ライフサイエンスコーパス: domain is required for

1 ther show that, as long assumed, dimerization of the sensor domain is required for activating the cadBA operon.

2 Accordingly, the R and STAS domains bind IRBIT, and the R domain is required for activation of CFTR by IRBIT.

3 The Atg13 HORMA domain is required for autophagy and for recruitment of the p

4 ind dsRNA termini, unexpectedly, we found that the helicase domain is required for binding blunt, but not 3' overhanging,

5 The RxGD motif of the GIL domain is required for c-di-GMP binding, similar to the c-di-

6 Formation of the DAG domain is required for Cdc42 and Rho activation and healing.

7 diation of DH-RhoA interactions and explains why the tandem domain is required for controlled GEF signaling.

8 The helicase domain is required for DNA binding but not threading.

9 Finally, we show that the SVV IIId2 sub-domain is required for efficient viral RNA synthesis and grow

10 RNase domains of IRE1b demonstrated that a functional RNase domain is required for endoplasmic reticulum stress tolerance

11 Rescue experiments demonstrated that RAP domain is required for FASTKD3 function in mRNA stability.

12 also demonstrate that the integrity of the VgrG5 C-terminal domain is required for fusogenic activity, and we identify se

13 Nonetheless, an intact HM domain is required for Glut4-mediated glucose uptake.

14 Consistently, GW182's AGO1 interaction domain is required for GW182's circadian function.

15 ain of Bclaf1 containing an arginine-serine-rich and a bZip domain is required for its effects on retinal cell differenti

16 esults demonstrate that DDX43 is a dual helicase and the KH domain is required for its full unwinding activity.

17 rovides the editing activity of ORRM4, whereas the Gly-rich domain is required for its interaction with ORRM3 and with it

18 es of SAMHD1 are associated with its HD domain, but the SAM domain is required for maximal activity and nucleic acid bind

19 s in PNAG deacetylation and demonstrate that the C-terminal domain is required for maximal deacetylation of longer PNAG o

20 The p33 domain is required for membrane channel formation and intrace

21 Although the CH domain is required for MICAL-1 cellular localization and acti

22 The unconventional myosin MYO18A that contains a PDZ domain is required for muscle integrity during zebrafish deve

23 The GTPase-activating protein (GAP)-related domain is required for node-based ring formation.

24 However, in the context of ORP4L, the PH domain is required for normal organization of the vimentin ne

25 The UBA domain is required for normal Ubc1 function and E2 competitio

26 An N-terminal glutamine/asparagine-rich nucleation domain is required for nucleation and fiber growth, while an

27 icate that membrane association of the CD3epsilon signaling domain is required for optimal thymocyte development and peri

28 The beta domain is required for passenger domain secretion, but its ex

29 dimers that remain bound to FACT in vivo Moreover, the HBR domain is required for purified FACT to efficiently assemble

30 erminal domains, indicating that the IL1RAPL1 extracellular domain is required for regulating dendrite development.

31 Further evidence shows that the TM domain is required for RNF144A self-association and that the

32 Molecular analysis revealed that the extracellular Kringle domain is required for ROR1/ROR2 heterooligomerization and th

33 It was found that the 10th transmembrane domain is required for Ser5 stable expression and plasma memb

34 We further demonstrate that the extra transmembrane domain is required for Ser5 stable expression and plasma memb

35 ition, previous reports suggested that Cys257 in the p75 TM domain is required for signaling.

36 This domain is required for slow deactivation in mammalian Erg1 ch

37 fasciclin 1 domain and that its amino-proximal fasciclin 1 domain is required for stabilization of plasma membrane local

38 Ubiquitination of lysines in Hrd1's RING-finger domain is required for substrate retrotranslocation in vitro

39 Here we show that this domain is required for the apoptotic K(+) current enhancement

40 We suggest that the ARM domain is required for the association of Vid vesicles with a

41 Moreover, the E5 domain is required for the formation of AID-dependent Igh-cMy

42 demonstrate that the DNA-binding function of the BRPF1 PZP domain is required for the MOZ-BRPF1-ING5-hEaf6 HAT complex t

43 Structural and biochemical studies revealed that the helix domain is required for the protein-protein interaction and cr

44 We found that the VASP-F-actin binding domain is required for the recruitment of F-actin seeds from

45 omain; however, we find that only the C-terminal polymerase domain is required for TLS opposite TG in human cells.

46 bsequent rapid search along DNA, whereas the central repeat domain is required for transitioning into the site-specific r

47 We show that the "bottom" surface of the C2B domain is required for triggering fusion, but not for docking

48 We show not only that the C27 domain is required for UVR8 activity but also that chemically

49 two N-terminal GAG chains of versican-V1 via its ancillary domain is required for versican processing at Glu(441)-Ala(44

50 and the cysteine-rich domain or intracellular proline-rich domain is required for Wnt5a-induced recruitment of GEFs to R