ライフサイエンスコーパス: double-knockout

1 e-specific mice lacking both GSK-3 isoforms (double knockout).

2 n B mRNA editing enzyme catalytic, APOBEC-1 (double knockout).

3 lacking both SSPN and alpha7 integrin (DKO, double knockout).

4 enotype is not modified by Hic-5 deficiency (double knockout).

5 cidin knockout; and ceruloplasmin/hephaestin double knockout).

6 r combined as EBA140/EBA175 or EBA175/EBA181 double knockouts.

7 etic knockouts, including DNA ligase 3 and 4 double-knockouts.

8 erator activated receptor alpha (Ppara(-/-)) double knockout 129/SvJ mice for 12 weeks from weaning.

9 sensitivity in hair cells of mouse Tmc1:Tmc2 double knockouts; 3) there is so far no evidence that ex

10 was supported by the fact that Nlrp3/miR-155 double-knockout allo-HCT recipient mice had no increased

11 Although both MHC class II/CD8alpha double-knockout and CD8beta null mice show a defect in t

12 In comparison with sperm from CAII and CAIV double knockout animals, pharmacological loss of CAIV in

13 rescued to a wild type identity in Moz;Bmi1 double knockout animals.

14 10 knockout does not alter sepsis mortality, double-knockout animals are highly protected.

15 traocular nor cardiac muscle was affected in double-knockout animals.

16 y led to massive muscle wasting and death in double-knockout animals.

17 (-/-) mice was fully blunted in CHOP-10/eNOS double-knockout animals.

18 -1 in chimeric Ldlr(-/-)Trem-1(-/-) mice and double knockout ApoE(-/-)Trem-1(-/-) mice, we pharmacolo

19 carotid artery ligation in apolipoprotein E double-knockout (ApoE(-/-)) mice was used (n = 82).

20 CD80/CD86 double knockout (B7 KO) mice had enhanced adipose macrop

21 e examined the skeletal phenotype of BgnFmod double knockout (BgnFmod KO) mice and found they were sm

22 The DNA-damage phenotype observed in double knockout brains was prevented by expression of a

23 Double-knockout cardiac myocytes showed cell cycle progr

24 The dcl2drb4 double knockouts caused a far smaller loss of antiviral

25 mary stem cell (MaSC)-specific Cbl and Cbl-b double knockout (Cbl/Cbl-b DKO) using Lgr5-EGFP-IRES-Cre

26 TLR2/MDR1A double-knockout CD11b(+) myeloid cells expressed MD-2/TL

27 aneous viral infection, and lung Fabp4/Fabp5 double-knockout CD8(+) TRM cells generated by skin vacci

28 s; this increase was not seen in Fabp4/Fabp5 double-knockout CD8(+) TRM cells.

29 nic lethality, whereas conditional Ssb1/Ssb2 double knockout (cDKO) in adult mice resulted in acute l

30 Here we introduce a CRISPR-based double knockout (CDKO) system that improves the efficien

31 tative analysis of the proteome of tankyrase double knockout cells using isobaric tandem mass tags re

32 enzymatic activity in vitro and in AKT1/AKT2 double knockout cells, but promoted growth factor indepe

33 tion but had no effect in PDE8A (-/-)/B(-/-) double-knockout cells, confirming the selectivity of the

34 By rescuing the viability of double-knockout cells, we demonstrate for the first time

35 promoting its focal erosion, as observed for double-knockout chimeras.

36 in decay-accelerating factor (DAF) and CD59 double-knockout (DAF(-/-)CD59(-/-)) mice.

37 By contrast, a double knockout displayed an abnormal rate of barren sil

38 cantly reduced the viability of both Bax/Bak double knockout (DKO) and DKO-Bax reconstituted hematopo

39 Constitutive Ssb1/Ssb2 double knockout (DKO) caused early embryonic lethality,

40 s in Trypanosoma brucei, we generated a umps double knockout (DKO) line by gene replacement.

41 blasts from Megf10-/- mice and Megf10-/-/mdx double knockout (dko) mice also show impaired proliferat

42 Here, we show that global Fxr (-/-) Shp(-/-) double knockout (DKO) mice are refractory to weight gain

43 In contrast, RAG(-/-) x IFNAR1(-/-) double knockout (DKO) mice developed accelerated severe

44 We previously reported that FE65/FE65L1 double knockout (DKO) mice display disorganized laminin

45 amine this question, we generated Fmr1/beta4 double knockout (dKO) mice to genetically upregulate BK

46 than murine MHC class II molecules, CD4 CD8 double knockout (DKO) mice transgenically expressing HLA

47 These double knockout (dKO) mice were able to form sarcomeres

48 -LTD is impaired in the hippocampus of MK2/3 double knockout (DKO) mice, an observation that is mirro

49 Using fibroblasts derived from macroH2A double knockout (dKO) mice, here we show that these hist

50 rednisolone treatment in dystrophin/utrophin double knockout (dKO) mice, which exhibit a severe dystr

51 We then generated Ces1g (-/-) Ldlr (-/-) double knockout (DKO) mice, which were fed a Western die

52 ria and salt-wasting by generating SPAK/OSR1 double knockout (DKO) mice.

53 em cell depletion in the dystrophin/utrophin double knockout (dKO) mouse model, which exhibits histop

54 In contrast, studies of mouse neurons with a double knockout (DKO) of complexin-1 and -2, largely car

55 We found that the double knockout (DKO) of Gcn5/PCAF inhibits expression o

56 Mice with enhanced cerebellar LTD, due to double knockout (DKO) of MHCI H2-K(b)/H2-D(b) (K(b)D(b-/

57 L is intrinsically inactive but only with a double knockout (DKO) of PKR and RNase L in A549 cells,

58 Here Mc3r and Mc4r single and double knockout (DKO) rats were generated using CRISPR-C

59 , MARCO (MARCO(-/-)), or both SR-A and MARCO double knockout (DKO).

60 Disrupting the porcine GGTA1 and CMAH genes [double knockout (DKO)] that produce the gal-alpha(1,3)-g

61 cking pyruvate dehydrogenase kinase 2 and 4 [double knockout (DKO)], which results in constitutively

62 t, we show that apolipoprotein E (apoE)-CD16 double knockout (DKO; apoE-CD16 DKO) mice have reduced a

63 Here we have generated Tet1 and Tet2 double-knockout (DKO) embryonic stem cells (ESCs) and mi

64 th gene expression in wild-type and CBP/p300 double-knockout (dKO) fibroblasts.

65 ine in hematopoietic repopulating ability of double-knockout (dKO) HSCs.

66 Tet2-Tet3 double-knockout (DKO) iNKT cells displayed pronounced sk

67 With each approach, Dlg1;Cask double-knockout (DKO) kidneys were severely hypoplastic

68 We generated B cell-specific Shp-1 and Syk double-knockout (DKO) mice and compared them to the sing

69 n-deficient mdx mice and dystrophin/utrophin double-knockout (dKO) mice are mouse models of DMD; howe

70 At birth, cardiac morphology and function of double-knockout (DKO) mice are normal.

71 These double-knockout (DKO) mice develop additional indication

72 We previously showed that TRPC1/4 double-knockout (DKO) mice lack epileptiform bursting in

73 Feeding Gsta4(-/-)/Ppara(-/-) double-knockout (dKO) mice liquid diets containing corn

74 Car5A/B double-knockout (DKO) mice showed additional abnormaliti

75 ous kidney failure, with that of Col4a3;Tsp1 double-knockout (DKO) mice.

76 sk the role of NDCBE, we generated Ndcbe/Ncc double-knockout (dKO) mice.

77 letely reversed in a newly generated dCK/TK1 double-knockout (DKO) mouse model.

78 skipping approach in the utrophin/dystrophin double-knockout (dKO) mouse which is a very severe and p

79 Herein, we have created the nesprin-desmin double-knockout (DKO) mouse, eliminating a major fractio

80 horylation was assessed in CaMKIIdelta/gamma double-knockout (DKO) mouse, transgenic CaMKIIdeltaC-ove

81 ic endothelial cells (AEC) from a GGTA1/CMAH double-knockout (DKO) pig (and a GGTA1-KO pig) and immun

82 We obtained double-knockout (DKO) pigs lacking GAL and Neu5Gc.

83 we found a defect in trafficking of EVL/VASP double-knockout (dKO) T cells to the inflamed skin and s

84 mal Interaction Molecule (STIM) 1 and STIM2 [double-knockout (DKO)] mice develop spontaneous and seve

85 (-/-), GzmB cluster(-/-), and GzmAxB cluster double knockout [DKO] mice) showed both delayed granulom

86 eta-catenin specifically in the heart (i.e., double knockout [DKO]).

87 one or both isoforms (Epac1-KO, Epac2-KO, or double knockout, DKO) to assess isoform localization and

88 genetic inactivation of both B7.1 and B7.2 (double knockout; DKO) revealed aggravated obesity-relate

89 crossed with 11beta-HSD1-KO mice to generate double knockouts (DKOs) and challenged with an atherogen

90 r2-KO mouse, the Mdr2:CCR5 and the Mdr2:CCR1 double knockouts (DKOs), and set out to compare inflamma

91 Using a BMF/BIM-double-knockout epithelial transplant model, we further

92 5mC are entirely suppressed in Tet1 and Tet2 double knockout ES cells.

93 The Wwox;p53(Deltaosx1) double knockout establishes a new osteosarcoma model wit

94 We show that Fgfr1 and Fgfr2 double knockouts (FGFR DKO) generated by Cre-mediated re

95 in primary betacyto- or beta/gammacyto-actin double-knockout fibroblasts.

96 To that end, we constructed all possible double knockouts for the S15, L33, and L36 ribosomal pro

97 o-expression of PIKE-A and CDK4 in TP53/PTEN double knockout GBM mouse model additively shortens the

98 generated heart-specific IRS1 and IRS2 gene double-knockout (H-DKO) mice and liver-specific IRS1 and

99 trols, Slc39a14 single and Slc30a10/Slc39a14 double knockouts had higher manganese levels in the bloo

100 kouts, Slc39a14 single and Slc30a10/Slc39a14 double knockouts had lower thyroid manganese levels and

101 generation of Bak knockout as well as BaxBak double knockout HCT116 human colon carcinoma cells.

102 al genes were increased in the alpha-catenin double knockout hearts indicating a less mature cardiac

103 iomyocyte proliferation in the alpha-catenin double knockout hearts.

104 that within 2 weeks of tamoxifen treatment, double-knockout hearts leads to excessive dilatative rem

105 regulators Klf1 and Epor, is upregulated in double-knockout hematopoietic stem cells (HSCs).

106 ncreased more than 100-fold when produced in double-knockout human CD4(+) T cells that lack both SERI

107 production is inefficient, we have generated double-knockout human cells lacking both Dicer and prote

108 adult cardiac myocytes and fibroblasts from double-knockout implicated cardiac myocytes intrinsic fa

109 vidually generated the same phenotype as the double knockout, indicating that both pafR and pafP are

110 We generated Mmp7 and Pten double knockout (KO) (Mmp7(-/-)) mouse model and demonst

111 ted genome engineering to create single- and double knockout (KO) cell lines of TorA and TorB as well

112 Double knockout (KO) mutants that are hemizygous for eit

113 1, a kinase-dead alpha2 AMPK (alpha2KD), and double knockout (KO) of beta1 and beta2 AMPK subunits (b

114 In this report, Cyp3a1/2 double knockout (KO) rats were generated by CRISPR-Cas9

115 In this study, diabetic RAGE apoE double-knockout (KO) mice with streptozotocin-induced di

116 H-DKO) mice and liver-specific IRS1 and IRS2 double-knockout (L-DKO) mice.

117 prolin-deficient mice (WSX-1/tristetraprolin double knockout) leads to a reduction in cytotoxic T lym

118 An Arabidopsis double knockout line of both BASS6 and the glycolate/gly

119 However, single and double knockout lines, as well as individual overexpress

120 lly completely eliminated in AtXTH31/AtXTH32 double knockout lines.

121 sulin receptor knockout (LIRKO) and IR/FoxO1 double knockout (LIRFKO) mice.

122 ning adapter-inducing interferon-beta (TRIF) double knockout littermates, we define the role of toll-

123 By generating TDP1 and PARP1 double-knockout lymphoma chicken DT40 cells, we demonstr

124 hway were found to be shared between Id2/Id3 double-knockout lymphomas and human NKT tumors.

125 onse to IFN-alphabeta is lost in Stat1-Stat2 double-knockout macrophages suggest that Stat1 and Stat2

126 In consequence, transmigrated double-knockout macrophages were seen to accumulate in t

127 When introduced into TLR2/TLR4 double-knockout macrophages, the TLR4 cDNA from BR mice

128 specifically in heart to generate myocardial double-knockout (MDKO) mice.

129 malignancy is accelerated, we show that the double-knockout methylome reflects regions of independen

130 Using Sr-bI/Abcg5 double knockout mice (dko), the present study investigat

131 In the cardiovascular system, MAGP1;MAGP2 double knockout mice (Mfap2(-/-);Mfap5(-/-)) show age-de

132 oduced Slc39a14 single and Slc30a10/Slc39a14 double knockout mice and compared their phenotypes with

133 olipoproteins worsened behaviour deficits of double knockout mice and their performance was undisting

134 KLF1(-/-) KLF2(-/-) double knockout mice are anemic at embryonic day 10.5 (E

135 Both Smug1-knockout and Smug1/Ung-double knockout mice breed normally and remain apparentl

136 b(-p50NF-kappaB-/-) and db(-)/db(-PARP-1-/-) double knockout mice compared with db(-)/db(-) mice.

137 ion of tumor growth and metastasis in NOX1/2 double knockout mice compared with WT mice.

138 In addition, the Wwox;p53(Deltaosx1) double knockout mice developed poorly differentiated ost

139 In addition, double knockout mice exhibit an impaired cardiac respons

140 pted in combination with RIP1, the resulting double knockout mice exhibit slightly prolonged survival

141 Because alpha(1)A/B double knockout mice fail to develop hypertrophy in resp

142 To answer this question, we produced double knockout mice for Bmp6 and beta2-microglobulin (a

143 Using single and double knockout mice for MMP-2 and MMP-9, we show that M

144 Analyses of double knockout mice further revealed that IL-36alpha an

145 cently found that macrophages from RhoA/RhoB double knockout mice had increased motility of the cell

146 Double knockout mice had increased p53 and H2AX phosphor

147 We also found that slit1, -2 or -3 single or double knockout mice have impaired development of the tr

148 Reprogramming of SSC from Tet1 and Tet2 double knockout mice however lacked demethylation of H19

149 Double knockout mice lacking both receptors showed super

150 that of single Ccl2, Cx3cr1 and Ccl2/Cx3cr1 double knockout mice obtained from backcrosses of CCDKO

151 dine phosphorylase and uridine phosphorylase double knockout mice recapitulated several features of t

152 nd the expression of PKCbeta in PKCalphabeta double knockout mice rescues PTP.

153 Here we report that iRhom1/2(-/-) double knockout mice resemble Adam17(-/-) and Egfr(-/-)

154 Electron micrographs of hearts from TPC1/2 double knockout mice showed that cardiomyocytes containe

155 Recent experiments on the double knockout mice showed, however, that their taste b

156 s were either partially or fully restored in double knockout mice that lack both caveolin-1 and eNOS.

157 fibrosis was observed in PAI-1(-/-)/uPA(-/-) double knockout mice that was associated with reduced in

158 dx/utrn(+/-) heterozygotes and mdx/utrn(-/-) double knockout mice to investigate the role of these cy

159 severe salt-wasting, and generated SPAK/OSR1 double knockout mice to test this.

160 We also generated apoE(-/-)/As3mt(-/-) double knockout mice to test whether As3MT-mediated biot

161 In double knockout mice we show that (125)I-amyloid-beta mi

162 clerosis, hyperglycemic TSP-1(-/-)/ApoE(-/-) double knockout mice were compared with age-matched hype

163 Fmr1/BKbeta4 double knockout mice were generated to genetically upreg

164 Most double knockout mice were largely protected from lymphom

165 Sperm taken from the cauda epididymides of double knockout mice were microscopically normal and mot

166 Double knockout mice were protected against fasting-indu

167 ochondrial DNA instability, we have stressed double knockout mice with exogenous thymidine and deoxyu

168 Deletion of LOX-1 (LDLR/LOX-1 double knockout mice) attenuated autophagy, TLR9 express

169 ) binding protein null mice (Mttp-LKO, i.e., double knockout mice) hepatic steatosis was greatly dimi

170 genetic deletion of P2X2 and P2X3 receptors (double knockout mice) lack responses to all taste stimul

171 uc1 and RAG1 were disrupted in mice (Muc/RAG double knockout mice); Th1-mediated colitis was induced

172 nesoid X receptor; Small Heterodimer Partner double knockout mice, a model for bile acid overload, di

173 a and total urinary iron was observed in the double knockout mice, and this was associated with compr

174 ssure and baroreflex function was reduced in double knockout mice, but no more than single knockout o

175 us model of oral staphylococcal infection in double knockout mice, deficient in the receptors for IL-

176 Administration of wild-type human LDLR to double knockout mice, expressing hPCSK9, led to diminish

177 In muscle from mdx/utrn(-/-) double knockout mice, MS channels also spend more time a

178 By analyzing DUSP5(-/-), SerpinB2(-/-) double knockout mice, we demonstrate that deletion of Se

179 By generating miR-31 and Gprc5a double knockout mice, we show that miR-31 promotes the d

180 rogrammed death-ligand 1', whereas in NOD1/2 double knockout mice, which cannot recognize peptidoglyc

181 depletion, but also in WSX-1/tristetraprolin double knockout mice, with substantial reduction in the

182 d neuron-specific Bcl7a and Bcl7b single and double knockout mice.

183 y to account for the attenuated phenotype in double knockout mice.

184 tion in lungs, we generated Ifit2/IFNAR(-/-) double knockout mice.

185 everse the observed heart dysfunction in the double knockout mice.

186 ts, wild-type and melatonin receptor MT1/MT2 double knockout mice.

187 e roles of HA in cutaneous injury responses, double-knockout mice (abbreviated as Has1/3 null) that l

188 We generated double-knockout mice (DKO) lacking the 2 cardiac CaMKII

189 )-induced diabetic homozygous PKC-alpha/beta double-knockout mice (PKC-alpha/beta(-/-)).

190 However, Nfil3/Rag1 double-knockout mice adoptively transferred with wild-ty

191 s have lower rate of neuritogenesis in vitro Double-knockout mice also have reduced levels of GM1 gan

192 We also generated RIG-I(-/-) x MDA5(-/-) double-knockout mice and found that a lack of both RLRs

193 axis, MI was induced in Cd36(-/-) Mertk(-/-) double-knockout mice and led to increases in myocardial

194 uTAC were near completely lost in M2/M4(-/-) double-knockout mice and potency of BuTAC was right-shif

195 Tet1/Tet2 double-knockout mice are characterized by developmental

196 tion that the enhanced flu susceptibility of double-knockout mice arises from an intrinsic impairment

197 e reductions also were observed in Rag1/IDO1 double-knockout mice compared with Rag1-/- mice (which l

198 However, only double-knockout mice continued to exhibit low liver Hamp

199 Moreover, the double-knockout mice could potentially serve as models i

200 against the Sprn 3' UTR, we established that double-knockout mice deficient in both Sho and PrP(C) ar

201 When placed on a high-fat diet, these double-knockout mice developed atherosclerosis at a much

202 ith Ku80, Lig4, and Atm deficiency, Paxx/Xlf double-knockout mice display embryonic lethality associa

203 Infection of the double-knockout mice displayed a lack of lung disease an

204 with this possibility, Fmr1(-/y); Cpeb1(-/-) double-knockout mice displayed amelioration of biochemic

205 ompared to littermate controls, flu-infected double-knockout mice exhibited increased mortality, cons

206 In the periphery, Apoe/Apoa1 double-knockout mice exhibited substantial atheroscleros

207 Using Dnmt3a and Tet2 double-knockout mice in which the development of maligna

208 Double-knockout mice lacking MCL-1 and cyclophilin D, an

209 Pkd1 and Smyd2 double-knockout mice lived longer than Pkd1-knockout mic

210 and TLR4 signaling in B6.TLR2(-/-).TLR4(-/-) double-knockout mice markedly reduced the severity of HR

211 IL-6 knockout in Axl(-/-)Mertk(-/-) double-knockout mice overcomes the inflammatory inhibiti

212 -alpha and Rev-erb-beta function by creating double-knockout mice profoundly disrupted circadian expr

213 yonic fibroblast cells derived from LPA(1&2) double-knockout mice reconstituted with the LPA(2) recep

214 Colitis exacerbation in TLR2/MDR1A double-knockout mice required the unaltered commensal mi

215 % reduction in DTH, and ALCAM(-/-) RAGE(-/-) double-knockout mice show a 27% reduction in DTH reactio

216 As a result, double-knockout mice show markedly altered circadian whe

217 e (PSI) in Cyp1a1(-/-) mice; Cyp1a1/1b1(-/-) double-knockout mice show no PSI cancer but develop squa

218 In contrast,Tmprss2(-/-)Tmprss4(-/-)double-knockout mice showed a remarkably reduced virus s

219 report rapid lymphoma development in Id2/Id3 double-knockout mice that is caused by unchecked expansi

220 We thus generated double-knockout mice to assess a potential genetic inter

221 n 'rescue' of muscular dystrophy, we created double-knockout mice to test the contributions of utroph

222 Enhanced mortality of double-knockout mice was not associated either with incr

223 icits and dendritic morphology of Apoe/Apoa1 double-knockout mice were compared to APP/Abca1(ko), APP

224 e (control), IDO1-/-, Rag1-/-, and Rag1/IDO1 double-knockout mice were exposed to azoxymethane and de

225 re necessary for colitis, because Nfil3/Rag1 double-knockout mice were protected from disease.

226 We hypothesized that Apoe/Apoa1 double-knockout mice would mimic the phenotype of APP/Ab

227 Mice lacking both entry receptors (double-knockout mice) showed no evidence of disease afte

228 with mice with disruptions in Vil1 and Gsn (double-knockout mice).

229 In double-knockout mice, constitutive phosphorylation of EI

230 In neuraminidase 3 and 4 double-knockout mice, GM3 ganglioside is stored in micro

231 In RGS7/RGS11 double-knockout mice, light-evoked responses in rod ON b

232 In these Dicer-Pten double-knockout mice, primary fallopian tube tumors spre

233 ch more pronounced in Sdc4(-/-); Pecam1(-/-) double-knockout mice, which develop severe edema.

234 ow that in thymi of alphaGalA(-/-)/Gb3S(-/-) double-knockout mice, which store isoglobosides but no g

235 g order) by WT, STC1 knockout, and STC1/STC2 double-knockout mice.

236 d Apoa1 knockout mice to generate Apoe/Apoa1 double-knockout mice.

237 as shown by megakaryocyte-specific (Pf4-Cre) double-knockout mice.

238 inding lectin-A and mannose-binding lectin-C double-knockout mice.

239 and an overall delay in ossification in the double-knockout mice.

240 he brain and viscera in all genotypes except double-knockout mice.

241 res was significantly ameliorated in TRPC1/4 double-knockout mice.

242 ne secretion that are exacerbated in Itk/Txk double-knockout mice.

243 ficiency, we generated Cited2 and HIF-1alpha double-knockout mice.

244 sence of particular muscles in the Msc;Tcf21 double-knockout mice.

245 ology and therefore created STAT1/STAT6(-/-) double-knockout mice.

246 n over 3 days; hgd40 reduced colitis in TNFR double-knockout mice.

247 ceptors serve complementary roles, such that double-knockout MIGIRKO mice displayed a marked reductio

248 However, previous studies have relied on double-knockout models, potentially skewing the role of

249 A rod-specific Kif3/Kif17 double knockout mouse demonstrated that KIF17 and KIF3 d

250 Furthermore, by generating a TC10/Cdc42 double knockout mouse model, we found that TC10 can comp

251 We have developed a double knockout mouse model, which also shows reduced mu

252 yons as the genomic key feature of Tet1/Tet2 double-knockout mouse embryonic fibroblasts.

253 were also observed in a DeltapauA2DeltaphoU double knockout mutant and complemented by the wild-type

254 ned the wild-type S. aureus cell but not the double knockout mutant DeltatarM/S, which lacks both alp

255 ntitative cell-wall analytical assays of the double knockout mutant demonstrated reduced levels of pe

256 tabolism, we generated two cyp71a12 cyp71a13 double knockout mutant lines.

257 Sperm of the double knockout mutant mice show responses to stimulus b

258 nes have markedly opposite phenotypes to the double knockout mutant, with increased cell-wall methyle

259 notypes of Arabidopsis, including single and double knockout mutants for the high-affinity transporte

260 nt human FH domains 6 and 7 fused to Fc than double knockout mutants prepared from two sensitive meni

261 Two constitutive double knockout mutants were generated (designated as dp

262 question, we generated dcl2drb4 and dcl4drb4 double knockout mutants, and subjected them to infection

263 In Munc13-1/2 double-knockout neurons, expression of a constitutively

264 cells and less mucin (Muc2) in Nod1 and Nod2 double-knockout (Nod DKO) mice after T. muris infection

265 obtained metabolomics data from a "chemical double" knockout (Oat3KO plus probenecid).

266 It was shown that double knockout of Bax and Bak from proximal tubules att

267 knockouts, developmentally early conditional double knockout of both cerebellin-1 and neuroligin-3 se

268 Double knockout of CSE and apolipoprotein E gene express

269 A double knockout of Cyp2r1 and Cyp27a1 maintained a simil

270 Furthermore, double knockout of FYN and PTPN23 via CRISPR/CAS9 also a

271 We show that double knockout of GRASP proteins disperses the Golgi st

272 nder baseline conditions, although mice with double knockout of pendrin and the Na(+)/Cl(-) cotranspo

273 ers to quantify this back-flux in single and double knockouts of genes relating to PEP synthetase and

274 Interestingly, double knockouts of HIF1alpha and HIF2alpha (HIF1alpha/2

275 resenting how much sicker (or healthier) the double-knockout organism will be compared to what would

276 os in wild-type and "taste blind" P2X2 /P2X3 double knockout (P2X-dbl KO) mice.

277 Here, we rapidly generated RAG2/IL2RG double knockout pigs using direct injection of CRISPR/Ca

278 We generated double knockouts (PINK1(-/-)/NLRP3(-/-)), as well as cel

279 ination were investigated in mMDH1 and mMDH2 double knockout plants.

280 e and tapx single-knockout plants, 2cpa 2cpb double-knockout plants showed an impairment of photosynt

281 ent mice and characterized phenotypes of the double knockout progeny.

282 ked presenilin genes (presenilin conditional double knockout [PS cDKO]) after one-trial contextual fe

283 ticle, we demonstrate that Rab27a and Rab27b double-knockout (Rab27DKO) mice that are deficient in ex

284 Furthermore, Brca1/Cobra1 double knockout restores developmental transcription at

285 Early in tumorigenesis, the double knockout results in an additive reduction in angi

286 features of the Brn3b single- and Dlx1/Dlx2 double-knockout retinas, including near total RGC loss w

287 Analysis of single and double knockouts revealed no significant phenotypes at d

288 Two double knockout seeds had approximately 3% of dry weight

289 Hepatocyte-specific double-knockout Smad1(fl/fl);Smad5(fl/fl);Cre(+) mice ex

290 Thyroid-specific Smad1 and Smad5 double-knockout (Smad1/5(dKO)) mice displayed growth ret

291 sis factor receptor (TNFR) 1 and TNFR2 (TNFR double knockouts); some mice were given a GATA3-specific

292 Furthermore, double knockout sperm were capable of producing normal o

293 Additionally, double knockout splenocytes displayed reduced chromosoma

294 yl-ACP in vitro, and the DeltatesS DeltaplsX double knockout strain was a fatty acid auxotroph.

295 However, both double-knockout strains displayed exacerbated muscle deg

296 By using double knockout strategies, we further prove that this p

297 However, perforin/FasL double-knockout T cells failed to reject, arguing that t

298 ectin protein disappeared in T-cadherin/ApoE double-knockout (Tcad/ApoE-DKO) mice with significant el

299 mouse was significantly higher in Apoe/Apoa1 double-knockout then in APP/Abca1(ko) mice.

300 Here we use an inducible double knockout to show that cells lacking both SCAR and