures for multiple species revealed seven

116 ms for a domain superfamily or all the multi-domain architectures for the human genome.

117 Prediction and comparison of protein domain architectures for TLR2 and TLR6 revealed six regi

118 ned in membranes; (iv) amino acid sequences, domain architecture, functional annotation and available

119 es only the presence or absence of a protein domain architecture has been used to determine the phylo

120 Further, TBC-domain architecture has been well conserved in modern eu

121 Their domain architecture has remained relatively fixed across

122 enzyme (BstCCA) have similar dimensions and domain architectures (head, neck, body, and tail), only

123 inherent dynamics of SSBs and PARP-1's multi-domain architecture hindered structural studies.

124 r results demonstrate that the multiple HRDC domain architecture in GcRecQ is critical for structure-

125 cterial multidrug exporter Sav1866 suggest a domain architecture in which both nucleotide-binding dom

126 two or more smaller proteins with equivalent domain architectures in other organisms.

127 recruits to sites of DNA damage where PARP-1 domain architecture initiates catalytic activation and s

128 gene/protein sequence retrieval, visualized domain architectures, interactive chromosomal views for

129 If the CSP domain architecture is altered such that the cell-adhesi

130 den Markov model-based sequence profiles and domain architecture is calibrated against manually curat

131 This three-domain architecture is compatible with interactions betw

132 The fold is similar to FIS protein, but the domain architecture is different from previously charact

133 The alpha CTD DNA-binding domain architecture is unlike any DNA-binding architectu

134 s a molecular mechanism by which conserved G domain architecture is used to energetically link GTP tu

135 ulting list of core and exclusive domain and domain architectures is provided in this paper.

136 nthase (PKS) is quite complex, with a simple domain architecture leading to elaborate products.

137 The NLR domain architecture likely evolved independently and con

138 Protein domain architectures link evolutionarily related protein

139 nd 70% on the domain level, unless the multi-domain architecture matches.

140 For example, the three-layer sandwich domain architecture may be divided into four structural

141 nd to dsRNA, which shows how, using the same domain architecture, MDA5 recognizes the internal duplex

142 ower clustering of proteins sharing the same domain architecture, MUSCLE multiple sequence alignment,

143 Domain architecture "neighbors" identified in this way m

144 The domain architecture of a large RNA can help explain and/

145 Furthermore, the domain architecture of a SONO ortholog cloned from Chlam

146 We defined the domain architecture of A6 and suggested that one of its

147 Overall, we have shown that the modular domain architecture of AAA proteins allows for precise c

148 Detailed examination of the domain architecture of aaRSs using sequence profile sear

149 We asked why CFTR, which shares the domain architecture of ABC proteins that function as tra

150 n types by name, for example, or to view the domain architecture of any protein in Entrez's sequence

151 In a previous study, we determined the domain architecture of ataxin-3, suggesting that it comp

152 The domain architecture of CBP and TAF(II)250 families of HA

153 ts of a gene correlated to variations in the domain architecture of corresponding protein isoforms.

154 Overall, the unique domain architecture of Csa3 suggests a transcriptional r

155 DXMS has verified the multi-domain architecture of D-AKAP2 implied by sequence homol

156 This newly revealed domain architecture of DISC1, therefore, provides a powe

157 The domain architecture of full-length XEEL is reminiscent o

158 ts provide an explanation for how the unique domain architecture of JAZ10.4 links transcription facto

159 on the proposed mode of restriction and the domain architecture of known antiretroviral env, we argu

160 Little is known about the functional domain architecture of long noncoding RNAs (lncRNAs) bec

161 A domain-containing proteins with the common domain architecture of N-terminal SRA domain and C-termi

162 lar structure in toxins evolved to match the domain architecture of Na(v)s.

163 The unique domain architecture of NgrRnl fortifies the theme that R

164 Determination of the higher-order domain architecture of NOS is essential to elucidate the

165 CsPABPN1 has a domain architecture of nuclear PABPs (PABPNs) with a sin

166 The domain architecture of PfCDPK7 is very different from th

167 The predicted domain architecture of PrkC comprises a cytoplasmic kina

168 s; (ii) color-coded graphical display of the domain architecture of proteins correlated with their co

169 hese analyses reject the hypothesis that the domain architecture of R-proteins and NLRs was inherited

170 experiments, we elucidate how the conserved domain architecture of RecQ supports geometry-dependent

171 Understanding the higher-order domain architecture of sGC is a prerequisite to elucidat

172 of the secondary (2 degrees ) structure and domain architecture of the 23S and 5S rRNAs, using 3D st

173 To define the domain architecture of the A-ATPase peripheral stalk, we

174 By comparing the multi-domain architecture of the enzymes and using sequence si

175 Here we characterize the domain architecture of the heme-independent yeast cystat

176 We present a model of the domain architecture of the PpsR protein according to whi

177 main fold and, at the finest level, with the domain architecture of the proteins containing them, hig

178 In addition, the protein domain architecture of these four TLRs was examined betw

179 The two-domain architecture of type 2 RNase H creates a positive

180 early energetically degenerate, hierarchical domain architectures of coexisting c/a and a1 /a2 domain

181 d highlights the specialization of the multi-domain architectures of DDR-PARPs.

182 By analyzing the domain architectures of fully sequenced var gene reperto

183 that may be reordered, as is common with the domain architectures of proteins.

184 Comparative analysis of the domain architectures of the beta, beta', and sigma(70) s

185 different TFIIB-like proteins and predicted domain architectures of the newly identified TFIIB-like

186 The domain architectures of the protein products of these 64

187 echanistically similar, PutAs vary widely in domain architecture, oligomeric state, and quaternary st

188 to highlight a chosen superfamily, family or domain architecture on the tree of life.

189 proteomes, and identified those domains and domain architectures only present in fungi.

190 Domain architecture or context is also found to affect s

191 obvious similarities in their extracellular domain architecture or homologies to their cytoplasmic d

192 roteins, the prediction of function based on domain architecture or the presence of sequence motifs a

193 ee different structures form as large single-domain architectures or as multidomain materials.

194 ew experimental studies and information from domain architectures point to several similar mechanisti

195 Using a data set of domain architectures present in 159 proteomes that repre

196 orphan protein phosphatase that possesses a domain architecture previously only described in Plantae

197 ees are annotated with gene organization and domain architecture, providing insights into the evoluti

198 The taxonomy and domain architecture representations can be used in combi

199 This domain architecture resembles, despite a lack of sequenc

200 nserved Domain Database (CDD), the Conserved Domain Architecture Retrieval Tool (CDART) and the PubCh

201 nserved Domain Database (CDD), the Conserved Domain Architecture Retrieval Tool (CDART) and the PubCh

202 The Conserved Domain Architecture Retrieval Tool (CDART) performs simi

203 nserved Domain Database (CDD), the Conserved Domain Architecture Retrieval Tool (CDART), Biosystems,

204 nserved Domain Database (CDD), the Conserved Domain Architecture Retrieval Tool (CDART), IBIS, Biosys

205 rved Domain Database (CDD) and the Conserved Domain Architecture Retrieval Tool (CDART).

206 rved Domain Database (CDD) and the Conserved Domain Architecture Retrieval Tool (CDART).

207 ved Domain Database (CDD), and the Conserved Domain Architecture Retrieval Tool (CDART).

208 the Conserved Domain Database, the Conserved Domain Architecture Retrieval Tool and the PubChem suite

209 the Conserved Domain Database, the Conserved Domain Architecture Retrieval Tool and the PubChem suite

210 the Conserved Domain Database, the Conserved Domain Architecture Retrieval Tool, Biosystems, Peptidom

211 In particular, the new domain architecture search tool is described and the pro

212 This region of AphA has a conserved domain architecture similar to that of MarR, a multiple

213 Our results may be used to compute domain architecture similarities, for example, based on

214 ucture of E. coli RF3*GDP, which has a three-domain architecture strikingly similar to the structure

215 The CR(ColIIA) structure manifests a two sub-domain architecture tethered by a flexible linkage.

216 ) (ADP, adenosine diphosphate) has a modular domain architecture that couples DNA damage detection to

217 They share a common domain architecture that features an N-terminal MIT (mic

218 nct ligand binding modes and a unique kinase domain architecture that has not been observed previousl

219 NOD-like receptors of animals (NLRs) share a domain architecture that includes a STAND (signal transd

220 l structure exhibiting a seven-transmembrane-domain architecture that is clearly distinct from that o

221 rmined to 2.1 A resolution and reveals a two-domain architecture that is responsible for these two re

222 We found that WNV E adopts a three-domain architecture that is shared by the E proteins fro

223 wo regions on its double-pleckstrin homology domain architecture that mediated histone binding.

224 d to the translational factors, with a multi-domain architecture that wraps around a highly distorted

225 families that possess sequence signatures or domain architectures that are conserved in all euryarcha

226 The FOZI-1 protein displays a highly unusual domain architecture, that combines two functionally esse

227 database contains the description of protein domain architecture, the definition of structural neighb

228 nt polypeptide pairs, to assess the proposed domain architecture, the function of the insertional ele

229 The functional probing of the L domain architecture through trans-complementation is ant

230 LepB further employs an unusual tandem domain architecture to clamp a switch I tyrosine in an o

231 thaliana) RING-type E3s that are similar in domain architecture to the rice (Oryza sativa) XA21 Bind

232 Tsr1 has a similar domain architecture to translational GTPases such as EF-

233 vR is a transcriptional regulator that has a domain architecture unique to a select group of methanog

234 the phylogenetic distribution of the NBS-LRR domain architecture, used maximum-likelihood methods to

235 ulting matches are refined into simple multi-domain architectures using a recently developed in-house

236 These contain background information, domain architecture via Pfam links, a list of all sequen

237 One of the new match views is the InterPro Domain Architecture view, which shows the domain composi

238 Domain architecture was further studied by limited prote

239 The most ancient domain architectures were hydrolase enzymes and the firs

240 The protein molecule has a three-domain architecture with a central hydrophobic channel.

241 the GALC-product complex, revealing a novel domain architecture with a previously uncharacterized le

242 essed three types of architectures: a single-domain architecture with an intact asparagine ladder, a

243 PfhB2 shares a common domain architecture with IbpA and contains two Fic domai

244 , show a similar overall seven-transmembrane-domain architecture with large unoccupied cavities and a

245 rity of these proteins have a characteristic domain architecture with one of several N-terminal 'Head

246 HLTF, like SHPRH, shares a unique domain architecture with Rad5 and promotes lysine 63-lin

247 UvsW has a four-domain architecture with structural homology to the euka

248 eceptor that combines the typical eukaryotic domain architecture with the 'TXVGYG' signature sequence

249 These structures reveal a conserved, three-domain architecture with the binding sites for UNAM and

250 state has been determined, and reveals a two-domain architecture with the four characteristic sequenc

251 interrupted in the middle, and a trans-three-domain architecture with the ladder broken in both termi

252 re with an intact asparagine ladder, a three-domain architecture with the ladder interrupted in the m

253 They share a conserved five-domain architecture with three globular domains separate

254 stal structure of SdeAgu115A revealed a five-domain architecture, with an additional insertion C(+) d

255 omain structure of UvrD2 shows a distinctive domain architecture, with an extended C terminus contain