ライフサイエンスコーパス: dosage

1 .6%; P = .01 for 2.5 mg, <.001 for all other dosages).

2 rosuvastatin, 40 mg/d; submaximal: all other dosages).

3 aking, were investigated to identify optimal dosage.

4 ation rather than by the maintenance of gene dosage.

5 y folic acid, regardless of the total weekly dosage.

6 parameters such as mass, size, porosity, and dosage.

7 mation, and the safety of reducing treatment dosage.

8 agnitudes increase with increasing antigenic dosage.

9 e, which was corrected by reducing Fgf9 gene dosage.

10 s also greatly reduced when using 0.7% (w/w) dosage.

11 side effects and reduce required therapeutic dosage.

12 sults from slight perturbations in signaling dosage.

13 nd regulated by a balanced SOX17-BLIMP1 gene dosage.

14 ith reductions scaling monotonically with UV dosage.

15 53 are consistent across cell types and gene dosage.

16 ve in palm oil crystallization at 0.7% (w/w) dosage.

17 ow connectivity varies with OXTR risk-allele dosage.

18 ein extensively already with 10nkat/g enzyme dosage.

19 rk1a inhibitor or by normalizing Dyrk1a gene dosage.

20 e consistent with selection on relative gene dosage.

21 isogenic iPSC line with normalized SNCA gene dosage.

22 evels of aneuploidy with decreasing Tau gene dosage.

23 treatment in comparison to lower blue light dosages.

24 olyphenylene structures featuring low doping dosages.

25 ations of multiple molecules with controlled dosages.

26 gars equivalents/g after 24h when applied at dosages 0.15 and 0.3U/g.

27 n 2 patients admitted to increase dofetilide dosage (0% versus 6.7%; P=0.050).

28 characterized the effect of different ozone dosages (0-1.0 mg O3/mg dissolved organic carbon) and BA

29 ome extent with transglutaminase with higher dosages (100 and 1000nkat/g).

30 uccessful or produces side effects at higher dosages; (3) treatment should be continued for 6-12 mont

31 age of statins (80 mg) compared with a lower dosage (40 mg) (HR, 1.03; 95% CI, 0.59-1.80; P = .91).

32 CI, 10% to 21%) for those receiving moderate dosages, 9% (CI, 6% to 14%) for those receiving low dosa

33 This would allow fine-tuning the dosage according to the patient's metabolism, a key cond

34 le continuous manufacturing, while enhancing dosage accuracy.Traditional approaches used in the pharm

35 eceptor profile and, following a therapeutic dosage, activates phagocytosis and resolution signals in

36 de at the same dose as previously tolerated, dosage adjustments or discontinuation was frequent and s

37 some required insulin or other diabetes drug dosage adjustments.

38 o began a moderate- or high-intensity statin dosage after hospitalization for MI between 2007 and 201

39 and that increased and decreased shn-1 gene dosage alter L-channel current and activity-induced expr

40 given rise to highly variable Hodgkinia gene dosages among species.

41 which might require careful optimization of dosage and dosing schedules.

42 nerable to disruption of RNA-binding protein dosage and dynamics.

43 ciation between Brugada syndrome risk allele dosage and HEY2 expression (beta=+0.159; P=0.0036).

44 t groups (n = 6 rats per group) included low-dosage and high-dosage gadodiamide and osmolality-matche

45 mines the association between corticosteroid dosage and incidence rates of corticosteroid-related AEs

46 Performance parameters (time, pH, adsorbent dosage and initial ion concentrations) effecting the ads

47 development is beneficial, we studied Atoh1 dosage and modifications in Shh-type medulloblastoma.

48 s a positive association between risk-allele dosage and symptom severity, whereas neurotypical youth

49 in the catalytic activity with the catalytic dosage and the durability after the reusing cycles were

50 lps inform researchers of a reasonable daily dosage and type of statin to use when designing randomiz

51 ed polyphenylenes featuring different doping dosages and orientations.

52 point-of-care information required to adjust dosages and personalize the management of schizophrenia.

53 Different daily dosages and types of statins.

54 remains regarding optimal antibiotic choice, dosage, and length of prophylaxis.

55 , 9% (CI, 6% to 14%) for those receiving low dosages, and 8% (CI, 6% to 11%) for those receiving no o

56 interferon alpha 2b and ribavirin different dosages, and long-term treatment with ribavirin monother

57 an be optimized by adjusting daily radiation dosage as a function of the degree of hypoxia in the tum

58 ased fungal lethality to mosquitoes at spore dosages as low as one conidium per mosquito.

59 as a function of increased OXTR risk-allele dosage, as well as a positive association between risk-a

60 uce a method to form coatings, with accurate dosages, as well as a means of closely controlling disso

61 hibitory concentration of an antibiotic, the dosage at which bacterial growth is thwarted, provides a

62 At this dosage, AX addition in white bread holds both increased

63 hypothesized to stem from constraints on the dosage balance between the genes concerned and their int

64 lly retained duplicates are often subject to dosage balance constraints for prolonged evolutionary ti

65 ce than other gene families, suggesting that dosage balance sensitivity is a general characteristic o

66 elationship between reciprocal retention and dosage balance sensitivity remains fragmentary.

67 y skin prick tests and/or serum-specific IgE dosages; being able to deal with an unlikely event such

68 female mammalian cells to balance expression dosage between XX females and XY males.

69 Low dosage bFGF promotes cell proliferation while high dosag

70 o gamma-crystallin-positive lentoids by high-dosage bFGF treatment.

71 In contrast, low-dosage bFGF was unable to sustain those markers and, com

72 such as process sterilization or antibiotic dosage carry excess costs or encourage the development o

73 r domain of coordinated gene regulation: the dosage-compensated male X chromosome.

74 ermaphrodite X chromosomes during C. elegans dosage compensation and demonstrated H4K20me1's pivotal

75 NA sequence motifs shown to be important for dosage compensation complex (DCC) recruitment are themse

76 The structure and the activity of the dosage compensation complex (DCC) subunit DPY-21 define

77 specialized condensin forms the core of the dosage compensation complex (DCC), which specifically bi

78 one modification sequencing data and revisit dosage compensation evolution in representative mammals

79 fied so far to fully support Ohno's original dosage compensation hypothesis.

80 es male-specific lethal 2 (msl-2) to prevent dosage compensation in females.

81 Dosage compensation in some animals involves up-regulati

82 Sex chromosome dosage compensation is essential in most metazoans, but

83 asma initiates male killing by targeting the dosage compensation machinery directly and independently

84 orresponding small non-coding RNA, helps the dosage compensation machinery preferentially find X sequ

85 he convergent emergence of a Drosophila-like dosage compensation mechanism in an ancient reptilian se

86 X chromosome inactivation is an epigenetic dosage compensation mechanism in female mammals driven b

87 The green anole dosage compensation mechanism is highly reminiscent of t

88 The highly efficient dosage compensation mechanism of Anolis represents the o

89 to be male-biased, since there is no global dosage compensation mechanism that restores expression i

90 sh miRNA regulation as a novel gene-specific dosage compensation mechanism.

91 nce of pathways excluding specific loci from dosage compensation mechanisms.

92 Whether X dosage compensation occurs in germ cells is unclear.

93 a cell lines and yeast strains, suggest that dosage compensation of aneuploidy is not general but con

94 at is distinct from canonical sex chromosome dosage compensation or meiotic inactivation.

95 functionally exploring the two X chromosome dosage compensation processes in early human development

96 iously established a role for the C. elegans dosage compensation protein DPY-21 in the control of dau

97 Somatic X dosage compensation requires two mechanisms: X inactivat

98 Thus, germline X dosage compensation states are determined by X chromosom

99 These unexpected differences in X dosage compensation states between germline and soma off

100 romosome inactivation (XCI) is the mammalian dosage compensation strategy for balancing sex chromosom

101 , an important component of the X chromosome dosage compensation system in Drosophila, regulates gene

102 thyltransferase SET-4, which also influences dosage compensation, promotes dauer arrest in part by re

103 unclear how X chromosomes are specified for dosage compensation, since DNA sequence motifs shown to

104 in general are exempt from Rtt109-dependent dosage compensation, suggesting the existence of pathway

105 rimary role in determining X identity during dosage compensation.

106 are therefore cis-acting elements that guide dosage compensation.

107 le X chromosome of males, a process known as dosage compensation.

108 nition elements (MREs) that are critical for dosage compensation.

109 Moreover, the system's dosage control and multi-molecular delivery capabilities

110 into various cell types at low voltage in a dosage-controlled manner.

111 sely, in males, erasure leads to permanent X dosage decompensation.

112 , while XO females, like XY males, develop X dosage decompensation.

113 ined deintensification as discontinuation or dosage decrease of at least 1 glycemic medication withou

114 Both FAc dosages demonstrated statistically significant improveme

115 Furthermore, varying foraging gene dosage demonstrates a linear dose-response on these phen

116 is, showed that the spch-5 leaf phenotype is dosage dependent and results from the decreased ability

117 t its transcriptional activation resulted in dosage-dependent activation of four neighbouring protein

118 We found dosage-dependent activation of immediate early genes aft

119 Mouse plasma PIP2 levels are apoA1 gene dosage-dependent and are >1 muM in apoA1 transgenic mice

120 rkably, this dominant repressive activity is dosage-dependent and causes strong developmental perturb

121 rowth defect of the sec3-913 strain was gene dosage-dependent and suppressed by blocking the proteaso

122 tide reductions were significant vs placebo (dosage-dependent estimated treatment difference [ETD] ra

123 glutide dosages of 10 mg or more vs placebo (dosage-dependent ETD range, -0.9 to -5.7 kg; P < .001).

124 An irradiation dosage-dependent formation of 2-ACBs was also observed i

125 e show that Crkl mutant embryos exhibit gene dosage-dependent growth restriction, and homozygous muta

126 d inactivation of the Tpm4 locus led to gene dosage-dependent macrothrombocytopenia in mice.

127 nteracted by the cochaperone Hsp40-Sis1 in a dosage-dependent manner, and show that the effect of Cur

128 ffectors YAP and TAZ are required, in a gene dosage-dependent manner, for the proliferation and migra

129 In a dosage-dependent manner, mice lacking Wdr47 showed letha

130 These mice exhibit an Ank3 gene dosage-dependent phenotype including behavior changes mo

131 to week 26 decreased with oral semaglutide (dosage-dependent range, -0.7% to -1.9%) and subcutaneous

132 y weight were greater with oral semaglutide (dosage-dependent range, -2.1 kg to -6.9 kg) and subcutan

133 ariant is associated with a specific, allele-dosage-dependent reduction in the expression of IGF2 iso

134 py number gains in E2f1 or E2f3b resulted in dosage-dependent spontaneous HCC in mice without the inv

135 erest in recent times, particularly for drug dosage development.

136 ity in study design, supplement formulation, dosage, duration, and subject population.

137 We conclude that dosage effect is the predominant regulatory response for

138 inimal to no iron loading, suggesting a gene dosage effect.

139 x differences are caused by extragonadal and dosage effects of genes encoded on sex chromosomes.

140 relevant to WRI1, complementary non-allelic dosage effects of the GmLEC1a/GmLEC1b homoeologous pair

141 we conducted the first study of 22q11.2 gene dosage effects on brain structure in a sample of 143 hum

142 lipoproteins significantly increases peptide dosage efficacy.

143 rently tested in a phase 1/2a first-in-human dosage escalation trial for patients with relapsed CD37+

144 -3.26; 95% CI: -5.51, -1.01).The use of FAS dosages exceeding the UL (>/=1000 mug/d) during the peri

145 state: XX males, like XX females, develop X dosage excess, while XO females, like XY males, develop

146 re follows loss of X inactivation, causing X dosage excess.

147 Phase 2, randomized, parallel-group, dosage-finding, 26-week trial with 5-week follow-up at 1

148 mportance of maintenance of a suitable SIRT1 dosage for metabolic and tissue homeostasis, which will

149 wettability must be considered in practical dosage form design.

150 inistered drugs is a critical factor guiding dosage form selection in drug development.

151 drugs in a children-friendly, flexible solid dosage form.

152 to satisfy regulatory requirements for nasal dosage forms and the polymer nanoparticles alone were fo

153 velopments are crucial to meet demands where dosage forms cannot be manufactured rapidly or when a pe

154 e provides an exciting opportunity to tailor dosage forms in a single-step with minimal excipients an

155 Conventional immediate release dosage forms involve compressing the powder with a disin

156 inkjet printing to produce drug loaded solid dosage forms is demonstrated using a naturally derived F

157 Release of antibiotic from PCL-PVP dosage forms was shown over 5 days and was slower compar

158 sodium (EC-MPS) and sirolimus (SRL) in oral dosage forms was well-preserved.

159 ion in spiked human serum and pharmaceutical dosage forms with acceptable recovery values.

160 ms present which result in poor retention of dosage forms, and the potential for irritation and other

161 rt channels can be adopted in the designs of dosage forms, implants or stents to enhance the release

162 However, these dosage forms, in particular, are poorly retained and tra

163 lternative to conventional immediate-release dosage forms.

164 considerable potential for patient-specific dosage forms.

165 justing for drug shortages, market size, and dosage forms.

166 The bioavailability of carotenoid from oral dosage formulations depends on their release, dissolutio

167 rats per group) included low-dosage and high-dosage gadodiamide and osmolality-matched saline control

168 s [iTaukei]) in Fiji were recruited for each dosage groups.

169 The use of FAS dosages >/=1000 mug/d during pregnancy should be monitor

170 The use of FAS dosages >/=1000 mug/d in this period was negatively asso

171 d, one-third of the women (n = 502) took FAS dosages >/=1000 mug/d.

172 flecainide or placebo twice daily, with the dosage guided by trough serum levels.

173 -dosage inhaled corticosteroids (ICS) or low-dosage ICS plus long-acting beta2 agonist fixed-combinat

174 However, the degree of X-autosomal dosage imbalance was less than anticipated (1.14-fold to

175 A reduction of Hand2 and Shh gene dosage improves the integrity of anterior limb structure

176 ire duration of the study using the approved dosages in the patients' respective countries and random

177 ly in parallel in this process, although OPS dosage increase mends defects caused by brx loss-of-func

178 as more influenced by lower (16%) blue light dosage, increasing about 1.3 times.

179 bFGF promotes cell proliferation while high dosage induces differentiation.

180 st have been receiving either low- to medium-dosage inhaled corticosteroids (ICS) or low-dosage ICS p

181 RIP limits radiation dosage, interrupts treatment, and lowers patients' quali

182 proach depends on delivering the proper cell dosage into the target region of the airway, tracking an

183 The resulting imbalance in gene dosage is corrected by increased expression from the sin

184 Bim gene dosage is critical in modulating nephron progenitor surv

185 mologous recombination, indicating that BAP1 dosage is critical.

186 cal investigations showed that as the doping dosage is increased, the strong luminescent signal is pr

187 Consistent with the hypothesis that LAT dosage is relevant to the CNV pathology, we observed sim

188 In planta, increasing NEDD8 gene dosage is sufficient to suppress den1 mutant phenotypes.

189 Alterations in alpha-synuclein dosage lead to familial Parkinson's disease (PD), and it

190 A significant correlation between the dosage level and tumor-absorbed dose was found.

191 a correlation between tumor dose and patient dosage level was found.

192 y, with a median of 264 cGy across different dosage levels and different predosing.

193 High-dosage/long-duration exposure induces more complete EMT,

194 Low dosages (</=1.37 g of alcohol/day) of alcohol consumptio

195 s indicate that IgH isotype-specific mIg/BCR dosage may play a larger role in B cell fate than previo

196 nd can accommodate imputed genotypes under a dosage model.

197 by modelling time to event outcomes under a dosage model.

198 that arise from BETi therapy by reducing the dosage necessary for treatment.Significance: This study

199 le intra-tracheal instillation at a very low dosage of 0.1 mg/kg.

200 An optimum dosage of 0.8% with 2.5% flour removal maintained simila

201 with low-dose naltrexone hydrochloride at a dosage of 1.5 to 3.0 mg per day.

202 Oral fluconazole at a dosage of 6.5-8 mg/kg/d for 28 days should not be consid

203 esults in the failure to regulate transcript dosage of a cohort of genes during oocyte maturation, wi

204 y the addition of a new class or increase in dosage of a current class.

205 ing the patient's treatment to an equivalent dosage of a dopamine agonist that can be administered on

206 ing the patient's treatment to an equivalent dosage of a dopamine agonist that can be administered on

207 Here, we manipulate the gene dosage of a signaling molecule, Fgf8, a critical regulat

208 to placebo-plus-diet or maximally tolerated dosage of acetazolamide-plus-diet.

209 Preconcentration optimizations including pH, dosage of adsorbent, adsorption-desorption time, concent

210 Several studies evaluated the optimal dosage of atropine with regard to myopic progression, re

211 tral genes through selection to maintain the dosage of broadly expressed regulators of key cellular p

212 proposed to drive disease by modulating the dosage of cancer driver genes and by promoting cancer ge

213 e our in vitro studies emphasize that a high dosage of CLI is essential.

214 The optimal dosage of cryotherapy during cryoballoon ablation of pul

215 openia, which can be rescued by reducing the dosage of Gli3.

216 A once-daily dosage of ledipasvir/sofosbuvir was similarly effective

217 ly and non-invasively control the timing and dosage of local anesthesia according to their needs woul

218 tpatient study evaluated a 25- and a 50-mg/d dosage of opicapone in a randomized, double-blind, 14- t

219 that results in an extra copy and increased dosage of peripheral myelin protein 22 (PMP22).

220 ve effect associated with taking the highest dosage of statins (80 mg) compared with a lower dosage (

221 cuity, central retinal thickness, number and dosage of systemic immunosuppression drugs, vitreous haz

222 rmed for each phenotype, dependent on allele dosage of the variant.

223 death of the host, depending on the initial dosage of the virus.

224 However, the optimal dosage of these interventions is currently unknown.

225 ticosteroids, especially when the cumulative dosage of topical corticosteroids throughout the pregnan

226 riptome acquires the appropriate content and dosage of transcripts is not fully understood.

227 we report the role of ASD-related increased dosage of Ube3A/E6AP in dendritic arborization during br

228 Results suggest that hormetic dosage of ultrasound treatment can enhance the activity

229 d (1:1:1:1) to receive either GBS vaccine at dosages of 0.5, 2.5, or 5.0 mug of each of 3 CRM197-glyc

230 s were added to 100g white bread formulae at dosages of 0.8-1.2% with flour removal of 2-3%(w/w).

231 .2 kg), and significant for oral semaglutide dosages of 10 mg or more vs placebo (dosage-dependent ET

232 eous nucleation compared to those with lower dosages of additive.

233 r I or II disorder who were receiving stable dosages of antimanic medication (excluding patients with

234 Lower dosages of atropine (0.5%, 0.1%, and 0.01%) were found t

235 Adult patients were treated with escalating dosages of BGJ398 5 to 150 mg once daily or 50 mg twice

236 mine the association between the use of high dosages of FASs during pregnancy and child neuropsycholo

237 ong-term effects of the maternal use of high dosages of FASs that exceed the Tolerable Upper Intake L

238 on, we infected HCE cells at three different dosages of HSV-1 and measured the outcomes in terms of v

239 e the efficacy and safety of 25- and 50-mg/d dosages of opicapone compared with placebo as adjunct to

240 CI, 14% to 20%) for patients receiving high dosages of opioids after the index overdose, 15% (CI, 10

241 METHOD: Three dosages of rat islets, that is, 400, 800, and 1200, were

242 Herein, we demonstrated that the same dosages of SERMs which induced cholesterol accumulation

243 ylenes featuring controlled orientations and dosages of the doping B3N3 rings have been prepared.

244 l recommendations include: (1) low to modest dosages of tricyclic antidepressants provide the most co

245 rant type of autism linked to increased gene dosages of UBE3A, which encodes a ubiquitin ligase with

246 hy older adult subjects for 4 wk at climbing dosages of, on average, 9.2, 22.5, 46.3 and 91 mg . d(-1

247 ections with more widespread effects of gene dosage on cortical surface area.

248 eveloping OAG and how it varied by the daily dosage or type of statin and whether any protective effe

249 sk of glaucoma varies depending on the daily dosage or type of statin taken.

250 ld be helpful to know whether specific daily dosages or types of statin confer a greater protective e

251 31; 95% CI: 0.19 to 0.51), lower epinephrine dosage (OR: 0.47; 95% CI: 0.25 to 0.87), and pulmonary e

252 d to compare the efficacy and safety of high-dosage oral fluconazole (6.5-8.0 mg/kg/d for 28 days) ve

253 Trusted decadal forecasts of UV dosage over the United States in summer require understa

254 or its suppression play a role in generating dosage phenotypes.

255 The new time-to-effect-based cryotherapy dosage protocol led to shorter cryotherapy and procedure

256 ased water absorption by 2% in the specified dosage range.

257 Thus, increased gene dosage rather than specificity divergence of the CELA3 i

258 al studies have examined the efficacy of low dosage red light exposure for cellular repair and increa

259 utionary pressures imposed by sex chromosome dosage reductions in different amniotes were resolved in

260 to moderate AD, however, with limitations on dosage regime.

261 experimental designs, such as time series or dosage response experiments.

262 to determine if expression patterns and gene dosage responses at the level of transcription are consi

263 children to provide evidence for the optimal dosage, safety, and efficacy of AIT vaccines using subcu

264 In our analysis, we used multiple dosage schedules and incorporated interactions among can

265 rosis (ALS) in mouse it is clear that FUS is dosage-sensitive and effects arise from overexpression p

266 lecting the functional contribution of other dosage-sensitive genes besides PLP1.

267 miR-2954-3p, shows conserved preference for dosage-sensitive genes on the Z Chromosome, based on com

268 ing of candidate kinases reveals a specific, dosage-sensitive interaction between Nuf and Polo with r

269 GATA6 haploinsufficiency, we also identified dosage-sensitive requirements for GATA6 and GATA4 in the

270 tory constraint, possibly reflecting greater dosage sensitivity of body-methylated genes.

271 nique small RNA transcripts in the segmental dosage series we tested.

272 Both telotristat ethyl dosages significantly reduced mean urinary 5-hydroxyindo

273 tients who were prescribed standard starting dosage sorafenib (800 mg/d per os) versus that of patien

274 y abnormal models exhibit a "sex-reversed" X dosage state: XX males, like XX females, develop X dosag

275 and human germ cells exhibit non-canonical X dosage states that differ from the soma and between the

276 Increased DYRK1A gene dosage, such as occurs in Down syndrome, is known to aff

277 Information on prescribed drugs, drug dosage, supply days, and numbers of dispensed pills was

278 Dosage suppression of essential genes encoding RNA polym

279 c robustness in budding yeast by genome wide dosage suppressor analysis of 53 conditional lethal muta

280 (SVM) and a new score the normalized allele dosage test to identify high quality variants from micro

281 tion were observed even at the minimum viral dosage tested, while a more pronounced dose-restricted i

282 Deutetrabenazine administration at a dosage thought to provide comparable systemic exposure t

283 n catalyze medical translation, we show that dosage time can temporally segregate efficacy from dose-

284 trol parameters for regulating the radiation dosage to achieve effective UVC protection.

285 predict outcomes and perhaps personalize RT dosage to improve survival.Significance: Radiotherapy ap

286 ntal disease diagnoses due to less radiation dosage to the patient, higher spatial resolution, and sh

287 and timing of PPI doses), or increasing PPI dosage to twice daily in select circumstances, can reduc

288 nolic apple and rosemary extracts at various dosages to a diluted purple sweet potato concentrate at

289 Low dosage treatment with the pBtk inhibitor Ibrutinib rever

290 dent film irradiation with either UVA or UVB dosages upwards of 80 J/cm(2) both reduce UV transmittan

291 In contrast, gene dosage varied negatively with mean cortical thickness (d

292 22q11.2 gene dosage varied positively with intracranial volume, gray

293 The target asenapine dosage was 10 mg b.i.d. in the open-label period but cou

294 In contrast, genetic IGF-1R dosage was effective only in females, where it also indu

295 RC risk haplotype and local African ancestry dosage was identified in locus 2q14 (p = 0.03).

296 tolerated dose and 2 at a lower dose; prior dosage was unknown in 4 patients.

297 e initiation of sorafenib therapy at reduced dosages was associated with reduced pill burden, reduced

298 e, at 2 and 4 wk during, and 2 wk after each dosage, we studied a complete panel of biochemical blood

299 ult ICU patients receiving VPI at submaximal dosages, we analyzed characteristics of sustained hypote

300 age at onset of schizophrenia or medication dosage were detected.

301 on patient weights, height, gender, and HCQ dosage were extracted from the EMR.

302 the controller to modulate the drug delivery dosage within a therapeutically effective range, while i