ライフサイエンスコーパス: dosing

1 ns), in combination with loperamide (labeled dosing).

2 acid-degradable carrier, even after multiple dosing.

3 phagocytosis several days after hexameric-Fc dosing.

4 lonization, primarily in the lung, 10 d post dosing.

5 e of greater than 1 were discontinued before dosing.

6 ciated with inferior OS relative to standard dosing.

7 al gluten challenge were discontinued before dosing.

8 duced cumulative drug use of 47% of standard dosing.

9 e half-life of 11.6 h, suggesting once-a-day dosing.

10 ylene adsorption occurring within 30 s after dosing.

11 guidelines had no appreciable effect on HCQ dosing.

12 CT scans were obtained every 24 h throughout dosing.

13 eron-gamma production decreased after RG-101 dosing.

14 fficacy, safety concerns, and multiple daily dosing.

15 its use is sparse and limited to use of oral dosing.

16 ocompatible, via the nasal route, on chronic dosing.

17 nd after (t=10, 20, 30, 45 and 60 min) d5 OT dosing.

18 ation during early or late time periods post-dosing.

19 eline to 6 months with 2-minute vs. 5-minute dosing.

20 h ISR emerged within 12 hours of active drug dosing.

21 13 different times from 30 min to 24 d after dosing.

22 ohen's d=0.48-0.85) at all time points after dosing.

23 nst influenza, even after extensive repeated dosing.

24 al cholesterol levels in rats following oral dosing.

25 surements were made forty-five minutes after dosing.

26 robust in vivo target engagement after oral dosing.

27 ten structure, carrier protein, adjuvant and dosing.

28 i) may allow more titratable and longer-term dosing.

29 were assigned to receive twice-daily divided dosing.

30 ingle morning doses versus twice-daily split dosing.

31 2.5 mg) colecalciferol or equivalent placebo dosing.

32 effects, thereby allowing for less frequent dosing.

33 mitochondrial biogenesis with in vivo human dosing.

34 ation occurred in the incurred samples after dosing.

35 tes were >80% with the proposed supplemental dosing.

36 On the tenth day following initiation of dosing, 10 patients underwent an intensive pharmacokinet

37 Following taper to once-daily vancomycin dosing, 22 of 36 patients (61%) who received every-other

38 ry end point, peak FEV1 within 3 hours after dosing (5 mug, 139 mL [95% CI, 75-203; P < .001]; 2.5 mu

39 We performed a comparison of carboplatin dosing accuracy on the basis of an absolute percentage e

40 However, daily dosing activated atrophic pathways, including F-box prot

41 aily in the morning or evening with a single dosing aid.

42 ol 0.5% (TRAV+TIM; unfixed) using electronic dosing aids.

43 TIM once daily in the morning using separate dosing aids.

44 administered medication, as recorded by the dosing aids.

45 The project has generated clinician-friendly dosing algorithms and pointed to circumstances where int

46 The aim was to develop dosing algorithms for achievement of a clinically desira

47 Autonomously adaptive dosing algorithms used data from a continuous glucose mo

48 However, daily prednisone dosing also correlated with increased muscle adipogenesi

49 onic steroid use usually involves once-daily dosing, although weekly dosing in children has been sugg

50 in the blood and brains of rats 1 week after dosing and 20 weeks after dosing with up to 20 repeat do

51 ow eyes (n = 207) were treated with 5-minute dosing and considered in the safety analysis.

52 e therapy compared with empiric weight-based dosing and explores the performance of different trough

53 ift that moves away from an era of empirical dosing and fractionation to an era focused on the develo

54 udies are warranted into optimization of the dosing and frequency of AD-MSC therapy, either alone or

55 , but they can represent high costs, complex dosing and management, and are not widely available arou

56 aboratory and clinical efficacy, but optimal dosing and monitoring regimens for Africa remain undefin

57 fety profiles, as well as additional data on dosing and safety among patients with severe renal insuf

58 Additional iterative experiments for optimum dosing and selecting BKIs with minimum levels of hERG ac

59 However, daily dosing and split dosing might increase serum hepcidin an

60 iation between temporal changes in treatment dosing and subsequent neoplasm risk.

61 en women were assigned to receive once-daily dosing and ten were assigned to receive twice-daily divi

62 nes in 2011 had no appreciable effect on HCQ dosing and that transitioning to the 2016 dosing modific

63 addressed the new data on intervals between dosing and the role of BMAs in control of bone pain.

64 st preclinical evidence, have solid phase II dosing and timing data, and recruit patients who have tr

65 est concern is the lack of adequate phase II dosing and timing studies when rushing from promising pr

66 Elucidation of optimal dosing and treatment content is critical for health care

67 178 (93%) completed directly observed dosing and were randomly assigned one of the three PrEP

68 e more recently introduced C60(++) (under NO dosing and with sample cooling) and argon cluster ion be

69 "real-world" practice with regard to timing, dosing, and sequence of antiepileptic therapy.

70 /kg maintenance doses) plus pertuzumab [same dosing as in the other group]).

71 or 16 weeks) or ofatumumab alone (ofatumumab dosing as per the combination group, except 2000 mg was

72 and anatomic outcomes compared with monthly dosing at 1 year.

73 ected mice in 3/6 derivatives following oral dosing at 4 x 30 mg/kg, with microsomal metabolic stabil

74 sustained adherence to once-daily ibrutinib dosing at 420 mg as clinically feasible to achieve optim

75 aphylaxis in C57BL/6 mice upon repeated i.p. dosing because of an anti-idiotypic anti-drug Ab immune

76 ching and preservation techniques, lower CNI dosing, BK viremia screening) may have had.

77 Whether genotype-guided warfarin dosing can prevent these adverse events is unknown.

78 operative warfarin, genotype-guided warfarin dosing, compared with clinically guided dosing, reduced

79 For the dosing condition used, approximately 50% of the added Ag

80 interventions; (d) mindfulness intervention dosing considerations; and (e) potential risks of mindfu

81 This intermittent sunitinib dosing continued until Response Evaluation Criteria in S

82 Dosing could be increased to every 2 weeks after 12 week

83 very 24 hours, for a minimum of four 24-hour dosing cycles.

84 Simulations with standard abiraterone dosing demonstrate strong selection for androgen-indepen

85 This innovative dosing device, along with the proteomic evaluation with

86 long-term efficacy and safety profile of PRN dosing driven by individualized VA stabilization criteri

87 hypothesis-driven protocols (i.e. empirical dosing, driven by both safety concerns and practical asp

88 re maintained and stable with individualized dosing during ENDURANCE, fluctuating by <1.5 mean letter

89 and 80 and 59 patients completed study drug dosing during the double-blind and open-label phases, re

90 ng amplitude individualization as a means of dosing especially for ECT.

91 -HSD1 enzyme for the first 12 h period after dosing followed by an "inhibition holiday" so that the p

92 mAb (2-, 10-, or 50-mg monthly subcutaneous dosing for 12 months) or placebo.

93 ials testing pharmacogenomic-guided warfarin dosing for patients with atrial fibrillation have demons

94 ects of naloxone route of administration and dosing for suspected opioid overdose in out-of-hospital

95 8 weeks, with response-guided individualised dosing for the remaining weeks up to week 24.

96 efficacies, but slight modifications in the dosing frequencies of the two drugs can significantly in

97 ments to dose (</=100 IU/kg per infusion) or dosing frequency (up to two times per week) as needed.

98 his approach has the potential to reduce the dosing frequency associated with retinal disease treatme

99 These data indicate that dosing frequency of glucocorticoid steroids affects musc

100 The capability of this dosing function was successfully evidenced by post colum

101 (29.5%) in the zoledronic acid every 4-week dosing group and 253 patients (28.6%) in the every 12-we

102 nd 253 patients (28.6%) in the every 12-week dosing group experienced at least 1 skeletal-related eve

103 ery 4-week dosing group vs the every 12-week dosing group for patients with breast cancer, prostate c

104 ts (14.7%) in the clinically guided warfarin dosing group met at least 1 of the end points (absolute

105 iffer significantly between the every 4-week dosing group vs the every 12-week dosing group for patie

106 mg/kg (n = 14) or received a placebo (n = 2/dosing group).

107 mprovements are evident 6 hours after (last) dosing, >/=24 hours maybe needed for clinically meaningf

108 To determine whether genotype-guided dosing improves the safety of warfarin initiation.

109 Peptide dosing in cells manifests KDM4A target stabilization.

110 involves once-daily dosing, although weekly dosing in children has been suggested for its reduced si

111 ered an extension (REFLEXION, REbif FLEXible dosing in early MS extensION): patients initially random

112 24-month double-blind REFLEX (REbif FLEXible dosing in early MS) study entered an extension (REFLEXIO

113 outcome associated with intermittent steroid dosing in LGMD 2B and 2C muscle.

114 ed with side effects that preclude effective dosing in many patients [8].

115 hat 13-d had properties compatible with oral dosing in mouse models of disease (Fpo 49%).

116 e is too short, it may require more frequent dosing in order to maintain desired exposures and avoid

117 dosing throughout therapy, and twice weekly dosing in the continuation phase appear to have worse mi

118 aluation may result in off-label use without dosing information as the only access to new drugs.

119 The optimal dosing interval for zoledronic acid is uncertain.

120 ver, the ability to adjust both the dose and dosing interval of beta-lactam agents allows the treatme

121 id every 12 weeks compared with the standard dosing interval of every 4 weeks did not result in an in

122 ed 5 mg/kg belatacept every 2 weeks, and the dosing interval was extended to 4 weeks after 5 applicat

123 AdjCmax and AdjTAC-area under the curve at dosing interval were both higher in the Eld compared to

124 tion (R = 0.76) with area under the curve at dosing interval.

125 valent with 2-minute and 5-minute riboflavin dosing intervals at 6 months (0.97 and 0.76 diopters, re

126 andomized to 2-minute or 5-minute riboflavin dosing intervals with standard corneal cross-linking (ep

127 ring different bone-modifying agents, doses, dosing intervals, and durations is required.

128 wed three phase III noninferiority trials of dosing intervals, one systematic review and meta-analysi

129 enafil suffers from the limitations of short dosing intervals, peripheral vasodilation, unwanted side

130 With both dosing intervals, the mean improvement in CDVA was 0.07

131 limumab given weekly, while every other week dosing is ineffective, with reductions in Dermatology Li

132 ypothesis, and its use, in the form of ALARA dosing, is responsible for misguided concerns promoting

133 get engagement in mouse liver following oral dosing, leading to improved lipid metabolism and insulin

134 tive deficits, these data suggest that daily dosing may be critical to allow for development of robus

135 aunorubicin, suggesting that optimizing drug dosing may improve outcomes while reducing toxicity.

136 sign of new interventions, drug delivery and dosing mechanisms, and public health policy.

137 However, daily dosing and split dosing might increase serum hepcidin and decrease iron a

138 CQ dosing and that transitioning to the 2016 dosing modification is unlikely to change this outcome u

139 ight patients were treated with every-2-week dosing (n = 10 at 0.6 mg/kg; n = 18 at 0.8 mg/kg).

140 ulation analysis and guided the supplemental dosing needed.

141 osing regimens through either evidence-based dosing nomograms or preferably through the use of dosing

142 Neither increased dosing nor half-life extension by fusion of A4 to IgG2a

143 Using a conventional dosing of 16 g/2 g/24 hr continuous infusion, obese pati

144 y contaminated soil with and without passive dosing of a competitive sorbate.

145 vels can serve as a biomarker of therapeutic dosing of AE, whereas IGF-1 is a key molecule coupled to

146 Identifying optimal dosing of antibiotics has proven challenging-some antibi

147 enables physicians to achieve fast adequate dosing of antibiotics to improve the outcome of patients

148 Metronomic dosing of chemotherapy-defined as frequent administratio

149 Overall, increased dosing of corrosion inhibitors is probably reducing the

150 pporting a potential role of these models in dosing of ECT and MST.

151 Oral dosing of EZM2302 demonstrates dose-dependent in vivo CA

152 of drug delivery vehicles, and ultra-precise dosing of high potency drugs.

153 d to establish the appropriate frequency and dosing of individualized turning protocols to prevent pr

154 ed on the presented results, a less frequent dosing of mavacoxib is proposed compared to celecoxib an

155 uble-masked trials reported here, once-daily dosing of netarsudil 0.02% was found to be effective and

156 ere assigned to one of three groups based on dosing of NTBC.

157 of 12-48 h is generally ideal for once daily dosing of oral drugs.

158 and acceptability of daily versus non-daily dosing of oral HIV pre-exposure prophylaxis (PrEP) among

159 improve standardization and provide accurate dosing of peanut preparations that are being used for OI

160 Conversely, intermittent dosing of prednisone, provided once weekly, enhanced mus

161 Optimal dosing of PRIT plus venetoclax cured 100% of mice with n

162 randomized trial found that treat and extend dosing of ranibizumab 0.3 mg with and without angiograph

163 , there is variability in the post-marketing dosing of regorafenib.

164 at RSV enhanced-disease model, as suboptimal dosing of several RSV F subunit vaccine candidates led t

165 studies are required to clarify the optimal dosing of tenapanor in patients with CKD-related hyperph

166 In vivo PCSK9 lowering by oral dosing of the candidate prodrug and quantification of th

167 Intraperitoneal dosing of the clinically used prodrug irinotecan produce

168 e research into the medicinal behaviours and dosing of this living antibacterial.

169 The passive dosing of toluene below its saturation level revealed co

170 In this experiment, passive dosing of toluene resulted in desorption of 13 +/- 0.4%

171 Concerns have been raised that intravitreal dosing of vascular endothelial growth factor inhibitors

172 We sought to identify the optimal dosing of VOR for effective serial reversal of HIV laten

173 Further, it is hypothesised that the dosing of xylanase and transglutaminase has a positive i

174 s study to evaluate the impact of vancomycin dosing on patient outcome in MRSA bloodstream infection

175 Herein, we assessed the efficacy of steroid dosing on sarcolemmal repair, muscle function, histopath

176 >/=18 years) who received directly observed dosing once a week for 5 weeks followed by random assign

177 nblinded PrEP regimens for self-administered dosing over 24 weeks: daily; time-driven (twice a week p

178 serum hepcidin concentration than once-daily dosing (p=0.013).

179 may guide the development of seizure therapy dosing paradigms with improved risk/benefit ratio.

180 rough October 2014, a prospective, replicate dosing, partially blinded, randomized, 3-treatment, 6-pe

181 At 4, 6, 24, and 48 hours from (last) dosing, patients' blood samples were supplemented with c

182 e goal of this study was to investigate NOAC dosing patterns and associated outcomes, i.e., stroke (i

183 Most SRs occurred during the up-dosing phase (75.8%) and were mild in severity (71.6%).

184 perenne peptides (LPP) and having a short up-dosing phase has been developed to treat grass pollen-in

185 nt predictors of failing to achieve complete dosing; private insurance status was predictive of compl

186 patients (61%) who received every-other-day dosing (QOD) and 50 of 64 (81%) who received QOD followe

187 e models of LGMD 2B and 2C, daily prednisone dosing reduced muscle damage and fibroinflammatory infil

188 arin dosing, compared with clinically guided dosing, reduced the combined risk of major bleeding, INR

189 rug half-life has important implications for dosing regimen and peak-to-trough ratio at the steady st

190 ermatology with ustekinumab according to the dosing regimen approved for psoriasis.

191 The improved selinexor dosing regimen described herein is crucial to help reduc

192 ) monotherapy using a consistent, comparable dosing regimen for 3 months after transplant.

193 Moreover, the use of a different dosing regimen for RTX and OBZ further complicates any i

194 ve allowed us to identify a linker, dose and dosing regimen for SN-38 conjugated to polyoxazoline-mod

195 Consistent with this mechanism, the repeat dosing regimen in a separate cohort of subjects led to i

196 bone who had previously received a standard dosing regimen of zoledronic acid and/or pamidronate dis

197 After a daily dosing regimen, a shift to excitatory-inhibitory balance

198 dual patient data on SAEs, assigned drug and dosing regimen, and baseline prognostic factors were req

199 nd strong translational evidence, an optimal dosing regimen, and better tolerability.

200 or racial origin, body-mass index, vitamin D dosing regimen, use of inhaled corticosteroids, or end-s

201 half-life, necessitating a three times daily dosing regimen.

202 und (SC-51322) to AGN 197727 in the systemic dosing regimen.

203 These findings suggest that dosing regimens could be individualised and tailored for

204 d in the development of increased and serial dosing regimens for somatic gene editing in vivo.

205 ATION: Both the 2-week and 4-week ixekizumab dosing regimens improved the signs and symptoms of patie

206 ity of two long-term intermittent vismodegib dosing regimens in patients with multiple basal-cell car

207 istance would be of great value in tailoring dosing regimens of antibiotics so as to maximize the dur

208 drugs and other biological treatments, both dosing regimens of sirukumab were well tolerated and sig

209 The 2 riboflavin dosing regimens produced equivalent reduction in the max

210 These customized dosing regimens should also be given as soon as practica

211 The two benralizumab dosing regimens significantly reduced the median final o

212 able optimized dosing, the use of customized dosing regimens through either evidence-based dosing nom

213 valence for the treatment difference between dosing regimens was considered clinically relevant.

214 ly limited by small sample sizes, inadequate dosing regimens, and high baseline vitamin D status amon

215 suffer from rapid clearance requiring 3-day dosing regimens.

216 vitro immunologic activity of the different dosing regimens.

217 that modulates its potency, concentration or dosing relative to a patient's dynamic glucose concentra

218 Oral dosing renders blood stage parasitaemia undetectable in

219 tic renal cell carcinoma (mRCC), but chronic dosing requires balancing toxicity with clinical benefit

220 r hydrophobic drugs is more challenging with dosing restrictions and the use of organic solvents impa

221 y to be compatible with the intravenous (iv) dosing route required in AP.

222 progressing disease received an accelerated dosing schedule (to 400 mg per day by week 3).

223 ons and dose scheduling showed that a weekly dosing schedule of 4mg SN-38/kg was the most efficacious

224 aimed to assess the effect of an intensified dosing schedule of subcutaneous methotrexate in patients

225 the quantitative model can determine optimal dosing schedule to enhance the effectiveness of the comb

226 udies are warranted to determine the optimal dosing schedule to improve therapeutic efficacy while re

227 atients started at a 120 mg continuous daily dosing schedule, different from the standard intermitten

228 ived daratumumab 16 mg/kg at the recommended dosing schedule, pomalidomide 4 mg daily for 21 days of

229 le, different from the standard intermittent dosing schedule.

230 There is interest in evaluating alternate dosing schedules and novel combinations of pano for the

231 amine the efficacy of different intermittent dosing schedules in first-line pulmonary tuberculosis th

232 We further noted that alternating dosing schedules of Gant61 and vemurafenib prevented the

233 Purpose The objectives were to evaluate dosing schedules of labetuzumab govitecan, an antibody-d

234 INTERPRETATION: Both intermittent dosing schedules of vismodegib seemed to show good activ

235 3(2H)-one] using simultaneous and sequential dosing schedules.

236 trong antitumor activities at well-tolerated dosing schedules.

237 ab, with no difference between pembrolizumab dosing schedules.

238 se, and acquired drug resistance (ADR) for 4 dosing schedules: daily throughout, thrice weekly throug

239 atients were treated with the initial weekly dosing scheme; 2 of these patients died of neutropenic s

240 cially since tender negotiations and reduced dosing schemes have driven down the cost of vaccination.

241 It was recommended that split dosing should be incorporated into all artemisinin combi

242 g nomograms or preferably through the use of dosing software supplemented by therapeutic drug monitor

243 tomycin-treated patients compared with other dosing strategies (risk ratio, 0.83; 95% CI, .74-.94; P

244 re observed between the different antibiotic dosing strategies and no treatment, suggesting that live

245 2 weeks is a suboptimal regimen; alternative dosing strategies are being investigated.

246 ailed dosimetry data that may lead to better dosing strategies in the future.

247 A randomised phase 2 trial of alternative dosing strategies of this combination is underway.

248 M, preparation of IT AmBd, and the different dosing strategies used in regard to route of administrat

249 l methods behind preparation, titration, and dosing strategies utilized.

250 Various dosing strategies were used for the administration of im

251 l laboratories to support cefepime MIC-based dosing strategies.

252 rity of a novel, individualized, cryotherapy-dosing strategy for each vein.

253 erance remains widely accepted: the use of a dosing strategy that provides an interval of no or low n

254 Using a blinded dosing strategy, we demonstrated that high dose sertrali

255 Continuous dosing studies were performed during which the sensor wa

256 cells increased significantly during MGN1703 dosing, suggesting an enhancement of cellular immune res

257 ed with omalizumab according to the approved dosing table.

258 determine the value of customized antibiotic dosing, that is, giving the right dose at the right time

259 Following dosing, the spheroids were harvested for quantitative pr

260 order to obtain a more stable form for oral dosing, the sulfhydryl group in conjugate 1 was converte

261 To enable optimized dosing, the use of customized dosing regimens through ei

262 To explore the potential effect of 2-week dosing, three additional participants were enrolled in a

263 on the date of distribution and recommended dosing throughout the 4 wk of follow-up.

264 Thrice weekly dosing throughout therapy, and twice weekly dosing in th

265 Delays in dosing time will result in transient periods of lower co

266 pheresis at study entry increased evolocumab dosing to every 2 weeks, with an additional mean reducti

267 More work is needed to optimize its dosing to minimize adverse events, such as peripheral ne

268 SV-associated ARI occurring >/=14 days after dosing was 1.7% and 1.6% in the vaccine and placebo grou

269 ved among those who did not achieve complete dosing was 34.2 Gy (interquartile range, 19.8-40.0 Gy).

270 Median duration of dosing was 36.4 weeks; 15 patients remained on treatment

271 Reduced dosing was not associated with inferior OS relative to s

272 Dosing was resumed at 400 mg, and four additional DLTs w

273 rial reversal of latency over 1 month of VOR dosing, we did not observe a measurable decrease (>0.3 l

274 pectrum was detected as early as 10 wk after dosing, well before evidence of neoplasia.

275 erences for RDR comparing single and chronic dosing were 3.26-fold (95% CI 1.46-7.29) and 2.51-fold (

276 transition from monthly to pro re nata (PRN) dosing were correlated in AMD (r = -0.27) and RVO (r = -

277 who received QOD followed by every-third-day dosing were cured (P = .03).

278 nital HSV-2 shedding rates immediately after dosing were reduced with GEN-003 (from 13.4% to 6.4% for

279 nimizing the risks of variations in allergen dosing when switching from one lot of manufactured extra

280 the inflection point between monthly and PRN dosing, when recurrence of edema is anticipated in many

281 uld be compatible with very infrequent, s.c. dosing while maintaining a similar level of immune suppr

282 d bioenergetics were confirmed in vivo after dosing with AZD3965 in mouse xenograft models of human l

283 ignificantly higher rates compared to repeat dosing with chemotherapy.

284 resent in the rat brain 1 and 20 weeks after dosing with contrast agent and to determine if there are

285 tly blunted after chronic compared to single dosing with either ICS/IND (P<.005) or ICS/IND/TIO (P<.0

286 1 mM Ca(2+) in dose-limited systems prior to dosing with FeCl3 increased Fe hydrolysis and zeta poten

287 linium are present in the brain after repeat dosing with gadodiamide, which is partially cleared over

288 Similar outcomes were observed following dosing with HMW PEO alone.

289 ly long serum half-life, allowing infrequent dosing with long-lasting effects.

290 to mice for 10 weeks, followed by five oral dosing with purified AHC or ovalbumin on alternate days

291 Continuous dosing with regorafenib at 120 mg daily is the preferred

292 Dosing with RG-101 is associated with a restoration of N

293 0 (IP-10) levels declined significantly upon dosing with RG-101.

294 opically overexpressing KDM5B in response to dosing with TCA cycle metabolite pro-drug esters, sugges

295 rats 1 week after dosing and 20 weeks after dosing with up to 20 repeat doses of gadodiamide (cumula

296 Edoxaban (DU-176b) vs. Standard Practice of Dosing With Warfarin in Patients With Atrial Fibrillatio

297 /WN/CSH rush OIT plus 3 weeks of maintenance dosing, with or without 3 weeks prior and 3 weeks BF2 co

298 to ascertain the effects of daily vitamin D dosing, with or without calcium.

299 52) and randomized 1:1 to morning or evening dosing within each treatment sequence.

300 60) and randomized 1:1 to morning or evening dosing within each treatment sequence.