ライフサイエンスコーパス: double helix

1 nfluenced by local environment (an adjoining double helix).

2 structural and dynamic perturbations in the double helix.

3 equence specificity and strongly distort the double helix.

4 -bending protein can do when it binds to the double helix.

5 ention has been paid to proteins leaving the double helix.

6 When it binds to DNA, it bends the double helix.

7 ize how Twist and Rise generate the familiar double helix.

8 ed DNA sequences interact to assemble into a double helix.

9 s overlap and occur on opposite faces of the double helix.

10 t orientations--stretching/distortion of the double helix.

11 undergo Watson-Crick base pairing to form a double helix.

12 perative over more than two turns of the DNA double helix.

13 complementary oligonucleotides together in a double helix.

14 DNA within the nucleus or the opening of the double helix.

15 he probe and target first collided to form a double helix.

16 equence of the interwound strands of the DNA double helix.

17 he two damaged base pairs to flip out of the double helix.

18 ) positions of the deoxyribose sugars in the double helix.

19 a single chain of bases at the center of the double helix.

20 ylic acid (poly(rA)) parallel and continuous double helix.

21 ng is the main stabilizing factor in the DNA double helix.

22 lding the nucleobases from damage within the double helix.

23 amino acid residues near one face of the DNA double helix.

24 dence of the stacking free energy of the DNA double helix.

25 the interstrand hydrogen bonding in the DNA double helix.

26 n part, by being bonded to the sugars of the double helix.

27 even led to a stabilization of the parallel double helix.

28 r strand separation and unwinding of the DNA double helix.

29 nd generally lie on the same face of the DNA double helix.

30 fundamental gap in our knowledge of the DNA double helix.

31 ve to be located in the same side of the DNA double helix.

32 ns between adjacent base-pairs in intact DNA double helix.

33 en the RFC spiral and the grooves of the DNA double helix.

34 ures of a variety of adduct molecules in DNA double helix.

35 pair of electrons to the minor groove of the double helix.

36 e been shown to produce curvature in the DNA double helix.

37 two ligands occupy opposite faces of the DNA double helix.

38 half-century following the discovery of the double helix.

39 that an A-tract imparts curvature to the DNA double helix.

40 contributed directly to the discovery of the double helix.

41 binding to the major or minor groove of the double helix.

42 pective of those times and the impact of the double helix.

43 with DNA, using its arm to clamp around the double helix.

44 of the four-letter nucleobase code to form a double helix.

45 ed to unwind and separate the strands of the double helix.

46 lation complexes via the major groove of the double helix.

47 the removal of DNA adducts that distort the double helix.

48 ly collected for the atoms in a few turns of double helix.

49 ted by flipping of a DNA base out of the DNA double helix.

50 esion sites, with the local unwinding of the double helix.

51 quadruplex structure is joined to a standard double helix.

52 is greatly slowed relative to that in a DNA double helix.

53 le, with concomitant transport along the DNA double helix.

54 y noncovalent binding of the compound to the double helix.

55 the major groove, and local unwinding of the double helix.

56 ing a transition in the chirality of the DNA double helix.

57 he intrinsic conformational mechanics of the double helix.

58 d array of E1 molecules that wrap around the double helix.

59 n fork requires an unwinding of the parental double helix.

60 ate charges along the inner face of the bent double helix.

61 tuations in local DNA shape occur within the double helix.

62 h minimal distortion of the structure of the double helix.

63 on of the N6-amino group of adenine in a DNA double helix.

64 zation of triple helix or destabilization of double helix.

65 s owing to its ability to locally unwind the double helix.

66 of all thermodynamic characteristics of the double helix.

67 to U when paired with A, G, U or C inside a double helix.

68 nks have to facilitate strong bending of the double helix.

69 sive mode of action of Aga50D on the agarose double helix.

70 NA depend on the nanoscale properties of the double helix.

71 nario is realized in the alpha-helix and DNA double helix.

72 stabilizing influence of base-stacking in a double helix.

73 ngle site, inducing little distortion in the double helix.

74 ate between successive base pairs of the DNA double helix.

75 in a conformation similar to the B-form DNA double helix.

76 diversity of DNA well beyond the ubiquitous double helix.

77 he flanking base pairs and straightening the double helix.

78 thread back and forth repeatedly through the double helix.

79 s often corresponding to the turn of the DNA double-helix.

80 nds differing in modes of binding to the DNA double-helix.

81 NA structure that differs from the canonical double-helix.

82 n years elapsed between the discovery of the double helix (1953) and the first DNA sequencing (1968).

83 The 0.74 A resolution structure of a B-DNA double helix, 5'-CCAGTACTGG-3', has been determined by X

84 to adjacent major grooves on one face of the double helix; a second dimer then binds to another face

85 bula having the morphology of an intertwined double helix about 100 parsecs from the Galaxy's dynamic

86 cholesterol concentration, the antiparallel double helix (ADH) conformation was observed to be most

87 Both strands in the double helix adopt a global conformation close to the A-

88 he angles between adjacent base pairs of the double helix affects the cyclization efficiency.

89 a ring-shaped heterohexamer, unwinds the DNA double helix ahead of the other replication machinery.

90 he DNA is achieved by destabilization of the double helix along its length through multiple interacti

91 ions of the threading and translation of the double helix along multistation rods were monitored by (

92 motile elements which extrude loops from the double helix along which they translocate, while excludi

93 removal and renewal of proteins bound to the double helix, an effect that likely plays a major role i

94 o DNA was identifiable by the grooves of the double helix and exhibited sharp bends at points downstr

95 dimers clamp DNA from opposite faces of the double helix and form a topological trap of the bound DN

96 re sufficient to distort both strands of the double helix and generate an enzyme-mediated double-stra

97 tation of a DNA or RNA nucleotide out of the double helix and into a protein pocket ('base flipping')

98 lieved to induce or stabilize bending of the double helix and mediate nucleoid compaction in vivo.

99 pends both on the intrinsic curvature of the double helix and on the thermal fluctuations of the angl

100 ll bending, i.e., persistence length, of the double helix and shows how known discrepancies in the me

101 own that the interactions that stabilize the double helix and the elastic rigidity of single strands

102 model that accounts for the softening of the double helix and the presence of transient denaturation

103 e template residue is displaced from the DNA double helix and the side chain of Arg-324 forms hydroge

104 de, depending on the specific details of the double helix and the single nucleotide polymorphism.

105 en used to reveal physical properties of the double helix and to characterize structural dynamics and

106 translocate by three modes: unzipping of the double helix and--in two distinct orientations--stretchi

107 nontemplate strand are extruded from the DNA double-helix and captured by sigma.

108 ouble-stranded helixes, which resemble a DNA double helix, and the inner wall is a quadruple-stranded

109 zinc-fingers interact with the backbone of a double helix; and second, the zinc-fingers specifically

110 Since both strands of the double helix are affected in cross-linked DNA, it is lik

111 of DNA lesions in which both strands of the double helix are covalently joined, precluding strand op

112 The obtained energy parameters of the DNA double helix are of paramount importance for understandi

113 tly link the Watson and Crick strands of the double helix, are repaired by a complex, replication-cou

114 We infer that segments of the double helix as large as 6 bp open in a cooperative proc

115 rs of N2-CEdG destabilized significantly the double helix as represented by a 4 kcal/mol increase in

116 sidue addresses the dynamic structure of the double helix at intermediate resolution, i.e., the mesos

117 a double cover of the graph and that the DNA double helix axes represent the designed graph.

118 nly responsible for the stability of the DNA double helix: base pairing between complementary strands

119 CRISPR RNA and target strands do not form a double helix but instead adopt an underwound ribbon-like

120 of two adjacently tethered cations into the double helix but not by a single cation: two adjacent am

121 nds to the minor groove of DNA and bends the double helix by 160 degrees.

122 We discovered that untwisting of the DNA double helix by bacterial non-specific DNA binding prote

123 into a potential precursor of a nucleic acid double helix by chemical synthesis and have demonstrated

124 The extension of a DNA double helix by one or two additional A:T base pairs is

125 aged dsDNA correlated with disruption of the double helix by the damaged bases and required RPAs ssDN

126 ccessible for recognition.Significantly, the double helix can be stretched by a factor of two and com

127 nt of fixed charges near one face of the DNA double helix can induce DNA bending by a purely electros

128 eotides promoting strand invasion in the DNA double helix can significantly enhance gene repair frequ

129 -stable biological structures known, the DNA double helix, can be melted once inside the liquid dropl

130 protamine and mu appear to destabilize pDNA double helix character to similar extents, according to

131 does not induce any final transition in DNA double helix conformation, and eventually, DNA presents

132 In each duplex, the RNA double helix consists of an annealed 12-mer and 14-mer t

133 mall decreases in relative crystallinity and double helix content.

134 cated that the B15D fibril was composed of a double helix defined by the selection rule l = n + 7m (w

135 SNP detection in large double-helix DNA strands (e.g., 47 nt) minimize false-po

136 one of the diimine ligands intercalated into double-helix DNA.

137 hromosome (SMC)1-SMC3 heterodimer with naked double-helix DNA.

138 Aside from the well-known double helix, DNA can also adopt an alternative four-str

139 In addition to the canonical double helix, DNA can fold into various other inter- and

140 It contains one long, imperfect double helix (domain I), one branched domain (domain II)

141 free DNA is often crystallized as an A-form double helix, Dsx(A) was crystallized as B-DNA and thus

142 The iconic image of the DNA double helix embodies the central role that three-dimens

143 energy to one strand at a time in the B-form double helix, enabling repair using the undamaged strand

144 ity maps now accounting for nicks in the DNA double helix, entropic elasticity of single-stranded DNA

145 in DNA minicircles and small DNA loops, the double helix experiences local disruptions of its regula

146 , although some of the bonds do break as the double helix extends at room temperature.

147 Lowering pH destabilizes the double helix, facilitating DNA translocation at lower fi

148 ends and other structural distortions of the double helix find in currently available X-ray structure

149 mage due to local destabilisation of the DNA double helix, followed by recruitment of specific repair

150 rovides a mechanism for smoothly bending the double helix, for controlling the widths of the major an

151 Single mismatches in the DNA double helix form nucleation sites for bubbles.

152 The canonical double-helix form of DNA is thought to predominate both

153 Urea m-values determined for double helix formation by DNA dodecamers near 25 degrees

154 o the zipping mechanism of the non-enzymatic double helix formation.

155 The second structure is the hairpin double helix formed by the DNA 20-mer 5'-AGAGAGAACCCCTTC

156 uest molecules bound at the extremities of a double helix formed by the host, as shown by NMR and CD

157 amics of self-assembly of a 14 base pair DNA double helix from complementary strands have been invest

158 in the A-form, fullerenes penetrate into the double helix from the end, form stable hybrids, and frus

159 ciated with the disruption in the unstressed double helix, G(d).

160 o more intricate secondary structures (e.g., double helix, G-quadruplex), a transition from planar to

161 rved to reduce the persistence length of the double helix, generating sharp DNA bends with an average

162 2) or more single-stranded template bases to double helix geometry in the polymerization site during

163 The discovery of the double helix half a century ago has so far been slow to

164 evidence that any anomalous behavior of the double helix happens when DNA fragments in the range of

165 t decade, the issue of strong bending of the double helix has attracted a lot of attention.

166 eriod close to the helical period of the DNA double helix has been associated with intrinsic DNA bend

167 The DNA double helix has been called one of life's most elegant

168 bases, but the fate of excited states in the double helix has been intensely debated.

169 The molecular structure of the DNA double helix has been known for 60 years, but we remain

170 tranded DNA surface exposed upon melting the double helix has been quantified for DNA samples of diff

171 Unfortunately the double helix has not, so far, revealed as much as one wo

172 pairing and induce little distortion in the double helix have modest effects on topoisomerase II-med

173 between the two complementary strands of the double helix, have an important role in chemotherapy reg

174 Type I hydrogel is formed via the PNA/DNA double-helix hybridization.

175 Type I double-helix hydrogel exhibits larger pore sizes than ty

176 ermodynamically destabilize the Watson-Crick double helix in a manner that facilitates the flipping-o

177 /oligomer alters the conformation of the DNA double helix in an ATP-dependent manner, as revealed by

178 dimers bind to opposite faces of the mec DNA double helix in an up-and-down arrangement, whereas MecI

179 the decay of excess electronic energy in the double helix in poorly understood ways.

180 with Hfq, but the RNAs are not released as a double helix in the absence of rim arginines.

181 f mutations in the H4 ARS that stabilize the double helix in the DUE region and impair replication.

182 air segment of the distorted nucleosomal DNA double helix, in a position predicted to exclude chromat

183 cluding plectoneme formation, melting of the double helix induced by torque, a highly overwound state

184 of the DNA replication machinery through the double helix induces acute positive supercoiling ahead o

185 ortions from the normal structure of the DNA double helix (initial recognition) and the second specif

186 The aesthetic appeal of the DNA double helix initially hindered notions of DNA mutation

187 3 heterodimer is able to restructure the DNA double helix into a series of loops, with a preference f

188 DNA unzipping, the separation of its double helix into single strands, is crucial in modulati

189 t the dimer lesion is flipped out of the DNA double helix into the substrate binding pocket.

190 nd in damaged DNA sites implies that the DNA double helix intrinsically codes for excited state Hoogs

191 ction between the circumnuclear disk and the double helix is ambiguous, but the images show a possibl

192 The DNA double helix is among the stiffest of all biopolymers, b

193 The double helix is apparently very similar to the standard

194 currence of such a sharp bend within the DNA double helix is confirmed and exploited through efficien

195 lting temperature of the poly(dA) . poly(dT) double helix is exquisitely sensitive to salt concentrat

196 The double helix is idealized for its aesthetic elegant stru

197 The double helix is known to form as a result of hybridizati

198 l concentration of GB in the vicinity of the double helix is much less than its bulk concentration.

199 Yet, as we know now, the DNA double helix is neither ideal nor rigid.

200 especially at jubilee celebrations, and the double helix is no exception.

201 confirm that the global conformation of the double helix is not altered by the presence of these pol

202 Charge transport through the DNA double helix is of fundamental interest in chemistry and

203 in DNA, forming a gate through which another double helix is passed, and acts as a DNA dependent ATPa

204 major contributions to the stability of the double helix: lateral pairing between the complementary

205 ntercalation of the bithiazole tail into the double helix likely brings the metal-bound complex close

206 scovery, 50 years ago, that RNA could form a double helix made possible a number of advances, includi

207 ering the perceived topological state of the double helix, making underwound DNA appear to be overwou

208 licase might trap a single DNA strand as the double helix melts, and before it is unwound.

209 The key finding in the DNA double helix model is the specific pairing or binding be

210 hey bear an interesting semblance to the DNA double helix model.

211 ility to recognize and cleave a deviated DNA double-helix near a nick or a strand-crossing site.

212 We show how double helix non-ideality and fluctuations broaden the d

213 Simulations associate the former with the double helix occupying the constriction and the latter w

214 nimal structural repeat of thin filaments: a double helix of actin subunits with each strand approxim

215 The stability of a DNA double helix of any particular sequence is conventionall

216 port remarkable chiral configurations with a double helix of disclination lines along the cylindrical

217 how non-symmetric protein motifs bind to the double helix of DNA through the formation of a pseudo-2-

218 RNA is a single strand rather than the double helix of DNA.

219 science has reached the iconic status of the double helix of DNA.

220 longated helical arrangement compared to the double helix of the porphyrin-DNA.

221 The resulting polymer consists of a double helix of two identical conjugated organic strands

222 re of the NsD7-PA complex reveals a striking double helix of two right-handed coiled oligomeric defen

223 dynamics (spontaneous local openings of the double helix) of double-stranded DNA, we simulated the d

224 e of wrapping around the major groove of the double helix, of displacing natural polyamines from thei

225 comprehensive structural description of the double helix on a genome-wide scale.

226 orm a heterodimer that binds to the bent DNA double helix on the underside of the preformed TBP-DNA c

227 exchange rates show that basepairs in a DNA double helix open on millisecond timescales.

228 at, in addition to the elastic moduli of the double helix, other factors contribute to loop formation

229 ls, H-DNA formation results in a kink in the double helix path.

230 dity, and an increased abundance of parallel double helix (PDH) and single-stranded head-to-head (SSH

231 trandedness and directional asymmetry of the double helix, play a defining role in CT efficiency.

232 r dual SECM/optical microscope, generating a double helix point spread function at the image plane, w

233 with a wide-field microscope that exhibits a double-helix point spread function (DH-PSF).

234 development of new techniques, including the double-helix point spread function (DHPSF), to accuratel

235 e used the dual-color three-dimensional (3D) double-helix point spread function microscope to study t

236 the bacterium Caulobacter crescentus using a double-helix point spread function microscope.

237 y inherent in the double-lobed nature of the Double-Helix Point Spread Function, we account for such

238 udding yeast cells using a microscope with a double-helix point spread function.

239 suggest that particular deformations of the double helix predicted by the V(step) algorithm can dist

240 AR2 flips the reactive nucleotide out of the double helix prior to deamination.

241 ntertwine between the two strands of the DNA double helix provides a massive challenge to the cellula

242 n mimicking that of a single strand within a double helix, providing insight into a mechanism for hai

243 On one hand it disrupts the double helix, providing the necessary strand separation

244 isingly, some chain pairs form unanticipated double-helix regions that result from mutual twisting of

245 y the intrinsic mechanical properties of the double helix reported here.

246 ng mode when the oligonucleotide threads the double helix results in a DNA kink that tends to occupy

247 t increased GC content accompanies increased double helix rigidity.

248 sic sites and other lesions that distort the double helix stimulate topoisomerase II-mediated DNA cle

249 as well as determining the magnitude of the double helix structural deformations during the dynamic

250 DNA is renowned for its double helix structure and the base pairing that enables

251 a banner year for biological chemistry: The double helix structure of DNA was published by Watson an

252 nce-directed variations in the canonical DNA double helix structure that retain Watson-Crick base-pai

253 quence-related and thermal variations in the double helix structure.

254 te wormlike chain that includes the explicit double-helix structure of DNA and where the linking numb

255 953, Watson and Crick not only described the double-helix structure of DNA, but also embraced the ide

256 efect lines that wind around each other in a double-helix structure.

257 forming sugar-like coats in the hairpin-like double helix structures of pre-miRNAs.

258 iscriminate between the end-to-end dimer and double-helix structures of gramicidin A.

259 In addition to the double helix symmetry revealed by Watson and Crick, clas

260 Chiral gratings with double helix symmetry were produced by twisting glass op

261 The two DX components are connected by a double helix that contains the binding site for MutS; wh

262 which the exons are arranged in a continuous double helix that facilitates the second reaction.

263 each other, giving rise to the assembly of a double helix that is stabilized by intermolecular [C-H..

264 ydrolysis of AE by inducing hydration of the double helix that spread approximately five base pairs o

265 tion to the intrinsic periodicity of the DNA double helix, the free energy has an oscillatory compone

266 l and local conformational properties of the double helix, the solvent environment, drug binding and

267 If sufficiently G + C rich, the double helix then propagated throughout the oligonucleot

268 e topological problems of DNA by passing one double helix through a transient break in another, in a

269 rusion of the target nucleobase from the DNA double helix to an extrahelical position is an essential

270 ively, allows a head-to-head or head-to-tail double helix to be generated.

271 lly derived conformational parameters of the double helix to evaluate the role of structural paramete

272 ws that the enzyme redirects the path of the double helix to expose the nick termini for the strand-j

273 atches near AE eliminated the ability of the double helix to strongly inhibit AE hydrolysis.

274 site of damage are translated across the DNA double helix to the active site of human topoisomerase I

275 ), which covalently link both strands of the double helix together resulting in cytotoxicity.

276 The local bending of the double helix, typically mediated by architectural transc

277 lity of DNA and observed the buckling of the double helix under high loads.

278 promoter region, forms a stable Watson-Crick double helix under physiological conditions.

279 ay define the length of backtracked RNA; DNA double helix unwinding in advance of the polymerase acti

280 uanine residue on the opposing strand of the double helix was recently identified, but the chemical c

281 A single DNA double helix was unzipped in the presence of DNA-binding

282 nformation, and stability in DNA and DNA-RNA double helixes was studied.

283 In describing the DNA double helix, Watson and Crick suggested that "spontaneo

284 In the canonical DNA double helix, Watson-Crick (WC) base pairs (bps) exist i

285 of electrostatics on the rigidity of the DNA double helix, we define DNA*, the null isomer of DNA, as

286 helicase and DNA prior to the melting of the double helix, we determined the structure of an archaeal

287 s between major and minor grooves of the RNA double helix, we explain much of the asymmetry with a si

288 om modular hydrogen bonds in the core of the double helix, whereas in proteins, specificity arises la

289 zation leads only to local distortion of the double helix while the overall structure of aps and ps D

290 In the conventional view, the highly charged double helix will be pushed toward isolation by favorabl

291 ed to a decrease in the stability of the DNA double helix with decreasing salt concentration.

292 is revealed that DNA was ejected as a single double helix with ejection occurring at one vertex presu

293 ed to a decrease in the stability of the DNA double helix with increasing temperature.

294 uplex part of the molecule resembles a B-DNA double helix with the third strand bound in its major gr

295 equence crystallizes as a left-handed Z-form double helix with Watson-Crick base pairing.

296 NA scission by altering the structure of the double helix within the cleavage site of the enzyme.

297 of a base pair if each can fit into the DNA double helix without steric strain.

298 ompound 1, can spontaneously assemble into a double helix without the need for a covalently connected

299 of DNA conformations with one segment of the double helix wrapped around the enzyme were constructed.

300 lly make use of the two-fold symmetry of the double helix, zinc fingers can be linked linearly in tan