ライフサイエンスコーパス: dopamine D1 receptor

1 e focused upon the effects of activating the dopamine D1 receptor.

2 eases in response to stimulation of striatal dopamine D1 receptors.

3 gic neurons, and (2) excitation initiated by dopamine D1 receptors.

4 c cholinergic, adenosine A2, dopamine D2, or dopamine D1 receptors.

5 g affinity (Ki = 49.3 nM) and selectivity to dopamine D1 receptors.

6 highest binding affinity (Ki = 60.3 nM) for dopamine D1 receptors.

7 uent activation of norepinephrine alpha2 and dopamine D1 receptors.

8 down by RNAi lead to elevated cAMP levels in dopamine D1 receptor-activated neuroblastoma cells.

9 spinogenesis are dependent on mating-induced dopamine D1 receptor activation in the NAc.

10 We show that dopamine D1 receptor activation promotes and D2 receptor

11 ing that it reduces hyperthermia produced by dopamine D1 receptor activation.

12 nvolved increased TrkB surface expression by dopamine D1 receptor activation.

13 phosphorylation, whereas the effects of the dopamine D1 receptor agonist are blocked by genistein, a

14 lated RGCs, the application of dopamine or a dopamine D1 receptor agonist decreased voltage-activated

15 In the Fyn knockout mice, the dopamine D1 receptor agonist failed to induce subcellula

16 hr34 DARPP-32 and phospho-Ser845 GluR1 after dopamine D1 receptor agonist or forskolin stimulation.

17 d by treatment of neostriatal neurons with a dopamine D1 receptor agonist or with forskolin, consiste

18 e-treated and normal individuals, whilst the dopamine D1 receptor agonist SKF 38393 (30 mg/kg, i.p.)

19 st dose tested (18 nmol) of a mixture of the dopamine D1 receptor agonist SKF 38393 and the D2 agonis

20 owing by conditioning rats under the partial dopamine D1 receptor agonist SKF 38393 or the opioid ant

21 e administration of a low dose of either the dopamine D1 receptor agonist SKF-38393 or the D2 recepto

22 The dopamine D1 receptor agonist SKF-82958 produces (1) an i

23 ain slices of neonatal (P7) rat striatum the dopamine D1 receptor agonist SKF-82958 significantly dec

24 Dopamine D1 receptor agonist treatment does not change t

25 acute behavioral response of DA-/- mice to a dopamine D1 receptor agonist was correlated with c-fos i

26 also attenuated the hyperthermia caused by a dopamine D1 receptor agonist, SKF 38393 (10 mg/kg, s.c.)

27 82958 (SKF), a previously characterized full dopamine D1 receptor agonist, to stimulate the transcrip

28 The selective dopamine D1 receptor agonists SKF 38393 (10 microM) and

29 harmacological roles of Gs- and Golf-coupled dopamine D1 receptor and adenosine A2A receptor in the b

30 an be used to reveal potentially therapeutic dopamine D1 receptor and adenosine A2A receptor ligands

31 ave been developed for 48 antagonists of the dopamine D1 receptor and applied to mining chemical data

32 We studied the dopamine D1 receptor and cocaine self-administration in

33 Simultaneous activation of dopamine D1 receptors and CPARs induced additive increas

34 This upregulation of NMDAR activity by dopamine D1 receptors and the previous finding on up-reg

35 These data reveal a rapid dopamine D1 receptor- and tyrosine kinase-dependent traf

36 It is interesting that dopamine D1 receptor antagonism counteracted the stimula

37 252a, a Trk tyrosine kinase inhibitor, and a dopamine D1 receptor antagonist could block the effects

38 Systemic administration of the selective dopamine D1 receptor antagonist SCH 23390 [R(+)-7-chloro

39 The dopamine D1 receptor antagonist SCH 23390 was ineffectiv

40 usion of 10 microg (but not 2 microg) of the dopamine D1 receptor antagonist SCH-23390 greatly impair

41 Pretreatment with the dopamine D1 receptor antagonist SCH23390 (0.1mg/kg, ip)

42 s sufficient to induce BDNF in the mPFC, and dopamine D1 receptor antagonist treatment blocked the an

43 way were attenuated by pretreatment with the dopamine D1 receptor antagonist, SCH23390, which also ca

44 kDa), in the absence or in the presence of a dopamine D1 receptor antagonist, we provide evidence tha

45 eceptors, and these effects are reduced by a dopamine D1 receptor antagonist.

46 eversed in the presence of 4 mum SCH23390, a dopamine D1 receptor antagonist.

47 sion of the AMPA-receptor antagonist CNQX or dopamine D1-receptor antagonist SCH-23390 into the DLS b

48 a CPP for cocaine that was not blocked by a dopamine D1-receptor antagonist.

49 Dopamine D1 receptor antagonists (SCH23390 and SKF83566)

50 Previous studies have shown that dopamine D1 receptors are preferentially expressed in st

51 In conclusion, neurokinin-1 and dopamine D1 receptors are required for the METH-induced

52 Blockade of dopamine D1 receptors attenuated prolonged wakefulness a

53 Importantly, systemic inhibition of dopamine D1 receptors attenuated the stroke-induced incr

54 Increased dopamine D1 receptor binding was found in the nucleus ac

55 and full intrinsic activity at cloned human dopamine D1 receptors but had much lower affinity at dop

56 One new receptor, DAMB, was identified as a dopamine D1 receptor by sequence analysis and pharmacolo

57 and the previous finding on up-regulation of dopamine D1 receptors by NMDAR activation provide a cell

58 Stimulation of dopamine D1-receptors by SKF 82958 increased extracellul

59 ecause of increased transmission through the dopamine D1 receptor/cAMP-dependent protein kinase pathw

60 These results indicate that stimulation of dopamine D1 receptors can be coupled to the neurotrophin

61 In particular, direct pathway (dopamine D1 receptor-containing; D1R-) spiny projection

62 They also demonstrate that activation of dopamine D1 receptors corrects these deficits, through a

63 firing, and that this effect is mediated by dopamine D1 receptor-coupled Ca2+ signalling pathways.

64 rebral cortical areas, substantially reduced dopamine D1 receptor coupling to G(s)-protein, and defic

65 inhibit movement, whereas those that express dopamine D1 receptors (D1+) project to the substantia ni

66 In this study, we show that mice lacking the dopamine D1 receptor (D1R KO mice) manifest greatly redu

67 ss impairs working memory via high levels of dopamine D1 receptor (D1R) activation of cyclic adenosin

68 disease, is associated with an alteration in dopamine D1 receptor (D1R) and glutamate receptor intera

69 A dopamine D1 receptor (D1R) antagonist blocked ghrelin-in

70 inding activity of agonist and antagonist of dopamine D1 receptor (D1R) by using quartz crystal micro

71 The dopamine D1 receptor (D1R) facilitates reward acquisitio

72 The dopamine D1 receptor (D1R) in the nucleus accumbens (Acb

73 omato BAC transgenic mice and found that the dopamine D1 receptor (D1R) is expressed in retinal bipol

74 ntrol of genetic regulatory elements for the dopamine D1 receptor (D1R) or dopamine D2 receptor (D2R)

75 rrent synaptic activity and was reduced by a dopamine D1 receptor (D1R) protein kinase A pathway.

76 r casein kinase 2 (CK2) in the modulation of dopamine D1 receptor (D1R) signaling in cells.

77 , removing NMDARs from MSNs that express the dopamine D1 receptor (D1R) significantly attenuated AMPH

78 Finally, conditional knock-out of Cav1.2 in dopamine D1 receptor (D1R)-expressing cells resulted in

79 The role of dopamine D1 receptors (D1R) and D2 receptors (D2R) in th

80 gh both angiotensin AT1 receptors (AT1R) and dopamine D1 receptors (D1R) modulates renal sodium excre

81 n cortical dopamine, and possible changes in dopamine D1 receptors (D1R).

82 ly in medium spiny neurons (MSNs) expressing dopamine D1 receptors (D1R).

83 rt of this, increased activation of striatal dopamine-D1 receptors (D1R) results in desensitization o

84 ippocampal neurons, we demonstrate here that dopamine D1 receptors (D1Rs) and NMDARs form dynamic sur

85 However, while dopamine D1 receptors (D1Rs) in the prefrontal cortex (P

86 quantify the effect of D3R overexpression on dopamine D1 receptors (D1Rs) in the striatum.

87 are medium spiny neurons (MSNs) that express dopamine D1 receptors (D1Rs) or D2 receptors (D2Rs), whi

88 The dopamine D1 receptor-D3 receptor (D1R-D3R) heteromer is

89 Changes in opioid and dopamine D1 receptor densities were more subtle and infl

90 mygdala enhanced cue-reward learning through dopamine D1 receptor-dependent mechanisms and suppressed

91 neurons of the PFC, which are regulated by a dopamine D1 receptor-dependent pathway.

92 An amphetamine challenge reversed CPD via a dopamine D1-receptor-dependent paradoxical presynaptic p

93 SRT in the rat using direct infusions of the dopamine D1 receptor (DRD1) antagonist SCH 23390 or dopa

94 with a single nucleotide polymorphism in the dopamine D1 receptor (DRD1) gene, which was associated w

95 Cells expressing the dopamine D1 receptor (DRD1) have significant functional

96 contrast, decreased dysbindin did not change dopamine D1 receptor (DRD1) levels, or its basal or dopa

97 cortical-limbic induced compulsions in which dopamine D1 receptor-expressing (D1+) neurons in restric

98 cholera toxin (CT) transgene in a subset of dopamine D1 receptor-expressing (D1+) neurons thought to

99 idence that supports a role of Cav1.2 within dopamine D1 receptor-expressing cells of the hippocampus

100 ent of excitatory synaptic transmission onto dopamine D1 receptor-expressing neurons (D1+ neurons) in

101 uced PGE2 targeted EP1 receptors on striatal dopamine D1 receptor-expressing neurons and that this si

102 diacylglycerol lipase alpha (DGLalpha), from dopamine D1 receptor-expressing or adenosine A2a recepto

103 ned mice that lack M4 mAChRs specifically in dopamine D1-receptor-expressing neurons, suggesting that

104 duced hypothyroidismin hamsters (HH) altered dopamine D1 receptor expression, D1 receptor-modulated v

105 R and beta2-AR), muscarinic (M1 and M2), and dopamine (D1) receptor families.

106 In this scheme, activation of dopamine D1 receptors following light exposure triggers

107 f dendritic spines in MSN-D1 (MSN-expressing dopamine D1 receptors) from the core and shell of nucleu

108 Stimulation of dopamine D1 receptors has profound effects on addictive

109 ined the regulation of NMDAR currents by the dopamine D1 receptor in PFC pyramidal neurons.

110 PK and JNK signaling pathways is mediated by dopamine D1 receptors in SK-N-MC neuroblastoma cells.

111 We recently demonstrated that dopamine D1 receptors in the ventral tegmental area (VTA

112 d by testing the hypothesis that blockade of dopamine D1 receptors in the VTA attenuates the rewardin

113 rable evidence suggests an important role of dopamine D1 receptors in these effects.

114 Dopamine D1 receptors, in contrast, stimulate GluA1 extr

115 The dopamine D1 receptor is involved in mediating cocaine-in

116 t the direct inhibition of NMDA receptors by dopamine D1 receptor ligands is due to the channel pore

117 dies and structure-activity relationships of dopamine D1 receptor ligands suggest that their intrinsi

118 tina that bright-light-induced activation of dopamine D1 receptors located on ON-center cone bipolar

119 Here we show that dopamine D1 receptors mediate prefrontal control of sign

120 The dopamine D1 receptor-mediated NMDA receptor trafficking

121 deletion of any other NF subunit, amplifies dopamine D1-receptor-mediated motor responses to cocaine

122 Multiple proteins of NMDA receptor and dopamine D1 receptor pathways are being regulated in way

123 Dopamine D1 receptors play an important role in movement

124 To determine whether the dopamine D1 receptor plays a crucial role in the behavio

125 What is known is that the dopamine D1 receptor plays an important role.

126 At low cortical frequencies, dopamine D1 receptors promote glutamate release to both

127 ing an amine-accepting binding domain on the dopamine D1 receptor protein that may be further explore

128 e, the PDE10A radioligand (18)F-MNI-659, the dopamine D1 receptor radioligand (11)C-NNC 112, and the

129 e, the PDE10A radioligand (18)F-MNI-659, the dopamine D1 receptor radioligand (11)C-NNC 112, and the

130 The dopamine D1 receptor, responsible for protein kinase A a

131 twork firing, whereas optimal stimulation of dopamine D1 receptors sculpts network inputs to refine m

132 STDP in MSNs expressing dopamine D1 receptors shifted from spike-timing-dependen

133 Both protein kinase A and dopamine D1 receptor signaling are required for the func

134 Several lines of evidence suggest that dopamine D1 receptor signaling enhances dendritic excita

135 Although considerable evidence implicates dopamine D1-receptor signaling in the nucleus accumbens

136 In rodents, dopamine D1 receptor stimulation causes a complex behavi

137 FosB and dynorphin-B expression mediated by dopamine D1 receptor stimulation in the development of 3

138 onal state of progestin receptors because of dopamine D1 receptor stimulation, facilitation of lordos

139 (SDS) in mice, here we identified a role of dopamine D1 receptor subtype in mPFC excitatory neurons

140 It is generally assumed that the coupling of dopamine D1 receptors to adenylyl cyclase is mediated by

141 Mice that incorporate the dopamine D1 receptor transgene controlled by the D1 rece

142 e previously reported that activation of the dopamine D1 receptor triggers a rapid redistribution of

143 neurotensin (NTR1), adrenergic (beta1), and dopamine (D1) receptors were treated with fluorescently

144 However, this effect diminished when the dopamine D1 receptors were pharmacologically blocked.

145 CPARs and dopamine D1 receptors were required in vivo for elevated

146 We also show that a mutant dopamine D1 receptor, which has likewise been described

147 NR2A, and NR2B was normal, and activation of dopamine D1 receptors with the agonist SKF-82958 [(+/-)-

148 sensitizing GABAergic input is controlled by dopamine D1 receptors, with horizontal cells serving as

149 lag in phosphorylation of a peptide from the dopamine D1 receptor without ATP preincubation.