ライフサイエンスコーパス: double-stranded RNA-dependent protein kinase

1 uced apoptosis by modulating the activity of double-stranded RNA-dependent protein kinase.

2 ctor 1, 2',5'-oligoadenylate synthetase, and double-stranded-RNA-dependent protein kinase as well as

3 We have investigated the role of the double-stranded RNA-dependent protein kinase gene (pkr)

4 oic acid + interferon-alpha --> upward arrow double-stranded RNA-dependent protein kinase --> downwar

5 R4-induced IFN-beta mRNA was MyD88- and PKR (double-stranded RNA-dependent protein kinase)-independen

6 PKR (double-stranded RNA-dependent protein kinase) is an impo

7 implicated in the anti-viral response, e.g., double-stranded RNA-dependent protein kinase, myxovirus

8 vator of IL-1beta and IL-18 - as well as the double-stranded-RNA-dependent protein kinase pathway and

9 ble to bind to and inhibit activation of the double-stranded RNA-dependent protein kinase PKR in cell

10 es expression and autophosphorylation of the double-stranded RNA-dependent protein kinase PKR leading

11 Interestingly, absence of the double-stranded RNA-dependent protein kinase PKR led to

12 hat interferes with the pathway regulated by double-stranded RNA-dependent protein kinase PKR.

13 the shutoff of protein synthesis mediated by double-stranded-RNA-dependent protein kinase PKR.

14 shutoff of protein synthesis mediated by the double-stranded-RNA-dependent protein kinase PKR.

15 Double stranded RNA-dependent protein kinase (PKR) is a

16 -23 p40 and IFN-gamma, and the activation of double-stranded RNA-dependent protein kinase (PKR) and e

17 Phosphorylation of double-stranded RNA-dependent protein kinase (PKR) and e

18 formation of SGs through the increase of the double-stranded RNA-dependent protein kinase (PKR) and f

19 d (iii) double-stranded RNA, which activates double-stranded RNA-dependent protein kinase (PKR) by mi

20 Here, we provide evidence that double-stranded RNA-dependent protein kinase (PKR) can r

21 The depletion of double-stranded RNA-dependent protein kinase (PKR) from

22 n as a result of repressed expression of the double-stranded RNA-dependent protein kinase (PKR) in th

23 Although the double-stranded RNA-dependent protein kinase (PKR) is ac

24 lls infected with herpes simplex virus 1 the double-stranded RNA-dependent protein kinase (PKR) is ac

25 The human double-stranded RNA-dependent protein kinase (PKR) is an

26 ed to be activated upon virus infection, the double-stranded RNA-dependent protein kinase (PKR) is be

27 imic the in vivo situation and show that the double-stranded RNA-dependent protein kinase (PKR) is in

28 In this study, we provide evidence that the double-stranded RNA-dependent protein kinase (PKR) is no

29 human tumor cells in which the activation of double-stranded RNA-dependent protein kinase (PKR) is su

30 vers, we discovered that viperin, ISG20, and double-stranded RNA-dependent protein kinase (PKR) noncy

31 ivation of c-Jun N-terminal kinase (JNK) and double-stranded RNA-dependent protein kinase (PKR) to in

32 Double-stranded RNA-dependent protein kinase (PKR), a ub

33 ter activity, it promotes the degradation of double-stranded RNA-dependent protein kinase (PKR), and

34 and promotes the proteasomal degradation of double-stranded RNA-dependent protein kinase (PKR), litt

35 ough inhibiting eIF-2alpha kinases including double-stranded RNA-dependent protein kinase (PKR), whic

36 report that Ad-mda7 induces andactivates the double-stranded RNA-dependent protein kinase (PKR), whic

37 hPNPase(old-35) is mediated by activation of double-stranded RNA-dependent protein kinase (PKR).

38 k the shutoff of protein synthesis involving double-stranded RNA-dependent protein kinase (PKR).

39 on of the pro-apoptotic interferon-inducible double-stranded RNA-dependent protein kinase (PKR).

40 f protein translation, suggesting a role for double-stranded RNA-dependent protein kinase (PKR).

41 n (CHOP) induction through activation of the double-stranded RNA-dependent protein kinase (PKR).

42 ease mechanisms, here we identify a role for double-stranded RNA-dependent protein kinase (PKR, also

43 Hri1p, Hri2p, or the human eIF2alpha kinase, double-stranded-RNA-dependent protein kinase (PKR), impe

44 t precludes translational arrest mediated by double-stranded-RNA-dependent protein kinase (PKR).

45 trol of virus replication indicated that the double-stranded RNA-dependent protein kinase, PKR, exert

46 We have shown recently that the double-stranded RNA-dependent protein kinase, PKR, is in

47 ent manner likely by the interferon-induced, double-stranded RNA-dependent protein kinase, PKR.

48 RNA and IFN-stimulated gene products such as double-stranded RNA-dependent protein kinase R (PKR), 2'

49 ing antiviral functions of the IFN-inducible double-stranded RNA-dependent protein kinase R or PKR.

50 prevents the translation arrest mediated by double-stranded RNA-dependent protein kinase R.

51 fectivity was not restored in the absence of double-stranded RNA-dependent protein kinase, RNase L, o

52 The double-stranded RNA-dependent protein kinase was not ess

53 PKR is a doubled-stranded RNA-dependent protein kinase which is i