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1 P < 0.01 vs. controls, P < 0.05 vs. standard-dose).
2 kin of tangerine fed animals despite a lower dose.
3 influenza vaccination consisting of a single dose.
4 scular delivery of a two-fold higher vaccine dose.
5 red a 6-month maintenance period on the same dose.
6 independent cells and lowers cumulative drug dose.
7 extended beyond 70 days following the final dose.
8 isit [FUV] 1) and 3 (FUV2) weeks after final dose.
9 elium ion irradiation with a well-controlled dose.
10 increase in titer following a second vaccine dose.
11 e association study of usual daily methadone dose.
12 be used to identify the optimum radiotherapy dose.
13 pharmacodynamically active at well-tolerated doses.
14 CT scans were obtained every 24 h throughout dosing.
15 al cholesterol levels in rats following oral dosing.
16 ocompatible, via the nasal route, on chronic dosing.
17 ingle morning doses versus twice-daily split dosing.
18 cks of six) to receive either two intranasal doses (0.25 mL per nostril) of LAIV H5N2 (101 participan
20 m to receive inotuzumab ozogamicin (starting dose 1.8 mg/m(2) per cycle [0.8 mg/m(2) on day 1; 0.5 mg
21 cible protein 10 (IP-10) were measured after doses 1 and 8, then 1 (follow-up visit [FUV] 1) and 3 (F
22 On the tenth day following initiation of dosing, 10 patients underwent an intensive pharmacokinet
24 ndently increased this value in the standard-dose (27.9 +/- 9 nmol x min(-1) x g(-1), P < 0.05 vs. co
27 c immune response approximately 28 days post-dose 4, measured by gpELISA (estimated geometric mean fo
28 xposure comparable with that of the standard dose (5 mg twice daily) in patients with preserved renal
34 showed increased CCR5 expression after high-dose allergen exposure while CXCR4, CXCR5, CCR6, and CCR
36 vaccines during 2012-2013, and 1508176 high-dose and 1877327 standard-dose recipients during 2013-20
39 We aimed to establish the maximum tolerated dose and establish the recommended phase 2 dose of velip
40 e beam configurations and variations in peak dose and irradiated area in the response of normal tissu
42 breast harder or firmer [p=0.002 for reduced-dose and p<0.0001 for partial-breast]) compared with who
43 -inferiority can be claimed for both reduced-dose and partial-breast radiotherapy, and was confirmed
45 Estimated total body clearance normalized by dose and weight was lower in the Eld group compared with
48 immunization regimen (dose, interval between doses, and drug partner), this vaccine could be used for
49 t the signaling duration and across Tgf-beta doses, and significantly increased the information trans
50 erates all of these cellular phenotypes in a dose- and age-dependent manner in cortex and striatum of
52 concurrently with an antiplatelet drug (low-dose aspirin and a VKA: 3.6% of cases and 1.1% of contro
53 ormed a cohort study of 601 527 users of low-dose aspirin for primary or secondary prevention in the
54 s (CIs) for cancer-specific mortality by low-dose aspirin use after adjusting for potential confounde
59 aphylaxis in C57BL/6 mice upon repeated i.p. dosing because of an anti-idiotypic anti-drug Ab immune
60 nivariate analysis, age >60 years, radiation dose, bilateral ocular involvement at presentation, and
61 d limited protection from a single antenatal dose, but revaccinating mothers during every pregnancy d
62 Although whole gut irradiation with these doses caused lethal GI syndrome, focal (5 mm) radiation
63 alan should thus be considered standard high-dose chemotherapy and ongoing randomised studies will co
64 the 4-week post-treatment period, ascending dose cohorts underwent a further double-blind crossover,
65 tricitabine, and tenofovir alafenamide fixed-dose combination [bictegravir group] and 330 with dolute
66 methoprim-sulfamethoxazole in a single fixed-dose combination tablet), 12 weeks of fluconazole, 5 day
67 Purpose To determine if the use of reduced-dose computed tomography (CT) for evaluation of kidney s
76 more, we observed that 1B6 displayed a rapid dose-dependent clearance (t(1/2) 10-60 h) in contrast to
77 psychoactive component of cannabis, produced dose-dependent conditioned place aversion and a reductio
79 intracellular Angpt-2 protein in a time- and dose-dependent fashion thereby indirectly reducing the r
81 SH2 overexpression results in a significant, dose-dependent increase in EGFR tyrosine phosphorylation
82 k of decompensation, mortality, and HCC in a dose-dependent manner (P for trend <0.0001, <0.0001, and
83 Plasma levels of fitusiran increased in a dose-dependent manner and showed no accumulation with re
84 elicase activities are inhibited by Rev in a dose-dependent manner, although ATP-independent helicase
85 ented amphetamine-induced hyperactivity in a dose-dependent manner, similar to the atypical antipsych
86 early initiation of liver regeneration in a dose-dependent manner, without modifying the peak regene
89 lusion A small but statistically significant dose-dependent T1-weighted signal enhancement was observ
90 dministration of ALN-GO1 resulted in potent, dose-dependent, and durable silencing of the mRNA encodi
91 ell-derived factor-1alpha-mediated migration dose-dependently but minimally affected cell viability.
92 tro ADME and pharmacokinetics properties and dose-dependently counteracted acute lung eosinophilia in
94 rcumin improved disease activity index (DAI) dose-dependently, while the anti-inflammatory efficacy o
97 coronary segment interpretability, effective dose (ED), and diagnostic accuracy were assessed at CT a
98 but patients with no chemotherapy still had doses equivalent to five tablets per day of 5-mg hydroco
99 andomized, double-blind, placebo-controlled, dose-escalating study of BMS-936559, including HIV-1-inf
104 and to establish a current average radiation dose for CT evaluation for kidney stones by querying a n
105 1,200 mg to be the recommended single-agent dose for future studies in FL and DLBCL, with 800 mg bei
109 of (11)C-nicotine and the absorbed radiation dose from whole-body (11)C-nicotine PET imaging of 11 he
112 eing more than 2.03 (p=0.003 for the reduced-dose group and p=0.016 for the partial-breast group, com
114 NA were similar for the 40-120 mg once-daily dose groups regardless of baseline Gag polymorphisms.
115 articipants received half their standard TKI dose (imatinib 200 mg daily, dasatinib 50 mg daily, or n
116 type 1 (Th1) immune responses, whereas high-dose immunization primes responses characterized by regu
121 5th and 75th (DRL) percentiles for volume CT dose index (CTDIvol), dose-length product (DLP), and siz
122 y due to competing causes of death over this dose interval.These results confirm and extend earlier f
123 ed 5 mg/kg belatacept every 2 weeks, and the dosing interval was extended to 4 weeks after 5 applicat
124 e able to optimize the immunization regimen (dose, interval between doses, and drug partner), this va
125 valent with 2-minute and 5-minute riboflavin dosing intervals at 6 months (0.97 and 0.76 diopters, re
126 Prospective open-label, unilateral single-dose, intravitreal injection of AAV2(Y444,500,730F)-P1ND
127 ypothesis, and its use, in the form of ALARA dosing, is responsible for misguided concerns promoting
128 f 15 to receive placebo (normal saline), low-dose ketamine (0.5 mg/kg), or high dose ketamine (1.0 mg
129 ine), low-dose ketamine (0.5 mg/kg), or high dose ketamine (1.0 mg/kg) after induction of anaesthesia
130 xhibit resistance to 10,000 times the lethal dose (LD50) of BoNT/A, and transfusion of these red bloo
131 centiles for volume CT dose index (CTDIvol), dose-length product (DLP), and size-specific dose estima
132 ose-limiting toxicity analysis set: three at dose level 1 (1 mg/kg), three at dose level 2 (3 mg/kg),
133 t: three at dose level 1 (1 mg/kg), three at dose level 2 (3 mg/kg), six at dose level 3 (10 mg/kg),
134 kg), three at dose level 2 (3 mg/kg), six at dose level 3 (10 mg/kg), and six at dose level 4 (20 mg/
137 ion data from 21 patients into six radiation dose levels (12.5%, 25%, 37.5%, 50%, 75%, and 100%) on t
138 ry estimates indicate that the kidney is the dose-limiting organ, with an estimated human absorbed do
139 ced peripheral neuropathy (CIPN) is a common dose-limiting side effect experienced by patients receiv
141 cation to FGF19-driven HCC may be limited by dose-limiting toxicities mediated by FGFR1-3 receptors.
144 ivity reactions to ASA, especially following doses lower than 100 mg, should directly undergo desensi
147 promise for efficient spectrum imaging, low-dose mapping of beam-sensitive specimens, trace element
150 oportion of women who received each elagolix dose met the clinical response criteria for the two prim
151 ing full-dose proton-pump inhibitor and high-dose Metronidazole in group A, and full-dose proton-pump
152 In this study, we explore the effect of low dose N-acetyl-L-cysteine therapy, delivered using a targ
156 osing regimens through either evidence-based dosing nomograms or preferably through the use of dosing
158 BC, and 2 UBC) received a single intravenous dose of (68)Ga-NOTA-AE105 (154 +/- 59 MBq; range, 48-208
159 s cerana olfactory learning in larvae (lower dose of 0.033 microg/larvae/day over 6 days) and, in a s
160 and, in a separate experiment, adults (lower dose of 0.066 microg/adult bee/day) at sublethal, field-
163 o, to receive subcutaneous tocilizumab (at a dose of 162 mg) weekly or every other week, combined wit
165 2:1 ratio to receive either adalimumab (at a dose of 20 mg or 40 mg, according to body weight) or pla
168 Patients and Methods We delivered PMRT at a dose of 36.63 Gy in 11 fractions of 3.33 Gy over 11 days
169 d whether rituximab maintenance therapy at a dose of 375 mg per square meter of body-surface area adm
170 ton's tyrosine kinase (BTK), at a once-daily dose of 420 mg achieved BTK active-site occupancy in pat
173 osis to receive intravenous ocrelizumab at a dose of 600 mg every 24 weeks or subcutaneous interferon
174 nazole, 5 days of azithromycin, and a single dose of albendazole, as compared with standard prophylax
175 -mts), starting from 4 hours after 600 mg/kg dose of APAP, resulted in early initiation of liver rege
177 ctive at delivering a therapeutically active dose of KAFAK to bovine cartilage explants, suppressing
179 ssigned treatment, 207 received at least one dose of MABp1 and 102 at least one dose of placebo.
181 Ps promotes ethylene capture, and subsequent dose of negative potential (-2.0 V) induces the release.
182 rimary care with acute sore throat, a single dose of oral dexamethasone compared with placebo did not
184 ( 1:1000 dilution) physiologically relevant dose of simulated mixture in air for two weeks in separa
185 assigned patients who received at least one dose of study drug during the maintenance period were in
190 d dose and establish the recommended phase 2 dose of veliparib combined with neoadjuvant capecitabine
191 was not identified; the recommended phase 2 dose of venetoclax in combination with rituximab was 400
199 ardial infarction to placebo or one of three doses of canakinumab (50 mg, 150 mg, or 300 mg) given su
200 l, prednisone, and custirsen received weekly doses of custirsen 640 mg intravenously after three load
201 th through 15 months who received at least 3 doses of diphtheria-tetanus-acellular pertussis vaccine
204 mographic Surveillance System to include two doses of HRV with the standard infant vaccines at 6 and
206 the low radiation absorption of tumors, high doses of ionizing radiations are often needed during RT,
207 nd randomized trials that compared different doses of naloxone, administration routes, or transport v
208 unoglobulins and two doses, showed that both doses of SCIg IgPro20 were efficacious and well tolerate
209 enables physicians to achieve fast adequate dosing of antibiotics to improve the outcome of patients
210 ed on the presented results, a less frequent dosing of mavacoxib is proposed compared to celecoxib an
211 uble-masked trials reported here, once-daily dosing of netarsudil 0.02% was found to be effective and
212 randomized trial found that treat and extend dosing of ranibizumab 0.3 mg with and without angiograph
214 ermine the effect of inhalational anesthetic dose on risk of severe postoperative respiratory complic
215 Herein, we assessed the efficacy of steroid dosing on sarcolemmal repair, muscle function, histopath
216 corded similar adverse effects after reduced-dose or partial-breast radiotherapy, including two patie
217 ng adjuvant chemotherapy had modestly higher doses ( P = .002), but patients with no chemotherapy sti
220 ratio of mean tumor to bone marrow absorbed dose per unit administered activity of (131)I, after THW
222 n the study (13 [24%] of 54 enrolled at this dose plus five [11%] of 45 initially administered D who
223 60 h) in contrast to 1F11, which presented a dose-proportional pharmacokinetic profile and a half-lif
224 lues for methylone and MDC were greater than dose-proportional, suggesting non-linear accumulation.
226 high-dose Metronidazole in group A, and full-dose proton-pump inhibitor and prescription from a Gastr
228 who require or choose active treatment, low-dose rate brachytherapy (LDR) alone, EBRT alone, and/or
229 of Ag dispersal but may also concentrate the dose received by organisms, which subsequently ingest th
232 unting detector (PCD) technology can improve dose-reduced chest computed tomography (CT) image qualit
233 Here, we report that a 0.1 Gy radiation dose reduces cancer progression by deactivating the JAK1
235 disease may increase bleeding risk, whereas dose reductions without a firm indication may decrease t
237 dual patient data on SAEs, assigned drug and dosing regimen, and baseline prognostic factors were req
238 able optimized dosing, the use of customized dosing regimens through either evidence-based dosing nom
240 rces of referral, body region scanned, type, dose, related adverse events and route of administration
242 in hemodynamic response shows characteristic dose-related effects that differ depending on agonistic
243 The biomarker results revealed multiphasic dose-response curves, which suggested toxicity mechanism
244 data for each country, we estimate a common dose-response function, which we use to compute national
245 85644 may contribute to variation in 25(OH)D dose-response in healthy postmenopausal Caucasian women.
248 hould generate biomarkers useful for in vivo dose responses of beta-lapachone treatment in humans, av
250 o administrations of immunoglobulins and two doses, showed that both doses of SCIg IgPro20 were effic
251 g nomograms or preferably through the use of dosing software supplemented by therapeutic drug monitor
257 mab (odds ratio = 9.52; P = 0.001), and high-dose steroids (odds ratio = 5.05; P = 0.01) retained sig
258 erance remains widely accepted: the use of a dosing strategy that provides an interval of no or low n
262 -1) x g(-1), P < 0.05 vs. controls) and high-dose subgroups (37.2 +/- 7.8 nmol x min(-1) x g(-1), P <
263 , combination fludarabine-melphalan with low-dose TBI after haplocord stem cell transplant assures go
264 n whole OSPW are acutely toxic at much lower doses than we previously reported for the OSPW-OF (i.e.,
266 developed profound RPE and retinal damage at doses that caused minimal effects in wild-type mice, and
271 ogroup B vaccines and the need for a booster dose to sustain individual protection against invasive m
273 ire dose range, there are negative mortality dose trends for all circulatory disease (p = 0.014) and
274 lind, placebo-controlled, multiple-ascending-dose trial of inclisiran administered as a subcutaneous
275 een age-eligible for HPV vaccination, with 3-dose uptake across age cohorts being about 50%-77%).
276 dose of tamoxifen less than 10% of the mean dose used for recombination induction, caused adverse ef
278 luated the comparative effectiveness of high-dose vaccine in preventing postinfluenza deaths during 2
279 high-dose and 1683264 recipients of standard-dose vaccines during 2012-2013, and 1508176 high-dose an
282 oints in the placebo group (P<0.001 for each dose vs. placebo), and everyday-activities scores improv
291 ds of a reduction in the oral glucocorticoid dose were more than 4 times as high with benralizumab as
293 for different grains at various irradiation doses were compared and revealed efficient defect absorp
297 to mice for 10 weeks, followed by five oral dosing with purified AHC or ovalbumin on alternate days
298 opically overexpressing KDM5B in response to dosing with TCA cycle metabolite pro-drug esters, sugges
299 Edoxaban (DU-176b) vs. Standard Practice of Dosing With Warfarin in Patients With Atrial Fibrillatio
300 ric analysis demonstrated a (64)Cu effective dose within the acceptable range for clinical PET imagin
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