ライフサイエンスコーパス: dose-response curve

1 tion (significant change in the slope of the dose-response curve).

2 significant rightward shift in the morphine dose-response curve.

3 uring in silico the mode of the experimental dose-response curve.

4 , as well as induced a vertical shift in the dose-response curve.

5 dose dependent, but exhibited a bell-shaped dose-response curve.

6 hilin A (CypA) were essential for the unique dose-response curve.

7 06 to 1.5 x 106 IU/m2, in order to model the dose-response curve.

8 eduction of tumor burden followed a U-shaped dose-response curve.

9 ement of the spinal morphine antinociceptive dose-response curve.

10 In male voles, all 3 drugs had an inverted-U dose-response curve.

11 shut correlation, and single-channel P(open) dose-response curve.

12 jects, implying a right shifted but parallel dose-response curve.

13 rial DNA damage in CHO cells with a biphasic dose-response curve.

14 However, AC2 displayed a distinct dose-response curve.

15 concentration-reactive oxygen species (ROS) dose-response curve.

16 evidence of nonlinearity was observed in the dose-response curve.

17 nts to determine IC(50) and the slope of the dose-response curve.

18 ormalized ATP levels and displayed drug-like dose response curves.

19 nd upward (short-term) shifts in fixed ratio dose-response curves.

20 ge and the interpatient variability in their dose-response curves.

21 measured by a leftward shift in the morphine dose-response curves.

22 be clustered into two groups based on their dose-response curves.

23 inhibition), data analysis and generation of dose-response curves.

24 between aggregate-based inhibition and steep dose-response curves.

25 or Co2+ ions generated bell-shaped activity dose-response curves.

26 ximately 2.0 and 1.5 in the mid-range of the dose-response curves.

27 cancer cell viability screen involving 11650 dose-response curves.

28 during primary screening and verified using dose-response curves.

29 RDA is equivalent to CA only for linear dose-response curves.

30 subjects and those with POAG by constructing dose-response curves across a wide range of corneal irra

31 0.25, 0.5, 1.0 mg/kg/infusion) followed by a dose-response curve after acquisition of cocaine self-ad

32 upled receptors, normalization stretches the dose-response curve along the y-axis, thereby masking th

33 te-based inhibition is correlated with steep dose-response curves, although not absolutely.

34 pproaches involving the use of concentration/dose response curves and antagonists have been replaced

35 esult in both a shift of the midpoint of the dose-response curve and a change of the slope of the cur

36 /L must consider the wide variability in the dose-response curve and basal 25(OH)D concentrations.

37 The dose-response curve and duration of pramipexole's effect

38 er of operator sites together determined the dose-response curve and gene expression noise.

39 tain most of the activity for modulating the dose-response curve and partial agonist activity.

40 trate that there is no ascending limb of the dose-response curve and that the cocaine priming and sat

41 pMHC affinity and dose produced bell-shaped dose-response curves and different optimal pMHC affiniti

42 Dose-response curves and heparin-Sepharose binding sugge

43 Dose-response curves and IC50 values were determined for

44 activity falls quickly for drugs with sharp dose-response curves and short half-lives, such as boost

45 The glycine dose-response curves and the effects of caffeine indicat

46 rformance of each analyte was optimized, and dose-response curves and the limits of detection (LODs)

47 y of factors to modulate the position of the dose-response curve, and the partial agonist activity, o

48 er pharmacology (and many other areas), most dose-response curves are satisfactorily described by a c

49 that Hap1 activity exhibits the same oxygen dose-response curves as Hap1-dependent aerobic genes and

50 Dopamine dose-response curves assaying intracellular calcium mobi

51 visual inspection or a global fit of ligand dose response curves at a series of inhibitor concentrat

52 We establish dose-response curves at realistic particle-concentration

53 " leads to a requirement that noninteractive dose-response curves be linear, whereas in toxicology, i

54 salivary gland swelling (P = 0.001, logistic dose-response curve) but not with dry mouth (P = 0.63),

55 ver, cause a left shift in the dexamethasone dose response curve by increasing intracellular dexameth

56 the newly derived rate equation to inhibitor dose- response curves can, in favorable cases, reveal wh

57 uired cocaine self-administration and showed dose-response curves characteristic of the schedule of r

58 id not cause a greater shift in the morphine dose-response curve compared to morphine pretreated alon

59 exhibited a rightward shift in the nicotine dose-response curve compared with WT littermates but tha

60 to the right of the THC self-administration dose-response curves, consistent with antagonism of the

61 The overall dose-response curves could be reconstructed by combining

62 specific for the target, was used to obtain dose-response curves, demonstrating the potential for qu

63 Dose-response curves determined defibrillation threshold

64 As assayed by a dose-response curve, different concentrations of the poo

65 drug target, ALLINIs display steep antiviral dose-response curves ex vivo.

66 se two questions: How can a first-order Hill dose-response curve (FHDC) arise from a multistep reacti

67 ty of quantification is shown by a sigmoidal dose-response curve fitting to analyze IL-6 protein.

68 Dose-response curves followed exponential pharmacodynami

69 Dose response curves for gemcitabine in the absence or p

70 expressing mENT1.1 and mENT1.2 show similar dose response curves for NBMPR and dipyridamole inhibiti

71 Dose response curves for oxidant production, actin polym

72 F2 and SRC-1 modulate the positioning of the dose-response curve for agonist-bound glucocorticoid rec

73 peated exposure, and produced a shift in the dose-response curve for alcohol on BSR threshold without

74 uitability of the technique for generating a dose-response curve for an enzyme inhibition assay.

75 nto the vPAG caused a rightward shift in the dose-response curve for antinociception whether the glut

76 1 antagonist also eliminated the bell-shaped dose-response curve for buprenorphine-induced antinocice

77 xposure and produced a leftward shift in the dose-response curve for cocaine on BSR threshold without

78 gene transfer during maintenance shifted the dose-response curve for cocaine self-administration upwa

79 ression of 5-HT1B receptors also shifted the dose-response curve for cocaine-conditioned place prefer

80 e alone but produced a leftward shift in the dose-response curve for cocaine-primed reinstatement.

81 A dose-response curve for cortisol was generated by relati

82 A dose-response curve for detection of DNA hybridization b

83 ngle lectin super-microarray to generate the dose-response curve for each glycan-lectin pair, from wh

84 A dose-response curve for each of the suicide inhibitors w

85 rs is a multistep process characterized by a dose-response curve for gene product that follows a firs

86 pplicable and amenable to predictions if the dose-response curve for gene repression is non-cooperati

87 deletion resulted in a leftward shift in the dose-response curve for glucose-stimulated insulin secre

88 otropin-releasing hormone and a left-shifted dose-response curve for gonadotropin-releasing hormone a

89 The dose-response curve for immunocomplex formation of TNT o

90 , as exemplified by a rightward shift in the dose-response curve for insulin stimulated 2-deoxyglucos

91 x orders of magnitude) leftward shift in the dose-response curve for intraplantar capsaicin-induced i

92 en 6.7 and 670 mug/kg (i.v.) and shifted the dose-response curve for isoprenaline to higher agonist c

93 nges in tadpole behavior shifted the ethanol dose-response curve for loss of righting reflex to lower

94 As the dose-response curve for many receptors can be fit to a B

95 einforcing effects of nicotine, shifting the dose-response curve for nicotine to the left, (2) inhibi

96 In the other words, the slope of the dose-response curve for one stimulus is an intrinsic pro

97 dition, GDNF induced a downward shift in the dose-response curve for operant self-administration of a

98 In contrast to NHK cells, the dose-response curve for ouabain inhibition of Na,K-ATPas

99 We also found a linear dose-response curve for peptide action, indicating a lin

100 We established a dose-response curve for rFVIIa that is useful to explain

101 reased expression of AtGA2ox8 exhibited a GA dose-response curve for stem elongation similar to that

102 Acidosis shifted the dose-response curve for suppression of proteolysis by in

103 the endogenous AHR protein pool shifted the dose-response curve for TCDD to the right.

104 e 72h after resuscitation revealed a complex dose-response curve for testosterone, such that low and

105 vity 17 +/- 6% (p < 0.05) and suppressed the dose-response curve for the 2C agonist.

106 Halothane shifted the ACh dose-response curve for the alpha 4 beta 2-type currents

107 conjugate, which was then used to generate a dose-response curve for the analyte in a convenient micr

108 ace preference (CPP) paradigm to determine a dose-response curve for the behavioral effects of AMPH i

109 h its mechanism of action and to construct a dose-response curve for the effect of allopurinol.

110 lain this effect, and the first quantitative dose-response curve for the effect of profilin on Ac fac

111 HI-231 cells and displayed a marked biphasic dose-response curve for the induction.

112 ct, produces a similar leftward shift in the dose-response curve for the inhibitory effect of capsaic

113 rence was found in steepness of the erythema dose-response curve for the two lamps at 24 or 72 h.

114 The CCK dose-response curve for TyrP for sites in each kinase wa

115 the basal cAMP content was elevated, and the dose-response curve for vasoactive intestinal peptide-el

116 The dose-response curve for Zn(2+) inhibition was identical

117 nal independent-action approach based on the dose-response curves for a single end point at a single

118 similar binding affinity and transactivation dose-response curves for both thyroid hormone receptor i

119 Dose-response curves for buprenorphine-induced antinocic

120 duced dose-dependent rightward shifts in the dose-response curves for cocaine self-administration and

121 ifies the mechanism and matches the measured dose-response curves for different concentrations of the

122 ties and inhibition by small-molecule drugs, dose-response curves for each enzyme were established fo

123 The EC50 dose-response curves for GCSF, GCSF-Fc and PEG-GCSF were

124 Dose-response curves for homopentameric alpha7 nicotinic

125 The dose-response curves for inhibition of gene transfer rev

126 A rightward-shift of cumulative dose-response curves for morphine analgesia upon chronic

127 Dose-response curves for muscimol in the presence of 3,3

128 We calculated dose-response curves for peptidoglycan-induced interleuk

129 Dose-response curves for several genotoxins were obtaine

130 Dose-response curves for smoking versus fetal growth par

131 ted with radiotherapy demonstrated different dose-response curves for specific SNs.

132 Ultraviolet radiation dose-response curves for sunburn/erythema and suppressio

133 To determine whether the insulin dose-response curves for suppression of endogenous gluco

134 These data indicate that the dose-response curves for suppression of glucose producti

135 here are assay-dependent complexities to the dose-response curves for the engineered resistant viruse

136 nalyte, run and batch of runs; (v) calculate dose-response curves for titrations; (vi) interpolate un

137 rapeutic approach and help establish optimal dose-response curves for training.

138 ional experiments were performed and yielded dose-response curves for two exposure parameters: number

139 conducted a systematic study of currents and dose-response curves for wild-type MscL in Escherichia c

140 e release by 40-50% at all points on the CCK dose-response curve from 3 to 300 pm.

141 Based on dose-response curves from in vivo fluorescence resonance

142 Our model compares favorably with dose-response curves from in vivo Forster resonance ener

143 Glutamate dose-response curves from NR1a/NR2D(T692A) receptor chan

144 Dose response curves generated in this manner were compa

145 were translated into health burdens using a dose-response curve generated from a systematic review a

146 Hap1-dependent aerobic genes and that these dose-response curves have a sharp break at approximately

147 ys given before the acquisition phase and no dose-response curves have ever been drawn up.

148 d cubic spline adiposity-residential density dose-response curve identified a turning point at a resi

149 neration of an unusual type of IFN-induction dose-response curve, (iii) the presence of IFPs that ind

150 tibiotics produced statistically significant dose response curves in which denitrification was stimul

151 The PCP site antagonist had a U-shaped dose-response curve in females, the opposite of that in

152 lipogenic genes also followed a nonmonotonic dose-response curve in response to BPA.

153 No differences were observed in the morphine dose-response curve in suppression of acute nociception

154 also suggest the existence of an inverted-U dose-response curve in the potential therapeutic effect

155 The dose-response curves in 10% PBS revealed a detection lim

156 for simultaneous acquisition of at least 32 dose-response curves in a single experiment, each curve

157 Iron dose-response curves in ALA- and PCB126-treated Cyp1a2(+

158 Most steep dose-response curves in screening may be due to this eff

159 rrent as a measure of P(o), and treatment of dose-response curves in the two-state approximation.

160 eness, such as the slope of the methacholine dose-response curve, in clinical practice and research b

161 percentage of maximal SkBF-[BQ123] sigmoidal dose-response curve indicated a vasodilatory response as

162 Biphasic dose-response curves indicated that the occupancy of the

163 be predicted from IC(50) if the shape of the dose-response curve is also known.

164 Despite this drastic reduction, the glucose dose-response curve is only shifted by approximately 2 m

165 This dose-response curve is strikingly similar to that for ce

166 nt manner at hmGluR2, shifting the glutamate dose-response curve leftward by 3-fold and increasing th

167 d that PD-1 ligation dramatically shifts the dose-response curve, making T cells much less sensitive

168 resistance to antiviral drugs show that the dose response curve may not be monotonic.

169 affected by ethanol with the midpoint of its dose-response curve moved to lower steroid concentration

170 Projection of the dose-response curves observed in this convenience sample

171 The dose-response curve obtained with benzo(a)pyrene incubat

172 behavior of previously reported experimental dose-response curves obtained for two different ligand-r

173 Tolerance measures the dose response curve of a host's health in reaction to a

174 The dose-response curve of 17beta-estradiol was established

175 The position of the dose-response curve of agonist complexes of glucocortico

176 pace is 3-dimensional, and predicts that the dose-response curve of an odor receptor can be obtained,

177 The dose-response curve of each compound was fitted with a s

178 Betaxolol compressed the dose-response curve of glutamate.

179 ibited a left and upward shift of the Ang II dose-response curve of hypertrophy compared with those e

180 As a result, the dose-response curve of myocyte contraction to betaAR ago

181 This work reveals that the dose-response curve of PF74 consists of two distinct inh

182 Here, we found that the dose-response curve of PF74 is triphasic, consisting of

183 obtained by a parallel line analysis of the dose-response curve of the test article in relation to t

184 A 2-log-range linear dose-response curve of transgene expression was obtained

185 endent, and it shifted the oxytocin and ACTH dose-response curves of 8-OH-DPAT to the right (increase

186 itself as a shift towards lower doses in the dose-response curves of individual antiandrogens that be

187 Dose-response curves of mtDNA damage were produced for e

188 Our analysis of dose-response curves of multiple LuxN mutants pins these

189 odel with independent sensors, the different dose-response curves of open probability for one stimulu

190 Dose-response curves of racemic fluoxetine (IC50 = 39 mu

191 The dose-response curves of ternary complex formation reveal

192 ns, followed by construction and analysis of dose-response curves of the most promising hits.

193 Steep dose-response curves of the percentage of responding cel

194 application resulted in an inverted U-shaped dose-response curve on inhibitory tDCS, excitability-dim

195 tor activation produced an inverted U-shaped dose-response curve on plasticity induced by both facili

196 right of the calcitonin gene-related peptide dose-response curve (p < 0.01).

197 ice, O(3) caused only a 0.5 log shift in the dose-response curve (p < 0.05 compared with wild-type).

198 Irreducible uncertainties regarding the dose-response curve prevent us from quantifying the mini

199 ononuclear cells and T cells, we constructed dose-response curves, profiled the secretory behavior of

200 al framework to study disease tolerance, the dose response curve relating health to microbe load; thi

201 Dose-response curves relating insulin secretion to gluco

202 g both BIR2 and BIR3 domains with a biphasic dose-response curve representing two binding sites with

203 o waves of activation differ in time course, dose-response curve, requirement for GRPr CTD, and sensi

204 Dose-response curves revealed dose-dependent profiles wi

205 These data, with dose response curves, show that SEN304 is a powerful inh

206 Analysis of the dose-response curve showed that 12 dimeric gp12 complexe

207 A leptin dose-response curve showed that subcutaneous leptin impr

208 Norepinephrine dose-response curves showed no HTN-related difference in

209 5-HT tension dose-response curves showed that 5-HT-induced myometrial

210 Dose-response curves showed that max2 seeds are hyposens

211 The resulting oxygen dose-response curve shows that an in vitro system with F

212 OFA showed overlapping dose response curves similar to those for RTX in phagocy

213 Our results emphasize the importance of the dose-response curve slope in determining the inhibitory

214 ation of a previously ignored parameter, the dose-response curve slope.

215 itory quotient, neglect a key dimension, the dose-response curve slope.

216 b potency at therapeutic levels by analysing dose-response curve slopes, and show that slope is indep

217 mpleted in less than 3 min and the sigmoidal dose-response curve spanned an antibody concentration ra

218 ase H by these metal ions followed sigmoidal dose-response curves suggesting cooperative metal ion bi

219 first signaling GOx enzyme and a far steeper dose-response curve than that observed for simple Michae

220 y, post-nicotine episodes showed a different dose-response curve than the pre-nicotine episodes: post

221 Trypsin also produced a vasodilator dose-response curve that was biphasic in nature (ED(50-1

222 ve voltammetry, yielded a sigmoidally shaped dose-response curve that was linear over eight orders of

223 They are characterized by highly cooperative dose-response curves that are not explained by current p

224 life cycle generates the highly cooperative dose-response curves that make these drugs uniquely effe

225 Dose-response curves that were generated within several

226 nistration according to an inverted U-shaped dose-response curve; this effect was specific to consoli

227 at 8 mmol/l glucose and shifted the glucose dose response curve to the left.

228 and expectedly right-shifted the terbutaline dose-response curve to 8 +/- 3 microM.

229 steinemia resulted in a reduction in the MBF dose-response curve to adenosine (p < 0.05).

230 Reduced cholesterol did not change the MC4R dose-response curve to alpha-MSH, but it decreased the a

231 A shift in the dose-response curve to APCs was also observed such that

232 The forearm blood flow dose-response curve to methacholine was significantly at

233 deficient mice have a rightward shift in the dose-response curve to morphine on the tail-flick test (

234 However, the morphine dose-response curve to suppress evoked viscerosomatic hy

235 sis and shifted its percent animals vomiting dose-response curve to the right.

236 eased potency of carbachol by a shift in the dose-response curve to the right.

237 isplaced the spinal morphine antinociceptive dose-response curve to the right.

238 of EphB2/Fc chimera with heparin shifted the dose-response curve to the right.

239 essed in isolated and perfused rat livers by dose-response curves to acetylcholine (ACh) and methoxam

240 ses a cell viability assay to generate broad dose-response curves to assess the efficacy of individua

241 weight and eight overweight/obese adults the dose-response curves to bradykinin and sodium nitropruss

242 tance is the assumption that mutations shift dose-response curves to the right without affecting the

243 Increasing pH(i) induced a shift in H(+) dose-response curve toward less acidic pH but a shift in

244 The TTX dose-response curve, using the whole cell voltage-clamp

245 aE and deltaA, extracted from 29 independent dose-response curves, varied in a linearly correlated ma

246 dependent function (narrow inverted-U-shaped dose-response curves) versus classroom/overt behavior (b

247 T(7) receptors, may underlie the bell-shaped dose-response curve via a mechanism of 'cross-talk' inhi

248 using UV detection at 260 nm, while a final dose response curve was quantified using fluorescence de

249 A similar rightward shift in the morphine dose-response curve was caused by morphine tolerance.

250 Also, dose-response curve was constructed to calculate the IC5

251 es C to higher temperatures, and the menthol dose-response curve was displaced to lower concentration

252 A linear dose-response curve was elicited at the fAb-IONs concent

253 A dose-response curve was generated, and the linear detect

254 this primary endpoint, a significant linear dose-response curve was observed: the higher the dose, t

255 An inverted U-shaped dose-response curve was obtained when animals self-admin

256 vessels with phenylephrine, an acetylcholine dose-response curve was obtained while monitoring change

257 From this dose-response curve, we calculated the appropriate dilut

258 Using scoring metrics based on experimental dose-response curves, we assessed 32 methods (31 communi

259 Dose response curves were generated in naive mice and mi

260 At these concentrations the dose response curves were strongly U shaped indicating a

261 Hill coefficients for the spermine dose-response curves were approximately 0.58, indicative

262 Dose-response curves were calculated for all four assay

263 Dose-response curves were carried out using a portable r

264 Dose-response curves were compared with previous individ

265 Dose-response curves were constructed from reflectance m

266 Dose-response curves were constructed using logistic reg

267 measured using a reflectance instrument, and dose-response curves were constructed.

268 Solar-simulated radiation dose-response curves were generated and immune protectio

269 Dose-response curves were generated in which Y79 retinob

270 In addition, two narrow bell-shaped dose-response curves were identified with maxima in eith

271 Time-course and dose-response curves were linear, yielding a limit of qu

272 Parallel dose-response curves were obtained between the universal

273 in at least seven concentrations, such that dose-response curves were obtained for all molecules in

274 Dose-response curves were obtained for quipazine (nonsel

275 ral Antigen, Listeria sp., and Shigella sp., dose-response curves were obtained, and limits of detect

276 Dose-response curves were predicted using Emax models.

277 release, bradykinin and sodium nitroprusside dose-response curves were repeated in the presence of 17

278 Linear and logistic regression and dose-response curves were used to evaluate relations of

279 tunes the system to the steepest part of the dose response curve, where the sensitivity to a given ty

280 OS' feedback loop leads to hysteresis in the dose-response curve, which can enable a capacity to sust

281 of action is consistent with analysis of CHA dose-response curve, which indicates that the reduction

282 ny screening hits inhibit enzymes with steep dose-response curves, which are considered pathological.

283 ost of these studies assayed changes in GABA dose-response curves, which are macroscopic measures tha

284 The biomarker results revealed multiphasic dose-response curves, which suggested toxicity mechanism

285 , the ssOPM system is also used to acquire a dose response curve with the concentration of glucose in

286 h-dose alcohol site show a saturable ethanol dose-response curve with a half-maximal enhancement at 1

287 vities, and the most sensitive peptide had a dose-response curve with an SC(50) (concentration of ana

288 A biological dose-response curve with concentration in a dynamic rang

289 h lower doses revealed a U-shaped (hormetic) dose-response curve with greater parasite suppression at

290 Dose-response curves with 7-84-103 showed that the diffe

291 and automated fitting procedure to describe dose-response curves with multiphasic features.

292 how our approach is successful in describing dose-response curves with multiphasic features.

293 Dose-response curves with the allergens in BAT allowed a

294 We thus provide a robust approach to fit dose-response curves with various degrees of complexity,

295 ml(-1) to 1.66 mg ml(-1)) produced a sigmoid dose response curve, with maximal sweating (measured as

296 d that the type B cells exhibited a biphasic dose-response curve, with mitotic arrest at low drug con

297 de novo lipogenesis followed a nonmonotonic dose-response curve, with more important effects at lowe

298 The method has demonstrated near-linear dose-response curves within a wide range of ~3 decades,

299 nositide turnover by a leftward shift of the dose-response curve without changing the maximum.

300 Glutamate depressed the GABA dose-response curve without shifting the curve laterally