ライフサイエンスコーパス: dose-response

1 I: HR = 1.87, 95% CI = 1.58-2.21) revealed a dose response.

2 uppressed, both temporally and in an insulin dose response.

3 th baseline serum 25(OH)D levels and 25(OH)D dose-response.

4 iations in serum 25(OH)D level and vitamin D dose-response.

5 etry) data the most predictive for different dose responses.

6 Extracts and dilutions showed a neat linear dose response (all: R(2) > 0.98) in 33 rhinitis patients

7 For most fetal SNPs, a dose-response allelic effect was observed.

8 Dose-response analysis indicated a trend of an approxima

9 A complete BPA dose-response analysis of prostate lesions across multip

10 Nonlinear dose-response analysis was modeled by using restricted c

11 method has been proven successful in testing dose-response analysis, the microliter consumption of ex

12 arettes, precluding detailed examinations of dose response and cessation.

13 le shot high-throughput screen, validated by dose response and subjected to further biochemical analy

14 nduce responses with profiles having typical dose-response and adaptation curves.

15 ation was further investigated by performing dose-response and breed group-specific analyses.

16 Products have undergone dose-response and confirmative studies in adults and chi

17 delamanid for 10 days confirmed the hormetic dose-response and improved the efficacy at all doses inv

18 A multicentre trial evaluated the dose-response and tolerability of SB.

19 We first considered dose-responses and pathogen dynamics within the host, an

20 scular disease (CVD) risk factors, including dose-responses and potential heterogeneity by nut type o

21 and high-dose data do not constrain the low-dose response, and different dose-response forms that ar

22 g., incidence, growth, latency, metastasis), dose-response, and mechanisms of action, when available.

23 A qAOP provides quantitative, dose-response, and time-course predictions that can supp

24 stic insights are elucidated and therapeutic dose responses are demonstrated.

25 model enables interpreting each phase of the dose-response as an independent dose-dependent process.

26 In dose-response assays, a blend of the five components eli

27 e rapidly, is slightly insensitive to ABA in dose-response assays, but also hypersensitive to the GA

28 efficacy of selected DAAs was determined in dose-response assays, in which the number of HCV-infecte

29 In a dose-response assessment using cubic splines, elevated r

30 aluated for use in hazard identification and dose-response assessment.

31 These data suggest a dose-response association between apoB in young adults a

32 We sought to examine the dose-response association between FV consumption and the

33 s cohort study provides strong evidence of a dose-response association between indoor tanning and ris

34 women, we observed an independent protective dose-response association between prepregnancy consumpti

35 However, the quantitative, dose-response association between sedentary time and CVD

36 l study aimed to explore 1) the shape of the dose-response association between sugars intake and cari

37 We also observed a dose-response association between the number of perinata

38 These cross-sectional results show a strong dose-response association between urinary sodium excreti

39 However, the dose-response association of different levels of lifelon

40 The continuous dose-response association was assessed using random-effe

41 The categorical dose-response association was evaluated by comparing the

42 ed meat and FV consumption and evaluated the dose-response associations at low, medium, and high FV i

43 This study sought to quantify dose-response associations between LTPA, BMI, and the ri

44 with cancer risk and mortality, including in dose-response associations in endometrial and post-menop

45 betes, and dyslipidemia have independent and dose-response associations with incident AS in an unsele

46 tional age and birth weight followed inverse dose-response associations, whereby an increasingly high

47 rtality rates, and these associations showed dose-response associations.

48 The dose-response behavior of the field-effect biosensor pre

49 , Gottschalk et al. report that differential dose-response behaviors of the NFkappaB and MAPK pathway

50 ion for the main analysis but also evaluated dose response by using cubic splines and generalized lea

51 Both sediments elicited a toxic dose-response by H. azteca early in the aging process; b

52 and normal breast tissue; (2) 291 pairs have dose-response co-expression pattern, in which the correl

53 ects of ClO4(-) in 12 species and revealed a dose-response concordance across KEs and taxa.

54 gical activity of RT does not exhibit linear dose-response correlation.

55 Both these phenomena show a rather linear dose-response correlation.

56 al framework to study disease tolerance, the dose response curve relating health to microbe load; thi

57 , the ssOPM system is also used to acquire a dose response curve with the concentration of glucose in

58 0.25, 0.5, 1.0 mg/kg/infusion) followed by a dose-response curve after acquisition of cocaine self-ad

59 ty of quantification is shown by a sigmoidal dose-response curve fitting to analyze IL-6 protein.

60 e alone but produced a leftward shift in the dose-response curve for cocaine-primed reinstatement.

61 The dose-response curve for immunocomplex formation of TNT o

62 einforcing effects of nicotine, shifting the dose-response curve for nicotine to the left, (2) inhibi

63 were translated into health burdens using a dose-response curve generated from a systematic review a

64 d cubic spline adiposity-residential density dose-response curve identified a turning point at a resi

65 pace is 3-dimensional, and predicts that the dose-response curve of an odor receptor can be obtained,

66 This work reveals that the dose-response curve of PF74 consists of two distinct inh

67 Here, we found that the dose-response curve of PF74 is triphasic, consisting of

68 this primary endpoint, a significant linear dose-response curve was observed: the higher the dose, t

69 h lower doses revealed a U-shaped (hormetic) dose-response curve with greater parasite suppression at

70 significant rightward shift in the morphine dose-response curve.

71 hilin A (CypA) were essential for the unique dose-response curve.

72 06 to 1.5 x 106 IU/m2, in order to model the dose-response curve.

73 Dose response curves generated in this manner were compa

74 pMHC affinity and dose produced bell-shaped dose-response curves and different optimal pMHC affiniti

75 The EC50 dose-response curves for GCSF, GCSF-Fc and PEG-GCSF were

76 Biphasic dose-response curves indicated that the occupancy of the

77 itself as a shift towards lower doses in the dose-response curves of individual antiandrogens that be

78 ns, followed by construction and analysis of dose-response curves of the most promising hits.

79 Dose-response curves revealed dose-dependent profiles wi

80 Norepinephrine dose-response curves showed no HTN-related difference in

81 ses a cell viability assay to generate broad dose-response curves to assess the efficacy of individua

82 Dose-response curves were predicted using Emax models.

83 Dose-response curves with the allergens in BAT allowed a

84 We thus provide a robust approach to fit dose-response curves with various degrees of complexity,

85 The biomarker results revealed multiphasic dose-response curves, which suggested toxicity mechanism

86 be clustered into two groups based on their dose-response curves.

87 The dose-response data for TNFalpha secretion demonstrate th

88 absorbed doses, PK properties, and in vitro dose-response data into a PK/pharmacodynamic (PD) model

89 Analysis of dose-response data reveals HMBPP-induced Hill coefficien

90 Random-effects meta-analyses with summarized dose-response data were performed for total, low-fat, an

91 Computational models and dose-response data were used to evaluate the effects of

92 Mixtures of BaP and PhIP produced dose responses different from those of the individual ch

93 to Fe oxide minerals, exhibited a consistent dose-response during aging.

94 Here we sought to quantify and model the dose response, dynamics, and stability of bacterial colo

95 To determine (1) the dose-response effect of potassium nitrate (KNO3) on exer

96 There was no evidence of a dose-response effect of task-specific training on functi

97 No evidence for a dose-response effect of weight loss on the change in ser

98 aniasis, CpG treatment similarly exhibited a dose-response effect on the production of IFN-gamma, IL-

99 A dose-response effect was shown with 10 and 20 g fiber fr

100 We noted a dose-response effect, which signals potential opportunit

101 free amino groups was observed in TBs with a dose-response effect, while addition of PEF in bread pro

102 ol levels, and adiposity, with evidence of a dose-response effect, with higher-intensity intervention

103 the most commonly tested chemicals suggested dose-response effects for copper, but not lead or zinc.

104 iple-treatment meta-regression, we estimated dose-response effects of isocaloric replacements between

105 Some dose-response effects were stronger for obese women.

106 ssess whether trends across assays indicated dose-response effects, (B) characterize the consistency

107 To assess dose-response effects, patients were randomly assigned b

108 l end points, (3) facilitating cross-species dose-response evaluation, and (4) highlighting data gaps

109 CLL patients to evaluate if an obinutuzumab dose response exists.

110 In vitro time/dose-response experiments reveal an ordered pattern of P

111 < 0.02 mg/kg siRNA against FVII (siFVII)] in dose-response experiments, and well tolerated in separat

112 tly related to the absorption of drug during dose-response experiments.

113 experienced higher risk of lung cancer in a dose-response fashion, with a doubling in PAr levels ass

114 litis increase with higher temperatures in a dose-response fashion.

115 t subtypes of hematologic malignancies, in a dose-response fashion.

116 challenged with Pen a 1 showed a bell-shaped dose response for secretion, with optimal Pen a 1 doses

117 To define the aldesleukin dose response for Tregs and to find doses that increase

118 ohol feeding induces a leftward shift in the dose-response for Ca(2+) -mobilizing hormones resulting

119 Individual dose-response for patients was simulated for 5 warfarin

120 The oxymetazoline dose-response for PNIF was blunted after single vs chron

121 ased measures, we 1) described the mortality dose-response for sedentary time and light- and moderate

122 PE dose-response for splanchnic flow and resistance were bl

123 nstrain the low-dose response, and different dose-response forms that are equally plausible given the

124 between 1982 and 2014, to produce an updated dose-response function for soybean.

125 he goal of this study was to investigate the dose-response function for the reinforcing and subjectiv

126 This amnesic shadow follows a dose-response function, becomes more pronounced after pr

127 data for each country, we estimate a common dose-response function, which we use to compute national

128 We statistically estimate country-level dose-response functions between daily peak/total electri

129 er health impact assessment studies based on dose-response functions corrected for exposure misclassi

130 To this end, we identify four properties of dose-response functions that should be considered when s

131 han all three lower AHI groups, indicating a dose-response impact of SDB.

132 85644 may contribute to variation in 25(OH)D dose-response in healthy postmenopausal Caucasian women.

133 We detected a moderate dose-response in one clinically approved indication, hep

134 ns, those receiving insulin injections had a dose-response increase in the odds of CUA involving lowe

135 se, a reliable method for analyzing combined dose response is essential.

136 w genetic variation contributes to vitamin D dose-response is important for personalized vitamin D tr

137 studies defining the most effective dose and dose-response latency for targeting the amygdala.

138 nisms of action, effectiveness on subgroups, dose-response, length of therapy, functional outcome, an

139 sing NLR was associated with sarcopenia in a dose-response manner (compared with NLR < 3, odds ratio,

140 ancy was associated with risk of TD/CTD in a dose-response manner but the association was no longer s

141 The risk of SAP increased in a dose-response manner with delays in SALT dysphagia asses

142 with a lower short-term risk of frailty in a dose-response manner, and the strongest association was

143 s excreted nitrogen to the water column in a dose-response manner, thereby shifting nutrient stoichio

144 0.001) and clinical (P = 0.01) relapses in a dose-response manner, with adjusted hazard ratios of 2.1

145 sed with maternal overweight or obesity in a dose-response manner.

146 d chloroplasts, they produced melatonin in a dose-response manner.

147 idual chemicals, as well as the nonmonotonic dose response, may be important for understanding the mu

148 city studies have demonstrated non-monotonic dose-response mechanisms for planted soybean that have a

149 The underlying primary data, together with dose-response meta-analysis and, finally, pooled analysi

150 This dose-response meta-analysis of observational studies sug

151 ased risk of all-cause mortality in a linear dose-response meta-analysis.

152 Dose-response metaregression analysis of cohort studies

153 iation, leading to deviation from the linear dose response model used in radiation protection.

154 activity in the HTS data using high-quality dose-response model fits and >/=40% efficacy gave "possi

155 The novel dose-response modeling algorithm has been tested against

156 orm for efficiently storing, normalizing and dose-response modeling of large high-throughput and high

157 experiment, the only extensive data-set for dose response modelling with a variety of particle types

158 Instead simple dose-response models are still often used although they

159 ding bisphenol-A (BPA), induce non-monotonic dose response (NMDR) relationships, which are unconventi

160 ma1R agonist (+)-pentazocine potentiated the dose response of cocaine self-administration in rats, co

161 s the efficacy and safety and to explore the dose response of esketamine intravenous (IV) infusion in

162 We compared the bioavailability and dose response of potassium from nonfried white potatoes

163 hould generate biomarkers useful for in vivo dose responses of beta-lapachone treatment in humans, av

164 By fitting a generic Hill function to the dose-responses of these genes we obtained a measure of t

165 ere their stimulation produces an inverted-U dose response on dlPFC neuronal firing and cognitive per

166 g foraging gene dosage demonstrates a linear dose-response on these phenotypes in relation to foragin

167 With biologically realistic sigmoidal dose-responses, our model predicted tri-phasic turning r

168 RA was significantly associated with 25(OH)D dose-response (P = 1.01 x 10(-4)).

169 atus when distributions were examined (i.e., dose response), particularly when diet was expressed in

170 used with a linear bone growth of 2.5 mm, a dose response pattern detected a plateau in the 0.3% and

171 No clear dose-response pattern was evident for heterologous recur

172 is to evaluate the potential association and dose-response pattern with accumulating evidence.

173 significantly to higher mortality rates in a dose-response pattern, and more stress-associated deaths

174 ion model was used to estimate the potential dose-response patterns of Mediterranean diet score on in

175 Secondary screens to evaluate dose-response performance and off-target effects, cell-b

176 interaction of two, individually monotonic, dose-response processes: one for the plant and the other

177 rectional responses, which are determined by dose-response profiles of activator and inhibitor to the

178 The 2-stage dose-response random-effects meta-analysis showed monoto

179 Dose-response ratio supports neurobiological plausibilit

180 d for analyzing multiple-stressor data using dose-response regression.

181 uble vitamins.The objective was to model the dose-response relation between the amount of soybean oil

182 Last, OMP also steepens the dose-response relation to improve concentration coding a

183 An inverse dose-response relation was also found between the baseli

184 An apparent dose-response relation was observed with intradermal adm

185 In site-specific analyses, although no dose-response relation was observed, processed meat was

186 A clear dose-response relation was seen between infection episod

187 edominant component throughout the olfactory dose-response relation, down to the threshold of signali

188 no study has yet assessed their prospective dose-response relation.

189 The individual-specific and group-average dose-response relations were investigated by fitting lin

190 s rose with increasing levels of stress in a dose-response relationship (P-trend < 0.0001), independe

191 ight of ten causality dimensions (all except dose-response relationship and specificity), we found th

192 esity is mediated by time, insights into the dose-response relationship and the cumulative impact of

193 nts who have more than 1 complication with a dose-response relationship as complications accrue.

194 To examine whether a continuous, dose-response relationship between amyloid burden and co

195 e studies should be conducted to clarify the dose-response relationship between beta-carotene and all

196 A strong significant and positive dose-response relationship between BMI and current asthm

197 ining the body of literature that supports a dose-response relationship between exercise and cardiova

198 We observed evidence of a positive, dose-response relationship between fast food intake and

199 However, there was no evidence of a dose-response relationship between frequency of use and

200 ies to clarify the strength and shape of the dose-response relationship between general and abdominal

201 There was a dose-response relationship between length of residence i

202 Spline regression showed a dose-response relationship between PM2.5 levels and COWO

203 k for subsequent new SCC but not BCC, with a dose-response relationship between risk and lower CD4 co

204 study among Finnish adults suggest a linear dose-response relationship between sugars and caries, wi

205 There is evidence for a dose-response relationship between the amount of mesh us

206 There was a positive dose-response relationship between the number and durati

207 A dose-response relationship between the number of adverse

208 A dose-response relationship between the number of chronic

209 ty regardless of BMI levels, and there was a dose-response relationship between the number of inciden

210 A strong dose-response relationship exists for the treatment of C

211 The dose-response relationship for BMI with HFpEF risk was a

212 tivity approach, a statistically significant dose-response relationship for both thyroid remnants and

213 We found a dose-response relationship for mGFP-GPI nanoplatform dis

214 With other CD20 antibodies, a dose-response relationship has been shown.

215 activity may still be suboptimal, because a dose-response relationship has not been defined.

216 risks of heart failure (HF), but a radiation dose-response relationship has not previously been deriv

217 The linear radiation dose-response relationship identified can be used to pre

218 The dose-response relationship in a fixed-activity approach

219 A dose-response relationship indicated higher IQ scores in

220 In regulatory toxicology, the dose-response relationship is a key element towards fulf

221 model calculations presented in this work, a dose-response relationship is demonstrated, and an analy

222 choice, yet information on the nature of the dose-response relationship is lacking.

223 As this dose-response relationship is observed across hospitals,

224 Although exploratory, a dose-response relationship may exist, but its relevance

225 Nevertheless, there is debate on the dose-response relationship of exercise and cardiovascula

226 The authors explored the dose-response relationship of ivabradine in children wit

227 l artery was not sufficient to yield a clear dose-response relationship on NE content and axon densit

228 diates UV-B responses in vivo with a similar dose-response relationship to wild-type.

229 through reevaluation of the lead absorption dose-response relationship using new bioavailability dat

230 A dose-response relationship was evident at each measured

231 in each period independently, among boys, a dose-response relationship was evident for each level in

232 A clear dose-response relationship was evident.

233 A strong and statistically significant dose-response relationship was found (P < 0.001).

234 A dose-response relationship was generated and the probabi

235 xposures did not interact synergistically, a dose-response relationship was observed between domestic

236 A dose-response relationship was observed between longer D

237 A dose-response relationship was observed with injury seve

238 In general, a dose-response relationship was observed, with the highes

239 A similar dose-response relationship was observed.

240 With decreasing financial reserves, a clear dose-response relationship was present across all measur

241 fections of the respiratory tract, whereas a dose-response relationship was seen for skin infections.

242 fects of dose and potential modifiers of the dose-response relationship were evaluated with hierarchi

243 In models examining TDP-43 stage, a dose-response relationship with clinical Alzheimer's-typ

244 uld respond, as evidenced by the significant dose-response relationship with ICS adherence.

245 Exposure to benzodiazepines showed a dose-response relationship with mortality (hazard ratios

246 atal stress further demonstrated a positive, dose-response relationship with symptoms of externalizin

247 iation, alternative explanations, cessation, dose-response relationship, animal experiments, analogy,

248 cient, nH, which measures the steepness of a dose-response relationship, may be a useful gauge of thi

249 ries of protocols to assess its methacholine dose-response relationship, shortening velocity, and res

250 ation in seven of ten dimensions (all except dose-response relationship, specificity, and animal expe

251 NE in the OB generated a non-monotonic dose-response relationship, suppressing mitral cell acti

252 w patient numbers-would not prove a positive dose-response relationship.

253 ive therapy, and with evidence of a positive dose-response relationship.

254 ciated with an elevated risk of suicide in a dose-response relationship.

255 er tested characteristics did not modify the dose-response relationship.

256 and (2) evaluate potential modifiers of the dose-response relationship.

257 fference in 5-y absolute risk), with a clear dose-response relationship.

258 ironmental pathogens and infection, i.e. the dose-response relationship.

259 iovascular mortality and highly inconsistent dose-response relationships between calcium intake and r

260 Cohort studies showed no consistent dose-response relationships between total, dietary, or s

261 These are treatment modalities for which dose-response relationships for healthy tissues and tumo

262 work characterizing the functional forms of dose-response relationships has used statistical fit to

263 tion, the complexity of exposure and dose in dose-response relationships is highlighted.

264 ffects models to model any alcohol intake or dose-response relationships of alcohol intake and cardio

265 ummarize available data on the dosimetry and dose-response relationships of several theranostic compo

266 Dose-response relationships were observed with respect t

267 Ln-vanadium concentrations showed non-linear dose-response relationships with risk of preterm deliver

268 stricted cubic spline models to evaluate the dose-response relationships.

269 spitalized with infection in prospective and dose-response relationships.

270 five different UV intensities to demonstrate dose-response screening in an HIV-1 protease activity as

271 The dose-response sensorgrams of BSA upon increasing concent

272 has been tested against millions of diverse dose-response series, and robustly fits data with outlie

273 (MAP) kinase seem to determine the different dose-response strategies at the two promoters.

274 Here we report results of in vivo dose response studies that analyzed the histology and mi

275 ects of intranasal oxytocin also need proper dose-response studies, and such studies need to include

276 A dose response study identified the drugs inhibit HUVEC c

277 The dose response study showed C15:0 had a linear response,

278 tinal germ-free study and a C15:0/C17:0 diet dose response study.

279 s phase 1b double-blind, placebo-controlled, dose-response study we enrolled and randomly assigned he

280 Confocal microscopic images and dose-response titration experiments showed that loading

281 A dose-response to allergen was seen in symptom scores and

282 Among smokers, we observed no dose-response trends with duration of smoking, intensity

283 In a dose-response trial, 110 adolescents (aged 15.9 +/- 1.4

284 Dose-response trials comparing free CPS with the conjuga

285 The association was of a dose-response type, at least as strong as that obtained

286 unteers (aged 15-27 years) challenged with a dose-response using the alpha1-agonist phenylephrine (PE

287 hey are difficult to use due to interpatient dose-response variability and the risks of bleeding.

288 The complex dose response was found to be largely a consequence of t

289 3; 95% CI, 1.4-3.6 for women 40-49 years); a dose response was observed among women regardless of age

290 The dose response was stronger (P for heterogeneity = .01) f

291 The doxorubicin-breast cancer dose response was stronger in survivors of Li-Fraumeni s

292 After 12 months, a dose-response was observed showing statistically signifi

293 >/=10 mIU/mL at 30 years and an 88% booster dose response, we estimate that >/=90% of participants h

294 ariants responsible for vitamin D status and dose-response, we performed two vitamin D3 and calcium c

295 king memory task also produced an inverted-U dose-response, where low doses improved performance but

296 ts as shown by morphology, estrogenic growth dose-response, whole genome gene expression and untarget

297 tanning, duration of tanning-device use, and dose response with melanoma risk and examined the role o

298 ral prostatic ducts exhibited a nonmonotonic dose response with peak PIN, proliferation and apoptotic

299 us 346.2+/-46, P<0.0001]) and demonstrated a dose-response with psoriasis severity.

300 from aMCI to AD dementia, with a significant dose-response with worsening B-SIT quartiles.