ライフサイエンスコーパス: dormancy

1 components, and quantified selection on seed dormancy.

2 o expand its size before entering a state of dormancy.

3 alian perilipin-1 and was upregulated in Mtb dormancy.

4 tical enzyme in cysteine biosynthesis during dormancy.

5 t antibiotics prior to a passive defense via dormancy.

6 together suggesting the cancer cells entered dormancy.

7 their formation has been attributed to cell dormancy.

8 r IFI16 to keep lytic cycle transcription in dormancy.

9 INATION 1 (DOG1) are essential regulators of dormancy.

10 well as developmental processes such as seed dormancy.

11 protecting total diversity through increased dormancy.

12 e impact of MSCs on breast cancer cell (BCC) dormancy.

13 ignificant role in the induction of PCa cell dormancy.

14 onal changes involving periods of growth and dormancy.

15 as moderate heat- and drought-stress delayed dormancy.

16 cling in preparation for light repression of dormancy.

17 luding angiogenic, immunologic, and cellular dormancy.

18 nction restricting HSC cycling and promoting dormancy.

19 variation affects Arabidopsis thaliana seed dormancy.

20 entering a state of metabolic inactivity or dormancy.

21 in abscisic acid signaling and control seed dormancy.

22 cytoplasm, cytoplasm fluidity, and cellular dormancy.

23 cy, angiogenic dormancy, and immune-mediated dormancy.

24 or cytotoxic therapy could trigger cellular dormancy.

25 main in a latency state, that is, metastasis dormancy.

26 c analyses indicated that APUM9 reduces seed dormancy.

27 ated cancer cells, promoting their permanent dormancy.

28 n during stress, cholesterol utilization and dormancy.

29 cting as germination barrier to control coat dormancy.

30 an important role of DNA methylation in seed dormancy.

31 the root system Spartina alterniflora during dormancy.

32 m the environment to promote the breaking of dormancy.

33 ecessary and sufficient to release HBCs from dormancy.

34 on traits, including flowering time and seed dormancy.

35 also proposed to be involved in controlling dormancy.

36 also had reduced ability to resuscitate from dormancy.

37 can be prevented by a property known as seed dormancy.

38 e function in modulating seed maturation and dormancy.

39 g treatment by entering cell cycle arrest or dormancy.

40 ditions in order to best decide when to exit dormancy?

41 the majority of seeds exhibit 'physiological dormancy' - a quiescence program initiated by either the

42 In the case of metabolic dormancy, a bet-hedging strategy that has been proposed

43 Attesting to this is the prevalence of tumor dormancy, a state of arrested growth of an otherwise ful

44 esponse through which cells enter reversible dormancy, acquiring distinct properties including reduce

45 rmination 1 (DOG1) gene, known for providing dormancy adaptation to distinct environments, determines

46 vidence that cancer cells under duress enter dormancy after cannibalizing MSCs.

47 lose HSCs and show a disrupted re-entry into dormancy after exposure to inflammatory stress stimuli.

48 but not Notch2, is required to maintain HBC dormancy after selective neuronal degeneration.

49 Specifically, entry into dormancy allows cells to withstand times of stress while

50 pletion of germination and its regulation by dormancy also depend on the degradation of specific subs

51 ntal signal determining the depth of primary dormancy, although the mechanisms though which temperatu

52 RNAs by MTOR inhibitors results in metabolic dormancy and a predominantly cytostatic effect.

53 AM) can undergo seasonal transitions between dormancy and activity; understanding this transition is

54 and potato inhibitor II, implicated in tuber dormancy and defence, respectively).

55 helial-to-mesenchymal transition, tumor cell dormancy and escape from immune surveillance, with emerg

56 Major alleles for seed dormancy and flowering time are well studied, and can in

57 segregating early and late alleles for seed dormancy and flowering time in a field experiment.

58 To examine how seed dormancy and flowering time shape annual plant life cycl

59 ongly upon interacting genetic variation for dormancy and flowering.

60 Thus, studies on comparing seed dormancy and germination among populations must consider

61 Therefore, genes affecting seed dormancy and germination are among those under strongest

62 Dormancy and germination characteristics of fresh and 6-

63 Seed dormancy and germination of S. bungeana differed with po

64 r-ripening and incubation conditions on seed dormancy and germination of Stipa bungeana, a perennial

65 cript levels of ATM and ATR, with changes in dormancy and germination potential modulated by environm

66 s methylomes from the globular stage through dormancy and germination to understand the role of methy

67 ogy clustering revealed novel actors of seed dormancy and germination.

68 nondormant seeds and revealed actors in seed dormancy and germination.

69 nown about molecular events involved in cyst dormancy and hatching, two key steps of their developmen

70 e a dominant mutation affecting release from dormancy and identified the corresponding gene EARLY BUD

71 This mutant also exhibited reduced dormancy and increased resistance to high temperature.

72 n, but in the course of diapause, a state of dormancy and increased stress tolerance, these genes und

73 Strong dormancy and late-flowering genotypes were both necessar

74 l to investigate liver stage development and dormancy and may facilitate the discovery of drugs targe

75 s pathways controlling flowering timing, bud dormancy and outgrowth in responses to seasonal cues.

76 s of E. coli PI-7 expressed genes related to dormancy and persister cell formation during the late de

77 be achieved by establishing permanent tumor dormancy and preventing distant recurrence of cancer or

78 ibitor fluridone, which broke somatic-embryo dormancy and promoted their normal development.

79 rts cell-extrinsic control over myeloma cell dormancy and reactivation.

80 gesting that IKKbeta may contribute to tumor dormancy and recurrence of ER(+) disease.

81 tumor microenvironment in the regulation of dormancy and recurrence.

82 a role for Notch signaling in mammary tumor dormancy and recurrence.

83 modified peptidoglycan, contributes to spore dormancy and resistance by maintaining the low water con

84 cer cells and MSCs in the evolution of tumor dormancy and resurgence in the micrometastatic microenvi

85 Their depletion causes G1-phase dormancy and reversible initiation of the slender-to-stu

86 etagenome is enriched in genes involved with dormancy and sporulation.

87 article reviews growing evidence about tumor dormancy and suggests that (i) cellular malignancy is a

88 inosa to resuscitate from starvation-induced dormancy and that HPF is the major factor associated wit

89 ew summarizes the basic principles of cancer dormancy and the applicability of the novel genetic mode

90 ironment can influence the intensity of seed dormancy and thus seasonal germination timing and post-g

91 physiological states, such as quiescence and dormancy, and create a new view of the cytoplasm as an a

92 ncer dormancy: cellular dormancy, angiogenic dormancy, and immune-mediated dormancy.

93 ays that support the survival, self-renewal, dormancy, and reactivation of cancer cells that initiate

94 al regulator responsible for maintaining bud dormancy, and results in rapid bud release.

95 s suggests that GPA represents a form of bud dormancy, and that dominance is gradually transferred fr

96 case of memory in the form of increased seed dormancy, and that persisted one generation removed from

97 formation on cellular processes that lead to dormancy; and (b) provide models that could account for

98 to be involved in cancer dormancy: cellular dormancy, angiogenic dormancy, and immune-mediated dorma

99 Overall, metabolism during dormancy appeared to involve discrete but interrelated e

100 Cellular dormancy appears to be an active process that can be tog

101 ory and transgenerational plasticity in seed dormancy are adaptations of I. violascens to its desert

102 on extant plants that tiny embryos and seed dormancy are basic for angiosperms as a whole.

103 Genetic studies of dormancy are challenging, because the trait is highly pl

104 echanistic framework that treats cancer cell dormancy as a dynamic cell state conferring a fitness ad

105 We focus on mechanisms of cellular dormancy as newer biologic insights have enabled better

106 Further analyses of dormancy associated MADS-box genes revealed that SVP- an

107 r bud growth arrest in phyB-1, expression of dormancy-associated genes such as DRM1, GT1, AF1, and CK

108 to-mesenchymal transition, pro-survival, and dormancy-associated genes.

109 escence, reducing "stemness," and activating dormancy-associated p38 MAPK signaling and p21 expressio

110 rmation on seasonal changes occurring during dormancy at both the transcriptome and metabolite levels

111 signals are integrated to overcome stem cell dormancy at the shoot apical meristem.

112 Antibiotics can cause dormancy (bacteriostasis) or induce death (cidality) of

113 Six months of dry storage broke seed dormancy, broadened the temperature range for germinatio

114 -implantation blastocysts enter biosynthetic dormancy but can progress through their normal developme

115 Aged spores exhibited higher dormancy but could efficiently geminate in the presence

116 g semilabile DOC consumption, AltSIO entered dormancy but remained viable, while the diverse assembla

117 s Therefore, the negative regulation of seed dormancy by asDOG1 in cis results in allele-specific sup

118 Seed dormancy, by controlling the timing of germination, can

119 At its simplest, dormancy can be imposed by the formation of a simple phy

120 hanisms are thought to be involved in cancer dormancy: cellular dormancy, angiogenic dormancy, and im

121 gulation of NAD synthesis under ATP-limiting dormancy conditions.

122 provides evidence for the recently proposed "dormancy continuum hypothesis" and substantiates the phy

123 elated phenomena which are part of a shared 'dormancy continuum'.

124 ther understand the mechanisms by which this dormancy control takes place in Arabidopsis (Arabidopsis

125 RIL seed dormancy could explain variation in seedling establishme

126 understanding of local and metastatic tumor dormancy could lead to novel cancer therapeutics for the

127 After breaking of spore dormancy, Ctr6 localizes to the vacuole membranes that a

128 persed to the soil in spring enter a shallow dormancy cycle dominated by spatial sensing that adjusts

129 serve as a thermal sensing mechanism during dormancy cycling in preparation for light repression of

130 The involvement of chromatin remodelling in dormancy cycling in the soil seed bank (SSB) is poorly u

131 of silencing KYP/SUVH4 (KRYPTONITE), during dormancy cycling in the SSB.

132 Seed dormancy cycling plays a crucial role in the lifecycle t

133 intenance and suppression of dormancy during dormancy cycling.

134 n DOG1 (DELAY OF GERMINATION1) in Cvi during dormancy cycling.

135 a large variability between the green-up and dormancy dates estimated using the six different methods

136 two periods (2041-2050 and 2090-2099), later dormancy dates were predicted in northern areas.

137 However, in coastal areas earlier dormancy dates were predicted.

138 further suberin-deficient mutants have seed dormancy defects.

139 stence are two well-recognized conditions of dormancy demonstrated to contribute to bacterial stress

140 ch the environmental signals control primary dormancy depth.

141 ncing for the maintenance and suppression of dormancy during dormancy cycling.

142 t but essential roles in the release of seed dormancy epistatic to DOG1.

143 ed in floral induction, bulb maturation, and dormancy establishment.

144 tion event that could occur during malignant dormancy even before primary cancer is clinically detect

145 ated mechanism limiting the duration of seed dormancy functions across the Brassicaceae.

146 A seasonal period of dormancy further improves tolerance of buds to environme

147 egion as the major seed dormancy QTL and the dormancy gene DELAY OF GERMINATION 1 (DOG1).

148 ritical for the induction of M. tuberculosis dormancy genes in response to nitric oxide (NO), carbon

149 The status of long-term quiescence and dormancy guarantees the integrity of hematopoietic stem

150 During relief of dormancy, H3K27me3 repressive marks slowly accumulated a

151 Dormancy has been hypothesized to be an adaptive physiol

152 ating resistance to therapy and an exit from dormancy have never been investigated.

153 niche is pivotal in controlling myeloma cell dormancy highlights the potential for targeting cell-ext

154 Dormancy holds a vital role in the ecological dynamics o

155 that seed coat suberin is essential for seed dormancy imposition by low temperature and that the excl

156 e suberin and tannin layers is important for dormancy imposition.

157 of Germination 1) is a key regulator of seed dormancy in Arabidopsis (Arabidopsis thaliana) and other

158 is a key player in the establishment of seed dormancy in Arabidopsis and characterizes a set of mutan

159 the major quantitative trait locus for seed dormancy in Arabidopsis and has been shown to control do

160 he DOG1 protein is a major regulator of seed dormancy in Arabidopsis.

161 Here, we study dormancy in different eukaryotic organisms and find it t

162 This phenomenon causes partial oxphos dormancy in glycolytic cells via disruption of ATP synth

163 ns, which is manifested in the form of tumor dormancy in healthy individuals as well as in cancer sur

164 e has drawn special attention to the role of dormancy in human disease, particularly in regards to re

165 in Arabidopsis and has been shown to control dormancy in many other plant species.

166 ure and light are well known to control seed dormancy in many plant species.

167 3' processing complex display weakened seed dormancy in parallel with defects in DOG1 proximal polya

168 s, suggesting that physiologically regulated dormancy in response to environmental cues was present a

169 screen to isolate mutants that fail to enter dormancy in response to variation in temperature during

170 tion of jasmonic acid-isoleucine and loss of dormancy in seeds of stressed plants.

171 PA, a phenomenon that is associated with bud dormancy in some perennials.

172 potential explanation for guard mother cell dormancy in soybean embryos.

173 rmining the sex of ferns to controlling seed dormancy in the earliest seed plants before being co-opt

174 in K. daigremontiana is essential to bypass dormancy in the leaf embryos and generate viable plantle

175 e molecular mechanisms underlying growth and dormancy in woody perennials are largely unknown.

176 Notch signaling maintains p63 levels and HBC dormancy, in contrast to its suppression of p63 expressi

177 ance to rifampicin in two in vitro models of dormancy including a three-dimensional human granuloma m

178 Strong dormancy increased within-season fecundity in an early-f

179 ssion is initially low and then increases as dormancy increases.

180 ther dormant or non-dormant, but seeds whose dormancy-inducing pathways are activated to higher level

181 We conclude that NR2F1 is a critical node in dormancy induction and maintenance by integrating epigen

182 We hypothesize that weak dormancy induction could synchronize germination of seed

183 ding innate immunity; adaptive immunity; and dormancy induction, or programmed cell death.

184 e systems; and coupling between immunity and dormancy induction/programmed cell death.

185 Tumor dormancy is a clinical phenomenon related to immune equi

186 Dormancy is a complex evolutionary trait that temporally

187 Seed dormancy is a complex life history trait that determines

188 and preclinical studies suggests that tumor dormancy is a critical step in the development of both p

189 Artemisinin-induced dormancy is a proposed mechanism for failures of monothe

190 We demonstrate that dormancy is a reversible state that is switched 'on' by

191 sidual tumor cells and provide evidence that dormancy is a targetable stage of breast cancer progress

192 Our studies suggest that mitotic dormancy is a unique phenotype that facilitates tumor ce

193 Microbial dormancy is a widespread phenomenon employed by bacteria

194 Given that cellular dormancy is an evolutionary conserved survival mechanism

195 Mechanical dormancy is conferred by preventing full phase-II water

196 Clinical cancer dormancy is evident from the detection of circulating tu

197 Seed dormancy is expected to provide ecological advantages by

198 Here we provide evidence that tumor dormancy is influenced by tissue factor (TF), the cancer

199 Seed dormancy is one of the most crucial process transitions

200 The function of ABA in dormancy is rather well understood, but the role of DOG1

201 As soil temperature declines in autumn, deep dormancy is re-imposed as seeds become part of the persi

202 NR2F1-dependent dormancy is recapitulated by a co-treatment with the DNA

203 This pericarp-imposed mechanical dormancy is released by the activity of common fungi, wh

204 When the favorable season is fleeting, seed dormancy is the only adaptive strategy.

205 nical remission, often referred to as cancer dormancy, is well documented but remains an incompletely

206 ts, but there is a striking increase in seed dormancy levels.

207 ultiple alleles at the previously identified dormancy locus DELAY OF GERMINATION1 jointly explain as

208 accelerated on exposure to light completing dormancy loss.

209 arasites, but pathways involved in microbial dormancy, maintenance of genome integrity and ATP homeos

210 mmunotherapeutic interventions in metastatic dormancy may help to control or eradicate cancer disease

211 The conserved DOG1-mediated coat-dormancy mechanism provides a highly adaptable temperatu

212 Reduction of seed dormancy mechanisms, allowing for rapid germination afte

213 a jasmonic acid-dependent reduction in seed dormancy, mediated by alteration of gibberellin and absc

214 However, the advantage conferred by dormancy might ultimately depend on other seed attribute

215 ead and neck squamous cell carcinoma (HNSCC) dormancy models and in DTCs from prostate cancer patient

216 Migrating infected cells reactivate from dormancy more than non-migrating cells and exhibit diffe

217 Thus, measurements of dormancy must always be accompanied by analysis of envir

218 environmental factors on the timing of fall dormancy of deciduous forest communities in New England,

219 nd high heat-stress tended to induce earlier dormancy of deciduous forests, whereas moderate heat- an

220 luripotency gene NANOG, which contributes to dormancy of DTCs in the bone marrow.

221 an important dynamic role in the control of dormancy of her progeny seed in response to environmenta

222 nt potency in a nutrient-starvation model of dormancy of Mycobacterium tuberculosis, with little or n

223 ted the ability of the osteoblasts to induce dormancy of PCa cells.

224 at SPARC plays a key role in maintaining the dormancy of prostate cancer cells in the bone microenvir

225 e stochastic mutations may accumulate during dormancy of stem-like cells, but technical limitations i

226 e modeling of MGUS suggest that the clinical dormancy of the clone may be regulated in part by growth

227 s an oncogenic signal promoting an exit from dormancy of therapy-induced cancer stem-like cells and l

228 ble for more in-depth analyses of metastatic dormancy, offering new opportunities for immunotherapeut

229 Seeds featuring this so-called 'physical dormancy' often require either scarification or passage

230 e as an alternative to explanations based on dormancy or death due to nutrient starvation.

231 le disseminated tumor cells to escape cancer dormancy or tumor latency.

232 her cells resist environmental stress, enter dormancy, or metastasize.

233 the convergence point of the DOG1-regulated dormancy pathway and signalling by the plant hormone abs

234 We propose that the ABA and DOG1 dormancy pathways converge at clade A of type 2C protein

235 with nondeep and intermediate physiological dormancy (PD).

236 s resurge as metastatic disease after a long dormancy period in the bone marrow, where cancer cells i

237 digrees, starch contents, cooking types, and dormancy periods, in five developmental stages from harv

238 at are capable of forming metastasis after a dormancy phase.

239 These dormancy phases can also be induced in growth chambers b

240 factor that is well known to induce the MTB dormancy phenotype.

241 ccurred through selection of pre-adapted low dormancy phenotypes from the wild.

242 nd varicose (vcs) mutants displayed distinct dormancy phenotypes.

243 O is sensed by M. tuberculosis to initiate a dormancy program.

244 Furthermore, immune dormancy promotes cancer cell growth arrest and angiogen

245 Immune-mediated metastasis dormancy provides an opportunity for targeting cancer in

246 located in the same region as the major seed dormancy QTL and the dormancy gene DELAY OF GERMINATION

247 iched in traits which emphasize survival and dormancy, rather than growth and activity; and the crypt

248 sites adjacent to members of the DosR (DevR) dormancy regulon.

249 m cells (CSCs) may be responsible for tumour dormancy, relapse and the eventual death of most cancer

250 memory CD4 T-cell responses specific to Mtb dormancy related (DosR) latency, but not classical immun

251 fection, in particular early secreted versus dormancy related latency antigens expressed later, that

252 primate tissue make two important plasmodial dormancy-related questions researchable.

253 deciduous tree species require chilling for dormancy release, and warming-related reductions in chil

254 gene is down-regulated in flower buds after dormancy release, concomitantly with changes in the meth

255 ever the molecular mechanisms regulating HSC dormancy remain poorly understood.

256 ms regulating their maintenance or exit from dormancy remain uncertain.

257 ects a chilling requirement or a delaying of dormancy remains to be tested.

258 phenotypes, but whether it also affects seed dormancy remains unexplored.

259 reprogramming, the ability to enter and exit dormancy, resistance to apoptosis, immune evasion, and c

260 eprogramming, respiration, oxidative stress, dormancy response, and virulence.

261 ultilayered protein coats are crucial to the dormancy, robustness, and germination of bacterial spore

262 Conversely, dormancy should be evolutionarily stable in temperate li

263 hat Myc-depleted stem cells enter a state of dormancy similar to embryonic diapause.

264 which temperature changes impart changes in dormancy state are still only partly understood.

265 finding not previously described for either dormancy state.

266 with a temperature-sensitive switch in seed dormancy state.

267 tions must consider year of collection, seed dormancy states and germination test conditions when sel

268 Two dormancy states, the viable but non-culturable state and

269 stic leukemia that combine the phenotypes of dormancy, stemness, and chemo-resistance.

270 ted with small-colony variation or metabolic dormancy such as had been seen previously.

271 signaling downstream components controlling dormancy, suggested that an alternative signaling route

272 f coupling between adaptive immunity and the dormancy/suicide systems.

273 Strong seed dormancy suppressed mid-summer germination in both early

274 The impact of brumation, the winter dormancy that is observed in ectotherms, on memory remai

275 In other types of seeds with 'morphological dormancy' the embryo remains under-developed at maturity

276 Deciphering the causal basis of tumor dormancy therefore has obvious therapeutic significance.

277 Currently described as two distinct forms of dormancy, they are rarely discussed in the same context.

278 In turn, FT controls seed dormancy through inhibition of proanthocyanidin synthesi

279 in C. lanceolata during the transition from dormancy to activation.

280 tion level dynamics that vary from long-term dormancy to aggressive progression.

281 We found morphophysiological dormancy to be the most likely ancestral state of seed p

282 ake were up-regulated during transition from dormancy to hydration.

283 q) analysis to show that the transition from dormancy toward cell-cycle entry is a continuous develop

284 cells with combined properties of long-term dormancy, treatment resistance, and stemness.

285 study, UABs induced into the three phases of dormancy under controlled conditions were used to compar

286 ch may potentially channel mycobacteria into dormancy under extreme oxidative and nitrosative stresse

287 These UABs undergo seasonal phases of dormancy under natural conditions, namely para-, endo-,

288 Physiological dormancy uses germination-inhibiting hormones to prevent

289 These cells exit metabolic dormancy via an IL6-driven feed-forward ER(lo)-IL6(hi)-N

290 Dormancy was also reduced by engineering seed-specific a

291 Loss of dormancy was dependent on an intact jasmonate signalling

292 Altered dormancy was only observed in the first generation follo

293 d that both the acquisition of longevity and dormancy were severely impaired.

294 uranium-rich biotope, showed no evidence of dormancy when exposed to this metal.

295 ls (PC3 and DU145) on the induction of their dormancy when they are co-cultured with a pre-osteoblast

296 he pABRE:NCED seeds exhibited unusually deep dormancy which lasted for more than 3 months.

297 iew of rhizome metabolism, especially during dormancy, which can be exploited in the future to improv

298 This timing is controlled by seed dormancy, which prevents germination under favourable co

299 S1 expression was positively correlated with dormancy while the reverse was observed for CLF and KYP/

300 ancer cells can induce a reversible state of dormancy, with decreased viral antigen synthesis and inc