ライフサイエンスコーパス: dosage compensation

1 uilibrate gene expression between the sexes (dosage compensation).

2 entire chromosomes (for example X-chromosome dosage compensation).

3 es die due to excessive, rather than lack of dosage compensation.

4 mic for the X chromosome, but survive due to dosage compensation.

5 gnition elements, the critical first step in dosage compensation.

6 the spreading model in the establishment of dosage compensation.

7 romosome arms in Drosophila miranda acquired dosage compensation.

8 data fails to support the authors' model for dosage compensation.

9 various subunits of the complex in mediating dosage compensation.

10 r somatic sex determination and X-chromosome dosage compensation.

11 the distinctive lack of avian sex chromosome dosage compensation.

12 suggest a role for this remodeling factor in dosage compensation.

13 es but males have a single X, thus requiring dosage compensation.

14 he male-specific lethal complex that affects dosage compensation.

15 oviding a potential mechanism for expression dosage compensation.

16 he majority of X-linked genes are subject to dosage compensation.

17 ransposons, and mechanisms of sex chromosome dosage compensation.

18 network structure facilitates network-level dosage compensation.

19 y regulated as well as in the degree of gene dosage compensation.

20 nation of the evolutionary forces underlying dosage compensation.

21 the Y chromosome does not appreciably affect dosage compensation.

22 evealing a germ line imprint that influences dosage compensation.

23 rimary role in determining X identity during dosage compensation.

24 use they are already hypertranscribed due to dosage compensation.

25 ion along hermaphrodite X chromosomes during dosage compensation.

26 and autosomal gene regulation independent of dosage compensation.

27 nce-mediated transcriptional repression, and dosage compensation.

28 have provided an ancestral form of mammalian dosage compensation.

29 ment, where it performs an essential role in dosage compensation.

30 n activator of hermaphrodite development and dosage compensation.

31 screen to identify new factors required for dosage compensation.

32 are therefore cis-acting elements that guide dosage compensation.

33 le X chromosome of males, a process known as dosage compensation.

34 develop to term in spite of a deficiency of dosage compensation.

35 e copy to be active diminishes, resulting in dosage compensation.

36 he MHM region is not consistent with nascent dosage compensation.

37 of RBP9, providing a maternal fail-safe for dosage compensation.

38 has been suggested to be a region of nascent dosage compensation.

39 plays a major role in shaping sex chromosome dosage compensation.

40 less complete evolution of Z compared with X dosage compensation.

41 09, by amplifying a causal gene that escapes dosage compensation.

42 heterozygous gene inactivation is not due to dosage compensation.

43 sed silencing of an entire chromosome during dosage compensation.

44 h their DNA copy number, with no evidence of dosage compensation.

45 nition elements (MREs) that are critical for dosage compensation.

46 ing a minimal RNA domain for chromosome-wide dosage compensation.

47 atin and are hypertranscribed as a result of dosage compensation.

48 d to ameliorate the effects of partial early dosage compensation.

49 mosomes in rattlesnakes lack chromosome-wide dosage compensation.

50 ream effectors of sexual differentiation and dosage compensation [1, 4].

51 ulates transcriptional elongation to control dosage compensation, a model subsequently supported by m

52 the expression of qrr, rather than removing dosage compensation, abolishes Qrr redundancy in V. chol

53 Gene dosage compensation adjusts the total Qrr1-4 sRNA pool a

54 Furthermore, the process of dosage compensation affects expression of the very XSEs

55 bursts reveals a separate mechanism for gene dosage compensation after DNA replication that enables p

56 use it lacks a specialized region of greater dosage compensation along the Z chromosome, and shows ot

57 rall, there were no neighborhoods of overall dosage compensation along the Z.

58 , sex chromosome-specific processes, such as dosage compensation, also may influence sex-biased gene

59 or histone H4 chromatin modification in worm dosage compensation analogous to those seen in flies, us

60 data suggest Xist-independent mechanisms of dosage compensation and demonstrate that small deviation

61 ermaphrodite X chromosomes during C. elegans dosage compensation and demonstrated H4K20me1's pivotal

62 nsuring synchronization between X chromosome dosage compensation and development.

63 ets of the ever-expanding field of mammalian dosage compensation and discuss its evolutionary, develo

64 tested RNA from these repeats for a role in dosage compensation and found that ectopic expression of

65 olution of the genome as it shows incomplete dosage compensation and is also present twice as often i

66 es of binding: one in males for X chromosome dosage compensation and the other in both sexes for X ch

67 form three complexes, one that functions in dosage compensation and two that function in mitosis and

68 The neo-X has evolved partial dosage compensation and we find that diverse mutational

69 bias of autosomal versus Z chromosome genes, dosage compensation, and evolution of sex bias.

70 printing, transposon silencing, X chromosome dosage compensation, and genome stability.

71 the result of pressures from X inactivation, dosage compensation, and sexual antagonism.

72 Thus, X is broadly permissive for dosage compensation, and the DCC acts via a chromosome-w

73 uences gene expression, quantitative traits, dosage compensation, aneuploid syndromes, population dyn

74 osage compensation evolves, and why complete dosage compensation appears to be limited to male hetero

75 , background selection, and the emergence of dosage compensation are expected to accelerate the proce

76 Genes subject to dosage compensation are under higher expression constrai

77 ibing lncRNA functions and discuss mammalian dosage compensation as a classic example of an lncRNA ne

78 Here we show that a different mechanism of dosage compensation, at the level of gene copy number, c

79 ear to lack a Z chromosome-wide mechanism of dosage compensation, because both have a similar pattern

80 p of IP metabolism in yeast and evidence for dosage compensation between IPs and PP-IPs downstream of

81 nvolving the sRNA-target HapR, promotes gene dosage compensation between the four qrr genes.

82 anscriptionally silenced in order to achieve dosage compensation between the genders in a process cal

83 e) is responsible for mammalian X-chromosome dosage compensation between the sexes, the process by wh

84 In mammals, dosage compensation between XX and XY individuals occurs

85 n turns off one female X chromosome to enact dosage compensation between XX and XY individuals.

86 Our work presents a model in which dosage compensation buffers gene amplification through a

87 igated the function of MLE in the process of dosage compensation by generating mutations that separat

88 We assess the functional output of early dosage compensation by measuring the expression of even-

89 er, we can explain growth-related effects in dosage compensation by paralogs and predict host-circuit

90 hal (MSL) ribonucleoprotein complex mediates dosage compensation by upregulating transcription from t

91 Thus, partial dosage compensation can be achieved without Xist, suppor

92 pical gene-specific controls may explain how dosage compensation can be imposed on the diverse set of

93 network motif that is essential for network-dosage compensation can reduce the effects of extrinsic

94 aster and D. simulans is due to a failure in dosage compensation, caused by incompatibilities between

95 The C. elegans dosage compensation complex (DCC) associates with both X

96 However, proximity of a dosage compensation complex (DCC) binding site (rex site

97 In Caenorhabditis elegans, the dosage compensation complex (DCC) binds both X chromosom

98 The ribonucleoprotein dosage compensation complex (DCC) binds hundreds of site

99 define a role for the Caenorhabditis elegans dosage compensation complex (DCC) in the regulation of D

100 elegans dosage compensation in which a large dosage compensation complex (DCC) is targeted to both X

101 In many species, a dosage compensation complex (DCC) is targeted to X chrom

102 In Caenorhabditis elegans, the dosage compensation complex (DCC) localizes to both X ch

103 In Drosophila, the dosage compensation complex (DCC) mediates the twofold h

104 NA sequence motifs shown to be important for dosage compensation complex (DCC) recruitment are themse

105 The structure and the activity of the dosage compensation complex (DCC) subunit DPY-21 define

106 ans XO males and XX hermaphrodites through a dosage compensation complex (DCC) that is homologous to

107 -21 functions canonically in the ten-protein dosage compensation complex (DCC) to downregulate the ex

108 The dosage compensation complex (DCC), a condensin complex,

109 tion of the X chromosome is dependent on the dosage compensation complex (DCC), suggesting that the t

110 We found that the dosage compensation complex (DCC), which acetylates X ch

111 specialized condensin forms the core of the dosage compensation complex (DCC), which specifically bi

112 rhabditis elegans by hermaphrodite-specific, dosage compensation complex (DCC)-mediated, 2-fold X chr

113 tein SDC-3, two components of the C. elegans dosage compensation complex (DCC).

114 ts from two known condensins: the C. elegans dosage compensation complex and mitotic condensin II.

115 ates histone H4 at Lys-16 and is part of the dosage compensation complex in Drosophila.

116 The Drosophila male-specific lethal (MSL) dosage compensation complex increases transcript levels

117 In the soma, DPY-28 associates with the dosage compensation complex on hermaphrodite X chromosom

118 y, the genomic regions being targeted by the dosage compensation complex on the neo-X and those becom

119 dozen novel binding consensus motifs for the dosage compensation complex on the neo-X, including simp

120 ctional but suboptimal binding sites for the dosage compensation complex to a newly formed X chromoso

121 21-bp consensus motif for recruitment of the dosage compensation complex, yet utilizing a diverse arr

122 s evolutionarily conserved in the Drosophila dosage compensation complex.

123 atically to increase binding affinity to the dosage compensation complex.

124 ion machinery and suggests that misregulated dosage compensation could contribute to male hybrid invi

125 Dosage compensation (DC) equalizes X-linked gene express

126 Here, we show that dosage compensation (DC) in Drosophila may contribute su

127 nalyze the essential process of X-chromosome dosage compensation (DC) to elucidate mechanisms that co

128 for the MSL protein Maleless, explaining the dosage compensation defect.

129 ase II (Pol II) genome-wide in wild-type and dosage-compensation-defective animals to dissect this re

130 Remarkably, strategies for dosage compensation differ between species.

131 dicate that the MSL complex does not mediate dosage compensation directly, but rather its activity ov

132 ur results also suggest that chromosome-wide dosage compensation does not occur in this plant.

133 Thus, dosage compensation enhances dauer arrest by repressing

134 X-chromosome gene regulatory process called dosage compensation ensures that males (1X) and females

135 In organisms with sex chromosomes, dosage compensation equalizes gene expression between th

136 The essential process of dosage compensation equalizes X-chromosome gene expressi

137 Dosage compensation equalizes X-linked gene expression b

138 Dosage compensation equalizes X-linked gene products bet

139 one modification sequencing data and revisit dosage compensation evolution in representative mammals

140 nes are likely to be dosage compensated, how dosage compensation evolves, and why complete dosage com

141 on the first) was initially discovered as a dosage compensation factor that regulates the epigenetic

142 ted that birds lack a mechanism of wholesale dosage compensation for the Z sex chromosome.

143 A mechanism of dosage compensation, for which we recently found evidenc

144 the affected chromosomes, to show that gene-dosage compensation functions at >30% of amplified genes

145 mutations in four essential D. melanogaster dosage compensation genes are shown here to moderately i

146 Dosage compensation has arisen in response to the evolut

147 Transcriptome analysis shows that dosage compensation has evolved multiple times in flies,

148 Complete sex chromosome dosage compensation has more often been observed in XY t

149 We use our model to test the dosage compensation hypothesis and show that decreasing

150 fied so far to fully support Ohno's original dosage compensation hypothesis.

151 Recent studies of dosage compensation, imprinting, and homeotic gene expre

152 for these RNA molecules, which have roles in dosage compensation, imprinting, enhancer function, and

153 ablish a specific postembryonic function for dosage compensation in any organism.

154 ism established through the lack of global Z dosage compensation in birds.

155 Our data suggest that the mechanism of dosage compensation in C. elegans involves redistributio

156 uring differentiation, resulting in complete dosage compensation in differentiated cell types.

157 Dosage compensation in Drosophila is mediated by a histo

158 ired for the regulation of X chromosome gene dosage compensation in Drosophila males.

159 Dosage compensation in Drosophila melanogaster males is

160 X-chromosome dosage compensation in Drosophila requires the male-spec

161 less expression, there is partial autosomal dosage compensation in Drosophila, which may be mediated

162 port 5' recruitment as the key mechanism for dosage compensation in Drosophila.

163 ng of roX2, a well-studied ncRNA involved in dosage compensation in Drosophila.

164 locus, suggesting an alternative process of dosage compensation in females.

165 es male-specific lethal 2 (msl-2) to prevent dosage compensation in females.

166 en searching for novel factors that regulate dosage compensation in flies.

167 nucleosomes in vitro and its involvement in dosage compensation in flies.

168 mmunication, synchronization, and chromosome dosage compensation in haploid cells.

169 ale specific lethal (MSL) complex to achieve dosage compensation in males.

170 This review focuses on dosage compensation in mammals, with comparisons to frui

171 is an untranslated RNA that is required for dosage compensation in mammals.

172 tors are involved in the fine tuning of gene dosage compensation in neutrophils.

173 rade-offs between sex-specific selection and dosage compensation in shaping the evolution of the geno

174 28 controls two such processes, X-chromosome dosage compensation in somatic cells and meiotic crossov

175 Dosage compensation in some animals involves up-regulati

176 f ways, ranging from complete sex chromosome dosage compensation in some species to active compensati

177 The predominant response of genes on 2L was dosage compensation in that similar expression occurred

178 th, we find that, as predicted by the model, dosage compensation in the chicken is most pronounced in

179 (MSL) HAT complex, which plays a key role in dosage compensation in the fly and is responsible for a

180 romosome, and this can lead to selection for dosage compensation in the heterogametic sex to rebalanc

181 6-fold higher in males, reflecting a lack of dosage compensation in the homogametic sex.

182 orms of regulation, including sex chromosome dosage compensation in the soma and meiotic sex chromoso

183 oters may bear on mechanisms of X chromosome dosage compensation in the soma, and chromosome-wide rep

184 de gene regulation is Caenorhabditis elegans dosage compensation in which a large dosage compensation

185 X-chromosome inactivation is a mechanism of dosage compensation in which one of the two X chromosome

186 Our study explains the pattern of weak dosage compensation in ZW systems, and suggests that sex

187 In marsupials, dosage compensation involves silencing of the father's X

188 This result suggested that dosage compensation is a target of Spiroplasma.

189 In Drosophila dosage compensation is achieved by increasing expression

190 In mammals, dosage compensation is achieved by X-chromosome inactiva

191 Dosage compensation is achieved in male Drosophila by a

192 Sex chromosome dosage compensation is essential in most metazoans, but

193 Although much is known about how dosage compensation is established, the consequences of

194 patterning to gt dose, indicating that early dosage compensation is functionally incomplete.

195 enitor cell maintenance, we demonstrate that dosage compensation is indispensable for the maintenance

196 embryogenesis, an essential process known as dosage compensation is initiated to equalize gene expres

197 strulation; whether it results in functional dosage compensation is not known.

198 Taken together, this suggests that dosage compensation is regulated on the Z chromosome ent

199 ses over time, indicating that selection for dosage compensation is relatively less important than ma

200 er the MSL complex or MOF histone acetylase, dosage compensation is retained but autosomal expression

201 The basic determinant of dosage compensation is suggested to be an inverse dosage

202 Dosage compensation is the crucial process that equalize

203 current hypothesis in the literature is that dosage compensation is the mechanism underlying redundan

204 The regulatory mechanism of dosage compensation is the paramount example of epigenet

205 ent cases underlying Qrr redundancy and that dosage compensation is unnecessary and insufficient to e

206 gulation of X-linked gene expression, termed dosage compensation, is required for the normal developm

207 lications of the diversity in sex chromosome dosage compensation, its realization has created excitin

208 lution among DNA-protein interactions of the dosage compensation machinery and suggests that misregul

209 asma initiates male killing by targeting the dosage compensation machinery directly and independently

210 uts and signaling outputs, suggests that the dosage compensation machinery may respond to external cu

211 orresponding small non-coding RNA, helps the dosage compensation machinery preferentially find X sequ

212 and autosomes does not depend on the somatic dosage compensation machinery.

213 MSL genes further suggests that misregulated dosage compensation may represent one of the underlying

214 he convergent emergence of a Drosophila-like dosage compensation mechanism in an ancient reptilian se

215 a consequence of constraints imposed by the dosage compensation mechanism in Drosophila.

216 X chromosome inactivation is an epigenetic dosage compensation mechanism in female mammals driven b

217 The dosage compensation mechanism is exquisitely sensitive t

218 The green anole dosage compensation mechanism is highly reminiscent of t

219 The highly efficient dosage compensation mechanism of Anolis represents the o

220 to be male-biased, since there is no global dosage compensation mechanism that restores expression i

221 sh miRNA regulation as a novel gene-specific dosage compensation mechanism.

222 of X chromosome inactivation, the mammalian dosage compensation mechanism.

223 It has been proposed that XCI is a dosage-compensation mechanism that evolved to equalize e

224 o X chromosomes is inactivated, serving as a dosage-compensation mechanism to equalize the expression

225 support Ohno's hypothesis that XCI acts as a dosage-compensation mechanism, and allow us to refine Oh

226 Dosage compensation mechanisms evolved to restore balanc

227 r with respect to their sex chromosomes, and dosage compensation mechanisms have evolved to equalize

228 Dosage compensation mechanisms provide a paradigm to stu

229 ergence between the sex chromosomes leads to dosage compensation mechanisms to restore balanced expre

230 nce of pathways excluding specific loci from dosage compensation mechanisms.

231 e, our results argue against an X-chromosome dosage compensation model contingent upon rex-directed p

232 Dosage compensation modifies the chromatin of X-linked g

233 The biochemical mechanisms used for dosage compensation must function over a wide dynamic ra

234 Dosage compensation not only corrects the imbalance in t

235 Whether X dosage compensation occurs in germ cells is unclear.

236 We conclude that widespread dosage compensation occurs neither in laboratory strains

237 a cell lines and yeast strains, suggest that dosage compensation of aneuploidy is not general but con

238 Thus, thiol peroxidase deficiency requires dosage compensation of CCP1 and UTH1 via chromosome XI a

239 and roX2 RNAs are functionally redundant for dosage compensation of the Drosophila melanogaster male

240 riched on the X, relative to females, due to dosage compensation of the hemizygous X.

241 discuss post-transcriptional regulation and dosage compensation of the histone genes.

242 ssures driving heterochromatin formation and dosage compensation of the recently formed neo-sex chrom

243 of the roX lncRNAs, which are essential for dosage compensation of the single X chromosome in Drosop

244 of a GAL4-MSL2 fusion protein does not cause dosage compensation of X and autosomal reporters in fema

245 Because alterations in dosage compensation of X-linked genes could impair somat

246 tivation (XCI) is an essential mechanism for dosage compensation of X-linked genes in female cells.

247 In eutherian mammals, dosage compensation of X-linked genes is achieved by X c

248 The influence of dosage compensation on dauer arrest, a larval developmen

249 of genes and their silencing on the neo-Y or dosage compensation on the neo-X.

250 During mammalian dosage compensation, one of two X-chromosomes in female

251 g to chromosome-specific adaptations such as dosage compensation or an accumulation of sex-specific m

252 at is distinct from canonical sex chromosome dosage compensation or meiotic inactivation.

253 viously shown that mutations in genes of the dosage compensation pathway of Drosophila melanogaster s

254 type of dpy-21 mutants is due to a defect in dosage compensation per se.

255 consequences of modulating the stability of dosage compensation postembryonically are not known.

256 Some genes escape dosage compensation, potentially resulting in sex-specif

257 functionally exploring the two X chromosome dosage compensation processes in early human development

258 thyltransferase SET-4, which also influences dosage compensation, promotes dauer arrest in part by re

259 iously established a role for the C. elegans dosage compensation protein DPY-21 in the control of dau

260 sed by incompatibilities between D. simulans dosage compensation proteins and the D. melanogaster X c

261 red for the chromosome-specific targeting of dosage compensation, providing new insights into how sub

262 Absent or partial early dosage compensation raises the possibility of sex-biased

263 Dosage compensation refers to the equal expression of X-

264 Dosage compensation refers to the equalization of most X

265 Dosage compensation refers to the equalization of X-link

266 Sex-chromosome dosage compensation requires selective identification of

267 In Drosophila, X chromosome dosage compensation requires the male-specific lethal (M

268 Somatic X dosage compensation requires two mechanisms: X inactivat

269 ial for Drosophila melanogaster X-chromosome dosage compensation, reveals a 'three-fingered hand' rib

270 group of genes enriched for those subject to dosage compensation show unique evolutionary signatures.

271 unclear how X chromosomes are specified for dosage compensation, since DNA sequence motifs shown to

272 more is known about molecular mechanisms of dosage compensation, specific protein complexes containi

273 Thus, germline X dosage compensation states are determined by X chromosom

274 These unexpected differences in X dosage compensation states between germline and soma off

275 romosome inactivation (XCI) is the mammalian dosage compensation strategy for balancing sex chromosom

276 d, and that some less-than-global pattern of dosage compensation, such as local or temporal, exists o

277 in general are exempt from Rtt109-dependent dosage compensation, suggesting the existence of pathway

278 , an important component of the X chromosome dosage compensation system in Drosophila, regulates gene

279 which has led to the coordinate evolution of dosage-compensation systems.

280 re potent influence on sex determination and dosage compensation than any other XSE by functioning in

281 We developed a plasmid-based model of dosage compensation that allows new experimental approac

282 ammals have developed an elaborate system of dosage compensation that includes both upregulation and

283 also appears to show diverse mechanisms for dosage compensation that may result in differences in co

284 Prior to the onset of dosage compensation, the difference in XSE expression be

285 Dosage compensation, the equalized X chromosome gene exp

286 pite the lack of a global mechanism of avian dosage compensation, the pattern of gene expression diff

287 In Drosophila, dosage compensation-the equalization of most X-linked ge

288 In this review, I survey the status of dosage compensation to answer these questions and identi

289 Our work further links dosage compensation to condensin and establishes a new r

290 e (or the Z in ZW systems), which may evolve dosage compensation to increase low expression or compen

291 t and -independent steps in MSL targeting of dosage compensation to the male X chromosome.

292 ing RNA splicing signal, effectively linking dosage compensation to transcribed genes.

293 of imprinted genes and have a proven role in dosage compensation via X-inactivation.

294 ive strength of selection for sex chromosome dosage compensation vs. the cumulative effects of mascul

295 However, we did not find evidence that dosage compensation was affected.

296 ed for genes subject to one or more modes of dosage compensation, where mRNA abundance is decreased i

297 s elegans genome and to dissect X chromosome dosage compensation, which balances gene expression betw

298 and females are buffered by a process called dosage compensation, which in Drosophila is achieved thr

299 of the X-linked genes in metafemales exhibit dosage compensation with an expression level similar to

300 mes in female mammals is silenced to achieve dosage compensation with males.