ライフサイエンスコーパス: dorsal horn

1 gene-related peptide (CGRP) staining in the dorsal horn.

2 matergic transmission within the superficial dorsal horn.

3 ses of these cells in the superficial spinal dorsal horn.

4 c plasma membranes (SPMs) of the ipsilateral dorsal horn.

5 creased CaV2.2 expression in the SPMs of the dorsal horn.

6 ojection neurons in the spinal and medullary dorsal horn.

7 idence of double labeling in the superficial dorsal horn.

8 M1alpha-facilitated CaV2.2 expression in the dorsal horn.

9 h reconsolidation-like effects in the spinal dorsal horn.

10 dk5) in dorsal root ganglia (DRG) and spinal dorsal horn.

11 ced pain behaviors and BIP expression in the dorsal horn.

12 o ascending projection neurons in the spinal dorsal horn.

13 ndogenous adenosine tone is increased in the dorsal horn.

14 citatory synaptic transmission in the spinal dorsal horn.

15 markedly elevated in the ipsilateral spinal dorsal horn.

16 n gene-related peptide-labeled fibers in the dorsal horn.

17 lements in pain signaling in the spinal cord dorsal horn.

18 proteins, including neuronal NOS (nNOS), in dorsal horn.

19 nal terminals in the superficial spinal cord dorsal horn.

20 regulated by inhibitory interneurons in the dorsal horn.

21 between these two populations in the medial dorsal horn.

22 injection exhibited CASP6 activation in the dorsal horn.

23 vities in postsynaptic neurons in the spinal dorsal horn.

24 eus caudalis (Vc), the homolog of the spinal dorsal horn.

25 nctive clusters in the ventral horn and deep dorsal horn.

26 labeled laminae I and II of the spinal cord dorsal horn.

27 % of nonaffected neurons were located in the dorsal horn.

28 pressed on glial cells in superficial spinal dorsal horn.

29 Ascl1-independent subpopulation of the deep dorsal horn.

30 ssed for labeled S1 CST terminals within the dorsal horn.

31 neuronal circuitry, particularly within the dorsal horn.

32 ociated with enhanced activity of the spinal dorsal horn.

33 among excitatory interneurons in superficial dorsal horn.

34 hibitory interneurons in the rat superficial dorsal horn.

35 ding nociceptive A-delta and C fibers in the dorsal horn.

36 se ganglia and spinal sensory input from the dorsal horn.

37 stimulation co-localized to the ipsilateral dorsal horn.

38 rons located in lamina II of the superficial dorsal horn.

39 al activity across all laminae of the spinal dorsal horn.

40 le encoding capability of the mechanosensory dorsal horn.

41 s regulate afferent input to the superficial dorsal horn.

42 tions in superficial laminae of the thoracic dorsal horn.

43 d inhibitory interneurons in the spinal cord dorsal horn.

44 hresholds by gating mechanical inputs in the dorsal horn.

45 ibers and both labels were quantified in the dorsal horns.

46 nt subtypes (A vs. C fibers) across thoracic dorsal horns.

47 activity in the ipsilateral L4/5 superficial dorsal horn 1 day after CFA injection.

48 ons via descending projections to the spinal dorsal horn [1].

49 to an overlapping region of the reorganizing dorsal horn; (2) S1 CST and primary afferent inputs conn

50 dendritic spine dynamics in the superficial dorsal horn; (2) that nerve injury-induced pain triggers

51 na I and II neurons within the rodent spinal dorsal horn, a principal site of action for opiate analg

52 nts sprouted in an overlapping region of the dorsal horn after injury, and that larger (presumably fa

53 1R sensitivity at excitatory synapses in the dorsal horn after nerve injury suggest that new generati

54 ble in neurons (not glia) of the superficial dorsal horn after noxious heat stimuli.

55 ) is present in lamina II of the superficial dorsal horn, an area involved in nociception.

56 hysiological evidence of reconnection to the dorsal horn and behavioral recovery in mechanical pressu

57 eurons in laminae I and V of the spinal cord dorsal horn and caudal spinal trigeminal nucleus and in

58 e is axonally transported to the spinal cord dorsal horn and contributes to characteristics of neurop

59 l afferents, which terminate medially in the dorsal horn and dorsolaterally in nTTD, terminate in spe

60 sphorylated p38 MAPK immunoreactivity in the dorsal horn and Iba1 and cluster of differentiation 45 e

61 processing of nociceptive information in the dorsal horn and in the generation of central sensitizati

62 g 16 channels, were inserted into the lumbar dorsal horn and peripheral neurons activated electricall

63 n parvalbumin-expressing interneurons in the dorsal horn and represents a pharmacological target to m

64 s-synaptic tracing of genetically identified dorsal horn and RVM neurons to uncover an RVM-spinal cor

65 (<0.1 Hz) frequency oscillations within the dorsal horn and somatosensory thalamus.

66 Crossings were detected in areas of dorsal horns and anterior white commissure.

67 hibition are normally balanced in the spinal dorsal horn, and how their imbalance disrupts somatosens

68 segmental correlations in the ventral horns, dorsal horns, and central spinal cord gray matter.

69 ine steady-state behavior in the spinal cord dorsal horn; and (3) this work opens the door to further

70 at GRP-expressing neurons of the superficial dorsal horn are predominantly interneurons, that a small

71 ion of synaptic strength at the level of the dorsal horn as an underlying mechanism.

72 e changes in dendritic spine dynamics in the dorsal horn associated with peripheral nerve injury and

73 glutamate transporter, GLT1, in superficial dorsal horn astrocytes are associated with both excitabi

74 Within the dorsal horn, besides KChIP3 in the inner lamina II and l

75 y excitatory interneurons in the superficial dorsal horn but preservation of primary afferents and sp

76 rger S1 CST terminal boutons in the affected dorsal horn, but no change in the size profile of the sp

77 microglia and reduced CGRP expression in the dorsal horn caudal to the lesion.

78 nset neuropathic pain behavior and increased dorsal horn cell sensitivity to cutaneous mechanical and

79 ntification of key components of the elusive dorsal horn circuit for mechanical allodynia.

80 s and mediated through at least two distinct dorsal horn circuit mechanisms.

81 To determine how dorsal horn circuitry alters to facilitate recovery post

82 iew highlights the complexity of superficial dorsal horn circuitry and addresses the question whether

83 ressing MGE-derived neuronal precursors into dorsal horn circuitry in intact, adult mice with short-

84 Little is understood about dorsal horn circuitry, despite the fact that this region

85 expression in the development of nociceptive dorsal horn circuits critical for mechanical and thermal

86 By examining the dorsal horn circuits that underlie the transmission of "

87 us of processes in superficial layers of the dorsal horn, commissural neurons in the intermediate are

88 YAP and TAZ distribution in the spinal cord dorsal horn consistent with their distinctive associatio

89 and mu-opioid receptors (MOR) in the spinal dorsal horn constitutively repress the expression of syn

90 The superficial spinal dorsal horn contains a heterogeneous population of neuro

91 spinoparabrachial neurons in the superficial dorsal horn contribute to persistent pain states, and th

92 ble of enhancing glycinergic tone within the dorsal horn could obtund nociceptor signaling to the bra

93 Tacr1 throughout the superficial and deeper dorsal horn (DDH), as well as the lateral spinal nucleus

94 atergic dorsal horn neurons and critical for dorsal horn development, is expressed in nociceptive dor

95 signaling and the descending control of the dorsal horn (DH) by brain regions such as the periaquedu

96 ns antagonize each other through spinal cord dorsal horn (DH) gating neurons.

97 The dorsal horn (DH) of the spinal cord is a complex laminar

98 ABSTRACT: The dorsal horn (DH) of the spinal cord is an important site

99 involves changes in sensory circuits of the dorsal horn (DH) where nociceptive inputs integrate for

100 cessing of painful stimulation occurs in the dorsal horn (DH), an area of the spinal cord that receiv

101 ociated regions of the CNS, including in the dorsal horn (DH), its contribution to pain remains undef

102 Using DRG and dorsal horn (DH; another key structure for CIPN pain res

103 litary tract, spinal trigeminal nucleus, and dorsal horn [DH]).

104 rcuits conveying mechanical allodynia in the dorsal horn differ by the nature of the injury.

105 Thus, based on the changes in dorsal horn, DRG and peripheral innervation, we suggest

106 How interneurons (INs) in the dorsal horn encode these modalities and transform them i

107 , we show that multiple microcircuits in the dorsal horn encode this form of pain.

108 ons facilitate mechanical pain by inhibiting dorsal horn enkephalinergic/GABAergic interneurons.

109 We conclude that different subsets of dorsal horn excitatory interneurons contribute to tissue

110 Dorsal horn excitatory interneurons that express gastrin

111 Functional connectivity of dorsal horns exhibited a U-shaped profile along the dors

112 s induced equivalent hyperalgesia and spinal dorsal horn expression of genes associated with microgli

113 pect of the superficial medullary and spinal dorsal horn from the trigeminal subnucleus caudalis to C

114 hological pain likely via modulation of deep dorsal horn GABAergic neurons.SIGNIFICANCE STATEMENT Pai

115 ovide further support for a critical role of dorsal horn gastrin-releasing peptide neurons in itch ci

116 upport a role in pain.SIGNIFICANCE STATEMENT Dorsal horn gastrin-releasing peptide neurons serve a we

117 ibitory neurotransmission in the spinal cord dorsal horn gates nociceptive signaling, is essential in

118 cord TRPV1-immunoreactive terminals, altered dorsal horn GRP immunoreactivity.

119 These data confirm a critical role of dorsal horn GRP neurons in spinal itch transmission but

120 ed circuitry for mechanical allodynia in the dorsal horn has important implications for the mechanist

121 calization of these receptor subtypes in the dorsal horn has not been fully resolved.

122 in the inner part of lamina II (IIi ) of the dorsal horn, has been implicated in the expression of ta

123 ivity for D1 in synaptic compartment (P3) in dorsal horn homogenates and presynaptic met-enkephalin-c

124 eased immunoreactivity for met-enkephalin in dorsal horn homogenates, which was dose-dependently atte

125 ctivations in the middle part of ipsilateral dorsal horn (iDH), along with significantly weaker activ

126 reach adolescence (postnatal day 25-30), the dorsal horn immune profile switches from an anti-inflamm

127 DA) receptor and PKCgamma in the spinal cord dorsal horn (immunohistochemistry; Western blot) was upr

128 teral pathway, a region of the sacral spinal dorsal horn important for the relay of pelvic visceral a

129 ned changes to the neuronal circuitry of the dorsal horn in monkeys following a lesion that deafferen

130 amina II but not lamina I of the spinal cord dorsal horn in nerve-injured versus control animals, sug

131 ay was activated in astrocytes of the spinal dorsal horn in the SNL model.

132 n the superficial laminae of the spinal cord dorsal horn in TOW mice, specifically in GABAergic inhib

133 ssion at C-fiber synapses in rat spinal cord dorsal horn in vivo.

134 nto DRGs, and microglia activation in spinal dorsal horns in wild-type mice, but all these changes we

135 roinflammatory immune response in the spinal dorsal horn, infant nerve injury triggers an anti-inflam

136 lectively in presynaptic Abeta-LTMRs removes dorsal horn inhibition that otherwise prevents Abeta-LTM

137 These results indicate that dorsal horn inhibitory synapses follow different rules o

138 s integration underlies normalization of the dorsal horn inhibitory tone after injury and may be resp

139 re combined to delineate specific changes to dorsal horn input circuitry.

140 "closes" the gate by engaging a superficial dorsal horn interneuron that inhibits the firing of proj

141 ansmitter expressed by a small population of dorsal horn interneurons (GRP neurons).

142 We conclude that Y1R-expressing excitatory dorsal horn interneurons facilitate neuropathic pain hyp

143 d "itch" circuits via excitatory superficial dorsal horn interneurons that express GRP and that likel

144 aberrant terminal label was observed in the dorsal horn ipsilateral to the lesion, indicating sprout

145 Dysregulated excitability within the spinal dorsal horn is a critical mediator of chronic pain.

146 The spinal dorsal horn is a major site for the induction and mainte

147 Lamina I of the spinal dorsal horn is a major site of integration and transmiss

148 The deep dorsal horn is a poorly characterized spinal cord region

149 odels suggests that neuronal loss within the dorsal horn is involved in the development and/or mainte

150 We demonstrate that the dorsal horn is organized into spatially restricted excit

151 a discrete population of neurons in the deep dorsal horn is required for mechanical pain and that act

152 h of R-profiles within the Vc/C2 superficial dorsal horn (lamina I) 3 weeks post-CCI-ION.

153 tic spines over time on the same superficial dorsal horn (lamina II) neurons before and after periphe

154 Activity mapping suggested dorsal horn laminae II-IV was activated in females but s

155 in the sacral parasympathetic nucleus (SPN), dorsal horn laminae II-IV, and dorsal commissural nucleu

156 bserved in central terminals innervating all dorsal horn laminae.

157 inin (CCK) neurons located deeper within the dorsal horn (laminae III-IV) are important for both type

158 ing neuronal components and functions of the dorsal horn LTMR-recipient zone (LTMR-RZ), a role for LT

159 In dorsal horn, males and females show increased GFAP(+) as

160 Paralleling the activation of dorsal horn microglia after peripheral nerve injury is a

161 In the dorsal horn, most NECAB1/2 neurons are glutamatergic.

162 n lateral lamina I and in lamina IV/V of the dorsal horn (n = 5).

163 By dissecting the cellular composition of dorsal-horn networks, studies are beginning to elucidate

164 work, we develop a mathematical model of the dorsal horn neural circuit to investigate mechanisms for

165 We found that when dorsal horn neurokinin 1 receptor-positive neurons or de

166 receptors (GlyRs) play a role in control of dorsal horn neuron excitability, their relative contribu

167 chanical and thermal hypersensitivity of rat dorsal horn neurones and enhanced perceptual responses o

168 measured as augmented evoked activity of rat dorsal horn neurones and increased perceptual responses

169 Here we show that in spinal dorsal horn neurons >80% of mGluR5 is intracellular, of

170 ranscriptional changes in superficial spinal dorsal horn neurons (SSDHN) are essential in the develop

171 ein translation, was activated in rat spinal dorsal horn neurons after repeated intrathecal morphine

172 ously shown to be expressed in glutamatergic dorsal horn neurons and critical for dorsal horn develop

173 We investigated the role of spinal dorsal horn neurons and descending circuitry in plastici

174 ed an increase in c-Fos expression in spinal dorsal horn neurons and displayed increased evoked activ

175 1R; encoded by Tacr1) is expressed in spinal dorsal horn neurons and has been suggested to mediate it

176 reveal that a novel SOC signal is present in dorsal horn neurons and may play an important role in pa

177 orn development, is expressed in nociceptive dorsal horn neurons and that its deletion results in the

178 m-chloride cotransporter KCC2 in spinal cord dorsal horn neurons are a major contributor to the centr

179 at less than 20% of superficial Tacr1(CreER) dorsal horn neurons are spinal projection neurons, and t

180 n results in the specific loss of excitatory dorsal horn neurons by apoptosis, without any effect on

181 ion of hyperexcitability of nociceptive deep dorsal horn neurons by TNF-alpha largely depends on the

182 Importantly, wide dynamic-range dorsal horn neurons continued to faithfully encode A-noc

183 To characterize the subtypes of dorsal horn neurons engaged by dopamine signaling in the

184 excitatory postsynaptic currents (EPSCs) of dorsal horn neurons evoked by dorsal root stimulation in

185 excitatory postsynaptic currents (EPSCs) of dorsal horn neurons evoked by dorsal root stimulation.

186 iation of glycine-activated current in mouse dorsal horn neurons from spinal cord slices.

187 tivation of non-NMDA receptors in the spinal dorsal horn neurons in neuropathic pain conditions.

188 thresholds of lamina IV-V wide dynamic-range dorsal horn neurons in response to both A- and C-nocicep

189 plex, and central sensitization of medullary dorsal horn neurons is a critical factor in muscle hyper

190 n processed in individual wide dynamic-range dorsal horn neurons is modulated by prostanergic descend

191 PSCs and the frequency of miniature EPSCs in dorsal horn neurons of FK506-treated rats.

192 ular recordings from mechanonociceptive deep dorsal horn neurons of normal rats in vivo, we found tha

193 we made extracellular recordings from lumbar dorsal horn neurons of the mouse in response to graded t

194 Blocking the Wnt5a-Ryk/Ror2 axis in spinal dorsal horn neurons prevented activity-dependent dendrit

195 d, as nothing is known about how superficial dorsal horn neurons process sensory input from muscle ve

196 lecular identity and function in spinal cord dorsal horn neurons remain elusive.

197 iniature excitatory postsynaptic currents in dorsal horn neurons that could be blocked by gabapentin.

198 e activity of second-order trigeminovascular dorsal horn neurons that receive peripheral input from t

199 urrents elicited by puff NMDA application to dorsal horn neurons was also significantly greater in FK

200 y of spontaneous and miniature EPSCs in most dorsal horn neurons was profoundly increased in FK506-tr

201 Dorsal horn neurons with stronger C-nociceptor input wer

202 afferent terminals vs inhibitory synapses on dorsal horn neurons).

203 w a loss of a subpopulation of glutamatergic dorsal horn neurons, abnormal sensory afferent innervati

204 at ATP induces ROS production in spinal cord dorsal horn neurons, an effect eliminated by ROS scaveng

205 g in the primary sensory neurons, the spinal dorsal horn neurons, and astrocytes.

206 us stimuli activate overlapping ensembles of dorsal horn neurons, and that stimulus type and intensit

207 hreshold neurons, but not wide dynamic-range dorsal horn neurons, and why it may not be effective in

208 mouse has abundant expression in superficial dorsal horn neurons, but not in the DRG.

209 abeled only about 5% of the normal number of dorsal horn neurons, mainly in lamina IV, below the leve

210 in vivo potentiates glycinergic synapses on dorsal horn neurons, suggesting that GlyR LTP is trigger

211 rons in primary afferents and in superficial dorsal horn neurons, there is little to no information a

212 ory synaptic inputs to mouse lamina I spinal dorsal horn neurons, using laser scanning photostimulati

213 sion between dorsal root ganglia neurons and dorsal horn neurons, we reconstructed the first pain syn

214 d with enhanced neuronal responses in spinal dorsal horn neurons.

215 signal-regulated kinase (ERK) in superficial dorsal horn neurons.

216 oked EPSCs and puff NMDAR currents in spinal dorsal horn neurons.

217 larizing shift in GABA reversal potential of dorsal horn neurons.

218 Ca(2+) release-activated Ca(2+) channels in dorsal horn neurons.

219 e, we demonstrate that SOCs are expressed in dorsal horn neurons.

220 ion of SOCs produced an excitatory action in dorsal horn neurons.

221 lutamatergic input from primary afferents to dorsal horn neurons.

222 stent hyperexcitability of these superficial dorsal horn neurons.

223 orsal root and puff NMDAR currents in spinal dorsal horn neurons.

224 s and the resulting synaptic transmission to dorsal horn neurons.

225 the spinal cord and oxidative DNA damage in dorsal horn neurons.

226 on of its receptors at multiple sites in the dorsal horn: NPY Y1 receptors (Y1Rs) on post-synaptic ne

227 tic degeneration develops in the spinal cord dorsal horn of HIV patients with chronic pain, but the p

228 synaptic protein, specifically in the spinal dorsal horn of patients with HIV-1 in whom pain develope

229 that were significantly downregulated in the dorsal horn of Ptf1a(-/-) mice.

230 ured spinal cord neurons and the superficial dorsal horn of rat spinal cord slices.

231 area synapse on second-order neurons in the dorsal horn of subnucleus caudalis and cervical C1/C2 sp

232 Large numbers of neurons in the dorsal horn of the cervical spinal cord were labeled, es

233 within the nociceptive neurocircuitry of the dorsal horn of the lumbar cord.

234 h microglia-mediated inflammation within the dorsal horn of the lumbar spinal cord.SIGNIFICANCE STATE

235 nd microglia and astrocyte activation in the dorsal horn of the spinal cord and pain-related brain re

236 CR Gpr160 and GPR160 increased in the rodent dorsal horn of the spinal cord following traumatic nerve

237 hingosine-1-phosphate (S1P) generated in the dorsal horn of the spinal cord in response to nerve inju

238 ibitory neurotransmission in the superficial dorsal horn of the spinal cord is thought to contribute

239 ceptor-mediated synaptic transmission in the dorsal horn of the spinal cord, an area critically invol

240 Here we report that in the superficial dorsal horn of the spinal cord, glycinergic synapses on

241 ial early enhancement of pain signals in the dorsal horn of the spinal cord, we combined a nocebo hea

242 uli at the primary synaptic afferents in the dorsal horn of the spinal cord.

243 to modulate incoming noxious stimuli in the dorsal horn of the spinal cord.

244 are initially integrated in the superficial dorsal horn of the spinal cord.

245 ond-order nociceptive neurons located in the dorsal horn of the spinal cord.

246 responding dorsal root ganglia (DRG) and the dorsal horn of the spinal cord.

247 d processed by neuronal circuits in the deep dorsal horn of the spinal cord.

248 thers, but also in the intermediate zone and dorsal horn of the spinal gray matter.

249 Each type was counted within the superficial dorsal horn of the Vc/C2 and the means from each rat wer

250 d host sensory axons only in the spinal cord dorsal horn of treated animals.

251 er of excitatory synapses in the superficial dorsal horn of Vc/C2 could lead to enhanced activation o

252 increased abundance of the kinase RSK in the dorsal horns of the spinal cord, which are heavily popul

253 tral nucleus of the amygdala and spinal cord dorsal horn only in mice with ongoing allodynia.

254 n active, constitutive immune suppression of dorsal horn pain activity.

255 Synaptic inhibition in the spinal dorsal horn plays a key role in that processing.

256 the Wnt5a-Ryk/Ror2 interaction in the spinal dorsal horn prevented spine remodeling and significantly

257 However, dorsal horn projection neurons that contribute to the po

258 and its upstream pathway in the spinal cord dorsal horn (SCDH).

259 ins in postmortem tissues of the spinal cord dorsal horn (SDH) from HIV-1/acquired immunodeficiency s

260 duced hyperesthesia, locomotor deficits, and dorsal horn (SDH) glial changes after SCI, similar to tr

261 at activation of ERK signaling in the spinal dorsal horn (SDH) is required selectively for histamine-

262 in a subpopulation of excitatory superficial dorsal horn (SDH) neurons.

263 citability of neurons within the superficial dorsal horn (SDH) of the spinal cord is thought to under

264 Neurons in the superficial dorsal horn (SDH) of the spinal cord play an important r

265 c transmission within the spinal superficial dorsal horn (SDH) that include a reduction in primary af

266 tamatergic neurons in the mature superficial dorsal horn (SDH), and modifies activity-dependent plast

267 ptic signaling across the mature superficial dorsal horn (SDH), remains unknown.

268 tivity within the developing rat superficial dorsal horn (SDH).

269 ciceptors and their terminals in superficial dorsal horn (SDH; laminae I-II) constitute two separate

270 n neuropathic pain, central sensitization of dorsal horn spinothalamic tract (STT) neurons is a major

271 rostral, as in other species, into cervical dorsal horn, subnucleus caudalis, subnucleus interpolari

272 ural circuits related to pain and SCS in the dorsal horn, supraspinal structures, and the Pain Matrix

273 th and regulate glutamate release at the DRG-dorsal horn synapse.

274 d modulation of glutamate release at the DRG-dorsal horn synapse.

275 neurotransmission at spinal cord superficial dorsal horn synapses in a rat partial nerve-injury model

276 P61 and upregulates phosphorylated GluN2B at dorsal horn synapses.

277 rtate receptor (NMDAR) responses at lamina I dorsal horn synapses.

278 A preferential ability of the dorsal horn synaptic network to amplify nociceptive inpu

279 , A fibers projected to deeper layers of the dorsal horn than did C fibers.

280 tion of excitatory interneurons (INs) in the dorsal horn that are important for transmitting innocuou

281 rimary afferent terminals in the superficial dorsal horn that co-expressed the neuropeptide CGRP.

282 ubset of neurons in lamina III and IV of the dorsal horn that coexpress PAX2, a transcription factor

283 ith ceramide and S1P formation in the spinal dorsal horn that corresponded with the engagement of S1P

284 neurons in the mouse superficial spinal cord dorsal horn that express estrogen receptor alpha (ERalph

285 orward inhibition circuit in the spinal cord dorsal horn that processes mechanical itch as well as sp

286 remodelling of synaptic spines in the spinal dorsal horn, thereby orchestrating functional and struct

287 ns (Bhlhb5) inhibit itch pathways within the dorsal horn; they may represent mediators between noxiou

288 ontribution of central terminal TRPV1 in the dorsal horn to chronic pain has not been investigated di

289 branches move from medial to lateral in the dorsal horn to dorsomedial to ventrolateral in nTTD, whe

290 ed mechanosensory columns of the spinal cord dorsal horn underlies the nervous system's enormous capa

291 ile activity in the healthy adult rat spinal dorsal horn via activation of spinal 5-HT3 receptors (5-

292 ptors depresses synaptic input to the spinal dorsal horn, via the inhibition of voltage-gated calcium

293 creased Cavalpha2delta1 in Vc/C2 superficial dorsal horn was associated with increased excitatory syn

294 For example, in sagittal sections the dorsal horn was significantly stiffer than the ventral h

295 This differs from GABAA receptors in the dorsal horn, where different receptor stoichiometries un

296 marily innervated layers I, II, and V of the dorsal horn, where pain-sensory afferents terminate.

297 n channels expressed in nerves of the spinal dorsal horn, where their activation is believed to reduc

298 interneurons in lamina IIi of the medullary dorsal horn, where they constitute 1/3 of total neurons.

299 n of excitatory synaptic transmission in the dorsal horn, which contributes to pain hypersensitivity

300 the effect of inhibition of VL-PAG COX-1 on dorsal horn wide dynamic-range neurons evoked by C- vs.