ライフサイエンスコーパス: double-stranded RNA

1 verse innate immune stimuli (e.g., TNF, IFN, double-stranded RNA).

2 and C. maculate larvae treated with dietary double stranded RNA.

3 ly recognize more complex structures such as double stranded RNA.

4 ircularly closed nanoobject made entirely of double-stranded RNA.

5 ependent on the formation of sense/antisense double-stranded RNA.

6 innate immunity by limiting accumulation of double-stranded RNA.

7 ing that the predominant precursor is a long double-stranded RNA.

8 TDP-1 is to limit formation or stability of double-stranded RNA.

9 t ATP hydrolytic activity in the presence of double-stranded RNA.

10 the eggs laid by females injected with Kr-h1 double-stranded RNA.

11 f defense against viral infection by sensing double-stranded RNA.

12 nts, thus increasing intracellular levels of double-stranded RNA.

13 As, whereas StDicer-2 can only cleave linear double-stranded RNAs.

14 denosine residues to inosine specifically in double-stranded RNAs.

15 CLR on TxA ileitis by local preinjection of double-stranded RNAs.

16 tion initiation factor upon binding to viral double-stranded RNAs.

17 ivity that degrades single-stranded, but not double-stranded, RNA.

18 f RIG-I that physically interacts with viral double-stranded RNA abolish the antiviral activity of C-

19 kinase PKR was originally characterized as a double-stranded RNA activated enzyme it can be stimulate

20 embly by NFAR2, NF45, and phosphorylation at double-stranded RNA-activated kinase PKR sites.

21 granule assembly by being phosphorylated at double-stranded RNA-activated kinase sites and by associ

22 se R (PKR) is an interferon (IFN)-inducible, double-stranded RNA-activated kinase that initiates apop

23 eased expression of the interferon-inducible double-stranded RNA-activated protein kinase (PKR) has b

24 previously unrecognized nuclear function of double-stranded RNA-activated protein kinase (PKR) in th

25 tol-requiring enzyme 1alpha (IRE1alpha), and double-stranded RNA-activated protein kinase (PKR)-like

26 odulated activator of the interferon-induced double-stranded RNA-activated protein kinase (PKR).

27 to subvert the innate immune system protein double-stranded RNA-activated protein kinase (PKR).

28 Leishmania amazonensis activates macrophage double-stranded, RNA-activated protein kinase R (PKR) to

29 itical component of interferon-regulated and double-stranded-RNA-activated antiviral host responses.

30 , catalyzed by adenosine deAminase acting on double-stranded RNA (ADAR) family of enzymes.

31 Adenosine deaminases acting on double-stranded RNA (ADARs) catalyze the deamination of

32 novirus vector expressing haemagglutinin and double-stranded RNA adjuvant delivered orally by tablets

33 By using a TLR3-restricted double-stranded RNA agonist, rintatolimod, we demonstrat

34 e a different cytosolic adapter cascade with double-stranded RNA agonists.

35 ory cytokine and type I IFN responses to the double-stranded RNA analogue poly(I:C) are reduced in mo

36 feron-induced antiviral response that senses double-stranded RNA and activates endoribonuclease RNase

37 c:polycytidylic acid (poly I:C), a synthetic double-stranded RNA and agonist of Toll-like receptor (T

38 receptors 3 and 4 (TLR3, TLR4), which sense double-stranded RNA and high-mobility group protein B1 (

39 ts, which in turn leads to the generation of double-stranded RNA and the recruitment of DICER, AGO1,

40 Double-stranded RNA and the synthetic analog polyinosini

41 ents of the genome replication complex (NS3, double-stranded RNA, and cellular lipids, including phos

42 House virus replication are dynamic, protect double-stranded RNA, and enhance RNA replication in gene

43 vation with poly(I:C), a synthetic analog of double-stranded RNA, and longitudinally imaged postsynap

44 s nuclear silencing in response to exogenous double-stranded RNA, and our data imply that RSD-2, RSD-

45 Moreover, synthetic double-stranded RNA as adjuvant and antigen targeting to

46 while DHX9, ADAR1, and NF90 bound a cognate double-stranded RNA bait.

47 propose that bivalent interactions with the double stranded RNA binding domain and the basic region

48 Arabidopsis encodes five double-stranded RNA binding (DRB) proteins.

49 Amino acid residues involved in double-stranded RNA binding are similar, but non-identic

50 NAs also activate PKR constructs lacking the double-stranded RNA binding domain and bind to a basic r

51 ADARs are modular enzymes with multiple double-stranded RNA binding domains (dsRBDs) and a catal

52 ng at the Q/R site of GRIA2 Furthermore, the double-stranded RNA binding domains of ADAR3 are require

53 ith pre-60S ribosomal particles requires the double-stranded RNA binding domains of NF90, while deple

54 non-catalytic factors containing one or more double-stranded RNA binding motif (dsRBM) that play impo

55 Also, phospho-hnRNP L recruits DRBP76 (double-stranded RNA binding protein 76) to the 3'UTR, wh

56 lation status, and thus the activity, of the double-stranded RNA binding protein and DICER-LIKE1 (DCL

57 e-stranded primary miRNA by interacting with double-stranded RNA binding protein DGCR8 and processes

58 We have identified a cytoplasmic double-stranded RNA binding protein, Stau1, which is cru

59 lencing pathways in Arabidopsis include five double-stranded RNA binding proteins (DRBs) related to D

60 we retrace the evolutionary history of plant double-stranded RNA binding proteins (DRBs), a group of

61 responsible for recognizing dsRNA is termed double-stranded RNA binding proteins (dsRBP).

62 Double-stranded RNA binding proteins (dsRBPs) are import

63 ists of the nuclear RNase III Drosha and the double-stranded RNA-binding domain protein DGCR8 (DiGeor

64 Double-stranded RNA-binding domains (dsRBDs) are commonl

65 the nonsequence-specific protein TRBP, whose double-stranded RNA-binding domains (dsRBDs) interact wi

66 zation signal (NLS) that overlaps one of its double-stranded RNA-binding domains (dsRBDs).

67 The double-stranded RNA-binding protein and RNA-editing enzy

68 The double-stranded RNA-binding protein DRB4 of Arabidopsis

69 chemical approaches, we identified TARBP2, a double-stranded RNA-binding protein implicated in microR

70 uding those coding for Dicer, Argonaute, and double-stranded RNA-binding proteins (dsRBP) as well as

71 Classical activators of PKR are long viral double-stranded RNAs, but recently, PKR has been found t

72 factors activated by the detection of viral double-stranded RNA by pattern-recognition receptors (RI

73 cleaved precursor fragments are converted to double-stranded RNA by RNA-dependent RNA polymerase 6 (R

74 t DRH-1 facilitates the acquisition of viral double-stranded RNA by the worm dicing complex for the s

75 24-nt siRNAs are known to be processed from double-stranded RNAs by Dicer-like 3 (DCL3) and loaded i

76 two such single-stranded RNA circles into a double-stranded RNA circle, and this strand-annealing ac

77 e the nuclease that might be responsible for double-stranded RNA cleavage, we analysed csp41a and csp

78 btypes of IFN-alpha in response to synthetic double-stranded RNA compared with plasmacytoid DCs in re

79 er-235 phosphorylated NS5A co-localized with double-stranded RNA, consistent with its role in HCV rep

80 Previous studies have shown that double-stranded RNA-dependent kinase, PKR, plays an impo

81 imic the in vivo situation and show that the double-stranded RNA-dependent protein kinase (PKR) is in

82 ough inhibiting eIF-2alpha kinases including double-stranded RNA-dependent protein kinase (PKR), whic

83 ich encodes an innate immune sensor of viral double-stranded RNA, depends on the interferon regulator

84 The sensor RIG-I detects double-stranded RNA derived from RNA viruses.

85 MDA5 is a cytosolic sensor of double-stranded RNA (ds)RNA including viral byproducts a

86 lasmid for in planta transient expression of double stranded RNA (dsRNA) homologous to the acetylchol

87 Considerable double-stranded RNA (dsRNA) accumulation in Xrn1-deplete

88 essive steps in mRNA degradation and prevent double-stranded RNA (dsRNA) accumulation, whereas the vi

89 Recognition of viral double-stranded RNA (dsRNA) activates interferon product

90 Double-stranded RNA (dsRNA) activates the innate immune

91 We also tested the effects of injecting double-stranded RNA (dsRNA) against XDH1, XDH2, or both.

92 ions that fully separate the strands of long double-stranded RNA (dsRNA) and allow the released RNAs

93 s have a much weaker response to cytoplasmic double-stranded RNA (dsRNA) and are only able to produce

94 Although cytosolic double-stranded RNA (dsRNA) and bacterial RNA are known

95 RNaseIII enzymes catalyze the cleavage of double-stranded RNA (dsRNA) and have diverse functions i

96 nnate immune system detection of cytoplasmic double-stranded RNA (dsRNA) and promotion of host antivi

97 nse in primary fibroblasts using exposure to double-stranded RNA (dsRNA) and to examine the expressio

98 has long been known to be activated by viral double-stranded RNA (dsRNA) as part of the mammalian imm

99 on early in infection upon exposure to viral double-stranded RNA (dsRNA) before the induction of inte

100 ressed by ADARs beyond their RNA editing and double-stranded RNA (dsRNA) binding functions.

101 , we report that nuclear factor 90 (NF90), a double-stranded RNA (dsRNA) binding protein, regulates c

102 abundance 22-nucleotide siRNAs produced from double-stranded RNA (dsRNA) by DCL4 and DCL2, respective

103 receptor 4 (TLR4), and enhance signaling to double-stranded RNA (dsRNA) by TLR3.

104 Long double-stranded RNA (dsRNA) can silence genes of matchin

105 er (OC), DNMTis trigger cytosolic sensing of double-stranded RNA (dsRNA) causing a type I interferon

106 Studies on double-stranded RNA (dsRNA) degradation by dsRNases and

107 rimarily focused on their functions in viral double-stranded RNA (dsRNA) detection and consequent ant

108 Viruses that generate double-stranded RNA (dsRNA) during replication must over

109 lose proximity to the RNA template entry and double-stranded RNA (dsRNA) exit tunnels of VP1 and near

110 lex (RC) characterized by HCV NS5A, NS4B, or double-stranded RNA (dsRNA) foci.

111 Topical application of pathogen-specific double-stranded RNA (dsRNA) for virus resistance in plan

112 Total RNA and double-stranded RNA (dsRNA) from mycelia and RNA from sa

113 kin, and the subsequent release of noncoding double-stranded RNA (dsRNA) from necrotic keratinocytes,

114 nematodes, planaria and many insects take up double-stranded RNA (dsRNA) from their environment to el

115 cting with the capsid protein VP2, the viral double-stranded RNA (dsRNA) genome and the RNA-dependent

116 BmCPV) which is characterized by a segmented double-stranded RNA (dsRNA) genome.

117 f the family Partitiviridae have bisegmented double-stranded RNA (dsRNA) genomes and are not generall

118 Bacteriophage Phi6 contains three double-stranded RNA (dsRNA) genomic segments, L, M, and

119 the VP35-based inhibitory functions of viral double-stranded RNA (dsRNA) IFN-beta induction.

120 e worm Caenorhabditis elegans, expression of double-stranded RNA (dsRNA) in neurons can result in the

121 Viruses induce double-stranded RNA (dsRNA) in the host cells.

122 Double-stranded RNA (dsRNA) induces phosphorylation of T

123 entation machinery, mediated in part through double-stranded RNA (dsRNA) induction.

124 are positive-sense RNA viruses that generate double-stranded RNA (dsRNA) intermediates during replica

125 tinct Dicer-like (DCL) proteins that process double-stranded RNA (dsRNA) into small-interfering RNAs

126 Double-stranded RNA (dsRNA) is a common by-product of vi

127 Double-stranded RNA (dsRNA) is a viral product essential

128 In support of this idea, when double-stranded RNA (dsRNA) is introduced into some anim

129 Poly(I.C), a double-stranded RNA (dsRNA) mimetic, also causes ROS-dep

130 lyinosinic-polycytidilic acid [poly(I.C)], a double-stranded RNA (dsRNA) mimetic, cause airway epithe

131 Endogenous double-stranded RNA (dsRNA) must be intricately regulate

132 port the discovery and characterization of a double-stranded RNA (dsRNA) mycovirus isolated from the

133 Here, we characterized a novel double-stranded RNA (dsRNA) mycovirus, Sclerotinia scler

134 all interfering RNAs (siRNAs) processed from double-stranded RNA (dsRNA) of virus origins mediate pot

135 The human sensor of double-stranded RNA (dsRNA) oligoadenylate synthetase 1

136 (FHV) suppresses RNAi induced by either long double-stranded RNA (dsRNA) or an FHV-based replicon and

137 Although the 5'-triphosphate double-stranded RNA (dsRNA) panhandle structure at the e

138 H3N2, viral RNA, a synthetic analog of viral double-stranded RNA (dsRNA) polyinosinic-polycytidylic a

139 that the biogenesis of viral siRNAs from IAV double-stranded RNA (dsRNA) precursors in infected cells

140 ssays, which require denaturation of the RVA double-stranded RNA (dsRNA) prior to assay setup.

141 DRB3 and DRB5 are not involved in double-stranded RNA (dsRNA) processing but assist in sil

142 MDA5, a viral double-stranded RNA (dsRNA) receptor, shares sequence si

143 eviously, our group has shown that noncoding double-stranded RNA (dsRNA) released during wounding is

144 storically been used as a model to study the double-stranded RNA (dsRNA) Reoviridae family, the membe

145 t encode an ExoN, which functions to degrade double-stranded RNA (dsRNA) replication intermediates.

146 of the auxiliary replication protein p23 and double-stranded RNA (dsRNA) revealed that the ER-derived

147 Bluetongue virus (BTV) is a double-stranded RNA (dsRNA) segmented virus and the caus

148 only egress, cells were transfected with the double-stranded RNA (dsRNA) targeting an individual ESCR

149 Diet based insect feeding assays using double-stranded RNA (dsRNA) targeting dvssj1 and dvssj2

150 Injection of double-stranded RNA (dsRNA) targeting gene coding for in

151 innate immune system uses several sensors of double-stranded RNA (dsRNA) to develop the interferon re

152 RIG-I detects double-stranded RNA (dsRNA) to trigger antiviral cytokin

153 PKR is activated upon binding to double-stranded RNA (dsRNA) to undergo dimerization and

154 ting the cascade of antiviral responses that double-stranded RNA (dsRNA) triggers in host cells.

155 iral response against infection of segmented double-stranded RNA (dsRNA) virus (CPV; Reoviridae) and

156 (GLV) is a small, nonenveloped, nonsegmented double-stranded RNA (dsRNA) virus infecting Giardia lamb

157 The endogenous double-stranded RNA (dsRNA) virus Leishmaniavirus (LRV1)

158 irus (FAKV), represents the first 9-segment, double-stranded RNA (dsRNA) virus to be isolated in natu

159 Most double-stranded RNA (dsRNA) viruses are transcribed and

160 including segmented negative-strand RNA and double-stranded RNA (dsRNA) viruses.

161 5 (MDA5) are paralogous receptors for viral double-stranded RNA (dsRNA) with divergent specificity.

162 Specifically, efficient synthesis of double-stranded RNA (dsRNA) within infected cells is req

163 2 generates small interfering RNAs from long double-stranded RNA (dsRNA), a process that requires ATP

164 a vaccine antigens coadministered with 5'ppp-double-stranded RNA (dsRNA), a RIG-I ligand, developed r

165 Invertebrates rely on Dicer to cleave viral double-stranded RNA (dsRNA), and Drosophila Dicer-2 dist

166 se transcripts, which are capable of forming double-stranded RNA (dsRNA), was accompanied by a strong

167 Poxvirus replication involves synthesis of double-stranded RNA (dsRNA), which can trigger antiviral

168 lication suggested that most viruses produce double-stranded RNA (dsRNA), which is essential for the

169 nting translational shutdown mediated by the double-stranded RNA (dsRNA)-activated kinase PKR and the

170 to viral infection through the action of the double-stranded RNA (dsRNA)-activated protein kinase (PK

171 Double-stranded RNA (dsRNA)-activated protein kinase (PK

172 Double-stranded RNA (dsRNA)-activated protein kinase (PK

173 In particular, NP associates with the double-stranded RNA (dsRNA)-activated protein kinase (PK

174 Injection of female mosquitoes with either double-stranded RNA (dsRNA)-ALAT1 or dsRNA ALAT2 signifi

175 y, a previously unidentified mutation in the double-stranded RNA (dsRNA)-binding domain (I64T) decrea

176 two conserved residues in its RNase IIIb and double-stranded RNA (dsRNA)-binding domains and that pho

177 Zaire ebolavirus (EBOV) VP35 is a double-stranded RNA (dsRNA)-binding protein that inhibit

178 enzyme that can associate with two different double-stranded RNA (dsRNA)-binding proteins, protein ac

179 protein (C(KO)) is a potent activator of the double-stranded RNA (dsRNA)-dependent protein kinase (PK

180 ble protein I (RIG-I)-like receptors (RLRs), double-stranded RNA (dsRNA)-dependent protein kinase rec

181 The growth of MAG was impaired after double-stranded RNA (dsRNA)-mediated knockdown in the ex

182 nic day 13.5), with activated interferon and double-stranded RNA (dsRNA)-sensing pathways.

183 ease III (RNase III) enzymes are a family of double-stranded RNA (dsRNA)-specific endoribonucleases r

184 The double-stranded RNA (dsRNA)-targeted knockdown of either

185 dsRBDs) interact with the A-form geometry of double-stranded RNA (dsRNA).

186 ication and the accompanying accumulation of double-stranded RNA (dsRNA).

187 stunt virus (TBSV) leads to the formation of double-stranded RNA (dsRNA).

188 nsfected poly(I.C), an analog of cytoplasmic double-stranded RNA (dsRNA).

189 mplex and the viral replication intermediate double-stranded RNA (dsRNA).

190 Double-stranded RNAs (dsRNA) produced during human cytom

191 Double-stranded-RNA (dsRNA)-activated protein kinase R (

192 catalyzed by Adenosine DeAminases acting on double-stranded RNA(dsRNA) (ADAR), occurs predominantly

193 In this study, we analyzed how non-coding double-stranded RNA (dsRNAs) act as a DAMP in the skin a

194 motifs that are required for p38 binding to double-stranded RNAs (dsRNAs) and interaction with RNA-i

195 Recent new studies demonstrate that spraying double-stranded RNAs (dsRNAs) and small RNAs (sRNAs) tha

196 ce primary transcripts that are converted to double-stranded RNAs (dsRNAs) by RDR2 to serve as siRNA

197 silencing is triggered by the production of double-stranded RNAs (dsRNAs) by RNA-DEPENDENT RNA POLYM

198 rus (CPV), all package a genome of segmented double-stranded RNAs (dsRNAs) inside the viral capsid an

199 Feeding with SmedOB1 double-stranded RNAs (dsRNAs) led to homeostasis abnorma

200 It relies on plants stably expressing double-stranded RNAs (dsRNAs) that target essential gene

201 terize the AlucJHEH gene, three fragments of double-stranded RNAs (dsRNAs) were designed to target di

202 ble elements that leads to the production of double-stranded RNAs (dsRNAs).

203 whereas Dicer-2 makes 21-nt siRNAs from long double-stranded RNAs (dsRNAs).

204 that Botrytis can take up external sRNAs and double-stranded RNAs (dsRNAs).

205 Because TLR-3 is activated via double-stranded RNA during most viral infections, the pr

206 PKR autophosphorylates in the presence of double-stranded RNA enabling it to phosphorylate its sub

207 Using these cells, which tolerate double-stranded RNA expression, we show that a mutant fo

208 We conclude that the interaction of double-stranded RNA from injured cells with toll-like re

209 the process of reassortment, whereby the 11 double-stranded RNA genome segments are exchanged among

210 BTV possesses a ten-segmented double-stranded RNA genome, and NS3 proteins are encoded

211 ted RNA polymerase (P2) that transcribes the double-stranded RNA genome.

212 tes to the biology of single stranded versus double stranded RNA genomes.

213 y viruses, such as the presence of segmented double-stranded RNA genomes selectively and tightly pack

214 hitefly genes by expressing their homologous double stranded RNAs in plants has great potential for m

215 , recombinant nsP2 demonstrated unwinding of double-stranded RNA in a 5'-3' directionally biased mann

216 Double-stranded RNA in bronchoalveolar lavage and serum

217 e of toll-like receptor 3 and the binding of double-stranded RNA in the pathogenesis of sterile injur

218 transcription site and its interaction with double-stranded RNA in vitro.

219 d region stem-loop structures, which contain double-stranded RNA, in vitro.

220 ction by masking the genome from RNase L and double-stranded RNA-induced innate immune sensors.

221 oth cytosolic double-stranded B-form DNA and double-stranded RNA-induced IRF3 activation and IFN-beta

222 his article reviews some key applications of double-stranded RNA interference (RNAi) in Schistosoma m

223 ; however, sequence-selective recognition of double-stranded RNA is challenging.

224 P binding confirmed that ATP binds only when double-stranded RNA is present.

225 Exogenous double-stranded RNA is processed by Dicer and RDE-1/Argo

226 element [KIL-d] alters killer activity of M double-stranded RNA killer virus and confers cell resist

227 When injected with whole virus, the double-stranded RNA knockdowns of either attC or dptB sh

228 ally, pretreatment with toll-like receptor 3/double-stranded RNA ligand inhibitor led to a reduction

229 A toll-like receptor 3/double-stranded RNA ligand inhibitor was injected into w

230 kness behavior, single-stranded RNA viruses, double-stranded RNA ligands, and IFNs shared pathways in

231 RNAs (siRNAs), which are negatively charged double-stranded RNA macromolecules, remains a major hurd

232 howing that activation of Toll receptor 3 by double-stranded RNA may be another pathway for activatio

233 Long double-stranded RNA may undergo hyper-editing by adenosi

234 raphic data demonstrate a mechanism in which double-stranded RNA mediates enzyme dimerization.

235 A levels in response to IFN and poly(I-C), a double-stranded RNA mimic compared with the parental cel

236 h broadly acting, because it is triggered by double-stranded RNA molecules derived from virtually any

237 r with cum1(+) sense mRNA, thereby producing double-stranded RNA molecules that could induce RNAi.

238 since transcripts from multi-copy loci form double stranded RNA more efficiently than transcripts fr

239 However, although both CTDs bind single- and double-stranded RNA, murine GCN2 does not appear to stab

240 Upon sensing double-stranded RNA, OAS produces 2',5'-oligoadenylates

241 maturation, encoding an enzyme that cleaves double-stranded RNA or stem-loop-stem RNA into 20-25 nuc

242 Upon injection of artificial double-stranded RNA (poly(I:C)), we observed severe live

243 esus monkeys given the viral mimic synthetic double-stranded RNA (polyinosinic:polycytidylic acid sta

244 modified form of the viral mimic, synthetic double-stranded RNA (polyinosinic:polycytidylic acid sta

245 cessive TLR3-mediated cell death, induced by double-stranded RNA present in the skin of SHARPIN-defic

246 osinic-polycitidilic acid (PIC) (a mimick of double-stranded RNA produced during viral infection) sho

247 hat is positioned in the minor groove of the double-stranded RNA product and lysine and arginine resi

248 that heterozygous mutations in the cytosolic double-stranded RNA receptor gene IFIH1 (also called MDA

249 enosine deaminases that edit and destabilize double-stranded RNA reducing its immunostimulatory activ

250 find that SMAD3 binds poorly to single- and double-stranded RNA, regardless of sequence.

251 (MAVS) by the antimicrobial peptide LL37 and double stranded-RNA released from necrotic cells.

252 RNA biogenesis machinery to recognize viral double-stranded RNA replication intermediates and transp

253 show that sigmaNS also binds to a partially double-stranded RNA, resulting in gradual helix unwindin

254 (HDV) form characteristic unbranched, quasi-double-stranded RNA secondary structures in which short

255 in the Reoviridae family, has a genome of 10 double-stranded RNA segments, with three distinct size c

256 insect-borne virus enclosing a genome of 10 double-stranded RNA segments.

257 plex of VP1, VP4, and VP6 and a genome of 10 double-stranded RNA segments.

258 pre-mRNA splicing, ribosome biogenesis, and double-stranded RNA sensing.

259 HEPN domains, and can bind to stem-loop and double-stranded RNAs simultaneously.

260 a RNA helicase Dhx9, Nlrp9b recognizes short double-stranded RNA stretches and forms inflammasome com

261 mmunity is independent of a 5' triphosphate, double-stranded RNA structure, or the primary sequence o

262 to allow flexibility in the unbranched quasi-double-stranded RNA structure.

263 RNase III proteins recognize double-stranded RNA structures and catalyze endoribonucl

264 approximately 22 nt microRNAs (miRNAs) from double-stranded RNA substrates by the endonuclease Dicer

265 clease share high catalytic activity against double-stranded RNA substrates, a rare quality among rib

266 itro for efficient nuclease activity against double-stranded RNA substrates, particularly at lower te

267 of cellular functions that are controlled by double-stranded RNAs, such as RNA interference, RNA edit

268 gulation of AsFAR expression by injection of double-stranded RNA suppresses ovarian development and f

269 l RNA molecules prior to capsid assembly and double-stranded RNA synthesis within viral inclusion bod

270 Microinjection of double-stranded RNAs targeting ku70 or lig4, both essent

271 ytoplasmic release of siGLO, a 22 nucleotide double-stranded RNA that has no mRNA targets, from its P

272 strated that the TBSV (-)RNA is present as a double-stranded RNA that serves as the template for TBSV

273 chanism involving formation of a PRUNE2/PCA3 double-stranded RNA that undergoes adenosine deaminase a

274 RNA polymerases (RDRs) catalyze synthesis of double-stranded RNAs that can serve to initiate or ampli

275 MicroRNAs (miRNAs) are genome-encoded small double-stranded RNAs that have emerged as key regulators

276 acting on RNA-1 (ADAR1), which catalyzes in double-stranded RNA the C-6 deamination of adenosine to

277 Double-stranded RNAs, the viral replication intermediate

278 show that DDX3X interacts specifically with double-stranded RNA through its D1 domain, with contact

279 y human hepatocytes activated with synthetic double-stranded RNA to mimic HCV infection.

280 e amino-terminal helicase domain can process double-stranded RNAs to produce high levels of siRNAs th

281 Silencing involves the generation of a double-stranded RNA trigger intermediate using the fkbA

282 eotide (HDO) with a structure different from double-stranded RNA used for short interfering RNA and s

283 ) was independently generated in single- and double-stranded RNA via photolysis of a ketone precursor

284 Yeast L-A double-stranded RNA virus furnishes its transcript with

285 ny Leishmania (Viannia) parasites harbor the double-stranded RNA virus Leishmania RNA virus 1 (LRV1),

286 isolates of L. braziliensis (>25%) contain a double-stranded RNA virus named Leishmaniavirus 1 (LRV1)

287 Rotavirus, a double-stranded RNA virus of the Reoviridae family, is t

288 Bluetongue virus (BTV), a nonenveloped double-stranded RNA virus, is a potent inducer of type I

289 Recently, we reported that a double-stranded RNA virus, Leishmania RNA virus 1 (LRV1)

290 cytotoxicity caused by reovirus, a prototype double-stranded RNA virus.

291 Rotaviruses (RVs) are 11-segmented, double-stranded RNA viruses that cause severe gastroente

292 Reoviruses are double-stranded RNA viruses that infect hosts via respir

293 rthoreoviruses (reoviruses) are nonenveloped double-stranded RNA viruses that infect most mammalian s

294 Reoviruses are double-stranded RNA viruses that infect the mammalian re

295 Destabilization of the double stranded RNA was measured as a function of number

296 us by plaque assay even though intracellular double-stranded RNA was detected by immunofluorescence.

297 The endoribonuclease RNase III cleaves double stranded RNAs, which can be formed during the int

298 prisingly, the condensation is suppressed in double-stranded RNA, which carries the same negative cha

299 mental and environmental cues; they may form double-stranded RNAs, which could be recognized by the s

300 NV RNA replicates efficiently and generates double-stranded RNA without inducing a detectable IFN re