ライフサイエンスコーパス: double

1 care providers with their own patient panel doubled.

2 The Bi-B double and triple bond strengths are calculated to be 3.

3 s the first experimental observation of Bi-B double and triple bonds, opening the door to design main

4 prescription of antidementia drugs more than doubled and the prescription of potentially hazardous an

5 9 million people worldwide; in isolation, it doubles annual health care costs and, when associated wi

6 d functionalized carbazole derivatives via a double annulation process that generates two C-C and two

7 esults; the other had a positive result on a double-antigen bridging assay but not on a competitive a

8 Double ATP injections sustained the activation of phosph

9 thetic route to yndiamides, a novel class of double aza-substituted alkyne, has been established by t

10 e and adenine methyltransferases to generate double base modifications.

11 Data were acquired according to a double baseline protocol in which PET examinations were

12 including 12 patients; a phase 3 randomized, double blind, placebo controlled study involving 186 pat

13 atment of actinic keratosis in a randomized, double-blind clinical trial involving 131 participants.

14 We performed a double-blind crossover challenge of 59 individuals on a

15 , ascending dose cohorts underwent a further double-blind crossover, placebo-controlled oral gluten c

16 s (n=7513) were randomized in a double-dummy double-blind fashion to either extended-duration oral be

17 le-blind phase for 8 weeks and a randomised, double-blind phase (parts 1 and 2, reported here) for 12

18 ASPIRE consisted of an open-label, double-blind phase for 8 weeks and a randomised, double-

19 During the double-blind phase, five (33%) patients assigned to BIIB

20 to BIIB074 or placebo for up to 28 days in a double-blind phase.

21 1.9%) discontinued from the study during the double-blind phase.

22 gnetic resonance imaging (fMRI) in a 2-drug, double-blind placebo-controlled crossover design conduct

23 In a double-blind placebo-controlled crossover design, the im

24 In a randomized double-blind placebo-controlled study, 56 patients with

25 METHODS AND We undertook a double-blind randomised controlled trial of small-quanti

26 In this double-blind randomised placebo-controlled trial, we enr

27 nrolled 10 SCA38 patients, and carried out a double-blind randomized placebo-controlled study for 16

28 pose LUME-Meso is a phase II/III randomized, double-blind trial designed to assess efficacy and safet

29 ndred forty-six CAE children in a randomized double-blind trial of ethosuximide, lamotrigine, and val

30 In a double-blind trial, patients were randomized to tolvapta

31 withdrawal, multicenter, placebo-controlled, double-blind trial.

32 This randomised, double-blind, multicentre, phase 3 trial was done in 87

33 In this randomised, double-blind, multicentre, placebo-controlled, non-infer

34 We did a double-blind, multicentre, placebo-controlled, randomise

35 with meropenem in a multinational, phase 3, double-blind, non-inferiority trial (REPROVE).

36 In a single-center, double-blind, noninferiority trial involving adults with

37 In this randomised, double-blind, parallel-group, phase 3 trial done at 152

38 This randomised, controlled, double-blind, parallel-group, superiority trial was done

39 In this randomized, double-blind, phase 3 study, we assigned 3396 patients w

40 (Randomized, Double-Blind, Placebo Controlled Study of the Short Term

41 f rural Bangladeshi children from 2 previous double-blind, placebo-controlled cluster-randomized tria

42 In a randomized, double-blind, placebo-controlled crossover study of indi

43 n = 221) had peanut sensitivity and positive double-blind, placebo-controlled food challenges to an e

44 In two double-blind, placebo-controlled immunotherapy studies,

45 To this end, we combined double-blind, placebo-controlled pharmacology [D2 recept

46 This multicenter, double-blind, placebo-controlled RCT was powered on a 5%

47 magnetic resonance imaging to a randomized, double-blind, placebo-controlled trial (RCT) of antidepr

48 This randomized, double-blind, placebo-controlled trial assessed the effe

49 METHODS AND TIME was a randomized, double-blind, placebo-controlled trial comparing 150 mil

50 We conducted a phase 2, randomized, double-blind, placebo-controlled trial in 27 centers acr

51 METHOD: This 6-week, randomized, double-blind, placebo-controlled trial included patients

52 In this randomised, double-blind, placebo-controlled trial, we randomly allo

53 In this multicenter, double-blind, placebo-controlled trial, we randomly assi

54 doxycyline in a pre-registered, randomised, double-blind, placebo-controlled trial.

55 t functional magnetic resonance imaging in a double-blind, placebo-controlled, crossover design to de

56 We conducted a phase I, randomized, double-blind, placebo-controlled, dose-escalating study

57 We did a phase 2, randomised, double-blind, placebo-controlled, dose-escalation trial

58 This randomized, double-blind, placebo-controlled, multicenter study eval

59 We conducted a phase 2, multicenter, double-blind, placebo-controlled, multiple-ascending-dos

60 In this multicenter, randomized, double-blind, placebo-controlled, parallel-group trial,

61 In this 12-week, double-blind, placebo-controlled, parallel-group trial,

62 The study was a 12-week, double-blind, placebo-controlled, phase 2 trial of patie

63 RADIANT-4 is a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial done in

64 In this randomised, double-blind, placebo-controlled, phase 3 trial, we recr

65 Rigorous double-blind, placebo-controlled, randomized controlled

66 This phase 2, randomised, double-blind, placebo-controlled, single-centre, crossov

67 This was a multicentre, double-blind, randomised placebo-controlled trial for wh

68 In this multicentre, double-blind, randomised trial in seven Danish universit

69 DEPICT-1 was a double-blind, randomised, parallel-controlled, three-arm

70 We report two double-blind, randomised, placebo-controlled trials in a

71 This parallel-design, double-blind, randomized clinical trial, called Resverat

72 screened as anemic.In this 2 x 2 factorial, double-blind, randomized trial, nonpregnant women (aged

73 This double-blind, randomized, controlled trial investigates

74 We conducted a double-blind, randomized, parallel-group, placebo-contro

75 In this multicenter, double-blind, randomized, placebo-controlled study, 74 p

76 In this multicenter, double-blind, randomized, placebo-controlled trial, we a

77 Using a double-blind, randomized, placebo-controlled, parallel d

78 In this double-blind, randomized, placebo-controlled, phase 2 tr

79 Purpose To determine, in a multicenter double-blinded placebo-controlled trial, whether maximal

80 ent (aspirin/clopidogrel vs aspirin/placebo; double-blinded).

81 motivation in 21 healthy human subjects in a double-blinded, placebo (saline)-controlled, cross-over

82 Double-blinded, placebo-controlled trial at 9 academic m

83 rican Region with Malaria) was a randomized, double-blinded, placebo-controlled trial conducted in ma

84 Patients and Methods In this double-blinded, placebo-controlled trial, patients with

85 In this 1-year, randomised, double-blinded, placebo-controlled, phase 3 study (LIBER

86 nt murine breast cancer model indicates that double blockade with two immune checkpoint inhibitors in

87 ir photo-oxidation up to O4-5 of mainly high double bond equivalence species (DBE > 9).

88 complete scission of the B horizontal lineB double bond in 6 was achieved by the treatment with an i

89 retinal chromophore featuring a C(11)=C(12) double bond locked in its cis conformation (Rh6mr), empl

90 alculations reveal a polarized-covalent Zr=P double bond, with a Mayer bond order of 1.48, and togeth

91 g on the position and stereochemistry of the double bond.

92 utilize carotenoids as substrate or perform double-bond cleavage.

93 rmine the relative contribution of the trans double-bond isomer in the mixed samples.

94 ion of M back to D involves only one C13=C14 double-bond isomerization.

95 spectra can be used to discern cis and trans double-bond isomers by virtue of the differences in the

96 h decreased intensity of the cardiolipin cis-double-bond stretching modes.

97 Transition-metal-boron double bonding is known, but boron-metal triple bonds ha

98 The electrophilic activation of double bonds in the bicyclic products with m-CPBA is an

99 Odor Activity Value (OAV) and the number of double bonds mostly contributed to the modulation of hab

100 , halides, isolated mono- and di-substituted double bonds, esters, silyl ethers, and silyl enol ether

101 ncluding the number of internal and external double bonds, number of methyl- and ethyl- functional gr

102 e carbon-carbon single bonds neighboring the double bonds.

103 Fracture mechanics concepts using double cantilever beam configuration were used to charac

104 (approximately US$14; 1 PKR = US$0.009543); double cash (DC), a cash transfer of 3,000 PKR; or a fre

105 The double cell MMFC (Stack) was tested using serum and huma

106 ndividuals, which derive from the chromosome-doubled cells of the haploid gametophyte.

107 rough the waveform signals from inspiralling double compact binaries, especially those with electroma

108 The size of the double cone-free zone differed between species.

109 (pooled sensitivity and specificity for the double contour sign: 74% [95% CI, 52% to 88%] and 88% [C

110 Double corundum-related polar magnets are promising mate

111 P, and waDP were administered to chicken and double-crested cormorant hepatocytes to determine effect

112 Spin-labeled double-cysteine mutants of VcSiaP were analyzed in the s

113 ch decays via 1,5-HAT (tau1/2 = 48 s, DeltaH(double dagger) = 10.0 +/- 0.3 kcal mol(-1)).

114 cal 2 has a half-life, tau1/2 = 49 h (DeltaH(double dagger) = 17.9 +/- 0.8 kcal mol(-1)), which is 3

115 ning isomeric transition states (DeltaDeltaE(double dagger)) in both the presence and absence of the

116 The large size of DeltaG (double dagger)r disproves that quasi-equilibrium exists

117 apacity of Jagged 1 and Jagged 2 single- and double-deficient DCs to induce AAI.

118 -degeneracy that interconnects 1D lines with double-degeneracy.

119 primitive cubic ([Formula: see text]) to the double diamond phase ([Formula: see text]) whilst still

120 , such as those observed in the ocean due to double-diffusive convection.

121 dent stop signal task, we found a functional double dissociation between the right ventrolateral pref

122 (non-disulfide-bonded) peptide, or when the double disulfide-bonded Wnt peptide contained Ala substi

123 Each treatment group was double dummy, and the patients, investigators, and centr

124 y ill subjects (n=7513) were randomized in a double-dummy double-blind fashion to either extended-dur

125 conventional cancer therapy is inherently a double-edged sword.

126 of sildenafil using a water-in-oil-in-water double emulsion solvent evaporation method with polyethy

127 rface ME effect to modulations of the strong double-exchange interaction between conducting electron

128 While many studies suggest exponential, double exponential or power laws as empirical forms, we

129 Purpose Double-hit lymphomas (DHLs) and double-expressor lymphomas (DELs) are subtypes of diffus

130 al reproduction in flowering plants involves double fertilization, the union of two sperm from pollen

131 nd PT rupture, releasing the sperm cells for double fertilization.

132 ion, the underlying mechanism of fine-tuning double flower formation remains largely unclear.

133 atory nodes contributing to the diversity of double flower forms.

134 miRNA-targets regulations in the control of double flowers, and we found that miR172-AP2, miR156-SPL

135 y seek to circumvent this process to produce doubled haploid individuals, which derive from the chrom

136 nerates in water result in the same ratio of double-headed to normal morphology, revealing a cryptic

137 ng the structure to a system that links four double-helical layers; we use a central weaving oligonuc

138 ulate the global folding and interactions of double helices with hundreds of basepairs.

139 hey bear an interesting semblance to the DNA double helix model.

140 We demonstrate that double heterojunctions designed into colloidal semicondu

141 rication of an open porous 3D self-organized double-hierarchical carbon nanotube tube structure with

142 seline risk of ICU admission would more than double his/her odds of ICU admission if moving to a high

143 Purpose Double-hit lymphomas (DHLs) and double-expressor lymphom

144 on and must be processed by dissolution (for double HJ) or resolution to ensure genome stability.

145 Cigarette smoking more than doubled HSIL risk.

146 erconnected ultrafine amorphous NiFe-layered double hydroxide (NiFe-LDH) (<5 nm) and nanocarbon using

147 Double immunofluorescence demonstrated that virtually al

148 Double immunofluorescence staining using antibodies agai

149 Using double-immunofluorescence labeling, we observed the pote

150 tion of CD3- and B220-postive lymphocytes by double immunohistochemistry (PCNA-staining) and flow cyt

151 fered additional survival costs when hosting double infections.

152 r reaction pathway requires a C13=C14, C15=N double-isomerization of the retinal chromophore, whereas

153 ll basic sites of the hybrid material nearly doubles its conformational space and accessible surface

154 comparable suppression on Ca(2+) entry with double knockdown of both.

155 nic lethality, whereas conditional Ssb1/Ssb2 double knockout (cDKO) in adult mice resulted in acute l

156 Constitutive Ssb1/Ssb2 double knockout (DKO) caused early embryonic lethality,

157 We also generated apoE(-/-)/As3mt(-/-) double knockout mice to test whether As3MT-mediated biot

158 depletion, but also in WSX-1/tristetraprolin double knockout mice, with substantial reduction in the

159 everse the observed heart dysfunction in the double knockout mice.

160 We have developed a double knockout mouse model, which also shows reduced mu

161 Feeding Gsta4(-/-)/Ppara(-/-) double-knockout (dKO) mice liquid diets containing corn

162 However, only double-knockout mice continued to exhibit low liver Hamp

163 report rapid lymphoma development in Id2/Id3 double-knockout mice that is caused by unchecked expansi

164 In double-knockout mice, constitutive phosphorylation of EI

165 The Cyp3a1/2 double KO rat model was successfully generated and chara

166 Double-transgenic mice showed 55% double labeling of periurethral neuroendocrine cells exp

167 Double labeling with other molecular markers confirmed t

168 Ionic redistribution within the electrical double layer by fluid flow has been considered to be the

169 ction of cardiac troponin I using electrical double layer gated high field AlGaN/GaN HEMT biosensor.

170 Our method utilizes double-layer colloidal crystal templates in conjunction

171 VP7, surround a transcriptionally competent, double-layer particle (DLP), which they deliver into the

172 Rates for death or double-lung transplant and the composite rates for death

173 ransplant and the composite rates for death, double-lung transplant, or restenosis at 36 months were

174 In 2 large, randomized, double-masked trials reported here, once-daily dosing of

175 Twelve-week, phase III, randomized, double-masked, multicenter, placebo-controlled study.

176 Double-masked, randomized noninferiority clinical trials

177 fer of such blastocysts to recipient females doubles mean litter size to about nine piglets per litte

178 the subsequent adult environment, more than double median lifespan.

179 onstrated that a ubiquitin E3 ligase, murine double minute-2 (Mdm2), is required for Gp1 mGluR-induce

180 Here, we used PA as a double mutant (N682A, D683A; mPA) which cannot bind to t

181 mphatic vascular defects seen in Fgfr1/Fgfr3 double mutant mice, while HK2 overexpression partly resc

182 0 value of 1 nM against the EGFR L858R/T790M double mutant.

183 ding of amyloid-beta pathology in transgenic double-mutant APPSwePSEN1dE9 mice.

184 -vis titrations in combination with chemical double-mutant cycles (DMCs) have been used to study the

185 arget genes was strongly reduced in eol1 clf double mutants compared with clf single mutants.

186 ptotic cell density in Foxg1(-/-);Wnt8b(-/-) double mutants compared with the Foxg1(-/-) single mutan

187 We show that tan1 air9 double mutants have a synthetic phenotype consisting of

188 lso seems to be involved, since dpe2-1/phs1a double mutants lacking both PHS1 and the cytosolic DISPR

189 Moreover, an analysis of ahk double mutants using CycB1;1:GUS/ahk introgressed lines

190 d the structure of vegetative SAMs in ltm sp double mutants, and late flowering was partially suppres

191 n ipk1Delta kcs1Delta or ddp1Delta kcs1Delta double mutants.

192 3-year OS of 18%, compared with 35% without double mutation (P = 0.023).

193 the different medical cohort, patients with double mutation had worse 3-year OS of 18%, compared wit

194 omes close to the HMBPP diphosphate, whereas double mutation of nonconserved residues (Ser/Thr(296/29

195 Available data suggests that double mutations in patients with hypertrophic cardiomyo

196 Double mutations in patients with hypertrophic cardiomyo

197 guide clinical decision making in cases with double mutations.

198 ene-positive patients were published to have double mutations.

199 only difference between using the single- or double-needle procedure when performing US-guided percut

200 We used the double-nicking CRISPR/Cas9 system to conduct site-specif

201 ed isogenic FANCI-, FANCD2- and FANCI:FANCD2 double-null cells.

202 global warming projections in response to a doubling of CO2-from 1.5 degrees C to 4.5 degrees C or g

203 and body weight and ultimately resulted in a doubling of fat mass in males and females.

204 glucose tolerance did not change, owing to a doubling of insulin sensitivity.

205 nce interval [CI]: 0.66 to 0.89; p < 0.001), doubling of serum creatinine (HR: 0.62; 95% CI: 0.40 to

206 f the nephrotic syndrome; and a composite of doubling of serum creatinine, ESRD, or death between 100

207 DNA replication results in the doubling of the genome prior to cell division.

208 nts, several exocyst subunits are encoded by double or triple paralogs, culminating in tens of EXO70

209 The purified autophagosomes had double- or multiple-membrane structures with a diameter

210 among patients aged 0-4 years were more than double overall IRs.

211 to design a new class of Mott multiferroics-double perovskite oxides A 2VFeO6 (A = Ba, Pb, etc).

212 d for selective targeting and eradication of double-positive human NCI-H358 non-small cell lung cance

213 ation of high-affinity signaled CD4(+)CD8(+) double-positive thymocytes and CD8(+) and CD4(+) single-

214 positive selection of immature CD4(+)CD8(+) double-positive thymocytes and their commitment to the C

215 Standard double-precision solvers may return inaccurate solutions

216 and increased numbers of IL-17A(+)GM-CSF(+) double-producing CD4, CD8, gammadelta and NK cells.

217 togenetic stimulation of axon collaterals of double-projecting vCA1 neurons induced monosynaptic exci

218 Online double-pulse TMS over rTPJ 300 ms (but not 50 ms) after

219 ron diffraction, and show that it features a double-Q conical magnetic structure that, apart from tri

220 high-resolution multidimensional single- and double-quantum (1)H solid-state NMR spectroscopy with de

221 With the exception of double radical MYBPC3 mutations, there is little data to

222 linear quadrupole ion trap using orthogonal double resonance excitation.

223 The double-resonance Raman process is affected by the indire

224 nerve findings included hypoplasia with the double-ring sign, pallor, and increased cup-disc ratio i

225 th replication forks, and sensitivity of the double rnhAB mutants to translation inhibition points to

226 on; our results highlight TMLE's property of double robustness.

227 ched to 7.0 mm and sutured into place with a double running 10-0 nylon suture.

228 this approach by analyzing a version of the double-slit experiment augmented with postselection, sho

229 n and a PMS2 variant; 9 patients (18.8%) had double somatic MMR mutations (including 2 with germline

230 New ultrahigh precision, double-spike mass spectrometry stable Pb isotope data al

231 nce of these Tms, indicating that single and double stabilizing substitutions compromise the full inh

232 and against current flow direction in Co/Pt double stack wires with Ta capping.

233 ing block for the divergent, convergent, and double-stage convergent-divergent iterative methods for

234 end-joining (NHEJ) is the most prominent DNA double strand break (DSB) repair pathway in mammalian ce

235 mers to higher order oligomers to generate a double strand break in DNA.

236 he Muta1 ends and catalyzes excision through double strand breaks (DSB) and the joining of newly exci

237 Double strand breaks (DSBs) represent highly deleterious

238 r removes an antioxidant barrier against DNA double strand breaks induced by TGFbeta expressed in the

239 by inhibiting cep-1/p53, endogenous meiotic double strand breaks, or the expression of MIRAGE1 DNA t

240 (HR) posit that extensive resection of a DNA double-strand break (DSB) by a multisubunit helicase-nuc

241 ual 53BP1 and RIF1 foci, suggesting that DNA double-strand break (DSB) repair by homologous recombina

242 Homologous recombination (HR) is a DNA double-strand break (DSB) repair pathway that protects t

243 us DNA end-joining (NHEJ) is the predominant double-strand break (DSB) repair pathway throughout the

244 Improper DNA double-strand break (DSB) repair results in complex geno

245 research, the spatio-mechanical processes of double-strand break (DSB)-repair, especially the auxilia

246 ndogenous chromosomal locus containing a DNA double-strand break (DSB).

247 BRCA1 is best known for its functions in double-strand break repair and resolution of DNA replica

248 malian proteins, SFPQ and NONO, promotes DNA double-strand break repair via the canonical nonhomologo

249 in X-chromosome inactivation, imprinting and double-strand break repair, and mutations in SMCHD1 cont

250 de of chromatin mobility induced by a single double-strand break requires active microtubule function

251 ly induced clustered DNA lesions (OCDL), DNA double-strand breaks (DSB), apoptosis, and the local and

252 spontaneous occurrence of single-strand and double-strand breaks (DSB).

253 ic recombination, a subset of programmed DNA double-strand breaks (DSBs) are repaired as crossovers,

254 ed protein 80 (RAP80) helps recruit BRCA1 to double-strand breaks (DSBs) through the scaffold protein

255 se (AID), the activity of which leads to DNA double-strand breaks (DSBs) within IgH switch (S) region

256 addition, Mlh1-Mlh3 can generate religatable double-strand breaks and form an active nucleoprotein co

257 sorders (eg, ataxia-telangiectasia), and DNA double-strand breaks are crucial to the modulation of ea

258 These methods involve the induction of double-strand breaks at endogenous loci followed by the

259 sive accumulation of DNA damage, genome-wide double-strand breaks enriched at Ssb-binding regions and

260 ternative end-joining (alt-EJ) repair of DNA double-strand breaks is associated with deletions, chrom

261 vity slows replication elongation and causes double-strand breaks.

262 mplexes in cells, which are converted to DNA double-strand breaks.

263 7 T) and the effect of contrast agent on DNA double-strand-break (DSB) formation in patients undergoi

264 s were labeled with three distinct monolayer double-stranded (ds) DNA-gold nanoparticles (DNA-AuNPs).

265 structure, thereby hiding telomere ends from double-stranded break repair and ATM signaling, whereas

266 e can form a nucleoprotein filament (NPF) on double-stranded DNA (dsDNA) that is capable of unwrappin

267 The ability to directly detect double-stranded DNA (dsDNA) without sequence-preference

268 are studied as models for viruses containing double-stranded DNA (polymer) and condensing proteins (p

269 antage that it does not require formation of double-stranded DNA breaks or provision of a donor DNA t

270 Mre11 and Rad50 to coordinate the repair of double-stranded DNA breaks.

271 bridging, condensation, and pairing between double-stranded DNA molecules.

272 linear HCR is a hairpin-free system in which double-stranded DNA monomers could dendritically assembl

273 Due to the linear double-stranded DNA nature of the adenovirus genome, the

274 e fever virus (ASFV) is a highly pathogenic, double-stranded DNA virus with a marked tropism for cell

275 Papillomaviruses are small, double-stranded DNA viruses that encode the E2 protein,

276 ckaging is strongly conserved in the complex double-stranded DNA viruses, including the herpesviruses

277 hich preferentially bind the minor groove of double-stranded DNA, inhibit vaccinia virus infection by

278 enables the translocation and processing of double-stranded DNA.

279 Double-stranded RNAs (dsRNA) produced during human cytom

280 m yields reaching 21% and 11% in single- and double-strands, respectively.

281 dicular spin component, keeping the diagonal double-stripe order.

282 y than simeprevir, an inhibitor to which the double substitution confers a significant reduction in p

283 Frequency Doubling Technology perimetry was used to assess for vis

284 Reconstruction of the double-tetrameric form, combined with small-angle X-ray

285 time to transplantation for such patients is double that of unsensitised patients at about 74 months.

286 that increased MBNL1 expression greater than double the baseline levels.

287 hane measured in the Bakken shale, more than double the expected value if 98% efficiency was represen

288 e expected no later than 2050 will more than double the frequency of extreme water-level events in th

289 S288c produced approximately double the higher alcohol levels and around twenty times

290 n rate (0.25 new genes per million years) is double the longer-term estimate, the fate of most new Y-

291 glycine point mutation suffices to more than double the mechanical stability.

292 g PTX formulated in nano-formulations, which doubled the maximum tolerated dose (MTD) of Taxol.

293 those modes, "ringing" mode, which more than doubles the number of non-trivial physical channels that

294 We identify 19 new TGCT risk loci, roughly doubling the number of known TGCT risk loci to 44.

295 rted number of subscribers and approximately doubling the transmission distance compared to the recen

296 the number of days of clinical training was doubled, the odds for trainee supervision or repeated pa

297 th slow rates of disease progression (median doubling time: 84 days, 95% uncertainty range 62-104) an

298 Double-transgenic mice showed 55% double labeling of per

299 one considers the collective behavior of the double-twist cylinders.

300 em climate sensitivity is K (1sigma) per CO2 doubling, which is notably higher than fast-feedback est