ライフサイエンスコーパス: domain structure

1 monofunctional proteins of similar size and domain structure.

2 data have not revealed a common, underlying domain structure.

3 ting the importance of maintenance of proper domain structure.

4 isin-like proteases, and it contains a novel domain structure.

5 rst thermal unfolding temperature of the mAb domain structure.

6 y is strongly modified by the STO tetragonal domain structure.

7 tion of GAGs and enables modeling of the GAG domain structure.

8 e two domains leading to collapse of the two-domain structure.

9 qlH, a RecQ-like helicase with a distinctive domain structure.

10 ng domain exhibits a dual Per-Arnt-Sim (PAS) domain structure.

11 dimer creates an amphiphilic membrane-anchor domain structure.

12 self-cleavage or ligation via a specific two-domain structure.

13 synthase genes that retain the ancestral tri-domain structure.

14 and temperatures and with different internal domain structure.

15 TopBP1, revealing an unexpected triple-BRCT domain structure.

16 by the overall stabilization of the helicase domain structure.

17 le, whereas the C-terminal half has a single domain structure.

18 de the first evidence-based model of IF head domain structure.

19 combinant CSPs contain a properly folded TSR domain structure.

20 ytic domain and the new C-terminal catalytic domain structure.

21 cal SMC proteins share a characteristic five-domain structure.

22 with regard to lipase maturation and DUF1222 domain structure.

23 s were not significant in determining the FH domain structure.

24 r to be crucial determinants of the cadherin domain structure.

25 energy of monolayers differing only in their domain structure.

26 dicted to impair CBFbeta binding or the Runt domain structure.

27 or H3K36 and H3K27 methylation in regulating domain structure.

28 leotidyl cyclases disrupt the normal helical domain structure.

29 mutants, we elucidated a new MLK4 catalytic domain structure.

30 MnO3/Nb:SrTiO3 (001) films showing twin-like domain structure.

31 nker region is not extended but folds into a domain structure.

32 Aux/IAA interactions have confirmed the PB1 domain structure.

33 n Top1 share a common reaction mechanism and domain structure.

34 in the loop regions compared with other TIR domain structures.

35 uously and they are also embedded in diverse domain structures.

36 distribution, and temperature dependence of domain structures.

37 t-manually curated classification of protein domain structures.

38 n architectures of coexisting c/a and a1 /a2 domain structures.

39 letion mutants, based on models of the known domain structures.

40 leads to novel defect-stabilized symmetrical domain structures.

41 involve founder 'p-loop' and 'winged helix' domain structures.

42 ications are unable to map titin variants to domain structures.

43 llography to determine three new MlotiK1 CNB domain structures: a second apo configuration, a cGMP-bo

44 overall fold of MAL compared with other TIR domain structures: A sequence motif comprising a beta-st

45 Once established, domain structure abrogates the need for precise initiati

46 The planar domain structure accompanies abundant charged domain wal

47 Electric-field control over domain structure allows the photovoltaic effect to be re

48 mRNA, and the predicted protein, TmCad1, has domain structure and a putative toxin binding region sim

49 lly structured and lacked the correct domain-domain structure and active-site cleft formed in the nat

50 es that grapevine GH3-1 has a highly similar domain structure and also undergoes a large conformation

51 urfactant protein (SP-A), which has the same domain structure and architecture as MBL but lacks any i

52 ttice and propagate through to the nanoscale domain structure and assembly, leading to microscale mor

53 ow temporal sequence variations affect the P domain structure and contribute to epochal evolution, we

54 udied the effects of phosphorylation on head domain structure and demonstrate that phosphorylation dr

55 gnore spatial features in Hi-C data, such as domain structure and distance dependence.

56 ide for the first time information about the domain structure and DNA-binding activity of D5, the pox

57 electric are substantially determined by its domain structure and domain wall dynamics at mesoscopic

58 and an evolutionary relationship between RNA domain structure and essential replicative functions.

59 ver time, resulting in subtle differences in domain structure and function.

60 They share a complex domain structure and have numerous binding partners in E

61 espite this research, the true ferroelectric domain structure and its relationship with structural do

62 d human mutant LTBP-2 proteins retain normal domain structure and keep the fibrillin-1-binding site i

63 rgely to a change in the conformation of the domain structure and local motion in the lid region of N

64 Based on its domain structure and localization in the nucleus, we pro

65 h the mammalian TBL1, which shares a similar domain structure and performs a parallel corepressor fun

66 Variations in apoA-I domain structure and physical properties exerted similar

67 Here we have investigated huntingtin's domain structure and potential intersection with epigene

68 emonstrate the significance of the tandem C2 domain structure and provide a plausible explanation for

69 findings with regard to L protein appendage domain structure and putative domain-domain interactions

70 these HIV-1 envelope proteins share the same domain structure and similar sequences, we performed mut

71 Magnetic domain structure and spin-dependent reflectivity measure

72 n DLBCL and reveal an unusual autoinhibitory domain structure and strategy for preventing unwarranted

73 re ligand binding induces alterations in PAS domain structure and subunit association that is relayed

74 le for cohesin in the global organization of domain structure and suggest that domains function to st

75 of resolution in the analysis of this simple domain structure and suggest that variation in sequence

76 lyzed their phylogeny, protein topology, and domain structure and surveyed their expression and local

77 The modular domain structure and the functionality of the individual

78 ion method for understanding polycrystalline domain structure and transport in plastic crystals and o

79 layer thickness and judicious engineering of domain structures and ferroelectric-electrode interfaces

80 hourglass patterns in rates of appearance of domain structures and functions, functional diversity, a

81 to be understood about switching in complex domain structures and in devices.

82 rovides annotations for over 235,000 protein domain structures and includes 25 million domain predict

83 The resource comprises over 300 000 domain structures and over 53 million protein domains cl

84 ications will require the ability to control domain structures and phase transitions in these materia

85 Analyses of the domain structures and properties of the interdomain inte

86 Phylogenies that describe the evolution of domain structures and proteomes were reconstructed from

87 thus proofreads SNARE domain and N-terminal domain structures and regulates the fusion capacity of t

88 Together with the individual domain structures and small-angle X-ray scattering, this

89 core that combines information from template domain structures and terminal and internal alignment ga

90 Despite similarities in sequence, domain structure, and biochemical activity, they play di

91 ilitate spatiotemporal control of alignment, domain structure, and birefringence.

92 gical mutations mapping in the NTD alter the domain structure, and decrease catalytic activity and st

93 gous relationship, intron evolution, protein domain structure, and gene expression.

94 e fields increase the pinning, stabilize the domain structure, and harden the magnet, until a point w

95 MscS homologs exhibit diverse topology and domain structure, and it has been proposed that the more

96 contribution of localization, glycosylation, domain structure, and the absence of substrate class I M

97 series of Cys/Gly mutant forms with aberrant domain structures, and as a double point-mutated probe (

98 cantly from previously described tandem BRCT domain structures, and presents two distinct sites for b

99 unexpected crystal structures, ferroelectric domain structures, and properties.

100 Gene3D is a database of protein domain structure annotations for protein sequences.

101 Overall, roughly one-third of the outer domain structure appeared to be fixed in conformation, i

102 In mutants R202Q and T263M, effects on the A-domain structure are responsible for a reduced rate of t

103 The polar CheA, CheA(2), has the same domain structure as E. coli CheA and can phosphorylate a

104 onal paratopes with the 3D antibody variable domain structure as input.

105 how that kindlins do indeed contain the same domain structure as the talin FERM domain.

106 of the open reading frame but share the same domain structures as in typical nuclear receptors: AF1,

107 1 transmembrane and rat Kir3.1 intracellular domain structures as templates.

108 sion and thus to a drastic disruption of the domain structures at a much lower number of nanoparticle

109 wave is engineered by properly designing the domain structure based on the Huygens-Fresnel principle.

110 cture classification hierarchically clusters domain structures based on structure and/or sequence sim

111 osynthetic pathway, minimally altering local domain structure but adversely impacting ABCC6 assembly

112 ERManI and GMIA have similar catalytic domain structures, but each enzyme cleaves distinct resi

113 rimentally demonstrate that large and stable domain structure can be mediated by lipids in single-pha

114 The evolution of complex domain structure can be understood by the process of occ

115 sNASP contains the domain structure characteristic of this family, which in

116 The unique domain structure characterized by a "split" SET domain,

117 Here, a new route to such effects involving domain-structure competition is demonstrated, which aris

118 e Spt6 C-terminal region reveal a tandem SH2 domain structure composed of two closely associated SH2

119 They have a unique three-domain structure, comprising a calcium-regulated N-termi

120 a superfamily II helicase with a distinctive domain structure, comprising an N-terminal NTPase domain

121 e demonstrated the destabilization of the A1 domain structure concomitantly results in a reduced inte

122 een predicted to have a conserved tripartite domain structure consisting of a largely alpha-helical c

123 ant ARABIDILLO-related proteins has a unique domain structure consisting of an F-box and leucine-rich

124 The E2 core has a compact, globular domain structure, consisting mostly of beta-strands and

125 ASC has a bipartite domain structure, consisting of an N-terminal pyrin doma

126 The AHNAK2 PDZ domain structure contains a bound class III ligand pepti

127 , and even the de novo prediction of protein domain structures, contingent on the existence of a larg

128 te full-length PGC-1alpha, but the truncated domain structure conveys unique properties with respect

129 tching (QPM) processes in a single nonlinear domain structure correct phase and group-velocity mismat

130 nker forms an integral part of the catalytic domain structure, covering a hydrophobic patch on the ca

131 of elementary functional loop sequences and domain structures defined at the fold superfamily level

132 ed for the refinement of the NMDA receptor M domain structure, demonstrate that this region can influ

133 d that biotype 3 MARTX toxin has an effector domain structure distinct from that of either biotype 1

134 of Nb ions in BFO films showed change in the domain structures due to doping induced change in lattic

135 ggesting that, despite their highly diverged domain structure, each receptor couples to a common repu

136 What to our knowledge is a novel domain structure emerges in which elemental nanodomains,

137 pinodal decomposition, forming compositional domain structures enriched in the immiscible element, an

138 ays and a component of the VA RNA(I) Central Domain structure essential for PKR inhibitory activity w

139 The domain structure explains how the S components with larg

140 298 protein-protein complexes and 356 domain-domain structures extracted from the previously develope

141 nificance of the HAMP and proximal signaling domain structure for signal transduction is discussed.

142 An electrically written domain structure formed by a biased tip, and visualized

143 tural rearrangement of more than half the 13-domain structure from a native to a compact induced form

144 g serves to shift the equilibrium of aptamer domain structures from a more open toward a more stable

145 ould be to systematically fit representative domain structures from a protein domain database into th

146 family, using all available kinase catalytic domain structures from any organism as structural templa

147 rance of homologous superfamilies of protein domain structures from CATH.

148 lar matrix proteins; provides new clues into domain structure, function, and pathogenesis for myocili

149 sly reported inactive and active EGFR kinase domain structures gave insight into the mechanism of HER

150 families based on manual curation of protein domain structures, Gene Ontology annotations, and 1487 N

151 clinical significance, only the IRAK4 kinase domain structure has been determined among the four IRAK

152 Although several individual FF domain structures have been determined by NMR, the tande

153 therapeutic value is limited by its complex domain structure, high cost of production, instability,

154 leads to large energy barriers resulting in domain structure, hysteresis and cracking.

155 at compartmental domains are responsible for domain structure in all eukaryotes, with CTCF playing an

156 Directed self-assembly (DSA) of the domain structure in block copolymer (BCP) thin films is

157 ting that spatial proximity derived from the domain structure in chromatin plays an important role in

158 e a-axis and c-axis enabled by the twin-like domain structure in DyMnO3 films, despite the polarizati

159 ults demonstrate smaller size highly ordered domain structure in grain-oriented specimen relative to

160 ribosomal proteins inferred from a census of domain structure in hundreds of genomes established a ti

161 ate NMR data were used to further refine the domain structure in phospholipid bilayers.

162 the present study, we investigated both, the domain structure in pure DPPC monolayers as well as in l

163 achieved by the creation of an adaptive nano-domain structure in these perovskite films via phase eng

164 d canonical SMC proteins share a common five-domain structure in which globular N- and C-terminal reg

165 d canonical SMC proteins share a common five-domain structure in which globular N- and C-terminal reg

166 ochondrial membrane transporters suggested a domain structure in which the N- and C-termini of the pr

167 visualization and reconstruction of magnetic domain structures in a 3D curved magnetic thin films wit

168 parameter for enabling the understanding of domain structures in CuMnAs imaged using x-ray magnetic

169 Protein domain structures in proteomes are highly conserved and

170 e have analyzed the existing database of PDZ domain structures in the context of a specificity tree b

171 falls reveal how ancient loops are shared by domain structures in two initial waves of functional inn

172 The domain structure includes: (i) a hydrophobic pocket at t

173 tator-like transposases also share a similar domain structure, including an N-terminal C2H2 zinc fing

174 n-ribosomal peptide synthetases with unusual domain structures, including several split modules and a

175 Here we discuss what is known about FinO-domain structures, including the recently solved Escheri

176 However, current approaches that map the domain structure involve either spatially resolved but p

177 Previously unobserved in a beta-grasp domain structure is a 48-residue helical hairpin insert

178 ndicate that the Torpedo nAChR transmembrane domain structure is a better model than the ELIC structu

179 e size and strain relaxation on the magnetic domain structure is also discussed.

180 activity in vitro and that proper N-terminal domain structure is critical for activity of the full-le

181 cess of in vitro assembly, we show that head domain structure is dynamic, changing as a result of fil

182 Our results show that the TgMyoA domain structure is more similar to other myosins than p

183 nly partially, indicating that the whole tri-domain structure is required for such capability in full

184 The PhoQ domain structure is similar to that of DcuS and CitA sen

185 in, Cin1 (cryptococcal intersectin 1), whose domain structure is similar to that of the human endocyt

186 The distribution of the domain structures is likely governed by the action of gl

187 Through a combination of domain structure knowledge and intermolecular and concen

188 The teleost TR consists of a compact three-domain structure, lacking most of the sequences in regio

189 ferroelectric response and the corresponding domain structures, magnetic behaviors and spin dynamics

190 onstrates similar sub-cellular localization, domain structure, membrane topology and enzymatic activi

191 s resemble Arabidopsis PIFs in their protein domain structure, molecular properties, and physiologica

192 NafY domain structure, molecular tumbling, and interdomain mo

193 ess has been made in determining central rod domain structure, no structural data have been reported

194 The subunit displays the typical three-domain structure observed for ThDP-dependent enzymes in

195 lutionary intermediates that underlie the bi-domain structure observed in the expansive plant TPS gen

196 Here, we explore the history of the three-domain structure of 5S rRNA using phylogenetic trees tha

197 te to epochal evolution, we determined the P domain structure of a 2004 variant with ABH and secretor

198 O3 leads to dramatic changes of the magnetic domain structure of a neighboring magnetic layer (La1/2S

199 A computational model of a possible single-domain structure of Cd(8)-betaalpha-rhMT is described.

200 egulation in the context of the higher-order domain structure of chromatin as determined from recent

201 se discrepancies are partly explained by the domain structure of DHODH and suggest both assays are us

202 Although PxaTPS8 adopts the typical three-domain structure of diTPSs, sequence phylogeny places th

203 The modular domain structure of extracellular matrix (ECM) proteins

204 ry has emerged as a method for analyzing the domain structure of GAGs.

205 r, our findings highlight the flexible multi-domain structure of KCC2 with variable anchoring points

206 tive kinase inhibitors to characterizing the domain structure of multidomain proteins.

207 The domain structure of PDI is a-b-b'-x-a', wherein the thio

208 The light chain binding domain structure of phosphorylated smHMM differs markedl

209 The multi-domain structure of relaxors that is revealed by our mol

210 ow modulus can also be explained by the nano-domain structure of strain glass.

211 nd validated in cytokine receptors by the TM domain structure of the cytokine receptor common subunit

212 have a role in establishing the topological domain structure of the genome.

213 n microscopy, we show that the ferromagnetic domain structure of the manganite electrodes is imprinte

214 ar hysteresis loop resulting from a peculiar domain structure of the microwire.

215 domains of R-proteins, and reconstructed the domain structure of the protein containing the common an

216 R spectroscopy, we show that the overall BAR domain structure of the rat endophilin A1 dimer determin

217 tranded deoxyoligonucleotide established the domain structure of the STATs and the structural basis f

218 FF4-6) of TCERG1, revealing a rigid integral domain structure of the tandem FF repeat that interacts

219 ous proteins, can be applied for mapping the domain structure of the viral nonstructural and structur

220 and assignment of inhibitor specificity and domain structure of these modular biosynthetic enzymes.

221 In one annotation of the domain structure of these proteins, an unusual internal

222 le explains such differences in terms of the domain structure of these proteins.

223 We show here that the two domain structure of Tim44 plays a central role in this p

224 The characteristic domain structure of typical calpains was observed in eac

225 Analysis of the putative protein domain structure of UvrD2 shows a distinctive domain arc

226 The domain structure of variants GluR6D and GluR6E revealed

227 The similar domain structures of alphavirus capsid proteins suggest

228 The two currently available receiver domain structures of atypical response regulators are ve

229 d compared it to the previously determined P domain structures of GI.1 and GI.2 strains.

230 d in complex with Cul3, along with the Kelch domain structures of KLHL2 (Mayven), KLHL7, KLHL12, and

231 olar pockets are also seen in the tandem LIM domain structures of LMO4 and Lhx3 bound to unrelated li

232 The domain structures of Spc97 and Spc98 suggest functions f

233 Here, the transmembrane domain structures of the helical membrane proteins are e

234 pact of experimentally determining a protein domain structure on comparative protein modelling covera

235 trates that there is no change in the lipoyl domain structure on complexation with E3.

236 ssed to drive PGNPs into spatially organized domain structures on submicrometer scale within topograp

237 on is through a process(es) in which protein domain structure plays a contributing factor.

238 In combination, the five MlotiK1 CNB domain structures provide a unique opportunity for analy

239 long this process, we analyze the defect and domain structure quantitatively via video microscopy and

240 1/3 exhibit complicated antiphase and chiral domain structures related to ordering of intercalated Fe

241 nce of JH III and found to have a double OBP domain structure reminiscent of salivary "long" D7 prote

242 TMC1 is thought to have a six-transmembrane domain structure reminiscent of some other ion-channel s

243 target capture complex together with our MLV domain structures, residues within the CCD alpha2 helica

244 found to exhibit an intriguing ferroelectric domain structure resulting from orthorhombic twins and (

245 Solving the RNA-binding domain structures revealed the canonical NS1 symmetrical

246 Our analyses of C. elegans chromatin domain structure show that genes are organized by type i

247 The two apo-FGFR4 kinase domain structures show an activation segment similar in

248 Structural alignments of TOG3 with other TOG domain structures show that the architecture of TOG3 is

249 Analysis of an OMP with a domain structure similar to that of LptD, FhuA, suggests

250 Although OGTs with domain structures similar to those of eukaryotic OGTs ar

251 The surface magnetic domain structure (SMDS) parameters of 45 mum diameter C

252 e electrical control of magnetic anisotropy, domain structure, spin polarization or critical temperat

253 ossati et al. (2016) report that through its domain structure, SRGAP2A, a Rho-GTPase-activating prote

254 architecture by providing direct evidence of domain structure stabilization and interdomain interacti

255 These observations, coupled with its domain structure, suggest that LrrB is an SH2 adaptor pr

256 -item questionnaire was found to have a four-domain structure ('symptoms', 'emotions', 'social life/f

257 ss of nanoparticles with an ordered, striped domain structure that can be readily manipulated by alte

258 The jaw joint is an intermediate-domain structure that expresses nkx3.2 and a more genera

259 ongly correlated electronic materials have a domain structure that greatly influences the bulk proper

260 n, all NB-ARC and NACHT domains) possessed a domain structure that included a STAND NTPase paired wit

261 but single-copy genes with a characteristic domain structure that may contain introns in evolutionar

262 ium (Kir) channel family share a cytoplasmic domain structure that serves as an unusual AP-1 clathrin

263 ar magnetic resonance revealed a classic LIM-domain structure that was highly related to LIM1 of PINC

264 y, we generalize the soft strain to generate domain structures that allow further tuning of the mater

265 teins revealed that they have unique modular domain structures that are divergent in sequence and siz

266 gives rise to instabilities of the magnetic domain structures that are reminiscent of Rayleigh-Plate

267 gments can provide accurate reporters on the domain structures that can be mapped directly to the int

268 ver a dynamics of modular motif embedding in domain structures that is ongoing, which transfers 'pref

269 n has increased dramatically based on solved domain structures, the exact mechanism of signal transdu

270 Compared with other BRCT domain structures, the most striking differences are an

271 Based on known SET domain structures, the mutations likely affect either th

272 y of bottlebrush block copolymers into large domain structures, the self-assembly of bottlebrush bloc

273 fication contributes to the tRNA's anticodon domain structure, thermodynamic properties and its abili

274 Given the domain structures, this suggests that the molecules occu

275 r anisotropy and follow the evolution of the domain structure through part of its magnetization hyste

276 ation site of MASP-3, a protein with similar domain structure to C1s that is not normally cleaved by

277 that shows active-site homology and similar domain structure to eukaryotic OGTs.

278 Here we use domain structure to study the evolution of molecular fun

279 o power conversion, depends crucially on its domain structure, traditionally crafted during materials

280 omain), and the early formation of the three-domain structure typical of modern 5S rRNA in Archaea.

281 The mutant fusion domain structure was solved by NMR spectroscopy in a lip

282 milar distribution of free sulfhydryl in the domain structures was observed in the four antibodies.

283 tinct differences in the TIM-1 and TIM-4 IgV domain structures, we sought to characterize TIM-4 IgV d

284 The domain structures were then docked in silico to provide

285 n is a crystallographic dimer with an I-type domain structure, which maintained in solution.

286 t only arises from noncentosymmetric ordered domain structures, which include crystals of chiral mole

287 e archaeal Nop56/58 NTD exhibits a conserved domain structure whose exceptionally stable interaction

288 s, one of which we show to have a unique two domain structure with a novel regulatory"plug".

289 The protease also has an atypically short domain structure with an odd number of Cys residues in t

290 B structural family whose members have a two-domain structure with both domains exhibiting a Rossman-

291 CLEL precursors share a similar domain structure with CLE precursors (i.e., they contain

292 or that shares an otherwise highly conserved domain structure with members of the protein family, con

293 Although DLC2 shares a similar domain structure with that of DLC1, the function of DLC2

294 significant amino acid sequence homology and domain structure with the MukB protein of Escherichia co

295 ese eight structural variants form a Z4 x Z2 domain structure with Z3 vortices and five distinct type

296 xhibiting complex, nanotwinned ferroelectric domain structures with high densities of 90 degrees doma

297 yme was confirmed by comparing the motif and domain structure within and across the plant kingdom.

298 A unique 6-cysteine-rich domain structure within Pfs230 have thwarted its recombi

299 terpene synthases (TPSs) generally has a bi-domain structure, yet phylogenetic analyses consistently

300 nsmembrane domain and existing extracellular domain structures, yielding a complete conformational mo