ライフサイエンスコーパス: double-stranded DNA break

1 double helix and generate an enzyme-mediated double-stranded DNA break.

2 resent at both scissile bonds to stabilize a double-stranded DNA break.

3 ilizing a strand-specific nick rather than a double-stranded DNA break.

4 leading to further processing of the initial double-stranded DNA break.

5 role in determining the response of cells to double stranded DNA breaks.

6 Mre11 and Rad50 to coordinate the repair of double-stranded DNA breaks.

7 ad3-related (ATR) kinase to induce transient double-stranded DNA breaks.

8 tivity and might prevent DME from generating double-stranded DNA breaks.

9 nation, which is essential for the repair of double-stranded DNA breaks.

10 e that initiates homologous recombination at double-stranded DNA breaks.

11 nonhomologous end-joining pathways to repair double-stranded DNA breaks.

12 rays and ultraviolet light that can lead to double-stranded DNA breaks.

13 nation, an important mechanism for repair of double-stranded DNA breaks.

14 l DNA replication in egg extracts containing double-stranded DNA breaks.

15 is, which leads to excessive accumulation of double-stranded DNA breaks.

16 with, 53BP1 after exposure to agents causing double-stranded DNA breaks.

17 e that initiates homologous recombination at double-stranded DNA breaks.

18 equired in order to increase enzyme-mediated double-stranded DNA breaks.

19 ily by the enzyme and can generate permanent double-stranded DNA breaks.

20 ert processed BER intermediates to permanent double-stranded DNA breaks.

21 ls by inhibiting topoisomerases and inducing double-stranded DNA breaks.

22 uring mitosis, meiosis, and in the repair of double-stranded DNA breaks.

23 re deficient in genes required for repair of double-stranded DNA breaks.

24 due to the involvement of ATM in monitoring double-stranded DNA breaks.

25 that are secondary to aberrant responses to double-stranded DNA breaks.

26 athway allows immature thymocytes to survive double-stranded DNA breaks.

27 A2, BRCA1 does not function in the repair of double-stranded DNA breaks.

28 important cellular pathway for the repair of double-stranded DNA breaks.

29 mologous recombination and for the repair of double-stranded DNA breaks.

30 ells revealed the presence of site-specific, double-stranded DNA breaks.

31 gether with experimentally induced telomeric double-stranded DNA breaks.

32 on, and is a major pathway for the repair of double-stranded DNA breaks.

33 sions, small duplications, and generation of double-stranded DNA breaks.

34 Cas9 as an RNA-guided nuclease that creates double-stranded DNA breaks.

35 , suggests sequence capture during repair of double-stranded DNA breaks.

36 ed in homologous recombination and repair of double-stranded DNA breaks.

37 forms distinct foci, and can associate with double-stranded DNA breaks.

38 defective lentiviruses into nuclease-induced double-stranded DNA breaks.

39 converting single-stranded DNA lesions into double-stranded DNA breaks.

40 ved in the early recognition and response to double-stranded DNA breaks.

41 with other telomeric loci, or non-telomeric double-stranded DNA breaks.

42 ase/nuclease that initiates recombination at double-stranded DNA breaks.

43 ferred DNA and protecting the genome against double-stranded DNA breaks.

44 maximal activity and induced a high ratio of double-stranded DNA breaks.

45 identify SMARCAL1 as a protein recruited to double-stranded DNA breaks.

46 cells through an accumulation of persistent double-stranded DNA breaks.

47 es responsible for homology-driven repair of double-stranded DNA breaks.

48 phosphorylated histone H2AX, an indicator of double-stranded DNA breaks.

49 ation of Rad50 foci, which are formed around double-stranded-DNA breaks.

50 striction sites as non-self and introduces a double-stranded DNA break [3].

51 colibactin, a genotoxic molecule(s) causing double-stranded DNA breaks(4) and enhanced colorectal ca

52 mit capture of the second processed end of a double-stranded DNA break, a step which is required for

53 Myc or GpIb alpha overexpression and include double-stranded DNA breaks, altered nuclear size and mor

54 s, probably due to the dramatic induction of double-stranded DNA breaks and chromosomal fragmentation

55 urthermore, these tumors were aneuploid with double-stranded DNA breaks and end-to-end telomere fusio

56 This resistant phenotype produced fewer double-stranded DNA breaks and enhanced a cytostatic res

57 usly we have shown that HCV infection causes double-stranded DNA breaks and enhances the mutation fre

58 sophila, a meiotic checkpoint which monitors double-stranded DNA breaks and involves Drosophila ATR a

59 various stressors, such as for the repair of double-stranded DNA breaks and protein quality control,

60 that has primarily evolved for the repair of double-stranded DNA breaks and stalled replication forks

61 CD complex, which acts in both the repair of double-stranded DNA breaks and the degradation of bacter

62 t during homologous recombination, repair of double stranded DNA breaks, and integron recombination.

63 ed replication forks, insufficient repair of double-stranded DNA breaks, and improper segregation of

64 Finally, GpIbalpha also promotes double-stranded DNA breaks, and induces profound nuclear

65 etabolism, archazolid caused S-phase arrest, double-stranded DNA breaks, and p53 stabilization, leadi

66 These data suggest single- and double-stranded DNA breaks are generated during the cell

67 NN, like NRG, attenuated the double-stranded DNA breaks associated with DOXO exposure

68 c manner, and is related to a site-specific, double-stranded DNA break at mat1.

69 isiae initiates when Ho endonuclease makes a double-stranded DNA break at the yeast MAT locus.

70 pyogenes (SpCas9) is more active in creating double-stranded DNA breaks at 37 degrees C than at 22 de

71 The identification of blunt-ended double-stranded DNA breaks at the embedded heptamers and

72 germline transcripts and increased levels of double-stranded DNA breaks at the recombination signal s

73 eplacement "footprints" in IgH sequences and double-stranded DNA breaks at V(H) cRSS sites in immatur

74 et (UV)-C radiation and reagents that induce double-stranded DNA breaks, but exhibit normal responses

75 s sufficient to stimulate the formation of a double-stranded DNA break by human topoisomerase IIalpha

76 ATM is recruited to double-stranded DNA breaks by a complex of sensor protei

77 d51 are important proteins for the repair of double-stranded DNA breaks by homologous recombination i

78 In diploid eukaryotes, repair of double-stranded DNA breaks by homologous recombination o

79 The error-free repair of double-stranded DNA breaks by homologous recombination r

80 o prevent telomeres from being recognized as double-stranded DNA breaks by sequestering the 3' single

81 s initiated by introduction of site-specific double-stranded DNA breaks by the RAG-1 and RAG-2 protei

82 However, both single-stranded and double-stranded DNA breaks can be labeled by this method

83 air pathway is required to prevent or repair double-stranded DNA breaks caused by defective DNA repli

84 found that some cells within biofilms incur double-stranded DNA breaks caused by endogenous oxidativ

85 g cellular metabolism; these lesions include double-stranded DNA breaks, daughter-strand gaps, and DN

86 Cell-cycle arrest induced by double-stranded DNA breaks depends on activation of the

87 ted T helper 17 cell differentiation through double-stranded DNA break (DSB) and ASC-mediated inflamm

88 ern expected as a consequence of repair of a double-stranded DNA break (DSB) of an unreplicated chrom

89 Impairment of double-stranded DNA break (DSB) repair is essential to m

90 recombination (HR) is a crucial pathway for double-stranded DNA break (DSB) repair.

91 ressing cells during the early stages of the double-stranded DNA break (DSB) response, accelerating a

92 al chromatin organization before and after a double-stranded DNA break (DSB), to estimate the level o

93 he RAG-1 and RAG-2 proteins, which introduce double-stranded DNA breaks (DSB) adjacent to the Ig and

94 ) are ancient selfish elements that catalyze double-stranded DNA breaks (DSB) in a highly specific ma

95 Recognition and repair of double-stranded DNA breaks (DSB) involves the targeted r

96 oci over large chromatin domains surrounding double-stranded DNA breaks (DSB).

97 sitivity specifically to agents that induced double-stranded DNA breaks (DSB).

98 amages mitochondria, leading to induction of double-stranded DNA breaks (DSBs) and accumulation of ox

99 by ATR (ATM and Rad3-related) in response to double-stranded DNA breaks (DSBs) but not to DNA replica

100 Double-stranded DNA breaks (DSBs) can result in chromoso

101 The activation of ATR-ATRIP in response to double-stranded DNA breaks (DSBs) depends upon ATM in hu

102 J) and homologous recombination (HR), repair double-stranded DNA breaks (DSBs) in all eukaryotes.

103 cent reports show it is enriched at sites of double-stranded DNA breaks (DSBs) in mammalian cells.

104 tein essential for recombinational repair of double-stranded DNA breaks (DSBs) in somatic cells and d

105 participates in the detection of chromosomal double-stranded DNA breaks (DSBs) in this system.

106 functionally dicentric chromosome undergoes double-stranded DNA breaks (DSBs) that can be repaired b

107 a heterodimer of Ku70 and Ku86 that binds to double-stranded DNA breaks (DSBs), activates the catalyt

108 ions have been implicated in the response to double-stranded DNA breaks (DSBs).

109 f the Rad52 epistasis group of genes, repair double-stranded DNA breaks (DSBs).

110 regions and by the subsequent generation of double-stranded DNA breaks (DSBs).

111 Rad52 and RPA participate in the repair of double-stranded DNA breaks (DSBs).

112 e two master checkpoint kinases activated by double-stranded DNA breaks (DSBs).

113 topoisomerase II generates a protein-linked double-stranded DNA break during its catalytic cycle, it

114 eveloped a new approach to study single- and double-stranded DNA breaks during chronic, moderate exci

115 important for the recombinational repair of double-stranded DNA breaks during meiosis.

116 gous recombination compete for the repair of double-stranded DNA breaks during the cell cycle.

117 In Escherichia coli, RecBCD processes double-stranded DNA breaks during the initial stages of

118 utant was shown to have a capacity to repair double-stranded DNA breaks equivalent to wild-type.

119 In bacterial cells, processing of double-stranded DNA breaks for repair by homologous reco

120 In bacterial cells, processing of double-stranded DNA breaks for repair by homologous reco

121 In bacterial cells, processing of double-stranded DNA breaks for repair by homologous reco

122 AddAB is a helicase-nuclease that processes double-stranded DNA breaks for repair by homologous reco

123 and replication fork restart, prevention of double-stranded DNA break formation, and avoidance of re

124 s recombination events that are initiated by double-stranded DNA breaks formed prior to replication.

125 non-homologous end-joining (NHEJ) repair of double-stranded DNA breaks generated by Cas9 are much le

126 F, XPC and AP-endonuclease-1), and repair of double-stranded DNA breaks (homologs of BRCA2, XRCC3, KU

127 because AID(+) dividing cells exhibited more double-stranded DNA breaks, IGH class switching, and new

128 e fact that there are two scissile bonds per double-stranded DNA break implies that there are two sit

129 recombination is important for the repair of double-stranded DNA breaks in all organisms.

130 nuclease, which is involved in the repair of double-stranded DNA breaks in Bacillus subtilis.

131 nstrate that DNA intercalating agents induce double-stranded DNA breaks in both immature thymocytes a

132 e analyzed the repair of transposase-induced double-stranded DNA breaks in cells deficient in either

133 Repair of double-stranded DNA breaks in Escherichia coli is initia

134 ded DNA and is required for the rejoining of double-stranded DNA breaks in mammalian cells.

135 otein kinase (DNA-PK) controls the repair of double-stranded DNA breaks in mammalian cells.

136 Cas9 can be reprogrammed to create specific double-stranded DNA breaks in the genomes of a variety o

137 20 are colocalized at the gamma-H2AX foci of double-stranded DNA breaks in the nucleus.

138 point mutations in the Ig variable region or double-stranded DNA breaks in the switch region DNA.

139 We generated double-stranded DNA breaks in yeast cells in vivo by exp

140 ions, and H2AX phosphorylation, a marker for double-stranded DNA breaks, in Hus1(neo/neo) and Hus1(ne

141 BRCA1 has no equivalent role at chromosomal double-stranded DNA breaks, indicating that tandem dupli

142 initiate recombination between homologs are double-stranded DNA breaks induced during S or G2 of the

143 However, double-stranded DNA break induction by CPT was significa

144 Here we introduced double-stranded DNA breaks into the nuclear genome of to

145 The mechanism by which a double-stranded DNA break is produced following collisio

146 rejoining of DNA ends at single-stranded or double-stranded DNA breaks is catalyzed by DNA ligases.

147 In bacteria, the repair of double-stranded DNA breaks is modulated by Chi sequences

148 e are two scissile bonds per enzyme-mediated double-stranded DNA break, it has been assumed that ther

149 cycle progression through mitosis following double-stranded DNA breaks leads to the formation of mic

150 f transposable elements, which suggests that double-stranded DNA breaks occur frequently here.

151 at large-scale, yet previously unrecognized, double-stranded DNA breaks occur normally in early postm

152 oksani et al. examine the impact of a single double-stranded DNA break on replication in the budding

153 e scissile bond is sufficient to stabilize a double-stranded DNA break or whether both drug sites nee

154 on at Ser(92) in response to the presence of double-stranded DNA breaks or DNA replication blocks in

155 antage that it does not require formation of double-stranded DNA breaks or provision of a donor DNA t

156 reaction of topoisomerase II, which creates double-stranded DNA breaks, plays a central role in both

157 (D)J recombinase directly, by monitoring the double-stranded DNA breaks produced in the process of V(

158 During recombinational repair of double-stranded DNA breaks, RAD51 recombinase assembles

159 Double-stranded DNA break repair and homologous recombin

160 critical role in sister chromatid cohesion, double-stranded DNA break repair and regulation of gene

161 Double-stranded DNA break repair by homologous recombina

162 5%) breakpoint junctions are consistent with double-stranded DNA break repair by nonhomologous end-jo

163 a crucial role in genetic recombination and double-stranded DNA break repair in Archaea, Bacteria, a

164 Homologous recombination and double-stranded DNA break repair in Escherichia coli are

165 s a key regulator of DNA replication timing, double-stranded DNA break repair, and replication fork r

166 n to their implications for the mechanism of double-stranded DNA break repair, these observations may

167 A-dependent protein kinase (DNA-PK) mediates double-stranded DNA break repair, V(D)J recombination an

168 , one component of a heterodimer involved in double-stranded DNA break repair.

169 is a DNA helicase/nuclease that functions in double-stranded DNA break repair.

170 luding DNA recombination, transcription, and double-stranded DNA break repair.

171 ast DNAs insert into nuclear genomes through double-stranded DNA break repair.

172 coli, homologous recombination initiated at double-stranded DNA breaks requires the RecBCD enzyme, a

173 AB translocation and hotspot scanning during double-stranded DNA break resection.

174 merase I and II create transient single- and double-stranded DNA breaks, respectively, it has been as

175 ling (TUNEL) were used to detect single- and double-stranded DNA breaks, respectively.

176 component of, or in close proximity to, the double-stranded DNA break-sensing machinery.

177 Unrepaired DNA lesions, such as single- and double-stranded DNA breaks (SSBs and DSBs), and single-s

178 Gmnn(-/-) spermatogonia exhibit more double-stranded DNA breaks than control cells, consisten

179 hat the two regions differ in the density of double-stranded DNA breaks that are generated.

180 ingle-stranded DNA breaks frequently lead to double-stranded DNA breaks that are not rapidly repaired

181 whether cells die via apoptosis by detecting double-stranded DNA breaks that are the result of endonu

182 omosome throughout the genome and can induce double-stranded DNA breaks that lead to chromosome trans

183 enesis is secondary to aberrant responses to double-stranded DNA breaks that occur during V(D)J recom

184 rcalating agents reflects their tolerance of double-stranded DNA breaks that occur normally during an

185 nocytes within psoriatic plaques do not have double-stranded DNA breaks, that they have a prolonged c

186 Although fluoroquinolones stabilize double-stranded DNA breaks, the antibacterial thiophenes

187 ough BRCA2 functions to help the cell repair double-stranded DNA breaks, the function of BRCA1 remain

188 horylated H2AX is a characteristic marker of double-stranded DNA breaks, this modification was widely

189 II topoisomerases (TOP2) introduce transient double-stranded DNA breaks through a covalent TOP2-DNA i

190 In all domains of life, the resection of double-stranded DNA breaks to form long 3'-ssDNA overhan

191 e ability of a single 1 Gy exposure to cause double stranded DNA breaks (TUNEL assay) was enhanced at

192 aks resulted in the generation of persistent double-stranded DNA breaks was found to be a primary cau

193 the BNP-based sunblock significantly reduced double-stranded DNA breaks when compared with a commerci

194 r growth by causing apoptotic cell death via double-stranded DNA breaks while causing a remodeling of

195 fork stalling, we suggest that formation of double-stranded DNA breaks within the Ytel sequences mig