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1 charomyces cerevisiae Pif1 can unwind dsDNA (double-stranded DNA).
2 e of introducing sequence specific breaks in double stranded DNA.
3 H1 association with mononucleosomes or bare double stranded DNA.
4 breaks or alkali-labile lesions in single or double stranded DNA.
5 by ATP, which allows efficient processing of double-stranded DNA.
6 les that are mixtures of single-stranded and double-stranded DNA.
7 on the transition of single-stranded DNA to double-stranded DNA.
8 53, which binds to specific DNA sequences on double-stranded DNA.
9 n guanine bases in either single-stranded or double-stranded DNA.
10 helicase domains bind tightly to single- and double-stranded DNA.
11 ng CMGs pass one another and dissociate from double-stranded DNA.
12 rate single-stranded DNA but largely exclude double-stranded DNA.
13 d on non-specific Rad51 binding to undamaged double-stranded DNA.
14 its of Cascade that are critical for binding double-stranded DNA.
15 on of viral core DNA and, in particular, the double-stranded DNA.
16 coherent and incoherent processes coexist in double-stranded DNA.
17 enables the translocation and processing of double-stranded DNA.
18 4) complex formation immediately adjacent to double-stranded DNA.
19 ate hydrolysis-dependent translocation along double-stranded DNA.
20 ble an Mcm2-7 double-hexamer around adjacent double-stranded DNA.
21 f potato is further able to bind and distort double-stranded DNA.
22 y structure which appears capable of binding double-stranded DNA.
23 y displaced one nucleotide when encountering double-stranded DNA after filling a gap or nicked DNA.
24 hed amphiphilic peptides that associate with double stranded DNA and promote in vitro transfection of
26 oprotein C1/C2 (hnRNPC1/C2) can also bind to double-stranded DNA and function in trans as a vitamin D
28 ether CMG translocation occurs on single- or double-stranded DNA and how ATP hydrolysis drives DNA un
29 dro-2'-deoxyguanine (8-oxoG) often occurs in double-stranded DNA and poses a threat to genomic integr
30 d by immunofluorescence antibody staining in double-stranded DNA and positive-strand RNA virus infect
31 psid shell, must be reverse transcribed into double-stranded DNA and released from the capsid (in a p
33 tor domains are specifically adapted to bind double-stranded DNA and to facilitate DNA sliding via a
34 facilitation of primer strand invasion into double-stranded DNA, and a suppression of non-homologous
35 lanoma 2 (AIM2) inflammasome is activated by double-stranded DNA, and AIM2 expression is reduced in s
36 igher in single-stranded DNA (ssDNA) than in double-stranded DNA, and copying the resulting uracils c
37 ystal structures of cyclic GMP-AMP synthase, double-stranded DNA, and inhibitors within the enzymatic
38 n of our method using the known structure of double-stranded DNA as a benchmark, resolve 10-base-pair
39 ting such models have been reported that use double-stranded DNA as donors, but their efficiency is t
42 sent a method that can be used to solubilize double-stranded DNA at high concentrations in organic me
43 assembly of head-to-head CMGs that encircle double-stranded DNA at the origin, the two CMGs must pas
45 hermore, our data indicate that the entry of double-stranded DNA beyond a short threshold distance fr
49 ted T helper 17 cell differentiation through double-stranded DNA break (DSB) and ASC-mediated inflamm
51 al chromatin organization before and after a double-stranded DNA break (DSB), to estimate the level o
53 and replication fork restart, prevention of double-stranded DNA break formation, and avoidance of re
54 A-dependent protein kinase (DNA-PK) mediates double-stranded DNA break repair, V(D)J recombination an
58 t during homologous recombination, repair of double stranded DNA breaks, and integron recombination.
60 F, XPC and AP-endonuclease-1), and repair of double-stranded DNA breaks (homologs of BRCA2, XRCC3, KU
61 Unrepaired DNA lesions, such as single- and double-stranded DNA breaks (SSBs and DSBs), and single-s
62 various stressors, such as for the repair of double-stranded DNA breaks and protein quality control,
63 CD complex, which acts in both the repair of double-stranded DNA breaks and the degradation of bacter
64 pyogenes (SpCas9) is more active in creating double-stranded DNA breaks at 37 degrees C than at 22 de
67 non-homologous end-joining (NHEJ) repair of double-stranded DNA breaks generated by Cas9 are much le
68 Cas9 can be reprogrammed to create specific double-stranded DNA breaks in the genomes of a variety o
71 cycle progression through mitosis following double-stranded DNA breaks leads to the formation of mic
72 antage that it does not require formation of double-stranded DNA breaks or provision of a donor DNA t
74 aks resulted in the generation of persistent double-stranded DNA breaks was found to be a primary cau
75 the BNP-based sunblock significantly reduced double-stranded DNA breaks when compared with a commerci
76 r growth by causing apoptotic cell death via double-stranded DNA breaks while causing a remodeling of
77 colibactin, a genotoxic molecule(s) causing double-stranded DNA breaks(4) and enhanced colorectal ca
78 ed replication forks, insufficient repair of double-stranded DNA breaks, and improper segregation of
79 etabolism, archazolid caused S-phase arrest, double-stranded DNA breaks, and p53 stabilization, leadi
80 et (UV)-C radiation and reagents that induce double-stranded DNA breaks, but exhibit normal responses
81 g cellular metabolism; these lesions include double-stranded DNA breaks, daughter-strand gaps, and DN
82 BRCA1 has no equivalent role at chromosomal double-stranded DNA breaks, indicating that tandem dupli
92 n a large set of 438 GQ forming sequences in double-stranded DNA by integrating fluorescence measurem
94 sembly and utilization of a surface-attached double-stranded DNA catenane composed of two intact inte
96 ersion of one base pair into another without double-stranded DNA cleavage, excess stochastic insertio
98 of the single stranded viral RNA genome into double-stranded DNA, competent for host-cell integration
99 cruitment domain) pyrin domain and the IFI16-double stranded DNA complex has established that the for
100 ional and linear joints that integrate stiff double-stranded DNA components and flexible single-stran
102 everse transcribe its RNA genome to create a double-stranded DNA copy and then integrate this viral D
107 report on e.g., the conformational state of double stranded DNA (dsDNA) following its interaction wi
108 via the solid-phase hybridisation, a 144-bp double stranded DNA (dsDNA) was then detected directly u
109 hematosus (SLE), IgE antibodies specific for double-stranded DNA (dsDNA) activated plasmacytoid dendr
111 flict with each other: i) the impact of anti-double-stranded DNA (dsDNA) antibodies that cross-react
112 ently repressed to prevent the generation of double-stranded DNA (dsDNA) breaks in cycling large pre-
115 ing via homology-directed repair (HDR) after double-stranded DNA (dsDNA) cleavage facilitates functio
117 cant correlation between the release of host double-stranded DNA (dsDNA) following rhinovirus infecti
118 the inner core of adenovirus containing its double-stranded DNA (dsDNA) genome and associated protei
119 Each strain encodes a 9.8- to 9.9-kb linear double-stranded DNA (dsDNA) genome with large inverted t
121 ection of circulating autoantibodies against double-stranded DNA (dsDNA) is used in the diagnosis of
122 that BLM localizes in the vicinity of ssDNA/double-stranded DNA (dsDNA) junction and reels in the ss
126 e mechanism studies on spCas9-sgRNA-mediated double-stranded DNA (dsDNA) recognition and cleavage, it
127 rategies that enable recognition of specific double-stranded DNA (dsDNA) regions has been a longstand
129 onjugate accumulation was dependent upon the double-stranded DNA (dsDNA) sensor cyclic GMP-AMP syntha
131 e can form a nucleoprotein filament (NPF) on double-stranded DNA (dsDNA) that is capable of unwrappin
132 cryo-EM), we show that the binding of target double-stranded DNA (dsDNA) to a type I-F CRISPR system
133 tion releases granule proteins together with double-stranded DNA (dsDNA) to form extracellular fibers
134 DNA helicases are motor proteins that unwind double-stranded DNA (dsDNA) to reveal single-stranded DN
135 termination of the complete 70.8-kb circular double-stranded DNA (dsDNA) viral genome content, and id
139 ies to prevent active infection with certain double-stranded DNA (dsDNA) viruses after allogeneic hem
142 mine (T)) on single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with acetone, ethanol, H2S a
145 u magnetic nanoparticles functionalized with double-stranded DNA (dsDNA), a sequence of the breast ca
146 hat is initiated upon cytosolic detection of double-stranded DNA (dsDNA), but how dsDNA is detected i
147 ost lupus patients develop autoantibodies to double-stranded DNA (dsDNA), but the source of DNA antig
148 dynamics, the division between the rates of double-stranded DNA (dsDNA), single-stranded RNA (ssRNA)
149 nsible for pairing the ssDNA with homologous double-stranded DNA (dsDNA), which serves as the templat
150 nt elucidation of the mechanism of the viral double-stranded DNA (dsDNA)-packaging motor with sequent
156 plex led to the release of the AuNPs-S2 from double-stranded DNA(dsDNA) and the recovery of the ECL s
157 robe (single stranded DNA-ssDNA) and hybrid (double stranded DNA-dsDNA) both via 3-NT reduction and g
162 ce) facilitates the crRNA-guided invasion of double-stranded DNA for complementary base-pairing with
163 g in aqueous solutions of monodisperse stiff double-stranded DNA fragments is known not to occur, des
164 nthetic DNA, through the in vivo excision of double-stranded DNA from an episomal replicon by CRISPR/
165 ination events are associated with repair of double-stranded DNA gaps and/or involve Mlh1-independent
166 Poxviridae are viruses with a large linear double-stranded DNA genome coding for up to 250 open rea
167 illus subtilis phage whose uracil-containing double-stranded DNA genome encodes distant homologs of b
173 enovirus (HAdV), a medium-sized virus with a double-stranded DNA genome, needs to be identified.
174 ruses, which we denote magroviruses, possess double-stranded DNA genomes of 65 to 100 kilobases in si
177 inner cavity, large enough to accommodate a double-stranded DNA helix, as well as a protruding Tower
184 on) to analyze the differential stability of double-stranded DNA in complex with either cisplatin or
188 complex shows reduced binding to single- and double-stranded DNA in vitro relative to wild-type MRX,
189 The latter allows MjAgo to process long double-stranded DNAs, including circular plasmid DNAs an
190 hich preferentially bind the minor groove of double-stranded DNA, inhibit vaccinia virus infection by
191 r using a custom synthesized ferrocenyl (Fc) double-stranded DNA intercalator as a redox marker is pr
196 P-AMP synthase (cGAS), a cytosolic sensor of double-stranded DNA, is activated in autoinflammatory di
197 finely designing the curvature and torsion, double-stranded DNA knots were accessed by hybridizing a
199 tes DNA topology by transiently breaking one double-stranded DNA molecule (cleavage), allowing a seco
200 s (Cas) that utilize RNA to find and cut the double-stranded DNA molecules at specific locations.
202 ombination, in which the repair of breaks in double-stranded DNA molecules is taking place with a hel
203 f the resulting diffusion coefficients using double-stranded DNA molecules ranging in size from 20 to
205 l plastid (chloroplast) genomes are circular double-stranded DNA molecules, typically between 100 and
208 linear HCR is a hairpin-free system in which double-stranded DNA monomers could dendritically assembl
211 ative DNA-binding domain, selectively senses double-stranded DNA of at least 40 base pairs in length
212 e analyze smFRET data of structurally rigid, double-stranded DNA-oligonucleotides in aqueous buffer a
213 and chromosomal gene conversion with either double-stranded DNA or single-stranded oligonucleotide d
215 action of cauliflower mosaic virus (CaMV), a double-stranded DNA pararetrovirus, with the model plant
218 s for T4, we show how the energetic costs of double-stranded DNA phages scale with the capsid size, r
219 ever, the assigned viruses were dominated by double-stranded DNA phages, and sequences associated wit
221 are studied as models for viruses containing double-stranded DNA (polymer) and condensing proteins (p
222 canonical 2'-deoxyribonucleosides) stabilize double-stranded DNA, RNA, and DNA-RNA hybrids with antip
224 ulator of interferon genes, a key adaptor in double-stranded DNA-sensing pathway, followed by its rap
225 Here, we show that mice deficient in the double-stranded DNA sensor AIM2 are protected from both
226 ize the replication origin (oriC) by binding double-stranded DNA sequences (DnaA-boxes); subsequently
227 as9-guide RNA complexes recognize and cleave double-stranded DNA sequences on the basis of 20-nucleot
228 PR)-associated 9 (Cas9) endonuclease cleaves double-stranded DNA sequences specified by guide RNA mol
231 es with a CRISPR RNA (crRNA) and cleaves the double-stranded DNA target complementary to the crRNA gu
237 NA guides to cleave both single stranded and double stranded DNA targets, and does not utilize RNA as
238 n bound to CRISPR RNA (crRNA), can recognize double-stranded DNA targets and recruit the Cas3 nucleas
240 The RNA-guided endonuclease Cas9 cleaves double-stranded DNA targets complementary to the guide R
241 The RNA-guided DNA endonuclease Cas9 cleaves double-stranded DNA targets with a protospacer adjacent
242 plex with a single guide RNA (sgRNA) and its double-stranded DNA targets, containing the 5'-TTGAAT-3'
244 correction is more efficient when using long double-stranded DNA than single- or double-stranded olig
245 t single-stranded RNA of the viral genome to double-stranded DNA that is then integrated into the DNA
246 genome of HIV-1 is reverse transcribed into double-stranded DNA that ultimately integrates into the
247 ll lines (A375 and HCT116), interaction with double stranded DNA through in vitro assay, and molecula
249 unreported conductance states that occur as double-stranded DNA translocates through a 2.4 nm solid-
250 V E2.IMPORTANCE The papillomavirus (PV) is a double-stranded DNA tumor virus infecting cervix, mouth,
251 II CRISPR-Cas surveillance complexes target double-stranded DNA, type III complexes target single-st
252 ere obtained for smaller single-stranded and double-stranded DNA using the benzyltrioctylammonium bro
253 g either single-stranded oligonucleotides or double-stranded DNA vectors as repair templates yielded
257 Human cytomegalovirus (HCMV) is an enveloped double-stranded DNA virus that causes severe disease in
258 Human cytomegalovirus (HCMV) is a large, double-stranded DNA virus that causes significant human
260 acmanvirus is a newly discovered icosahedral double-stranded DNA virus that was isolated from an envi
261 e fever virus (ASFV) is a highly pathogenic, double-stranded DNA virus with a marked tropism for cell
262 werful ATP-hydrolyzing motor, formed in many double-stranded DNA viruses by a complex of a small term
263 dataset to present a global map of abundant, double-stranded DNA viruses complete with genomic and ec
264 e complement of alpha-helical TM proteins in double-stranded DNA viruses infecting bacteria and archa
265 rtant aspect of viral particle stability for double-stranded DNA viruses is the energetically unfavor
266 and complex genomes make evolution in these double-stranded DNA viruses more efficient than that in
269 Virophages are a unique group of circular double-stranded DNA viruses that are considered parasite
271 simplex virus 1 (HSV-1) and HSV-2 are large, double-stranded DNA viruses that cause lifelong persiste
273 s) are an ancient and heterogeneous group of double-stranded DNA viruses that preferentially infect t
274 steric regulatory mechanism we report allows double-stranded DNA viruses to achieve rapid, high-densi
275 e that Epstein-Barr virus and possible other double-stranded DNA viruses use TRIM29 to suppress local
276 g been thought that the genetic diversity of double-stranded DNA viruses was generated over long peri
277 ighlight the emergence of previously unknown double-stranded DNA viruses which delineate and extend t
281 ckaging is strongly conserved in the complex double-stranded DNA viruses, including the herpesviruses
287 conformationally constrained acpcPNA probes, double stranded DNA was detected sensitively and specifi
288 fficient fluorescent labelling of single and double-stranded DNA was carried out using dyes functiona
289 nst autoantigens, such as thyroperoxidase or double-stranded DNA, whereas other patients make IgG aut
290 n, the viral RNA is reverse transcribed into double-stranded DNA, which is then incorporated into hos
291 erase binds to the -12T base pair as part of double-stranded DNA while opening base pairs from -11A t
292 ity to telomeric DNA substrates comprised of double-stranded DNA with a 3' single-stranded extension.
293 ApoE4 undergoes nuclear translocation, binds double-stranded DNA with high affinity (low nanomolar),
297 ct a single DNA-nanogold conjugate, an 84-bp double-stranded DNA with two 5-nm nanogold particles for
299 SE1/NSE3/NSE4 sub-complex of SMC5/6 binds to double-stranded DNA without any preference for DNA-repli
300 ) contain large numbers of repeats that bind double-stranded DNA, wrapping around DNA to form a conti
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