ライフサイエンスコーパス: donor

1 k donors (3.9 vs 4.2 organs transplanted per donor).

2 2015 (donation after circulatory death [DCD] donors).

3 oven successful when performed with a living donor.

4 e an organ transplant from an HIV uninfected donor.

5 s to be even worse when applied to pediatric donors.

6 ntext of complex health systems and multiple donors.

7 greater that were procured from 338 deceased donors.

8 lerotic (n=38) and nonatherosclerotic (n=42) donors.

9 expressing pDCs in the blood of HIV-infected donors.

10 HCT from 9/10 or 10/10 HLA-matched unrelated donors.

11 s provided according to the last will of the donors.

12 ife conversations with families of potential donors.

13 ophilicity on the stereoselectivity of these donors.

14 ents, compared to control samples from organ donors.

15 compared with those who did not and healthy donors.

16 m 1.10 for overweight to 1.93 for very obese donors.

17 ed decline that may be more rapid in related donors.

18 lished RA cohorts in comparison with healthy donors.

19 liferation response only in CMV-seropositive donors.

20 but not from MHC class II- or CD40-deficient donors.

21 whereas thymic or splenic B cells were poor donors.

22 We used donors/100 000 population age 18 to 84 years (D/100K) as

23 transplanted compared with the standard risk donors (3.9 vs 4.2 organs transplanted per donor).

24 uded the following: eligibility criteria for donors (47%), materials used for collecting stools and t

25 olymer acceptor PZ1 by embedding an acceptor-donor-acceptor building block into the polymer main chai

26 s, which provided access to a series of four donor-acceptor copolymers.

27 We have shown that the reactivity of the donor-acceptor cyclopropane increases with the increase

28 st method for regioselective ring-opening of donor-acceptor cyclopropanes with the Zn-AcOH reductive

29 ten invoked in the excited-state dynamics of donor-acceptor dyads, but their involvement could never

30 transfer (CT) excitons dissociate at organic donor-acceptor interfaces has been a long-standing quest

31 rophores Cy3 and Cy5 are extensively used as donor-acceptor pairs in fluorescence resonance energy tr

32 cular fluorophores based on a shielding unit-donor-acceptor-donor-shielding unit (S-D-A-D-S) structur

33 Given a well-controlled donor/acceptor bilayer system, we uncover the genuine ef

34 her show that nucleolar size correlates with donor age in primary fibroblasts derived from healthy in

35 Donor allografts from Brown Norway rats treated with Uni

36 ectron transfer (PCET) reactions at a phenol donor and a monoquat acceptor triggered by excitation of

37 und to be widely tunable on the basis of the donor and acceptor groups selected.

38 ained by providing acetylene as the electron donor and carbon source while TCE or cis-DCE served as t

39 myocardial preparations isolated from human donor and heart failure (HF) left ventricle.

40 Medical records of the donor and infected transplant recipients were reviewed f

41 to uncertainty resulting from variability in donor and listing rates.

42 Mismatches between donor and patient in these alleles are associated with a

43 the management of uncertainty, the extent of donor and recipient consent, the scope of the obligation

44 istributed across the genome to discriminate donor and recipient DNA molecules.

45 at is derived to predict graft failure using donor and recipient factors, based on local data sets, w

46 y explained by the large differences between donor and recipient RBC survival times.

47 ." In nonallelic gene conversion (NAGC), the donor and the acceptor are at distinct genetic loci.

48 ation of the light that excites the electron donor and the imprinted chirality of the acceptor QDs af

49 drogen bond sites (less than 4 hydrogen bond donors and 10 acceptors), with a moderate molecular weig

50 sed organic frameworks, wherein the electron donors and acceptors form ordered, segregated pi-stacked

51 ng analysis in 26 libraries from three blood donors and negative controls.

52 lding and amenable to a wide range of glycal donors and OH nucleophiles.

53 nd late-stage pancreatic cancer from healthy donors and patients with benign pancreatic disease.

54 Compared with healthy donors and patients with HCV infection without CV, patie

55 ited by the availability of suitable matched donors and potential immunologic complications.

56 Liver grafts procured from heart-beating donors and preserved by SCS served as controls.

57 generated viral genome sequences from blood donors and recipients, we assess the dynamics of dengue

58 clinical and demographic characteristics of donors and recipients, were selected to assess their ind

59 ntation and red cell incompatibility between donors and recipients.

60 risk factors for ZIKV infection among organ donors and transplant outcomes among recipients of donor

61 es in macrophages from control blood donors (donor) and patients with either FPN1 p.A77D, p.G80S, and

62 30, 2015, (donation after brain death [DBD] donors) and March 1, 2013, and April 30, 2015 (donation

63 th S-adenosylmethionine, the reactive methyl donor, and by reaction with alkylating agents.

64 inical manifestations suggests that patient, donor, and transplant factors modulate the phenotype.

65 of ESRD has been reported for living kidney donors, and appears to be higher for those donating to a

66 RK-52E) with the mitochondrial-targeted H2 S donor, AP39, during in vitro cold hypoxic injury improve

67 poor predictive power of the KDPI for adult donors appears to be even worse when applied to pediatri

68 modeling is reversible, and hydrogen sulfide donors are likely to improve pregnancy outcomes.

69 o assessed by flow cytometry (high-responder donors) are cleared more quickly from the circulation th

70 ncial support interventions toward potential donors at higher risk of perceiving donation-related fin

71 l), composed of a near linear arrangement of donor atoms, exhibits a large energy barrier to spin rev

72 fluorometric method; passive HR-IgE-stripped donor basophils were incubated with participants' serum

73 cells in the HIV-negative (HIV-) brain-dead donor (BDD) is not known.

74 Donor obesity, defined as donor body mass index (D-BMI) of 30 kg/m or greater, has

75 show very limited ability to repopulate from donor bone marrow.

76 ively using electric fields by employing the donor-bound electron as a quantum transducer, much in th

77 iopsy associate with outcomes after deceased donor but not living donor renal transplants, thus donor

78 d after multiple cell divisions from C57BL/6 donors but not from MHC class II- or CD40-deficient dono

79 er live kidney donation necessary to support donor candidates in well informed decision-making requir

80 o assess UCP2 expression in pancreas from BD donors (cases) and subjects who underwent pancreatectomy

81 lso prevented by BCL6 or Stat3 deficiency in donor CD4(+) T cells, with the induction of cGVHD amelio

82 completely suppressed by Stat3 deficiency in donor CD4(+) T cells.

83 ave demonstrated that temporary depletion of donor CD4+ T cells early after hematopoietic cell transp

84 hypersensitivity), then given fungicide and donor cecum content via oral gavage.

85 Intercellular MHC transfer was donor-cell specific; thymic DC readily acquired MHC from

86 ated from the culture medium of drug-treated donor cells (Donor cells) using ultra-centrifugation, an

87 em cells have been envisioned as a source of donor cells for transplantation and vectors for the deli

88 of these polymers to the cryopreservation of donor cells is also introduced.

89 g peak numbers, around day 3, the "licensed" donor cells migrate to the circulation and initiate infl

90 In all, tested organs donor cells undergo "licensing" for pathogenicity, consi

91 culture medium of drug-treated donor cells (Donor cells) using ultra-centrifugation, and analyzed fo

92 replacement of the host's immune system with donor cells, although the heterogeneity of clinical mani

93 All patients engrafted with donor cells.

94 ients, either stable mixed chimerism or full donor chimerism were observed.

95 features, longitudinal immunoreconstitution, donor chimerism, and quality of life (QoL) of IL2RG/JAK3

96 pproach through inclusion of a hydrogen bond donor cocatalyst significantly improved enantioselectivi

97 f a transfusion from an ever-pregnant female donor, compared with a male donor, was associated with i

98 All 5 consecutive donors completed a pure laparoscopic procedure.

99 d samples of ILD tissue (n = 45) and healthy donor control samples (n = 10), as well as fibrotic skin

100 can serve as an alternative to conventional donor corneal transplantation.

101 The greatest concern about the use of donor corneas supplied by foreign eye banks is the effec

102 f PB1 genetic material via introduction into donor cytoplasm may offer a source of oocytes for infert

103 spective review of de-identified region-wide donor data January 1, 2010 through December 31, 2013 was

104 but not living donor renal transplants, thus donor death and organ preservation-related factors may b

105 ign eye banks is the effect of the increased donor death-to-operation time which inevitably occurs du

106 Genome transplant dynamics (GTD) quantifies donor-derived cfDNA (dd-cfDNA) by taking advantage of si

107 We describe a case of probable donor-derived KS in the recipient of a liver-kidney tran

108 HLA-DR15(+) and HLA-DR1(+) healthy human donors display altered alpha3135-145-specific T-cell ant

109 double-stranded DNA breaks or provision of a donor DNA template.

110 findings enable rational design of synthetic donor DNAs for efficient genome editing.

111 on studies in macrophages from control blood donors (donor) and patients with either FPN1 p.A77D, p.G

112 xperiments using a series of organic triplet donors (E((3)pipi*) from 1.83 to 0.78 eV).

113 ase through a mutation of the primary proton donor (E108Q).

114 Use of expanded criteria donor (ECD) kidneys, which are associated with a reduced

115 Two donors exceeded 10-point declines in SF-36 summary score

116 Photodriven electron transfer from a donor excited state to an assembly of electronically cou

117 settings of islet and renal transplantation, donor exosomes with respective tissue specificity for is

118 Total of 39 679 cornea donor eyes from SightLife Eye Bank between 2012 and 2016

119 ith a cuticular drusen phenotype and 4 human donor eyes with cuticular drusen (n = 2), soft drusen (n

120 Little is known about how donor factors, timing of procurement, and geographic loc

121 Among recipients of male donors, females of all ages had significantly higher gra

122 owever, there is considerable variability in donor follow-up processes, including information provide

123 c glycosylation with an enantiopure glycosyl donor followed by separation of the derived diastereomer

124 H2 is a favorable electron donor for autotrophs and causes fixation of organic carb

125 ut also to identify more suitably mismatched donors for nonsensitized patients.

126 ta to make regional projections of available donors from 2016 to 2025, incorporating the proposed 8-r

127 ol (SA-2) containing both antioxidant and NO donor functionalities that provide a therapeutic level o

128 , and such viruses were also detected in the donor genital tract.

129 stimates dd-cfDNA levels in the absence of a donor genotype.

130 nnanes via O-glycosylation with Schmidt-type donors, glycal epoxides, or under dehydrative conditions

131 Although KFTS kidneys have less favorable donor, graft, and recipient risk factors than NKAS kidne

132 factor-mobilized peripheral blood stem cell donor grafts and successful treatment of older recipient

133 tissue parameters of 84 consecutive corneal donor grafts used for big-bubble DALK surgery between Ju

134 Weakly stabilizing or electron-poor donor groups provide better yields of the ABL products.

135 t matching criteria, the outcomes of LT with donors >/=70 and <70 years are comparable with appropria

136 ed to similar levels of the nonspecific H2 S donor, GYY4137 and also improved syngraft function and s

137 ro(pyridine)cobaloxime co-catalyst, and TEOA donor, H2 evolution rate of 782 mumol h(-1) g(-1) and TO

138 The donor had multiple risk factors for HHV-8 infection.

139 ction between a halogen atom and an electron donor has been exploited in knowledge-based drug design.

140 urement organization use of HbA1c shows that donor HbA1c levels between 3.5 and 6.2 in otherwise tran

141 Although routinely measured, the impact of donor HbA1c levels on pancreas graft outcomes has not be

142 7, to September 30, 2015, and identified 472 donor hearts with LVSD (left ventricular ejection fracti

143 Purpose T-cell-replete HLA-haploidentical donor hematopoietic transplantation using post-transplan

144 e of the poor proliferative capacity of aged donor hepatocytes or the regenerative impairment of the

145 ), and (3) a patient simulated by a deceased donor (high-fidelity anatomy).

146 llowing KAS, including: (i) use of pediatric donors, (ii) use of Public Health System (PHS) high infe

147 lic Health System (PHS) high infectious risk donors, (iii) wait time, and (iv) living donor transplan

148 With the use of data reported by donors in 2015, we provided estimates of official develo

149 ated a low prevalence of ZIKV among deceased donors in our community.

150 the antibody negative window period in blood donors in resource limited settings where nucleic acid t

151 The more axial-rich donors in skew and boat conformations are thus preorgani

152 We reviewed echocardiograms of all cardiac donors in the United Network of Organ Sharing database t

153 modification, over 20% of all deceased organ donors in the United States were identified as PHS incre

154 iation between estimated bottleneck size and donor infection severity, as measured by temperature.

155 ceptors end-capped with two guanine electron donors into crystalline G-quadruplex-based organic frame

156 n and that the quantitation and profiling of donor intra-exosomal cargoes may constitute a biomarker

157 onsent to accept kidneys from increased risk donors (IRD), but poorly understand them.

158 zed several important predictors of deceased donor kidney discard.

159 ft loss in pediatric and adolescent deceased donor kidney transplant recipients aged 21 years or youn

160 The presence of sex disparity in living donor kidney transplantation (LDKT) remains controversia

161 D) is an important tool to facilitate living donor kidney transplantation (LDKT).

162 ant Registry data were collected on deceased donor kidneys implanted between November 1, 2012, and Ap

163 The adjusted HRs for living donor KT were 0.35 (95% CI, 0.24-0.51), 0.27 (95% CI, 0.

164 al niches, and the evolutionary selection of donor L1s driving neuronal mosaicism.

165 c L1 insertions in neurons, the existence of donor L1s that are highly active ('hot') in specific spa

166 stromal surface),7.0 mm in diameter, with a donor lamella obtained by microkeratome-assisted dissect

167 e than 2000 days of operation under electron donor limitation, increasing the electron donor to TCE r

168 A measure of donor liver quality, the donor liver index, was developed and validated for the U

169 A measure of donor liver quality, the donor liver index, was develope

170 because it may lead to better utilization of donor liver.

171 Of 11,328 donor livers offered to children, 2533 (12%) were transp

172 me assists utilization of scarce resource of donor livers, while ensuring that patients who are urgen

173 We surveyed 51 living kidney donors (LKDs) who donated from 01/2015 to 3/2016 about s

174 poor functional status (KPS 10%-40%), living donor LT, pre-LT hemodialysis, and the donor risk index

175 ors <70 years of age), sex, or height (among donors </=190 cm tall).

176 t vary significantly according to age (among donors <70 years of age), sex, or height (among donors <

177 itial TTE that resolved (LVEF >/=50%) during donor management on a subsequent TTE.

178 nd <70 years are comparable with appropriate donor management.

179 of casein kinase 2 to use GTP as a phosphate donor, may be a source of differences between our data a

180 Among 14532 donors (mean [SD] age, 58.6 [13.4] years; 8516 men and 6

181 lesser extent, cardiac CD3(+) T cells) from donor mice with HF induced long-term left ventricular dy

182 duct from both alpha and gamma phosphates of donor molecules.

183 patients were grafted from matched unrelated donor (MUD), of these, 129 (64.5%) received an in vivo T

184 t, 3 of these patients experienced declining donor myeloid chimerism (DMC) levels with eventual retur

185 rom allergic patients (n=11) and nonallergic donors (n=5).

186 Donor natural killer (NK) cell alloreactivity in HCT can

187 sing segment can be rescued by tethering the donor near the break.

188 Donor neutralizing serostatus correlates significantly w

189 brane-bound interleukin 21 (mbIL21) expanded donor NK cells infused before and after haploidentical H

190 Donor obesity, defined as donor body mass index (D-BMI)

191 e that chloride cannot act as a two-electron donor of compound I, whereas thiocyanate, iodide, and br

192 al isolates derived from single and multiple donors of osteoarthritic cartilage revealed the presence

193 Fresh and frozen corneal donors offer similar clinical outcomes when used as carr

194 Although the substitution on the donor olefins was initially limited to alkyl and aryl gr

195 difluoromethyl group acts as a hydrogen bond donor on a scale similar to that of thiophenol, aniline,

196 Donors on extracorporeal membrane oxygenation were signi

197 the current policy of not selecting platelet donors on the basis of platelet function for prophylacti

198 cells in six samples from four HIV-infected donors (one with viremia and not on ART and three with v

199 ed in clinical trials are either polyclonal, donor- or antigen-specific.

200 The limited availability of donor organs has led to a search for alternatives to liv

201 Living donor pancreas transplant is a potential treatment for d

202 ines MOLM-4, THP-1 or primary AML cells with donor peripheral blood mononuclear cells elicited a cell

203 nic transition dipole moment of the electron donor perylene is aligned along the axis of the electric

204 ls with IFNbeta, but not IFNalpha2, selected donor plasma isolates that exhibited a transmitted virus

205 ation of single nicks in the target gene and donor plasmid (SNGD) using Cas9D10A nickase promotes eff

206 the same size distribution as infused human donor platelets and are preferentially incorporated into

207 Donor pool restrictions were associated with worse 3-yea

208 ms to be a feasible option for expanding the donor pool without additional donor risks.

209 is current clinical practice to increase the donor pool.

210 obabilistic mixture models, to 148 potential donor populations in North America representing 46 disti

211 repair, coupled with a shortage of available donors, poses an urgent clinical need for the developmen

212 The donor, qAN1, has quantum yields reaching 21% and 11% in

213 2(amide)(Pr,Pr)](-) (8), shows that oxo atom donor reactivity correlates with the metal ion's ability

214 The top 15 donor, recipient, and transplant factors influencing the

215 Donor-recipient match quality was estimated from the don

216 We retrospectively studied 1199 paediatric donor-recipient pairs with allele-level HLA matching who

217 Even without specific donor/recipient matching criteria, the outcomes of LT wi

218 processes, including information provided to donors regarding self-care.

219 is the copying of a genetic sequence from a "donor" region to an "acceptor." In nonallelic gene conve

220 outcomes after deceased donor but not living donor renal transplants, thus donor death and organ pres

221 he circulation than those from low-responder donors, resulting in lower platelet count increments fol

222 The primary outcome measures were positive donor rim fungal culture results and the development of

223 iving donor LT, pre-LT hemodialysis, and the donor risk index (all P < .001).

224 Pancreas donor risk index (PDRI) was highest in high volume cente

225 The combination of the factors used in Donor Risk Index with the model for end-stage liver dise

226 cipient match quality was estimated from the donor risk index.

227 expanding the donor pool without additional donor risks.

228 Maintenance of proper levels of the methyl donor S-adenosylmethionine (SAM) is critical for a wide

229 und that treatment with the physiological NO donor S-nitrosoglutathione (GSNO) increased the abundanc

230 Stool was collected from 5 donors selected by the patients, and fully characterized

231 recurrence, alphafetoprotein at recurrence, donor serum sodium, and pretransplant recipient neutroph

232 res based on a shielding unit-donor-acceptor-donor-shielding unit (S-D-A-D-S) structure is reported.

233 onsequent overreduction of plastoquinone and donor-side limitation of photosystem I (PSI).

234 he white recessive allele is due to a splice donor site mutation in the scavenger receptor B1 (SCARB1

235 ared to function redundantly with the splice donor site of intron 36.

236 nized and the higher number of hydrogen bond donor sites provides a remarkable enhancement of its bin

237 GVHD prophylaxis, conditioning regimen, and donor source, we explored the correlation of 10 previous

238 and have been postulated to be activated by donor-specific anti-HLA antibodies triggering their CD16

239 Development of donor-specific antibodies (DSA) after lung transplantati

240 were: HLA antibodies at transplant, de novo donor-specific antibodies (DSA), antibody-mediated rejec

241 , such as capillary C4d or complement-fixing donor-specific antibodies (DSA).

242 We hypothesized that HLA class II de novo donor-specific antibody (dnDSA) development correlates w

243 We hypothesized that de novo donor-specific antibody (DSA) causes complement-dependen

244 pothesized that transplanted tissues release donor-specific exosomes into recipient circulation and t

245 c allografts were passively transferred with donor-specific MHC I antibodies, mTOR inhibition signifi

246 thout immunosuppression to assess for robust donor-specific tolerance.

247 e normal pattern despite the presence of the donor splice site mutation, likely due to the action of

248 ch, particularly under conditions of limited donor stem cell availability.

249 res during flowering and grain filling using donors such as NL-44, will minimize the negative impact

250 isms had been dependent on hydrogen/electron donors, such as H2S, NH3, organic acids and Fe(2+), that

251 ) was observed in the pancreata of cadaveric donors, suggesting that beta-cells are prone to attract

252 sely, abrogating IL-21 receptor signaling in donor T cells and inhibiting the elimination of thymic I

253 rough the in vivo conversion of alloreactive donor T effectors (Teffs; CD4(+)CD25(-)FOXP3(-)) and the

254 elated (MRD), or HLA-matched unrelated (MUD) donor T-cell-replete bone marrow allografting, obviating

255 er, combining RNPs with transgene-containing donor templates for targeted gene addition has proven ch

256 individuals, but none of the European blood donors tested, have high levels of LAIR1-containing anti

257 it is considered a lipophilic hydrogen bond donor that may act as a bioisostere of hydroxyl, thiol,

258 new approach complements available prodrugs/donors that directly deliver a single species, including

259 mpared with the standard risk deceased organ donor, the PHS donor was younger, male, died from anoxia

260 Among healthy adult kidney donors, the single-nephron GFR was fairly constant with

261 l heterogeneity was noted in BMI of accepted donors; the MOR varied from 1.10 for overweight to 1.93

262 w protocol in which an achiral hydrogen bond donor thiourea catalyst was utilized to enhance the reac

263 Donor tissue parameters of 84 consecutive corneal donor

264 Using our organ donor tissue resource, we analyzed cDC subset distributi

265 To evaluate main features of donor tissue that may influence clinical outcome or comp

266 on donor limitation, increasing the electron donor to TCE ratio facilitated a recovery of the vcrA-co

267 isk donors, (iii) wait time, and (iv) living donor transplantation.

268 e survival rate of HLA poorly matched living donor transplants is not inferior to that of HLA well-ma

269 nferior to that of HLA well-matched deceased donor transplants.

270 In univariate analysis donor type (mother) and GVHD prophylaxis (T-cell depleti

271 at use myeloablative conditioning, unrelated donor (URD), and methotrexate are not known.

272 of preparative chemotherapy, or the type of donor used, did not impact survival.

273 Besides grants, donors used a variety of sources to help offset expenses

274 cific CD8 T cells were expanded from healthy donors using artificial APCs.

275 ipheral blood mononuclear cells (PBMCs) from donors vaccinated with a tetravalent DLAV vaccine (TV005

276 ty and selectivity of 2-azidofucosyl (FucN3) donors, valuable synthons in the synthesis of 2-acetamid

277 standard risk deceased organ donor, the PHS donor was younger, male, died from anoxia, more likely t

278 ent product release, revaccination of plasma donors was investigated as a means to boost titers.

279 sover design, the immune system in 22 sample donors was transiently activated with an endotoxin injec

280 Renal transplantation (from the same BMT donor) was performed 4 months post-BMT without immunosup

281 -pregnant female donor, compared with a male donor, was associated with increased all-cause mortality

282 The resulting unnatural UDP-sugar donors were then tested as substrates in glycosaminoglyc

283 creased the alpha-selectivity of the studied donors, whereas substitution of the 4,6-benzylidene acet

284 ound onto upconversion nanoparticles (energy donor), which allows for upconversion luminescence reson

285 be B cell responses to C-PfCSP from European donors who underwent immunization with live Pf sporozoit

286 tion of the adamantanyl thioglycoside in the donor with N-iodosuccinimide and trifluoromethanesulfoni

287 Glycosylations of 4,6-tethered glucosazide donors with a panel of model acceptors revealed the effe

288 n endometrial stromal cells from nonpregnant donors with a previous pregnancy that was complicated by

289 We excluded donors with anatomical kidney abnormalities.

290 tween red blood cell transfusion from female donors with and without a history of pregnancy and morta

291 the hypothesis that platelets collected from donors with highly responsive platelets to agonists in v

292 tcomes of recipients of organs from deceased donors with ITP recorded in the UK Transplant Registry b

293 Organs from donors with ITP resulted in 49 organ transplants (31 kid

294 Organs from the 18- to 34-year-old deceased donors with PHS risks (but relatively few medical comorb

295 and transplant outcomes among recipients of donors with positive ZIKV testing.

296 Advances in identification of donors with the most potent and broad anti-HIV serum neu

297 reased IL-6 pathway signaling in islets from donors with type 2 diabetes.

298 afts can be obtained from deceased or living donors, with different logistical requirements and impli

299 , biological, renal, and liver insults) than donors without extracorporeal membrane oxygenation.

300 s the acceptor and the polymer PBDB-T as the donor yield the best power conversion efficiency (PCE) o