ライフサイエンスコーパス: double-positive

1 The first population was: 1) CD4(+)/CD8(+) double-positive; 2) specific for an HLA class I-restrict

2 5(-)CD44(-)) proliferation, and CD4(+)CD8(+) double-positive activation as well as developmental bloc

3 In this paper, we show human CD4/CD8 double-positive, acute graft-versus-host disease-protect

4 jor defects in the generation of CD4 and CD8 double-positive alphabeta T cells, whereas gammadelta T

5 CD4 is expressed in double-positive and CD4 cells but irreversibly silenced

6 n of CD4 single-positive thymocytes, whereas double-positive and CD8 single-positive thymocytes were

7 into monovalent activating modifications in double-positive and CD8 SP cells.

8 of mSin3A specifically decreases survival of double-positive and CD8 T cells.

9 ermore, identification of IL-17A(+) Foxp3(+) double-positive and ex-IL-17-producing IL-17A(neg)Foxp3(

10 Adult marrow progressed through double-positive and single-positive stages only when IL-

11 However, the numbers of double-positive and single-positive thymocytes after CD3

12 show that this role of Ikaros is specific to double-positive and single-positive thymocytes because d

13 4(-) thymocytes (that included CD4(+)/CD8(+) double-positive, and CD4(+) and CD8(+) single-positive c

14 at multiple stages; from DN3 through to DN4, double-positive, and single-positive CD4 and CD8.

15 for phenotypic markers further identified a double-positive aSma+ Mac3+ cell population, which is sp

16 ese included expansion of CD19(+) and CD5(+) double-positive B cells similar to the aggressive form o

17 Cross-arm avidity targeting of antigen double-positive cancer cells over single-positive normal

18 kewed in PGN+poly(I:C)-treated uterus toward double-positive CD11c(+) (M1) and CD206(+) (M2) cells, w

19 istant cells were enriched 5- to 22-fold for double-positive (CD133(+)/CD44(+)) cells.

20 Foxp3 Eomes double-positive CD4(+) T cells were capable of eliminati

21 stricted deletion resulted in the absence of double-positive CD4(+)CD8(+) thymocytes, whereas bone-ma

22 recedes acute cell loss in the TN3, TN4, and double positive (CD4(+), CD8(+)) cell stages.

23 Double-negative (CD4(-)8(-)) and double-positive (CD4(+)8(+)) thymocytes were confined to

24 y of mainstream thymocyte development at the double-positive (CD4(+)CD8(+)) stage.

25 Immature double-positive (CD4(+)CD8(+)) thymocytes respond to neg

26 ere characterized as IL-17 (IL-17 and GM-CSF double-positive) CD4 cells.

27 ions exhibited an increased CD14(+)/CD206(+) double-positive cell population compared with normal tis

28 LZF-expressing cells were first found at the double-positive cell stage.

29 (-)CD8(-) (double negative) to CD4(+)CD8(+) (double positive) cell stages, whereas T cell activation

30 well as TrkA(+)/TrkB(+) and TrkA(+)/TrkC(+) double positive cells at early embryonic stages.

31 In comparison, the double positive cells remained at a basal level in mice

32 inefficient differentiation of CD4(+)CD8(+) double positive cells.

33 tivated cell sorting, only Prominin-1/Nestin double-positive cells fulfilled the defining stem cell c

34 ers of IFN-gamma-positive or IL-17/IFN-gamma-double-positive cells generated under Tc17 conditions al

35 Array analysis of TCR-stimulated double-positive cells identified SAP-1-dependent inducib

36 d in an induction of doublecortin- and Sox10 double-positive cells in the adult SVZ.

37 determine percentages of Kit and FcepsilonRI double-positive cells in the peritoneum of wild-type (WT

38 resulted in the early expression of FoxP3 on double-positive cells in the thymic cortex.

39 T and B cells in the spleen and CD4(+)CD8(+) double-positive cells in the thymus of OPN(+/+) mice.

40 triple-positive and INF-gamma and TNF-alpha double-positive cells increasing over time, while INF-ga

41 During this process, agonist-selected double-positive cells lose CD4/8 coreceptor expression a

42 ments demonstrate that these nestin and BLBP double-positive cells represent a population of glial pr

43 ature single-positive and CD3(+)CD4(+)CD8(+) double-positive cells showed severe restriction of reper

44 Additionally, the number of Flk-1/CD34 double-positive cells towards the ischemic penumbra was

45 e transition from CD4/CD8 double-negative to double-positive cells was blocked, and lck-cre(+) double

46 Most double-positive cells were also positive for costimulato

47 ection with NC/02 or MN/99 plus TX/96, H1/H3 double-positive cells were identified.

48 e-positive cells was blocked, and lck-cre(+) double-positive cells were more prone to apoptosis and s

49 a dramatic increase in alpha-SMA(+), EP4(+) double-positive cells were observed in EP4cKO(S100a4) su

50 Finally, IL-17 and interferon gamma double-positive cells were significantly increased in IL

51 TCR activation in double-positive cells with stabilized beta-catenin trigg

52 green-dominant cells converted to green/red double-positive cells within 6 h.

53 gative thymocytes, expressed in CD4(+)CD8(+) double-positive cells, and silenced in cells committing

54 se receptor (CD206) and the CD14(+)/CD206(+) double-positive cells, suggesting a polarization of macr

55 imilarly enhanced Pou4f3/GFP and myosin VIIa double-positive cells, when compared to hATOH1 alone.

56 ansition stage between double-negative 4 and double-positive cells.

57 ridge cells into Pou4f3/GFP and myosin VIIa double-positive cells.

58 impaired accumulation of alphabeta T lineage double-positive cells.

59 w cytometry and distinguished from green/red double-positive cells.

60 ue and further differentiate into IL-6/IL-17 double-positive cells.

61 re than a 5-fold increase in active Casp1/PI double-positive cells.

62 and a decreased percentage of CD4(+)/CD8(+) (double-positive) cells; the DN1/DN2 population was incre

63 traversal of the DN (double negative) > DP (double positive) checkpoint are required for ThPOK-media

64 ercentage of CD29(hi)/CD24(neg), CK5(+), and double-positive CK14/CK18 cells.

65 ) Sca-1(+), CD24(hi) CD29(+), CK19, CK6, and double-positive CK14/CK18 progenitor cells.

66 APP/beta-amyloid and Atg8/LC3 double-positive compartments were almost exclusively obs

67 CS analysis of CRH receptor (CRHR) and c-kit double-positive disaggregated mouse skin mast cells.

68 in T-cell development at the double-negative/double-positive (DN/DP) stages cooperate with cytokine-m

69 BAT was double positive/double negative/single positive in 6/2/1

70 Adoptive transfer of WT CD11b(+) Gr1(+) double positive (DP) cells, but not T cells, was suffici

71 Loss at the double positive (DP) stage of thymocyte development caus

72 is essential for maturation to the CD4+CD8+ double positive (DP) stage.

73 Y alpha chain at the physiological CD4+ CD8+ double positive (DP) stage.

74 pre-TCR beta-selection of thymocytes to the double positive (DP) stage.

75 lations and demonstrate that mitochondria in double positive (DP) thymocytes are more primed for deat

76 is constitutively ubiquitylated in immature double positive (DP) thymocytes, but not mature single p

77 inactivate the immature CD8(III) enhancer in double positive (DP) thymocytes, explaining in part the

78 CD8(-) double negative (DN) and CD4(+)CD8(+) double positive (DP) thymocytes, respectively.

79 ly regulated plexinD1 expression on CD4+CD8+ double positive (DP) thymocytes.

80 ore sensitive than more mature CD4(+)CD8(+) [double positive (DP)] thymocytes to a weak pMHC-I agonis

81 velopment, with a reduction in the number of double-positive (DP) and an increase in the number of do

82 and CD8 cells, but expressed in CD4(+)CD8(+) double-positive (DP) and CD4 cells.

83 The number of double-positive (DP) and single-positive (SP) T cells ar

84 Peripheral blood and thymic double-positive (DP) CD4(+)CD8(+) T cells from neonates

85 The differentiation of double-positive (DP) CD4(+)CD8(+) thymocytes to single-p

86 s the degradation of the TCR in preselection double-positive (DP) CD4(+)CD8(+) thymocytes.

87 )CD8(-) double-negative (DN)-to-CD4(+)CD8(+) double-positive (DP) cell transition, and this may be pa

88 because of a diminished number of CD4+ CD8+ double-positive (DP) cells and were associated with T-ce

89 Thymic CD4+CD8+ double-positive (DP) cells from these mice were striking

90 , we demonstrate that ADAP-deficient CD4/CD8 double-positive (DP) cells have a diminished ability to

91 ve thymocytes and their differentiation into double-positive (DP) cells, where Trbv recombination is

92 aling cascades that allow for DN to CD4+CD8+ double-positive (DP) differentiation, proliferation, and

93 -lineage, thereby decreasing the size of the double-positive (DP) pool, which is efficiently positive

94 -) double-negative stage to the CD4(+)CD8(+) double-positive (DP) stage and from the DP stage to the

95 uble-negative (DN) 3 cells progressed to the double-positive (DP) stage and up-regulated TCRalphabeta

96 ent, but their roles beyond the CD4(+)CD8(+) double-positive (DP) stage are unknown.

97 EB was uniquely required at the CD4(+)CD8(+) double-positive (DP) stage of T cell development.

98 ry for their progression to the CD4(+)CD8(+) double-positive (DP) stage of T cell development.

99 ymocytes to the DN4, and subsequently to the double-positive (DP) stage.

100 a differentiation block at the CD4(+)CD8(+) double-positive (DP) stage.

101 inase (MMP)-1/2/9 genes compared with DN and double-positive (DP) subpopulations.

102 and DN2 T cell progenitors and CD4(+)CD8(+) double-positive (DP) T cell precursors, but increased fr

103 tion in RAG expression at the immature B and double-positive (DP) T cell stages is mediated through t

104 individuals possess circulating CD4(+)CD8(+) double-positive (DP) T cells specific for HIV Ags.

105 knockout mice due to increased cell death of double-positive (DP) T cells.

106 and to cause a partial block in CD4(+)CD8(+) double-positive (DP) thymocyte development in mice.

107 Death by neglect requires that CD4+8+ double-positive (DP) thymocytes avoid cytokine-mediated

108 The mutant double-positive (DP) thymocytes exhibited spontaneous hy

109 Deficiency in the TF Bcl11b in double-positive (DP) thymocytes has been shown to cause

110 s that regulate the lifespan of CD4(+)CD8(+) double-positive (DP) thymocytes help shape the periphera

111 Moreover, the signals that retain CD4+CD8+ double-positive (DP) thymocytes in the cortex and preven

112 Survival of CD4(+)CD8(+) double-positive (DP) thymocytes plays a critical role in

113 ranscriptional control of gene expression in double-positive (DP) thymocytes remains poorly understoo

114 Double-positive (DP) thymocytes respond to intrathymic T

115 cell development from immature CD4(+)CD8(+) double-positive (DP) thymocytes to the mature CD4 or CD8

116 involves coculture of TCR(hi)CD5(int)CD69(-) double-positive (DP) thymocytes with peptide-pulsed OP9

117 The iNKT cells derive from CD4(+)CD8(+) double-positive (DP) thymocytes, and their generation re

118 CD4+CD8+ double-positive (DP) thymocytes, which are extremely sen

119 tion of V(beta)-to-DJ(beta) recombination in double-positive (DP) thymocytes, which correlates with r

120 Their positive selection is mediated by double-positive (DP) thymocytes, which present glycolipi

121 r cells that differentiate into CD4(+)CD8(+) double-positive (DP) thymocytes, which then rearrange th

122 ntiation that is highly expressed in CD4/CD8 double-positive (DP) thymocytes.

123 protein and mRNA levels of CD4 in CD4+ CD8+ double-positive (DP) thymocytes.

124 es variegated Cd8 expression in CD4(+)CD8(+) double-positive (DP) thymocytes.

125 Cs) promotes apoptosis of the CD4(hi)CD8(hi) double-positive (DP) thymocytes.

126 The double-positive (DP) to single-positive (SP) transition

127 repertoire selection and the transition from double-positive (DP) to SP cell in a physiological situa

128 subsequent transition from the CD4(+)CD8(+) double-positive (DP) to the CD4(+) or CD8(+) single-posi

129 stalls the developmental transition from the double-positive (DP) to the single-positive (SP) thymocy

130 Immature CD4(+)CD8(+) (double-positive (DP)) thymocytes are signaled via T cell

131 periments and the identification of CD4(+)8+ double-positive (DP), V alpha 14J alpha 18 natural T (iN

132 ansiently expressed during the CD4(+)CD8(+) (double positive [DP]) stage of T cell development, in as

133 - CD8- (double negative [DN]) and CD4+ CD8+ (double positive [DP]) thymocytes, respectively.

134 ecombine, and inaccessible in CD4(+)/CD8(+) (double-positive [DP]) thymocytes, when they do not rearr

135 CD4((+))CD8((+)) "double positive" (DP) thymocytes differentiate into dive

136 The CD4(+)CD8(+) (double positive, DP) stage of thymic development is thou

137 ce of maturational conversion of EEA1/NEEP21 double-positive endosomes.

138 Among the 112 serum samples, we found 22 double positive (EP-I and EP-II), 6 EP-II positive only,

139 increased numbers of vimentin- and alpha-SMA-double-positive fibroblasts were detected in the dermis

140 ed as being negative for lineage markers and double-positive for CD45/CD127.

141 erial endothelium, and identified many cells double-positive for HMGA1 and SM22alpha in occlusive and

142 nts; however, its effect on patients who are double-positive for wheals and angioedema has not been s

143 Recently, traces of double-positive FoxP3(+)RORgammat(+) T cells were identi

144 (TNF-alpha) and gamma interferon (IFN-gamma) double-positive functional phenotype was associated with

145 The CD161high CCR6+ double-positive gammadelta T-cell population was further

146 nitors are derived from the tcf21 and nkx2.5 double-positive head mesoderm and require these two tran

147 d for selective targeting and eradication of double-positive human NCI-H358 non-small cell lung cance

148 whereas galectin-1 kills double-negative and double-positive human thymocytes with equal efficiency,

149 There were double-positive IL-17+IL-22+ cells [TH17(22)], and the I

150 at prevention of maturation of CD4(+)/CD8(+) double-positive immature T cells is important in ZNF198-

151 pha (TCRalpha) rearrangement in CD4(+)CD8(+) double-positive immature thymocytes is a prerequisite fo

152 ession in thymocytes blocks progression from double-positive immature thymocytes, resulting in comple

153 ll intestine contains CD4(+)CD8alphaalpha(+) double-positive intraepithelial lymphocytes (DP IELs), w

154 Quantification of double-positive LacZ(+) and CD31(+) endothelial cells or

155 (-)CD8(-) (double-negative) to CD4(+)CD8(+) (double-positive) maturation because of low TCR expressio

156 aled an enrichment in AhR/IL-6 and AhR/IL-17 double-positive MCs within bronchial lamina propria.

157 se, they form a distinct pool of KLRG1 CD127 double-positive memory T cells and rapidly produce both

158 class II molecules and that more than 40% of double-positive muscle fibers had contact with CD4(+) an

159 appearance of VEGF receptor 1 (VEGFR1)/CD11b double-positive myeloid cells in peripheral blood.

160 tment increased the numbers of granulocytes, double-positive myeloid cells, and macrophages at sites

161 e numbers or proportions of CD4(+),CD8(+) or double-positive or double-negative thymocytes, except th

162 Double-positive (PD-1(+)CTLA-4(+)) CD8(+) TIL had charac

163 D45 negative, EpCAM/pan-cytokeratin (pan-CK) double-positive population after excluding debris, doubl

164 The lymphoblasts were composed of a CD4/CD8 double-positive population that aberrantly expressed CD4

165 centage of apoptotic cells were found in the double-positive population, and down-regulation of thymo

166 similarities between this VE-cadherin+CD45+ ;double-positive' population and endothelial cells sugges

167 teral genetic ablation of the 175 Cdh9/Dbx1 double-positive preBotC neurons in adult mice left breat

168 tive' thymocytes from CD4(+)CD8alphabeta(+) 'double-positive' precursors.

169 The double-positive result indicated 46% and 39% point risk

170 ite expression of the DC marker CD11c, these double-positive rMPs displayed the features of Msmall ef

171 Depleting EP-II antibodies from double-positive serum samples increased 50% inhibitory d

172 and Treg, as well as co-inhibitory molecules-double-positive, severely exhausted PD-1(+)CD8(+) T cell

173 negatively selected cells are deleted at the double positive stage in the thymic cortex, compared wit

174 ce of gammadelta potential through the early double positive stage of development.

175 row progenitor cells fail to progress to the double positive stage when cultured on OP9 stromal cells

176 mainstream thymocyte differentiation at the double positive stage, and recent work has revealed how

177 s in a block in thymocyte development at the double positive stage.

178 gulation of CD34, and plateaued at the early double positive stage.

179 ) progenitors and stays high until the early double-positive stage (CD3(-)CD4(+)CD8alpha(+)beta(-)).

180 ng Valpha14 to Jalpha18 recombination at the double-positive stage and enhanced proliferation of iNKT

181 on from the beta-selection checkpoint to the double-positive stage in an osmostress-independent manne

182 lection and lineage fate at the CD4(+)CD8(+) double-positive stage of intrathymic T-cell development.

183 y demonstrates that removal of Bcl11b at the double-positive stage of T cell development or only in T

184 the TCR for selection from the CD4(+)CD8(+) double-positive stage to the CD4 or CD8 single-positive

185 thymocytes, development to the CD4(+)CD8(+) double-positive stage was impaired, due to increased apo

186 abeta T cell development at the CD4(+)CD8(+) double-positive stage, although other lymphoid lineages

187 of a rec-Valpha14-Jalpha18 transgene at the double-positive stage, thus defining a role for NKAP in

188 single-positive (ISP) stage and the CD4/CD8 double-positive stage, with few mature CD4(+) or CD8(+)

189 arrangement early in development, before the double-positive stage.

190 locked in the transition to the CD4(+)CD8(+) double-positive stage.

191 or PRLR all imparted some progression to the double-positive stage.

192 killer T cell development is blocked at the double-positive stage.

193 uring the DN4, immature single-positive, and double-positive stages of development before thymic sele

194 partial block between the double-negative to double-positive stages of development.

195 ed during transition from DN to CD4(+)CD8(+) double-positive stages, it is maintained through heritab

196 especially during transition from the DN3 to double-positive stages, possibly through its regulation

197 larity and blocks at the double-negative and double-positive stages.

198 e CD8 immature single-positive and CD4+ CD8+ double-positive stages.

199 population, specifically the CD24(+)CD15(+) double-positive subpopulation, was selectively decreased

200 activity is elevated in cell-sorted DN4 and double-positive subpopulations.

201 and the highly proliferative ELF5(+)/CDX2(+) double-positive subset of cytotrophoblast cells demarcat

202 n important role for RASA1 as a regulator of double-positive survival and positive selection in the t

203 for IL-17 production by Th17, generation of double positive T cells expressing IL-17 and IFN-gamma,

204 cells displayed a predominant population of double-positive T cells (TNF-alpha(+)IFN-gamma(+)).

205 xpression for miR-323-3p in IL-22- and IL-17-double-positive T cells and its capacity to suppress mul

206 17 single-producing T cells, IL-17/IFN-gamma double-positive T cells are found in significantly eleva

207 nd CD3epsilon it was possible to isolate the double-positive T cells in spleen and head kidney.

208 nd from CD4-CD8- double-negative to CD4+CD8+ double-positive T cells in the thymus.

209 )CD11c(-) cells, which resemble CD4(+)CD8(+) double-positive T cells in the thymus; and (e) CD34(-)CD

210 w) immature single-positive CD8(+) cells and double-positive T cells.

211 or LMO1 was found in primary human TAL1/LMO1 double-positive T-ALL samples previously described by Fe

212 bone marrow pro-B cells and in CD4(+)CD8(+) double positive thymic T cells.

213 gy in lymphoid tissues but preserved CD4/CD8 double-positive thymic T cell pools.

214 and that was critical for double-negative to double-positive thymocyte differentiation and survival i

215 n is markedly higher in the Glut1-expressing double-positive thymocyte population than in any of the

216 -1 functions together with Bcl-xL to promote double-positive thymocyte survival.

217 nterleukin-22 (IL-22) in response to loss of double positive thymocytes and upregulation of IL-23 by

218 n of CD4- CD8- double negative and CD4+ CD8+ double positive thymocytes and was followed by a complet

219 l stage-specific regulation, being active in double positive thymocytes but not in DN thymocytes as i

220 eceptor (TCR) signaling in immature CD4+CD8+ double positive thymocytes leads to an instructive bias

221 Surprisingly, however, some early double positive thymocytes retained gammadelta potential

222 ious difference in the apoptosis of CD4+CD8+ double positive thymocytes was observed between CnAbeta-

223 Preincubation of double positive thymocytes with exogenous bacterial liga

224 quires MHC-related 1-expressing CD4(+)CD8(+) double positive thymocytes, whereas thymic B cells, macr

225 identified was negative selection of CD4/CD8 double positive thymocytes.

226 ation of high-affinity signaled CD4(+)CD8(+) double-positive thymocytes and CD8(+) and CD4(+) single-

227 hat phosphorylation of Bim occurs in CD4/CD8 double-positive thymocytes and does not depend on activa

228 CD44(hi)CD122(hi) cells were found among double-positive thymocytes and increased in frequency du

229 difying factor TRIM28 is highly expressed in double-positive thymocytes and persistently phosphorylat

230 positive selection of immature CD4(+)CD8(+) double-positive thymocytes and their commitment to the C

231 Shn2(-/-) double-positive thymocytes are more sensitive to TCR-ind

232 However, double-positive thymocytes are positively selected to su

233 s no role in Notch target gene repression in double-positive thymocytes but rather that it is Ikaros

234 d further V(beta)-DJ(beta) rearrangements in double-positive thymocytes by separating the V(beta) gen

235 l tuner of TCR signaling, mir-181a-1/b-1, in double-positive thymocytes dampened TCR and Erk signalin

236 ymocytes but is not affected in CD4(+)CD8(+) double-positive thymocytes despite high expression of Th

237 gen receptor (TCR) signaling in CD4(+)CD8(+) double-positive thymocytes determines cell survival and

238 4(+) and CD8(+) single-positive subsets, and double-positive thymocytes exhibited increased Ca(2+) mo

239 CD4/CD8 double-positive thymocytes express the transcriptional r

240 Because double-positive thymocytes expressing CD1d select natura

241 rescue the transition of double-negative to double-positive thymocytes in RAG-null mice, but is unab

242 beta-catenin/Tcf signaling was activated in double-positive thymocytes in response to alphabetaTCR e

243 Our results indicate that Shn2(-/-) double-positive thymocytes inappropriately undergo negat

244 MHC class II-expressing double-positive thymocytes induce progression of CD4(+)

245 28 costimulation of T cell receptor-signaled double-positive thymocytes induced expression of Foxp3,

246 Differentiation of CD4+CD8+ double-positive thymocytes into CD8+ single-positive (SP

247 Rescue in SLP76(-/-)Cbl(-/-)Y3F double-positive thymocytes is associated with enhanced t

248 selection of MHC class I-restricted CD4+CD8+ double-positive thymocytes is markedly inhibited in mice

249 sustained entry of Ca(2+) into CD4(+)CD8(+) double-positive thymocytes is required for positive sele

250 s are able to detect early stage CD4(+)CD8(+)double-positive thymocytes on which T-cell receptors are

251 etion of Tet2 and Tet3 in mouse CD4(+)CD8(+) double-positive thymocytes resulted in dysregulated deve

252 Notably, Git2(-/-) double-positive thymocytes showed greater activation of

253 In contrast, double-positive thymocytes showed increased V(beta) tran

254 Conditional ablation of c-Myc in double-positive thymocytes specifically impacted iNKT bu

255 thymus of CD5DeltaCK2BD mice contained fewer double-positive thymocytes than did that of both CD5WT a

256 ransgene led to highest expression levels in double-positive thymocytes that are normally devoid of D

257 ent uniquely depends on interactions between double-positive thymocytes that provide key homotypic in

258 his study that costimulation of preselection double-positive thymocytes through the signaling lymphoc

259 s to assemble Tcrd genes and in CD4(+)CD8(+) double-positive thymocytes to assemble Tcra genes.

260 double-negative thymocytes and CD4(+)CD8(+) double-positive thymocytes to generate diverse TCRdelta

261 f miR-181a/b-1 reduced the responsiveness of double-positive thymocytes to TCR signals and virtually

262 at Themis protein expression is increased in double-positive thymocytes undergoing positive selection

263 Death of CD4(+)CD8(+) double-positive thymocytes was increased in RASA1-defici

264 r p300 or CBP led to a decrease in CD4+ CD8+ double-positive thymocytes, but an increase in the perce

265 ighly similar with respect to the numbers of double-positive thymocytes, CD4(+)CD8(-) T cells, regula

266 ively suppressed in late double-negative and double-positive thymocytes, coinciding with the peak in

267 In double-positive thymocytes, concomitant binding of Mi-2b

268 shows decreased cell number, reduced CD4CD8 double-positive thymocytes, diminished expression of TCR

269 Bcl11b locus results in failure to generate double-positive thymocytes, implicating a critical role

270 otch target genes is observed in Ikaros null double-positive thymocytes, in the absence of detectable

271 AC7), a class IIa HDAC expressed in CD4+CD8+ double-positive thymocytes, is regulated by its nucleocy

272 Furthermore, using this approach, double-positive thymocytes, macrophages, and dendritic c

273 I or II, and are selected by CD1-expressing double-positive thymocytes, rather than by the thymic st

274 teractions by looping in double-negative and double-positive thymocytes, respectively.

275 ow that TH-POK can also upregulate GATA-3 in double-positive thymocytes, suggesting the existence of

276 When YY1 was depleted in double-positive thymocytes, they underwent increased cel

277 e block in positive selection of CD4 and CD8 double-positive thymocytes, yet the role of the NFATc pr

278 tributed across this domain, specifically in double-positive thymocytes.

279 ocytes despite high expression of Themis1 in double-positive thymocytes.

280 cytes and Tcra gene segments in CD4(+)CD8(+) double-positive thymocytes.

281 d triggered by the depletion of CD4(+)CD8(+) double-positive thymocytes.

282 ) and J(alpha) segments for recombination in double-positive thymocytes.

283 gen receptor (TCR) signals by CD4(+ ) CD8(+) double-positive thymocytes.

284 egulating the chemokine-mediated motility of double-positive thymocytes.

285 ctivator RBP-Jkappa was abrogated in Ik(-/-) double-positive thymocytes.

286 st the DN3 to DN4 checkpoint and to generate double-positive thymocytes.

287 CD4 gene in CD4-positive hybridoma cells and double-positive thymocytes.

288 as well as differentiation into CD4(+)CD8(+) double-positive thymocytes.

289 ocytes (IELs), arose from a unique subset of double-positive thymocytes.

290 gments remain refractory to recombination in double-positive thymocytes.

291 increases and peaks on CD3(high)CD4(+)CD8(+) double-positive thymocytes.

292 a-chain genes are assembled in CD4(+)CD8(+) (double positive) thymocytes due, in part, to the develop

293 ng the attenuation of CD8 avidity during the double-positive to CD8 single-positive progression.

294 ocyte development during transition from the double-positive to single-positive stage.

295 lls displayed further block from CD4 and CD8 double-positive to single-positive transition compared w

296 yte development was partially blocked at the double-positive to single-positive transition.

297 T cell development at the double-negative 4:double-positive transition in the thymus, a loss of B ce

298 ors and thymocytes at the double-negative to double-positive transition.

299 velopmental arrest at the double-negative to double-positive transition.

300 (-)CD8(-) (double-negative) to CD4(+)CD8(+) (double-positive) transition, chromatin regulation was th