ライフサイエンスコーパス: dose-response relationship

1 l fMRI activity was weak or strong (U-shaped dose-response relationship).

2 20/40, and topical corticosteroid use (in a dose-response relationship).

3 compound 11 for one week revealed a biphasic dose response relationship.

4 izophrenic prodrome and demonstrates a clear dose-response relationship.

5 lity, with a non-significant trend towards a dose-response relationship.

6 r pain and sciatica in men and women, with a dose-response relationship.

7 There was also evidence of a dose-response relationship.

8 analysis with secondary analysis exploring a dose-response relationship.

9 eclinical internal radiotherapy to study the dose-response relationship.

10 fference in 5-y absolute risk), with a clear dose-response relationship.

11 termediate fluoridation exposure suggested a dose-response relationship.

12 he main determinants of ERT, with a definite dose-response relationship.

13 usibility was supported by the presence of a dose-response relationship.

14 es increased the risk of mood disorders in a dose-response relationship.

15 ironmental pathogens and infection, i.e. the dose-response relationship.

16 relationship was fairly linear, suggesting a dose-response relationship.

17 l cortical neurons with an inverted U-shaped dose-response relationship.

18 tion as indicated by a left shift in the ATP dose-response relationship.

19 sion volumes decreased with doxycycline in a dose-response relationship.

20 cross diverse populations, consistent with a dose-response relationship.

21 thout infectious complications to describe a dose-response relationship.

22 w patient numbers-would not prove a positive dose-response relationship.

23 ive therapy, and with evidence of a positive dose-response relationship.

24 ciated with an elevated risk of suicide in a dose-response relationship.

25 er tested characteristics did not modify the dose-response relationship.

26 and (2) evaluate potential modifiers of the dose-response relationship.

27 indings suggesting a threshold rather than a dose-response relationship.

28 overy approaches commonly assume a monotonic dose-response relationship.

29 Larger studies are needed to estimate true dose response relationships.

30 stricted cubic spline models to evaluate the dose-response relationships.

31 linical trials, and we were unable to detect dose-response relationships.

32 t disease, thrombotic stroke, and COPD, with dose-response relationships.

33 and sunlamp use, but we found no significant dose-response relationships.

34 provided unstable estimates and inconsistent dose-response relationships.

35 sion models to test the linear and nonlinear dose-response relationships.

36 ects have been well characterized, including dose-response relationships.

37 gh further work is required to elucidate the dose-response relationships.

38 -squares trend estimation was used to assess dose-response relationships.

39 thrombin or factor Xa, and have predictable dose-response relationships.

40 spitalized with infection in prospective and dose-response relationships.

41 ropose a nonparametric model to describe the dose response relationship and fit the curve using local

42 The association exhibits a dose-response relationship and is strongest for death fr

43 ight of ten causality dimensions (all except dose-response relationship and specificity), we found th

44 esity is mediated by time, insights into the dose-response relationship and the cumulative impact of

45 erated very consistent results and evinced a dose-response relationship and therefore represents an u

46 The association demonstrated a dose-response relationship and was stronger (more than 2

47 Use of antibiotics (supported by the dose-response relationship) and gastrointestinal infecti

48 exhibited encouraging activity but no clear dose-response relationship, and few patients had aggress

49 evidence of falsification, an even stronger dose-response relationship, and psychological costs that

50 se II trial assessed the antitumor activity, dose-response relationship, and safety of nivolumab in p

51 rability of transgene expression, the vector dose-response relationship, and the level of persistent

52 vo situations, increase our understanding of dose-response relationships, and facilitate extrapolatio

53 hat better delineation of sensitive periods, dose-response relationships, and long-term longitudinal

54 te target engagement, differential efficacy, dose-response relationships, and prediction of clinicall

55 iation, alternative explanations, cessation, dose-response relationship, animal experiments, analogy,

56 The better dose-response relationship appeared to be the one based

57 nts who have more than 1 complication with a dose-response relationship as complications accrue.

58 The primary objective was to evaluate the dose-response relationship as measured by progression-fr

59 The study also found a strong dose-response relationship: As retrospective reports of

60 The absence of a dose-response relationship based on breastfeeding durati

61 Furthermore, dose response relationship between cigarette consumption

62 There was no dose response relationship between MMF and PTLD risk.

63 A dose-response relationship between adherence and HIV tra

64 s reported within the first year of RRA, the dose-response relationship between administered activity

65 Available data suggest that the dose-response relationship between allergen exposure and

66 To examine whether a continuous, dose-response relationship between amyloid burden and co

67 e objective of this study was to examine the dose-response relationship between As and global methyla

68 e studies should be conducted to clarify the dose-response relationship between beta-carotene and all

69 A strong significant and positive dose-response relationship between BMI and current asthm

70 idney disease (CKD) and explored a potential dose-response relationship between bone loss and CKD-rel

71 There was a dose-response relationship between both 2D:4D phalangeal

72 dle-income country: there was a differential dose-response relationship between childhood maltreatmen

73 coronary heart disease at baseline, a strong dose-response relationship between cigarette smoking and

74 These findings suggest that there is a dose-response relationship between cigarette smoking and

75 We have found a dose-response relationship between COPD duration and ris

76 d parietal cortical thinning, and an inverse dose-response relationship between CPF and cortical thic

77 omponent of this complex and that there is a dose-response relationship between cystic dilation and l

78 There was evidence of a dose-response relationship between duration of bicycling

79 In the population, there was a dose-response relationship between early gestation and t

80 We observed a strong dose-response relationship between ECG abnormalities and

81 dditional evidence is needed to evaluate the dose-response relationship between environmental arsenic

82 There is a strong dose-response relationship between events known to resul

83 ining the body of literature that supports a dose-response relationship between exercise and cardiova

84 There was no suggestion of a dose-response relationship between exposure to 5-alpha r

85 We observed evidence of a positive, dose-response relationship between fast food intake and

86 However, there was no evidence of a dose-response relationship between frequency of use and

87 The t-test revealed a significant dose-response relationship between fresh frozen plasma a

88 ies to clarify the strength and shape of the dose-response relationship between general and abdominal

89 We detected a dose-response relationship between increased prenatal PA

90 This meta-analysis suggests a dose-response relationship between infused albumin and s

91 inate friendliness and that there might be a dose-response relationship between institutional rearing

92 Furthermore, the data indicate a possible dose-response relationship between intensive care unit i

93 Modeling of a nonlinear dose-response relationship between IR-induced DSBs and C

94 There was a dose-response relationship between length of residence i

95 clearly and accurately depict the well-known dose-response relationship between light intensity and p

96 subjects with gout, there was a significant dose-response relationship between mean temperature in t

97 Preliminary evidence suggests a dose-response relationship between metformin use and inc

98 In each group, there was a sigmoidal dose-response relationship between MPS at 1-2 h post-exe

99 There is an inverse dose-response relationship between PA and HF risk.

100 ates a statistically significant (P < 0.001) dose-response relationship between paclitaxel concentrat

101 The dose-response relationship between plasma lead and M/P r

102 Spline regression showed a dose-response relationship between PM2.5 levels and COWO

103 We observed a strong dose-response relationship between porewater Cu and H. a

104 There was a strong dose-response relationship between prediagnostic sCD30 c

105 We found a significant dose-response relationship between preexposure cognitive

106 A clear dose-response relationship between quintiles of suppleme

107 There was a similar linear dose-response relationship between radiation exposure an

108 We also estimated the dose-response relationship between receipt of increasing

109 k for subsequent new SCC but not BCC, with a dose-response relationship between risk and lower CD4 co

110 May 2014 in which investigators assessed the dose-response relationship between serum levels of 2,3,7

111 The dose-response relationship between serum TCDD and DM acr

112 A dose-response relationship between statin use and HCC ri

113 There was a dose-response relationship between statin use and the ri

114 study among Finnish adults suggest a linear dose-response relationship between sugars and caries, wi

115 Our data provide evidence for a dose-response relationship between tanning bed use and t

116 There was a dose-response relationship between tertiles of mtDNA cop

117 There was a dose-response relationship between tertiles of telomere

118 There is evidence for a dose-response relationship between the amount of mesh us

119 rnational normalized ratio (INR) suggested a dose-response relationship between the degree of anticoa

120 almitic acid with oleic acid; evidence for a dose-response relationship between the intake of dietary

121 Among NDM patients, there was a dose-response relationship between the level of BG and c

122 We noted a strong dose-response relationship between the lowest-yield cate

123 There was a positive dose-response relationship between the number and durati

124 A dose-response relationship between the number of adverse

125 A dose-response relationship between the number of chronic

126 ty regardless of BMI levels, and there was a dose-response relationship between the number of inciden

127 There was a dose-response relationship between the number of psychos

128 There was a significant dose-response relationship between the number of reflux

129 There was a strong dose-response relationship between the number of risk al

130 Quantitative analyses show a log-linear dose-response relationship between the sucrose or its mo

131 There was a significant positive dose-response relationship between uncontrolled hyperten

132 There was a dose-response relationship between weekend nurse/bed rat

133 ralized additive models were used to examine dose-response relationships between blood, plasma, and m

134 iovascular mortality and highly inconsistent dose-response relationships between calcium intake and r

135 We explored the dose-response relationships between maternal blood, plas

136 addition, we observed significantly positive dose-response relationships between number of nevi and h

137 Categorical dose-response relationships between PA and HF risk were

138 Cohort studies showed no consistent dose-response relationships between total, dietary, or s

139 The "dose-response" relationship between baseline and follow-

140 the degree of blast exposure, suggesting a 'dose-response' relationship between the number of blast

141 pproach to the simple example of agents with dose-response relationships described by Hill functions

142 he presence of 2'-O-Me-cAMP (50 microM), the dose-response relationship describing ATP-dependent inhi

143 Pigs were sacrificed 21 days later for dose-response relationship evaluation by immunohistopath

144 Cs without SPMs (P < or = 0.01, n = 6), with dose-response relationships evident for the 300- and 100

145 etic responses are characterized as biphasic dose-response relationships exhibiting a low-dose stimul

146 Among Medicare beneficiaries, a strong dose-response relationship existed between the number of

147 r the first time, we have shown that a steep dose-response relationship exists between allopurinol an

148 aim of the study was to determine whether a dose-response relationship exists between cumulative run

149 It is clear that a dose-response relationship exists following treatment wi

150 A strong dose-response relationship exists for the treatment of C

151 The choice of dose response relationship for physical activity had a l

152 biomedical data that exhibits a nonmonotonic dose response relationship for which traditional paramet

153 nd products, it is necessary to quantify the dose-response relationship for a wide range of doses for

154 A dose-response relationship for additional quarters of th

155 The dose-response relationship for BMI with HFpEF risk was a

156 tivity approach, a statistically significant dose-response relationship for both thyroid remnants and

157 The dose-response relationship for CRF on EDS performance re

158 tio [RR] 2.1 [95% CI 1.5-3.1]), with a clear dose-response relationship for dosages >5 mg/day (for <

159 Is there a dose-response relationship for efficacy and safety?, and

160 tments and lysosomes alongside a PTH-induced dose-response relationship for fractional phosphate excr

161 g hypo- and hyperglycemia, respectively, the dose-response relationship for glucose-induced [ATP]pm g

162 at model of acute myocardial infarction, the dose-response relationship for intracoronary CSCs is fla

163 We found a dose-response relationship for mGFP-GPI nanoplatform dis

164 set (IRR = 1.24, 95% CI: 1.07, 1.43), with a dose-response relationship for number of courses (P-tren

165 A significant dose-response relationship for occurrence of cases was s

166 aim of the present work was to evaluate the dose-response relationship for pancreatic neuroendocrine

167 e new model: 1), quantitatively reproduces a dose-response relationship for the effects of changes in

168 treated with neocarzinostatin showed a clear dose-response relationship for the formation of N(6)-for

169 These studies indicate a clear dose-response relationship for tumor control with escala

170 uccessfully describe experimentally observed dose-response relationships for a variety of cell types.

171 Dose-response relationships for alkylating chemotherapy

172 ing safety of nonalkylating chemotherapy and dose-response relationships for alkylating chemotherapy

173 d population dose responses are distinct; b) dose-response relationships for all (including quantal)

174 These are treatment modalities for which dose-response relationships for healthy tissues and tumo

175 ctal cancer but no statistically significant dose-response relationships for prostate and breast canc

176 With other CD20 antibodies, a dose-response relationship has been shown.

177 activity may still be suboptimal, because a dose-response relationship has not been defined.

178 specific and all-cause mortality, although a dose-response relationship has not been established.

179 risks of heart failure (HF), but a radiation dose-response relationship has not previously been deriv

180 work characterizing the functional forms of dose-response relationships has used statistical fit to

181 enoic acid (DHA) have been demonstrated, and dose-response relationships have been defined.

182 threshold effect on survival, rather than a dose-response relationship (highest v lowest tertile: SA

183 The linear radiation dose-response relationship identified can be used to pre

184 The dose-response relationship in a fixed-activity approach

185 nder and low-dose-rate effects influence the dose-response relationship in a manner not predicted by

186 The lack of a dose-response relationship in both the efficacy and safe

187 r clinical trials of vericiguat based on the dose-response relationship in this study are needed to d

188 There was no apparent dose-response relationship in treatment-emergent adverse

189 conditions and a meta-analysis that found a "dose-response relationship" in observational studies of

190 A dose-response relationship indicated higher IQ scores in

191 In regulatory toxicology, the dose-response relationship is a key element towards fulf

192 model calculations presented in this work, a dose-response relationship is demonstrated, and an analy

193 choice, yet information on the nature of the dose-response relationship is lacking.

194 As this dose-response relationship is observed across hospitals,

195 tion, the complexity of exposure and dose in dose-response relationships is highlighted.

196 swamp bordering the parish showed a strong "dose-response" relationship; living in the swamp was the

197 Although exploratory, a dose-response relationship may exist, but its relevance

198 cient, nH, which measures the steepness of a dose-response relationship, may be a useful gauge of thi

199 metry are thus crucial to the development of dose-response relationships needed to optimize these the

200 To estimate this value, the dose response relationship needs to be established, whic

201 a nearly 3-fold higher risk for VTE, with a dose-response relationship of 18% higher risk for each 2

202 A dose-response relationship of compounds 1-4 was determin

203 tude at which a patient lives may affect the dose-response relationship of EPO.

204 Nevertheless, there is debate on the dose-response relationship of exercise and cardiovascula

205 es GABA turnover by reuptake mechanisms, the dose-response relationship of IL15 on (3)H-GABA uptake w

206 The authors explored the dose-response relationship of ivabradine in children wit

207 A meta-analysis was performed to assess the dose-response relationship of long-term coffee consumpti

208 ffects models to model any alcohol intake or dose-response relationships of alcohol intake and cardio

209 e present study was performed to examine the dose-response relationships of moderate levels of hormon

210 ummarize available data on the dosimetry and dose-response relationships of several theranostic compo

211 l artery was not sufficient to yield a clear dose-response relationship on NE content and axon densit

212 in death; however, little is known about the dose-response relationship or effects of potential overd

213 A significant dose-response relationship (p = .0022) was observed acro

214 shorter LTLs, respectively, with evidence of dose-response relationship (P for trend < 0.05).

215 s rose with increasing levels of stress in a dose-response relationship (P-trend < 0.0001), independe

216 of topical (aHR, up to 8.77 that followed a dose-response relationship; P < 0.001), periocular (aHR,

217 sed the PKCalpha activity with a bell-shaped dose-response relationship peaking at 10 nM, thereby inc

218 There was also a significant pitrakinra dose-response relationship (placebo/1 mg/3 mg/10 mg) for

219 ries of protocols to assess its methacholine dose-response relationship, shortening velocity, and res

220 A dose-response relationship showed that VEGF(165)b (EC(50

221 ation in seven of ten dimensions (all except dose-response relationship, specificity, and animal expe

222 g them suitable for quantitative imaging and dose-response relationship studies in animals.

223 We found a dose-response relationship such that individuals with CO

224 ared with nonobese patients, and there was a dose-response relationship such that obese (odds ratio =

225 There was evidence of a dose-response relationship such that the effect of age o

226 ath or ventricular arrhythmia, the lack of a dose-response relationship suggests that this associatio

227 6.0) for developing colorectal cancer with a dose-response relationship supported (P(trend) = 0.006).

228 NE in the OB generated a non-monotonic dose-response relationship, suppressing mitral cell acti

229 gnificant challenge in assessing an accurate dose-response relationship that is predictive of toxicit

230 de a more sophisticated understanding of the dose-response relationship, the integration of genetic a

231 To determine dose-response relationships, the association between smo

232 luenced by the microinjections in a biphasic dose-response relationship; the lowest (0.3mug) and high

233 Incident mortality was associated with a dose-response relationship to the number of coronary ves

234 MACE was associated with a dose-response relationship to the number of vessels exhi

235 diates UV-B responses in vivo with a similar dose-response relationship to wild-type.

236 o contaminants and nutrients in fish, employ dose-response relationships to convert exposure to healt

237 simetry, thus complicating extrapolations of dose-response relationships to human patients.

238 ic studies should focus on the evaluation of dose-response relationships, types of solid cancers, lat

239 3 is activated slowly and exhibits a steeper dose-response relationship (ultrasensitivity).

240 high resolution of the data reveals complex dose-response relationships unambiguously.

241 through reevaluation of the lead absorption dose-response relationship using new bioavailability dat

242 In cells incubated with oleic acid, a dose response relationship was observed between medium d

243 A strong dose-response relationship was also seen among current s

244 Furthermore, for L. innocua, the dose-response relationship was demonstrated and found to

245 A significant dose-response relationship was demonstrated between chro

246 No dose-response relationship was detected as measured by P

247 A dose-response relationship was evident (P < .001).

248 A dose-response relationship was evident at each measured

249 in each period independently, among boys, a dose-response relationship was evident for each level in

250 We also expected to determine whether a dose-response relationship was evident.

251 A clear dose-response relationship was evident.

252 A strong and statistically significant dose-response relationship was found (P < 0.001).

253 A dose-response relationship was generated and the probabi

254 A dose-response relationship was identified, with an 18% h

255 ccording to age/hormonal status and the full dose-response relationship was not available in all expe

256 Overall, a significant dose-response relationship was noted between NO exposure

257 A significant dose-response relationship was observed between adduct q

258 xposures did not interact synergistically, a dose-response relationship was observed between domestic

259 No dose-response relationship was observed between GSK21417

260 A dose-response relationship was observed between longer D

261 A dose-response relationship was observed between severity

262 subjects were categorized into quartiles, a dose-response relationship was observed for all of the a

263 A dose-response relationship was observed for transient tu

264 A dose-response relationship was observed with injury seve

265 A dose-response relationship was observed, such that previ

266 In general, a dose-response relationship was observed, with the highes

267 A similar dose-response relationship was observed.

268 With decreasing financial reserves, a clear dose-response relationship was present across all measur

269 A trend toward a dose-response relationship was seen for AC cells and fla

270 fections of the respiratory tract, whereas a dose-response relationship was seen for skin infections.

271 FB1) and proliferation of cells M12.C3.F6; a dose-response relationship was showed.

272 fects of dose and potential modifiers of the dose-response relationship were evaluated with hierarchi

273 Dose-response relationships were evaluated between cance

274 currents, the current amplitudes, and the pH dose-response relationships were not altered in mice wit

275 Dose-response relationships were observed with respect t

276 ant exposure pathways, and pathogen-specific dose-response relationships were then used to estimate p

277 e exploratory secondary analysis suggested a dose-response relationship whereby higher vericiguat dos

278 wever, additional research on the timing and dose-response relationship will be crucial for designing

279 Full dose response relationships with inductions over 100-fol

280 in Scyc during the first POD demonstrated a dose-response relationship with 3-month graft function.

281 to the total set of QIs showed a significant dose-response relationship with a shorter LOS.

282 rability to developing PTSD or the lack of a dose-response relationship with amygdala volume.

283 a from 8 studies, there was a trend toward a dose-response relationship with an increase in the poole

284 es measured by 31P-MRS or 1H-MRS there was a dose-response relationship with aura duration and severi

285 y measure of DBPs that yielded the strongest dose-response relationship with bladder cancer risk.

286 ated with child ASB and showed a significant dose-response relationship with child ASB at 7 years of

287 In models examining TDP-43 stage, a dose-response relationship with clinical Alzheimer's-typ

288 indicated that advancing paternal age had a dose-response relationship with every index of morbidity

289 A dose-response relationship with final median infarct siz

290 uld respond, as evidenced by the significant dose-response relationship with ICS adherence.

291 Exposure to benzodiazepines showed a dose-response relationship with mortality (hazard ratios

292 d individual apoptotic cells, showed a clear dose-response relationship with NMDA, and colocalized wi

293 FGF23 exhibited a dose-response relationship with outcomes (HR=1.30 per do

294 SAR236553 demonstrated a clear dose-response relationship with respect to percentage LD

295 atal stress further demonstrated a positive, dose-response relationship with symptoms of externalizin

296 f migraine, these abnormalities might show a dose-response relationship with the duration and severit

297 placebo, and secondary analysis evaluated a dose-response relationship with vericiguat and the prima

298 Ln-vanadium concentrations showed non-linear dose-response relationships with risk of preterm deliver

299 There was a dose response relationship, with increased odds ratios w

300 The dose-response relationship, with the 400 U dose showing