ライフサイエンスコーパス: dorsal neural tube

1 lly distinct subpopulations within the chick dorsal neural tube.

2 potent inducing activity is localized to the dorsal neural tube.

3 o bFGF inhibited myogenic signaling from the dorsal neural tube.

4 of the Wnt transcripts characteristic of the dorsal neural tube.

5 and in vitro by co-culture of notochord and dorsal neural tube.

6 mation is regulated by interactions with the dorsal neural tube.

7 crest cells from the neuroepithelium of the dorsal neural tube.

8 rams for excitatory neuronal lineages in the dorsal neural tube.

9 RNA in the cortical hem, dorsal thalamus and dorsal neural tube.

10 -Cre, which is expressed more broadly in the dorsal neural tube.

11 tion of neural progenitor populations in the dorsal neural tube.

12 ams, two major developmental programs of the dorsal neural tube.

13 neurons, DI1 and DI2, that arise within the dorsal neural tube.

14 ural progenitors while still residing in the dorsal neural tube.

15 ctions in specifying neuronal subtype in the dorsal neural tube.

16 or Wnt-1, both of which are expressed in the dorsal neural tube.

17 lizing signals derived from the ectoderm and dorsal neural tube.

18 d in neural crest cells that emerge from the dorsal neural tube.

19 overgrowth and premature neurogenesis of the dorsal neural tube.

20 delamination of neural crest cells from the dorsal neural tube.

21 of ventrally projecting interneurons in the dorsal neural tube; ablating this region in vivo leads t

22 CC delamination, and for emigration from the dorsal neural tube and along cNCC migration pathways.

23 at conditional knockout (CKO) of Cx43 in the dorsal neural tube and CNC mediated by Wnt1-Cre failed t

24 hed once neural crest cells migrate from the dorsal neural tube and differentiate.

25 rate peripheral nervous system, arise in the dorsal neural tube and follow prescribed routes into the

26 which competing diffusible signals from the dorsal neural tube and from the notochord/floorplate spe

27 Based on its expression in the dorsal neural tube and in all neural crest lineages exce

28 hat transgene expression was targeted to the dorsal neural tube and in subpopulations of neural crest

29 R4) by neural crest cells migrating from the dorsal neural tube and in the dorsal root ganglia (DRGs)

30 n of an additional notochord adjacent to the dorsal neural tube and in vitro by co-culture of notocho

31 ls delaminate along the entire length of the dorsal neural tube and initially migrate as a non-segmen

32 rhoB is expressed in the dorsal neural tube and its expression persists transient

33 crest cells (NCCs) that originates from the dorsal neural tube and later migrates to the heart and p

34 independent lines expressed PAX3-FKHR in the dorsal neural tube and lateral dermomyotome.

35 neurula, opl expression is restricted to the dorsal neural tube and neural crest.

36 generating chordate features, including the dorsal neural tube and notochord, are downregulated duri

37 cumented expression of Wnt1 and Wnt3a in the dorsal neural tube and of Wnt4 and Wnt6 in the surface e

38 ls its extensive expansion in the vertebrate dorsal neural tube and pharyngeal arches, implying co-op

39 iption factor expressed in somitic mesoderm, dorsal neural tube and pre-migratory neural crest during

40 bryos had an up-regulation of Delta-1 in the dorsal neural tube and redistribution of Notch-1 to the

41 3 is a transcription factor expressed in the dorsal neural tube and somite of the developing embryo.

42 and its expression becomes expanded into the dorsal neural tube and somites, where Pax3 would normall

43 amily members that are expressed in both the dorsal neural tube and surface ectoderm are also potent

44 Dorsalisation by signals from dorsal neural tube and surface ectoderm stimulates the d

45 MATH1 protein to the nucleus of cells in the dorsal neural tube and the external germinal layer (EGL)

46 tome, a ventral somite derivative, while the dorsal neural tube and the surface ectoderm have been sh

47 he dorsal neural tube because when pieces of dorsal neural tube and unsegmented paraxial mesoderm are

48 Pax3 is also expressed in the dorsal neural tube, and by myogenic progenitors in the p

49 vous system, including cranial neural crest, dorsal neural tube, and mesencephalic tectum, pretectum,

50 tor YAP65, are co-expressed with Pax3 in the dorsal neural tube, and mutation of the Tead2 binding si

51 tube closure, when BMP-4 is expressed in the dorsal neural tube; and (3) a later pre-migratory phase

52 crest cells from progenitors located in the dorsal neural tube appears to involve three sequential s

53 Trunk neural crest cells delaminate from the dorsal neural tube as an uninterrupted sheet; however, t

54 show that myogenesis can be regulated by the dorsal neural tube because when pieces of dorsal neural

55 coincided with a morphological change in the dorsal neural tube between stages mature G15 and G16.

56 In the dorsal neural tube, bone morphogenetic protein (BMP) and

57 s to the time when BMPs are expressed in the dorsal neural tube but are down-regulated in the non-neu

58 ed in anteroposterior regionalisation of the dorsal neural tube but its role in patterning ventral mi

59 Neural crest cells originate in the dorsal neural tube but subsequently undergo an epithelia

60 ell population, initially resides within the dorsal neural tube but subsequently undergoes an epithel

61 ing and the differentiating zones within the dorsal neural tube, but within the EGL of the cerebellum

62 c environment, a dorsalizing signal from the dorsal neural tube can compete with the diffusible ventr

63 ammed to secrete Wnt1, which is expressed in dorsal neural tube, can induce somitic Noggin expression

64 populations of prospective neural crest and dorsal neural tube cells near the lateral margin of the

65 is responsible for the loss of competence of dorsal neural tube cells to generate emigrating neural c

66 e as well as for the survival of ventral and dorsal neural tube cells.

67 have been implicated in directing aspects of dorsal neural tube closure and cell fate specification.

68 ifferentiating MATH1-expressing cells in the dorsal neural tube co-express TAG-1, DCC-1 and LH2, mark

69 luding dreher(J) (dr(J)), all of which cause dorsal neural tube defects.

70 and the activity of the Dll3-promoter in the dorsal neural tube depends on the basic helix-loop-helix

71 Here we show that the development of the dorsal neural tube-derived melanoblasts in turtle Trache

72 Second, if we ablate the dorsal neural tube, dermamyotomes are absent in the majo

73 scription factor expression is essential for dorsal neural tube, early neural crest and muscle cell l

74 sion of wnt3a was detected in regions of the dorsal neural tube encompassing r6, and reduction of wnt

75 A Neurog2 dorsal neural tube enhancer localized 3' of the Neurog2

76 In contrast, a single discrete dorsal-neural tube enhancer was located in the 5' sequen

77 The remaining cells of the dorsal neural tube extend protrusions both medially and

78 Later, it is expressed in dorsal neural tube, eyes, and cephalic neural crest.

79 zed with confocal microscopy, shows that the dorsal neural tube gene xpax3 and the neural-crest-speci

80 Several dorsal neural tube genes were upregulated by alleviating

81 ploy Id genes at the neural plate border and dorsal neural tube in a manner similar to vertebrates.

82 l neural crest cells (CNCCs) emerge from the dorsal neural tube in a rostrocaudal manner and are spat

83 dorsal ectoderm may be less potent than the dorsal neural tube in inducing dermamyotome, it does non

84 us to map the origin of the neural crest and dorsal neural tube in the early avian embryo.

85 ignaling along the rostrocaudal axis, in the dorsal neural tube, in the notochord, and in the somites

86 'medial lip') to demonstrate that BMP in the dorsal neural tube indirectly induces formation of the m

87 the experimental perturbations in vivo, the dorsal neural tube induced dorsal structures from the me

88 Other TGF-beta ligands expressed in the dorsal neural tube interact with the Activin receptors,

89 in avian and murine embryos emerge from the dorsal neural tube into a migration staging area (MSA).

90 Third, if we graft pieces of dorsal neural tube into a ventral position between the n

91 Patterning of the dorsal neural tube involves Bmp signaling, which results

92 ssion in the lateral neural plate border and dorsal neural tube is a vertebrate novelty.

93 ased BMP signaling observed in the Noggin-/- dorsal neural tube is not sufficient to cause exencephal

94 The dorsal neural tube marker, Pax7, was maintained 12 h aft

95 rm of opl is able to induce neural crest and dorsal neural tube markers both in animal caps and whole

96 elopment, neural crest cells emerge from the dorsal neural tube, migrate into the periphery, and form

97 mesoderm is induced by Wnt signals from the dorsal neural tube, myogenesis in the cranial paraxial m

98 After leaving the dorsal neural tube NCC undergo extensive migration, prol

99 Expression in dorsal neural tube neurons is observed at later stages,

100 deficient for Wnt signaling, which patterns dorsal neural tube, nor did they develop in embryos defi

101 o ectopically express full-length Shh in the dorsal neural tube of transgenic mouse embryos commencin

102 salizing effects of the surface ectoderm and dorsal neural tube on somites.

103 We found that explants of dorsal neural tube or hindbrain roof plate chemorepelled

104 ithin the tail bud, and are not found in the dorsal neural tube or overlying epidermal ectoderm.

105 In contrast to dorsal neural tube, pieces of ventral neural tube, dorsa

106 lapse imaging, we find that neural crest and dorsal neural tube precursors are present in a broad, cr

107 organization movements, the neural crest and dorsal neural tube precursors become regionally segregat

108 aging studies show that the neural crest and dorsal neural tube precursors undergo choreographed move

109 ular, cadherin6B (Cad6B) is expressed in the dorsal neural tube prior to neural crest emigration but

110 evelopment, whereas the surface ectoderm and dorsal neural tube provide a dorsalizing signal(s) direc

111 le the dorsally located surface ectoderm and dorsal neural tube provide the dorsalizing signals to sp

112 ral crest cells and their progenitors in the dorsal neural tube, regions where the endogenous alpha1

113 n of several genes normally expressed in the dorsal neural tube (slug, Pax3, Msx1, FoxD3, cadherin 6B

114 s distribution of Rohon-Beard neurons in the dorsal neural tube, suggesting that the Delta-MAGI inter

115 controlled by antagonistic signals from the dorsal neural tube/surface ectoderm, mediated by WNTs, a

116 til embryonic day 9 and is restricted to the dorsal neural tube surrounding the source of BMP ligands

117 ing population of neuronal precursors in the dorsal neural tube that appear to give rise specifically

118 in the retention of Pax7+ precursors in the dorsal neural tube that fail to upregulate neural crest

119 ed during mid-gestation in the region of the dorsal neural tube that gives rise to migrating neural c

120 in multiple neuronal domains, including the dorsal neural tube, the EGL of the cerebellum and the ha

121 tebrate embryos, these cells emerge from the dorsal neural tube then migrate long distances to differ

122 In the dorsal neural tube, this coordination is achieved by the

123 Conversely, BMP-4 is expressed in the dorsal neural tube throughout the time when neural crest

124 ind that, although Wnts are expressed in the dorsal neural tube throughout the time when neural crest

125 cranial neural crest cells migrate from the dorsal neural tube to populate the forming face and phar

126 ntil stage 12 and that the competence of the dorsal neural tube to respond to this inductive signal d

127 lts show that the coordinated actions of the dorsal neural tube (via BMP and Wnts), the ventral neura

128 specification of neuronal cell types in the dorsal neural tube, we devised a genetic strategy to abl

129 dermomyotomal cells that lie adjacent to the dorsal neural tube, we have found that coculture of somi

130 Pax-3 is expressed in the dorsal neural tube, where the neural crest cells origina

131 t1(-/-) neural crest cell defects within the dorsal neural tube, which exhibits an expanded domain of

132 control by notochord and floor plate (Shh), dorsal neural tube (Wnt1) and surface ectoderm (Wnt1-lik