ライフサイエンスコーパス: dopaminergic neuron

1 y be compounded by the unique anatomy of the dopaminergic neuron.

2 e to mitochondrial mass (porin and GRP75) in dopaminergic neurons.

3 and differentiated them into macrophages and dopaminergic neurons.

4 TA), subsequently increasing SP release onto dopaminergic neurons.

5 ease is characterized by progressive loss of dopaminergic neurons.

6 ed that Hsc70 and TH co-localize in midbrain dopaminergic neurons.

7 napses on VTA dopaminergic neurons than SNpc dopaminergic neurons.

8 ns in TRP-4 reduce the mechanosensitivity of dopaminergic neurons.

9 by inducing the selective death of midbrain dopaminergic neurons.

10 produces many specific cell types including dopaminergic neurons.

11 drial transcription factor A specifically in dopaminergic neurons.

12 maintenance of mitochondrial homeostasis in dopaminergic neurons.

13 nclusions, followed by a progressive loss of dopaminergic neurons.

14 a-synuclein aggregation, and the survival of dopaminergic neurons.

15 nphilin-1 as well as in primary cortical and dopaminergic neurons.

16 , and astrocytes in turn modulate downstream dopaminergic neurons.

17 a narrow set of circadian neurons as well as dopaminergic neurons.

18 required for the survival of adult midbrain dopaminergic neurons.

19 d arousal-state-dependent alterations in VTA dopaminergic neurons.

20 SH-SY5Y cells, and rat primary cortical and dopaminergic neurons.

21 he membrane potential of mitochondria in SNc dopaminergic neurons.

22 cholinergic interneurons compared with SNpc dopaminergic neurons.

23 egation and degeneration of substantia nigra dopaminergic neurons.

24 ortical regions, but also excite neighboring dopaminergic neurons.

25 , forming asymmetric synapses on neighboring dopaminergic neurons.

26 provide a means to inhibit substantia nigra dopaminergic neurons.

27 underlying spike repolarization in midbrain dopaminergic neurons.

28 ould be expected to increase excitability of dopaminergic neurons.

29 is decreased in PD, specifically within the dopaminergic neurons.

30 erentiation from immature to mature midbrain dopaminergic neurons.

31 l mechanism for restoring dopamine levels in dopaminergic neurons.

32 s overexpression of VMAT2 completely rescued dopaminergic neurons.

33 h local excitatory synapses on mesoaccumbens dopaminergic neurons.

34 h classically described dopaminergic and non-dopaminergic neurons.

35 coupling it results in a greater loss of SNc dopaminergic neurons.

36 ted into reduced microglial toxicity towards dopaminergic neurons.

37 in which the mitochondrial DNA is damaged in dopaminergic neurons.

38 of PPN axons reliably evoked spiking in SNc dopaminergic neurons.

39 network and distinct subsets of reinforcing dopaminergic neurons.

40 tDNA) undergoes double-strand breaks only in dopaminergic neurons.

41 n-G (Ank-G) was used to visualize the AIS of dopaminergic neurons.

42 mice led to a clear age-related loss of SNc dopaminergic neurons.

43 s, and induced pluripotent stem cell-derived dopaminergic neurons.

44 ene function in specific subsets of midbrain dopaminergic neurons.

45 l1R), which modulate the activity of the VTA dopaminergic neurons.

46 mous activation of the UPR(MT) in C. elegans dopaminergic neurons.

47 igra of rat brains, DOPAL causes the loss of dopaminergic neurons accompanied by the accumulation of

48 Ca(2+) signalling was sufficient to silence dopaminergic neuron activity, which was mediated by astr

49 is effect is triggered by a specific pair of dopaminergic neurons afferent to the mushroom bodies, vi

50 Moreover, ablating spinally projecting dopaminergic neurons after the resolution of the IL-6- o

51 stantia nigra in vivo of adult mice protects dopaminergic neurons against degeneration in experimenta

52 We also showed that CDNF was able to protect dopaminergic neurons against injury caused by alpha-synu

53 In Drosophila, negatively reinforcing dopaminergic neurons also provide the inhibitory control

54 produces neuroprotective effects in cultured dopaminergic neurons, an experimentally tractable, mecha

55 on handling might be involved, we focused on dopaminergic neurons and asked how inactivation of trans

56 Finally, we find that JH acts through dopaminergic neurons and conclude that an ETH-JH-dopamin

57 lar and anatomical heterogeneity of midbrain dopaminergic neurons and contribute to a better understa

58 dies in the brain, as well as a reduction in dopaminergic neurons and defective dopamine signaling in

59 evoked abnormal plasticity in nigrostriatal dopaminergic neurons and DMS D1-neurons, contributing to

60 t overexpression of KCNQ channels in the VTA dopaminergic neurons and either local infusion or system

61 between leptin, NTS, and hypocretinergic or dopaminergic neurons and establish the zebrafish as a mo

62 ymes or transporters necessary to operate as dopaminergic neurons and exert widespread GABAergic inhi

63 to the VTA to activate postsynaptic OX1Rs of dopaminergic neurons and generate 2-AG through a Gq-prot

64 x3, whilst FolR1 negative cells generate non-dopaminergic neurons and glia cells.

65 zyme, lead to the selective loss of midbrain dopaminergic neurons and juvenile-onset Parkinson's dise

66 sm that reduces its lysosomal degradation in dopaminergic neurons and may contribute to alpha-synucle

67 lture model of the human midbrain containing dopaminergic neurons and neuromelanin.

68 erscore the complex organization of midbrain dopaminergic neurons and provide an entry point for futu

69 DAT delivery to the presynaptic terminals of dopaminergic neurons and restored sleep to normal length

70 ncluding locomotor activity, degeneration of dopaminergic neurons and shortened lifespan.

71 lpha-synuclein pathology, persistent loss of dopaminergic neurons and striatal neurotransmitters, and

72 ncluding the mechanosensory TRP-4 channel in dopaminergic neurons and the D2-like dopamine receptor D

73 , the precise movement-related firing of SNc dopaminergic neurons and the resultant striatal dopamine

74 d of maturation and function of mesocortical dopaminergic neurons and their sensitivity to glucocorti

75 or octopamine to live preparations silenced dopaminergic neurons and this inhibition required astroc

76 chanisms underlying burst firing in midbrain dopaminergic neurons and those that suppress activity du

77 ea (VTA), potentiated synaptic inputs to VTA dopaminergic neurons, and induced drug-reinforced behavi

78 age-progressive degeneration of a subset of dopaminergic neurons, and motor deficits.

79 d cytotoxicity in primary cultures of nigral dopaminergic neurons, and recombinant proSAAS blocks alp

80 hila has demonstrated that water-reinforcing dopaminergic neurons are different to those for nutritio

81 Midbrain dopaminergic neurons are essential for appropriate volun

82 Low dopamine levels and death of the dopaminergic neurons are hallmarks of Parkinson's diseas

83 Midbrain dopaminergic neurons are highly heterogeneous.

84 nographic recordings to demonstrate that VTA dopaminergic neurons are necessary for arousal and that

85 neurotoxicity in nerve cells, especially in dopaminergic neurons are not yet fully understood.

86 In addition, morphologically distinct dopaminergic neurons are produced within a given lineage

87 the paired anterior medial (PAM) cluster of dopaminergic neurons, as the ones relevant for the caffe

88 asal ganglia network dysfunction and loss of dopaminergic neurons assessed with dopamine transporter

89 During olfactory learning in fruit flies, dopaminergic neurons assign value to odor representation

90 Dendritic spines were present on dopaminergic neurons at low densities in live and fixed

91 8alpha MAPK by Cre recombinase expression in dopaminergic neurons blocked place aversion to the KOR a

92 tudying mouse substantia nigra pars compacta dopaminergic neurons both in brain slice and after acute

93 Activation of alpha1 receptors increases dopaminergic neuron burst firing by decreasing the calci

94 onoamine transporter-2 with EGFP in midbrain dopaminergic neurons but not in any of the striatal EGFP

95 found inhibitory control exerted on midbrain dopaminergic neurons by the lateral habenula (LHb), whic

96 tion.SIGNIFICANCE STATEMENT Substantia nigra dopaminergic neurons can be divided into two populations

97 ed that the movement-related firing of these dopaminergic neurons can manifest as rapid and robust fl

98 l mesencephalon have shown that transplanted dopaminergic neurons can survive and function in the lon

99 Dopaminergic neuron cell counts and striatal levels of d

100 kout of D2R either in MSNs (MSN-D2RKO) or in dopaminergic neurons (DA-D2RKO), we show that D2R signal

101 porter (DAT) activity, ultimately leading to dopaminergic neuron damage.

102 BON synapses receive a direct synapse from a dopaminergic neuron (DAN).

103 We subsequently discovered that a few dopaminergic neurons (DAn) that innervate the MBn mediat

104 tomy of the adult MB and defined 20 types of dopaminergic neurons (DANs) that each innervate distinct

105 Here, we purified iPSC-derived human dopaminergic neurons (DaNs) using the intracellular mark

106 activity is one of the major hypotheses for dopaminergic neuron death in Parkinson's disease.

107 gizes with mitochondrial dysfunction causing dopaminergic neuron death modeling PD pathogenic process

108 the mitochondrial complex I, does not cause dopaminergic neuron death or motor impairment.

109 mHTTx1) modulates the expression of IL-34 in dopaminergic neurons derived from a human embryonic stem

110 hod to quantitatively assess the fidelity of dopaminergic neurons derived from human pluripotent stem

111 Here we studied dopaminergic neurons derived from patients with idiopath

112 ell proliferation, developmental timing, and dopaminergic neuron development.

113 In contrast, deletion of RGS7 in dopaminergic neurons did not influence morphine reward.

114 ther found that different projections of VTA dopaminergic neurons differentially modulate arousal.

115 l models to study PD and the degeneration of dopaminergic neurons (DNs) that characterizes this disea

116 e are attributed to degeneration of midbrain dopaminergic neurons (DNs).

117 mune cells contribute to the degeneration of dopaminergic neurons (DNs).

118 racterized by massive degeneration of nigral dopaminergic neurons, dramatic motor and cognitive alter

119 been observed in individual muscle cells and dopaminergic neurons during ageing.

120 ition, LXRbeta is involved in the genesis of dopaminergic neurons during development and protection o

121 t PK2 expression is highly induced in nigral dopaminergic neurons during early stages of degeneration

122 ity between mushroom body output neurons and dopaminergic neurons enables memory re-evaluation driven

123 Consistent with previous reports, dopaminergic neurons encoded the expected reward, but we

124 differentiation of neuronal precursors into dopaminergic neurons (Engrailed 1) and for the oligodend

125 ntrast, KOR activation acutely inhibited VTA dopaminergic neuron firing, and repeated exposure attenu

126 ronal PC12 cells as well as ventral midbrain dopaminergic neurons from 6-OHDA, MPP+, or alphaSYN.

127 Here we report that NCEH-1 protects dopaminergic neurons from alpha-synuclein-dependent neur

128 Dopaminergic neurons from MitoPark mice exhibited decrea

129 Additionally, dopaminergic neurons from MitoPark mice showed a progres

130 al deficits in the ion channel physiology of dopaminergic neurons from MitoPark mice that both preced

131 truct a timeline of functional decline in SN dopaminergic neurons from MitoPark mice.

132 Dopaminergic neurons from patients with Type 2 and Type

133 PK2 expression increased in surviving nigral dopaminergic neurons from PD brains, indicating that PK2

134 l redox status and membrane potential of SNc dopaminergic neurons from Sirt3 knockouts.

135 n, NCGC607 reduced alpha-synuclein levels in dopaminergic neurons from the patients with parkinsonism

136 Here, we compare directly the activity of dopaminergic neurons from the substantia nigra pars comp

137 We mapped 18 dopaminergic neurons from three distinct clusters to six

138 ls, suggesting a role for ErbB4 signaling in dopaminergic neuron function.

139 ronal morphology and firing rate showed that dopaminergic neurons function as a coupled oscillator wh

140 n of GDNF in the CNS affects the function of dopaminergic neurons has remained unknown.

141 While VTA dopaminergic neurons have previously been targeted and d

142 at CIB1 negatively regulates degeneration of dopaminergic neurons in a mouse model of Parkinson's dis

143 nhibitory neurotransmission between midbrain dopaminergic neurons in brain slices from mice we have d

144 cus enables rapid and easy quantification of dopaminergic neurons in cell culture throughout the enti

145 gene enhances MPTP-induced neurotoxicity in dopaminergic neurons in CIB1(-/-) mice.

146 tor function or cause degeneration of nigral dopaminergic neurons in control rats.

147 hrough DAT in heterologous cells and primary dopaminergic neurons in culture.

148 fferentiated state of a set of central brain dopaminergic neurons in Drosophila, referred to as the p

149 tier and calbindin-negative ventral tier SNc dopaminergic neurons in mice comprise functionally disti

150 , can cause neurodegeneration in a subset of dopaminergic neurons in mice.

151 ions in intrinsic and synaptic properties of dopaminergic neurons in MitoPark mice occurring at ages

152 loss of substantia nigra pars compacta (SNc) dopaminergic neurons in Parkinson's disease (PD).

153 can lead to long term stable preservation of dopaminergic neurons in PD-related mouse models remains

154 tochondrial oxidative stress and loss of SNc dopaminergic neurons in PD.

155 , accompanied by progressive degeneration of dopaminergic neurons in SN, neuritic swelling, reduced s

156 we observed the recovery in the activity of dopaminergic neurons in SNpc, and improvement in the mot

157 ore, these animals showed better survival of dopaminergic neurons in substantia nigra and an increase

158 neurons, did not cause a significant loss of dopaminergic neurons in substantia nigra pars compacta (

159 ffeine action, we have identified a role for dopaminergic neurons in the arousal-promoting effect of

160 A recent study of dopaminergic neurons in the brain of larval zebrafish ha

161 DAT were confined to the cell bodies of the dopaminergic neurons in the fly brain and failed to reac

162 ings demonstrate a novel role for descending dopaminergic neurons in the maintenance of pathological

163 stem to decipher the roles of two classes of dopaminergic neurons in the mouse nucleus accumbens in a

164 went unilateral transplantation of embryonic dopaminergic neurons in the putamen and subsequently exh

165 RK2 expression, in both cultured neurons and dopaminergic neurons in the rat substantia nigra pars co

166 or type of somatic synapses were evident for dopaminergic neurons in the SNpc of Wistar vs. Sprague-D

167 y projection neurons than onto the somata of dopaminergic neurons in the SNpc or dorsal striatal chol

168 this, RGMa induced selective degeneration of dopaminergic neurons in the substantia nigra (SN) and af

169 mical analysis revealed a reduced density of dopaminergic neurons in the substantia nigra and reduced

170 e has long been known to involve the loss of dopaminergic neurons in the substantia nigra and the coi

171 son's disease (PD) is defined by the loss of dopaminergic neurons in the substantia nigra and the for

172 disease (PD) is characterized by the loss of dopaminergic neurons in the substantia nigra and the pre

173 Most dopaminergic neurons in the substantia nigra pars compac

174 (PD) is characterized by the degeneration of dopaminergic neurons in the substantia nigra pars compac

175 Progressive degeneration of dopaminergic neurons in the substantia nigra pars compac

176 PD is characterized by the degeneration of dopaminergic neurons in the substantia nigra pars compac

177 ections in the striatum followed by death of dopaminergic neurons in the substantia nigra.

178 motor symptoms due to the selective loss of dopaminergic neurons in the substantia nigra.

179 rodegenerative disease caused by the loss of dopaminergic neurons in the substantia nigra.

180 terized by slow, progressive degeneration of dopaminergic neurons in the substantia nigra.

181 's disease (PD) characterized by the loss of dopaminergic neurons in the substantia nigra.

182 ecific marker for a novel subset of midbrain dopaminergic neurons in the ventral midbrain that projec

183 al nucleus (RMTg), which strongly innervates dopaminergic neurons in the ventral midbrain.

184 (CB1Rs) on GABAergic neurons that disinhibit dopaminergic neurons in the ventral tegmental area (VTA)

185 u haploinsufficiency causes prenatal loss of dopaminergic neurons in the ventral tegmental area and r

186 Reductions in PHD2 activity within dopaminergic neurons in vivo and in cultured human induc

187 ,2,3,6-tetrahydropyridine, selectively kills dopaminergic neurons in vivo and in vitro via a variety

188 Thus, PPN-evoked burst spiking of SNc dopaminergic neurons in vivo may not only be extrinsical

189 K/STAT pathway prevented the degeneration of dopaminergic neurons in vivo These results indicate that

190 fic dysregulation, exacerbates disruption of dopaminergic neurons in vivo, resulting in the neurodege

191 fects on the survival and function of nigral dopaminergic neurons in which the chronic expression of

192 thout an increase in the numbers of midbrain dopaminergic neurons, in conditional Zeb2 (Nestin-Cre ba

193 storage in both iPSC-derived macrophages and dopaminergic neurons, indicating its potential for treat

194 chaperone reduced alpha-synuclein levels in dopaminergic neurons, indicating that chaperoning glucoc

195 ization requires odor-evoked activity in the dopaminergic neuron innervating this compartment.

196 This pathway recruits negatively reinforcing dopaminergic neurons innervating the same compartment an

197 king in substantia nigra pars compacta (SNc) dopaminergic neurons is a key signaling event in the cir

198 ation of human pluripotent stem cell-derived dopaminergic neurons is a promising approach to treating

199 In Parkinson's disease, the loss of dopaminergic neurons is associated with elevated histami

200 vements in the firing of identified midbrain dopaminergic neurons is cell-type selective.

201 ed SOCE alters transcriptional regulation of dopaminergic neurons, leading to downregulation of the e

202 aracterization of a novel subset of midbrain dopaminergic neurons located in the ventral tegmental ar

203 ent synaptic disruption, occur in absence of dopaminergic neuron loss in PD.

204 amine-lesioned mice: asymptomatic (42 +/- 7% dopaminergic neuron loss) and symptomatic (85 +/- 5% cel

205 e-formed fibrils into non-neuronal cells and dopaminergic neurons matched the efficacy of alpha-syn m

206 ous expression of Nav 1.2 by the majority of dopaminergic neurons may explain their high threshold fo

207 These results suggest that CB2Rs in dopaminergic neurons may play important roles in the mod

208 r molecular targets and function in midbrain dopaminergic neurons (mDAn) as well as their role in neu

209 tau in maintaining the survival of midbrain dopaminergic neurons (mDANs) during aging.

210 priate connections for cell therapy.Midbrain dopaminergic neurons (mDAs) in the VTA and SNpc project

211 It is thus warranted to understand which dopaminergic neurons mediate which function.

212 Dopaminergic neurons mediating reinforcement in insect o

213 Midbrain dopaminergic neurons (mesDA) are the nerve cells prefere

214 kin mutant phenotypes, in particular loss of dopaminergic neurons, mitochondrial network structure, r

215 aptic transmission in ventral tegmental area dopaminergic neurons more readily in adolescent mice com

216 e in which Ndufs4 was selectively deleted in dopaminergic neurons (Ndufs4 cKO).

217 riments demonstrate that Neurod6(+) midbrain dopaminergic neurons neurons project to two distinct sep

218 ons alone did not alter the number of nigral dopaminergic neurons nor striatal dopamine levels.

219 expressed human wild-type or R1441C LRRK2 in dopaminergic neurons of Drosophila and observe reduced l

220 report markedly decreased APP expression in dopaminergic neurons of human PD nigra and that APP(-/-)

221 mplex polymer pigment found primarily in the dopaminergic neurons of human substantia nigra.

222 studies reporting mtDNA depletion in nigral dopaminergic neurons of PD patients.

223 Expression of dominant-negative Orai in dopaminergic neurons of pupae abolished flight.

224 Re-expression in the dopaminergic neurons of the active, but not a catalytica

225 is a neurodegenerative disorder with loss of dopaminergic neurons of the brain, which results in insu

226 In the dopaminergic neurons of the Drosophila model, unlike kno

227 as via the projections from reward-sensitive dopaminergic neurons of the midbrain ventral tegmental a

228 rable in Parkinson's disease (PD), including dopaminergic neurons of the substantia nigra (SN) and ch

229 Dopaminergic neurons of the substantia nigra (SN) play a

230 X1 and NFE2L1 levels are severely reduced in dopaminergic neurons of the substantia nigra of Parkinso

231 synuclein in primary cultured neurons and in dopaminergic neurons of the substantia nigra pars compac

232 cell death in cortical pyramidal neurons and dopaminergic neurons of the substantia nigra pars compac

233 ort that Trib3 immunostaining is elevated in dopaminergic neurons of the substantia nigra pars compac

234 dopamine (DA) biosynthesis, specifically in dopaminergic neurons of the substantia nigra pars compac

235 us deep brain stimulation (STN DBS) protects dopaminergic neurons of the substantia nigra pars compac

236 disease are attributed to selective loss of dopaminergic neurons of the substantia nigra.

237 o examine striatal imbalance after lesioning dopaminergic neurons of the substantia nigra.

238 In dopaminergic neurons of VTA slices, orexin A presynaptic

239 omplexes are found at the plasma membrane of dopaminergic neurons or mammalian cells and that the amp

240 d is associated with the progressive loss of dopaminergic neurons over the course of aging.

241 um channel current (SK), as well as elevates dopaminergic neuron pacemaker firing through modulation

242 Evidence increasingly suggests that dopaminergic neurons play a more sophisticated role in p

243 unctional heterogeneity within the rewarding dopaminergic neuron population.

244 and mouse OB to show that a subset of bulbar dopaminergic neurons possess an AIS and that these AIS-p

245 , RNAi-mediated depletion of CIB1 in primary dopaminergic neurons potentiated 1-methyl-4-phenyl pyrin

246 e somatodendritic domain of adult male mouse dopaminergic neurons, previously recorded in vivo We obs

247 These dopaminergic neurons project to the beta'2 and gamma4 re

248 Midbrain dopaminergic neurons project via the nigrostriatal pathw

249 , consisting of ventral tegmental area (VTA) dopaminergic neurons projecting to the IPN, as a potenti

250 duced AMPA/NMDA receptor-dependent firing of dopaminergic neurons projecting to the nucleus accumbens

251 beta'2a, whose dendritic fields overlap with dopaminergic neuron projections in the tips of the beta,

252 ss, before inducing sleep, inhibition of VTA dopaminergic neurons promoted goal-directed and sleep-re

253 that mitochondrial complex I dysfunction in dopaminergic neurons promotes non-motor symptoms of Park

254 Dopaminergic neurons provide reward learning signals in

255 ling in the striatum depended on the type of dopaminergic neuron providing inputs, the striatal regio

256 ypical Lewy bodies, in 11-12% of the grafted dopaminergic neurons, reflecting the spread of pathology

257 rgic neurons.SIGNIFICANCE STATEMENT Midbrain dopaminergic neurons regulate diverse brain functions, i

258 tanding how the firing of different types of dopaminergic neuron relates to movement and how this act

259 In vivo dopaminergic neuron reprogramming by EMF stimulation of

260 Stereological counts of nigral dopaminergic neurons revealed a significantly greater ce

261 Reconstructions of sampled AIS of dopaminergic neurons revealed variable lengths (12-60 mu

262 We find that a spinally directed lesion of dopaminergic neurons reverses hyperalgesic priming in bo

263 Dopaminergic neurons serve multiple functions, including

264 nctions of the Neurod6(+) subset of midbrain dopaminergic neurons.SIGNIFICANCE STATEMENT Midbrain dop

265 tantia nigra pars compacta) mesodiencephalic dopaminergic neuron subset, using Dkk3 mutant mice and m

266 In the mouse, two mature fetal dopaminergic neuron subtypes diversified into five adult

267 We demonstrate that the uncovered dopaminergic neuron subtypes encoded distinct aspects of

268 nitor differentiation efficiency and compare dopaminergic neuron survival under different conditions.

269 es greater number of somatic synapses on VTA dopaminergic neurons than SNpc dopaminergic neurons.

270 ory neuroprotective PK2 signalling in nigral dopaminergic neurons that could have important therapeut

271 oom body, which drive negatively reinforcing dopaminergic neurons that innervate neighbouring zones.

272 Dopaminergic neurons that project from the ventral tegme

273 ependent long-term memory requires different dopaminergic neurons that project to the gamma5b regions

274 dentifies for the first time a population of dopaminergic neurons that regulates motor behavior capab

275 nction, plasticity, and survival of midbrain dopaminergic neurons, the dysfunction of which contribut

276 gly, rotenone-induced degeneration of nigral dopaminergic neurons, their dendrites, and their striata

277 Additionally, dopaminergic neurons themselves require D2R, suggesting

278 urvival and an age-dependent degeneration of dopaminergic neurons thereby creating a new PD-like mode

279 rst-firing frequency of rat ventral-midbrain dopaminergic neurons through an alpha1 adrenergic recept

280 red branch-specific plastic changes in these dopaminergic neurons, thus enabling sustained protein co

281 rtment and re-engages positively reinforcing dopaminergic neurons to reconsolidate the original rewar

282 ed only a moderate effect on the survival of dopaminergic neurons treated with the toxin.

283 vidence that glutamatergic transmission onto dopaminergic neurons underlies incentive motivation, a w

284 in mouse, we targeted RGMa to adult midbrain dopaminergic neurons using adeno-associated viral vector

285 ex I activity in all cells or selectively in dopaminergic neurons via conditional deletion of the Ndu

286 The degeneration of dopaminergic neurons was accompanied by a strong microgl

287 ,2,3,6-tetrahydropyridine, and protection of dopaminergic neurons was quantitatively assessed by tyro

288 of p38alpha MAPK in ventral tegmental (VTA) dopaminergic neurons was required for conditioned place

289 ABAergic inputs onto DMS-projecting midbrain dopaminergic neurons was suppressed.

290 for cell type-specific profiling of midbrain dopaminergic neurons, we established and compared transl

291 ring of substantia nigra pars compacta (SNc) dopaminergic neurons, we identified and characterized th

292 n genetic risk factor for Parkinson disease, dopaminergic neurons were generated from iPSC lines deri

293 at mutant primary cortical and mesencephalic dopaminergic neurons were more susceptible to rotenone-i

294 cases of synaptic innervation of the AIS of dopaminergic neurons were observed.

295 The epigenetic changes in the mesocortical dopaminergic neurons were prevented when animals were tr

296 Primary neurons, particularly dopaminergic neurons, were more vulnerable to MNPs@SiO2(

297 te of the effect that alpha-synuclein has on dopaminergic neurons, where its accumulation causes neur

298 acetylation, decreased MnSOD activity in SNc dopaminergic neurons, whereas mutagenesis of lysine 68 t

299 D) is characterized by a progressive loss of dopaminergic neurons with limited treatment options.

300 s occurred selectively in calbindin-negative dopaminergic neurons within the SNc.