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1 epicardial cells (for at least 25 population doublings).
2 tro cellular tolerance to spontaneous genome doubling.
3 nsis (BB) followed by spontaneous chromosome doubling.
4 4D MAS spectra, all of which show cross-peak doubling.
5 the TCGA breast cancer cohort precede genome doubling.
6 .015) were significantly associated with CNV doubling.
7 g daughters of the opposite within four cell doublings.
8 Isotopic labeling of proteins takes 5-7 cell doublings.
12 period of 2.1 to 4.6 degrees Celsius per CO2 doubling (66 per cent confidence), which is similar to t
13 ve risk of regional antibiotic use, 1.36 per doubling [95% CI, 1.15 to 1.60]; relative risk of import
14 ed behavior from the video recordings nearly doubling a person's odds of getting a "yes" response fro
18 s, small indels, large deletions, chromosome doubling and chromosome translocations in these lines.
22 ity (62.5%) of EACs emerged following genome doubling and that tumors with genomic doubling had diffe
23 etween the pair-rule genes lead to frequency doubling and the patterning of 14 parasegment boundaries
24 (p63, Ki67, K12), percentage of LESCs, cell doubling, and number of passages in culture did not diff
25 sed linearly with helix G:C content, roughly doubling as the G:C content increased from 0 to 100%.
26 ng (e.g., slaf = ball, slaflaf = balls), the doubling aversion shifts into a reliable (morphological)
27 a mathematical instability, called a period-doubling bifurcation, in a model of the cardiac cells.
31 in blood entering the membrane lung, almost doubling CO2 extraction compared with ECCO2R (112 +/- 6
32 segregation, and elimination within six cell doublings, consistent with a measured LRV1 copy number o
33 h a causal relative risk for CVD of 1.00 per doubling cystatin C (95% CI: 0.82 to 1.22; p = 0.994), w
34 are based on bacterial growth in antibiotic doubling dilution series, which means that any error in
36 was greater in non-smokers (1.5- and twofold doubling dose difference from placebo after FP 100 mug a
37 in Asthma Control Questionnaire score, and 2 doubling dose or greater increase in provocative concent
38 0 increased by a mean (+/-SD) of 1.73+/-0.60 doubling doses in the imatinib group, as compared with 1
40 stion, we investigate the double identity of doubling (e.g., slaflaf, or generally, XX; where X stand
42 bstitution mutations occur per cell per cell-doubling event in early human embryogenesis and these ar
43 daughter cells of many early embryonic cell-doubling events contribute asymmetrically to adult blood
44 ced data has exceeded Moore's Law, more than doubling every 2 years since the next-generation sequenc
46 and 2013, with the number of cases more than doubling every decade, from 8.3 million (3.3 million-17.
49 10%, and increased HbF by 4%-9% (P < 0.001), doubling fetal hemoglobin-enriched red blood cells (F-ce
50 whereby a TP53-mutant cell undergoes genome doubling, followed by the acquisition of oncogenic ampli
52 ase the fitness of the involved organisms by doubling gene dosage or neofunctionalization, it may als
53 genome doubling and that tumors with genomic doubling had different patterns of genomic alterations,
55 ion model assesses the cost-effectiveness of doubling HCV case-finding (achieved through introducing
58 fferences in neurobehavioral outcomes with a doubling in BPA concentration and sex-specific associati
61 disliked (e.g., slaflaf < slafmak), but once doubling in form is systematically linked to meaning (e.
62 rd ratios (95% confidence interval [CI]) per doubling in insulin of 1.21 (CI, 1.12-1.31), in HOMA-IR
63 f 6-8 years, only interrupted by a temporary doubling in levels from 1986 to 1987 due to the Chernoby
66 ng cancer in a dose-response fashion, with a doubling in PAr levels associated with 52% higher odds o
67 Structural equation models showed that a doubling in PFAS exposure at 7 y was associated with los
68 transfer cascade that correlates with a near-doubling in photocatalytic activity from 2050 to 3810 mu
69 At baseline, in cross-sectional analysis, a doubling in plasma perfluorooctanesulfonic acid (PFOS) a
70 eased with the spatial scale of seed mixing, doubling in plots that received seed from large (>/=5 km
71 fidence interval (CI)] of blood %-5hmC for a doubling in prenatal RBC-Hg concentration was -0.013% (-
72 n the genomic ratio of %-5mC to %-5hmC for a doubling in prenatal RBC-Hg concentration was 4.70% (0.0
73 hair cells in the cochlea and an approximate doubling in the number of afferent synapses was observed
74 tion domain (p50-RARalpha model) exhibited a doubling in the rate of leukemia, with a reduced latency
75 ral-blood cells was associated with nearly a doubling in the risk of coronary heart disease in humans
77 ead exposure among female infants (-4.3% per doubling increase in lead exposure; p=1.1x10-06), was an
78 ation with prenatal lead exposure (-1.4% per doubling increase in lead exposure; p=2.3x10-7) and was
80 ignificant reduction in mobility, population doubling, increased levels of reactive oxygen species an
81 Viewed as meaningless (phonological) forms, doubling is disliked (e.g., slaflaf < slafmak), but once
83 ne expression, we demonstrate that frequency-doubling is precipitated by multiple coordinated changes
85 at (i) 264 new viral genera were identified (doubling known genera) and (ii) cross-taxon genomic reco
87 tegories based on OCTA area measurement: CNV doubling, modest growth of less than 50%, and shrinkage.
89 an ambulance was associated with a more than doubling of 30-day survival even in case of long ambulan
92 perature rise in in vitro studies caused the doubling of apoptosis and reduced epithelial resistance
93 ge in global average surface temperature per doubling of atmospheric carbon dioxide over millennium t
94 cent to a 60 per cent increase in GPP for a doubling of atmospheric CO2 concentrations in model stud
95 er cent for extratropical ecosystems under a doubling of atmospheric CO2 concentrations on the basis
96 lobal mean surface temperature response to a doubling of atmospheric CO2, measured by the equilibrium
99 between plasma ADMA level and renal events (doubling of baseline serum creatinine, dialysis, or kidn
104 pits (CCPs) to "necked"/"closed" CCVs and a doubling of CCP/CCV diameter, whereas AP2 depletion has
106 global warming projections in response to a doubling of CO2-from 1.5 degrees C to 4.5 degrees C or g
108 val, 1.08-1.43; P=0.003 and hazard ratio per doubling of creatine kinase-MB, 1.30; 95% confidence int
109 mary outcome was progression CKD, defined as doubling of creatinine or decrease in estimated glomerul
111 proportional hazard models (hazard ratio per doubling of cTnT, 1.24; 95% confidence interval, 1.08-1.
113 tional risk factors (relative risk: 1.82 per doubling of cystatin C; 95% confidence interval [CI]: 1.
115 etween prenatal PFHxS and TGs z-score [for a doubling of exposure, beta=0.11; 95% confidence interval
118 nfidence interval [95% CI], 1.03 to 1.20 per doubling of FGF23) during a median follow-up of 8.6 year
119 to 1.42) and 1.06 (95% CI, 0.97 to 1.17) per doubling of FGF23, respectively (P=0.13 for interaction)
120 ippocampal CA1 cell groups showing frequency doubling of firing periodicity relative to theta rhythmi
121 e a reduction in connections between MSNs, a doubling of FSI inhibition to D2 MSNs, an increase in D2
122 r adjusting for potential confounders, every doubling of GDF-15 level associated with a 72% higher (9
124 process due to an increase by 10 degrees C; doubling of growth rates with a 1 degrees C change gives
125 ulation has doubled in size, necessitating a doubling of health and social services to maintain cover
126 s were 2.2 (P = 0.01) and 1.9 (P = 0.04) per doubling of image counts for 60- and 120-min uptake imag
129 nt defense pathways and results in an almost doubling of insect herbivore infection by entomopathogen
133 sion of a potent preadipocyte enhancer and a doubling of IRX3 and IRX5 expression during early adipoc
134 f Sox9(+) Neurog3(TA.LO) progenitors, with a doubling of its mitotic index relative to normal Neurog3
135 are insufficient to explain the approximate doubling of knee OA prevalence that has occurred in the
136 k) cohort, COPD status was associated with a doubling of lung cancer incidence, no apparent overdiagn
138 ncides with fragmentation of the chondriome, doubling of mitochondrial number, and heterogeneous redi
139 S part III scores (increase in MDS-UPDRS per doubling of odds 0.52, 95% CI 0.31 to 0.72; p<0.001), wh
140 association was revealed (RRcontinuously per doubling of omentin concentrations = 1.07; 95% CI, 0.63-
141 r colorectal cancer risk (RRcontinuously per doubling of omentin concentrations = 1.98; 95% CI, 1.45-
142 rticipants with BMI < 30 (RRcontinuously per doubling of omentin concentrations = 2.26; 95% CI, 1.57-
144 associated with the risk of renal outcomes (doubling of plasma creatinine concentration and/or progr
146 yer counting uncertainty, our record shows a doubling of precipitation since 1840 CE, with recent va
147 (NICU); new onset of hypertension; new onset/doubling of proteinuria; CKD stage shift; "general" comb
149 reproductive rate of bacteria doubles with a doubling of rrn copy number, and the efficiency of carbo
151 nce interval [CI]: 0.66 to 0.89; p < 0.001), doubling of serum creatinine (HR: 0.62; 95% CI: 0.40 to
152 rovascular events (n = 53), graft failure or doubling of serum creatinine (n = 140), noncardiovascula
153 surrogate outcome (change in proteinuria or doubling of serum creatinine [DSCR]) for ESRD during a >
154 d no benefit of aliskiren on renal outcomes (doubling of serum creatinine and end-stage renal disease
155 PI also had a significantly elevated risk of doubling of serum creatinine level (HR, 1.53; 95% CI, 1.
157 other surrogates, including acute rejection, doubling of serum creatinine level, and eGFR at year 1 o
158 ; need for the neonatal intensive care unit; doubling of serum creatinine or increase in CKD stage.
159 tion in 1301 donors (111 had AKI, defined as doubling of serum creatinine) and ascertained outcomes i
160 14.8%, and 1.7% for >/=30% decline in eGFR, doubling of serum creatinine, AKI, and kidney failure, r
161 with lower risks of >/=30% decline in eGFR, doubling of serum creatinine, and AKI; however, apixaban
162 outcome-and end-stage renal disease [ESRD], doubling of serum creatinine, and all-cause mortality-si
163 tcome of ALTITUDE was defined as a sustained doubling of serum creatinine, end-stage renal disease, o
164 f the nephrotic syndrome; and a composite of doubling of serum creatinine, ESRD, or death between 100
166 There were 503 incident HF events, and each doubling of serum erythropoietin was associated with a 2
167 ly limited tumor progression, resulting in a doubling of survival in the p48-Cre;LSL-Kras(G12D);Trp53
169 ngth in infant males only; among males, each doubling of tAs was associated with a 0.28-cm increase (
171 girls born of overweight/obese mothers, each doubling of tAs was associated with a 62.9-g decrease (9
173 flow [milliliters per minute per 100 ml] per doubling of the albumin-to-creatinine ratio, -0.31; 95%
174 isease have evolved in recent decades with a doubling of the average patient age and an increased pre
175 or obesity, the past few decades have seen a doubling of the diabetes mellitus incidence with an incr
176 local field size on age at diagnosis, with a doubling of the expected field diameter between ages at
177 of the water column, resulting in an overall doubling of the fallout background from atmospheric nucl
180 ce a significant decrease in lifespan, and a doubling of the incidence of premature coronary artery d
181 single to double valency, consistent with a doubling of the molecular brightness of mCherry-tagged b
182 n duplication of whisker representations and doubling of the number of barrels without changes in the
183 n the left ventricle, but there is an almost doubling of the number of discs with a surface area of <
187 ese subjects, high levels of pro-NT denote a doubling of the risk of developing obesity later in life
190 estimated glomerular filtration rate (eGFR), doubling of the serum creatinine level, acute kidney inj
191 nset persistent macroalbuminuria, persistent doubling of the serum creatinine level, end-stage renal
192 ephropathy (progression to macroalbuminuria, doubling of the serum creatinine level, initiation of re
193 se in 15-F2t-IsoP (95% CI: 3.2, 14.7), and a doubling of toenail As was associated with a 1.7% increa
194 However, in contrast with expectations, a doubling of toenail As was associated with a 2.3% decrea
195 te-adjusted estimates of associations with a doubling of urinary As suggested an 8.8% increase in 15-
196 study (192 participants, 231 controls), each doubling of urine PIIINP associated with 22% higher odds
197 ings are important because they suggest that doubling or tripling the only globally enforced marine r
203 ed lower colony-forming capacity, population-doubling rate, cell proliferation, multipotency, in vivo
204 played stem-like features with a slower cell doubling rate, increased sphere formation capability, an
205 sence, which was associated with a more than doubling risk of MACE (hazard ratio [HR]: 2.22; 95% conf
207 atest achievements in the field of frequency doubling (SHG) and tripling (third-harmonic generation,
208 ction of four complementary views in 250 ms, doubling speed and improving information content relativ
209 ed a longer window of antibiotic protection, doubling survival rates from 40% with free tobramycin to
210 logMAR visual acuity measurement, Frequency Doubling Technology (FDT) visual field testing, autorefr
211 anterior chamber depth assessment, frequency-doubling technology perimetry (FDT, C-20-5), confocal sc
213 multiple, cyclical episodes of whole-genome doubling that were followed by myriad fractionation proc
215 hat exponentially replicates a seed pattern, doubling the copies in each diurnal-like cycle of temper
216 ughput DNA methylation analysis, effectively doubling the coverage compared to the older 450 K array.
217 agulation activity by nearly a half, whereas doubling the dose of argatroban from its IC50 would decr
219 of forest fire area during 1984-2015, nearly doubling the forest fire area expected in its absence.
220 containing lysine are labeled with two tags, doubling the imparted mass defect to up to 90.6 mDa for
222 residence time of under 10 min, effectively doubling the molecular weight of an oligomeric species i
223 -specific differences in translation, almost doubling the number of differentially expressed genes.
224 teracted the decrease of fertilization rate, doubling the number of fertilized oocytes compared with
226 assified into 2737 homologous superfamilies, doubling the number of predicted protein domains in the
227 in 569 humans across four continents, nearly doubling the number of previously established viral epit
228 million unique protein sequences, more than doubling the number of protein sequences since our last
230 both CD4(+) and CD8(+)) in adult and old RM, doubling the numbers of these cells in circulation and m
231 er day; the dose level was then escalated by doubling the previous dose if there were no adverse even
233 rted number of subscribers and approximately doubling the transmission distance compared to the recen
234 gen [PSA] failure, PSA nadir >0.5 ng/mL, PSA doubling time <9 months, and interval to PSA failure <30
235 dynamically on the basis of two factors: PSA doubling time (</= 3 v > 3 months) and nodal versus non-
236 gnificant association could be found for PSA doubling time (82.7%, 96.2%, and 90.7% in >6, 4-6, and <
238 s pT58 levels, leading to an increase in the doubling time and impairment of cell cycle progression.
239 s individual-level dynamics-including a long doubling time and low probability of immune recovery-tha
243 for in vitro growth correlated directly with doubling time in blood, in the case of B-CLL with Ig H c
245 t, with a lower-dose inoculum, the bacterial doubling time increased to 56 min and the S. pneumoniae
247 aHR], 1.72; 95% CI, 1.17-2.52; P = .01), PSA doubling time less than 9 months (aHR, 2.06; 95% CI, 1.2
250 from which biosulfur showed fastest growth (doubling time of 1.9 days), followed by colloidal, chemi
253 as characterised by fast exponential growth (doubling time of 5-7 days) and fast spatial expansion (4
254 d a maximum growth rate of 0.078 h(-1) and a doubling time of 9 h, and the DeltaG of the reaction ran
258 study was a prostate-specific antigen (PSA) doubling time of less than 12 mo after initial treatment
259 ffered for a prostate-specific antigen (PSA) doubling time of less than 3 years, Gleason score progre
261 st, including an approximately 12 h delay in doubling time on exposure to 25 mg/L CdTe QD ( approxima
263 tic disease (rapid prostate-specific antigen doubling time or velocity) but otherwise is not suggeste
264 wth from glucose is feasible up to a minimum doubling time that is proportional to the OxPhos burden
268 ation of simulated aggressive (2-month tumor doubling time) and nonaggressive (18-month tumor doublin
269 ling time) and nonaggressive (18-month tumor doubling time) tumors as early as 7.2 months and 8.9 yea
270 on the DNA copy number, gene location, cell doubling time, and the rates of transcription and degrad
272 g exponential growth with a decreased volume doubling time, or 2) Gompertz-repopulation using the gra
278 th slow rates of disease progression (median doubling time: 84 days, 95% uncertainty range 62-104) an
279 emi-automatically measured volume and volume-doubling time; that national quality assurance boards sh
280 ind excellent agreement between the observed doubling-time distribution and the predicted universal d
283 Additionally, we provide measurements of doubling times and in-vivo metabolic fluxes through the
284 GF-C expression and COX2 expression, shorter doubling times and reduced expression of angiopoietin 2
286 st recent literature on volumetry and volume doubling times in lung nodule management, outlining thei
288 tic growth coalescent models reveal epidemic doubling times of 0.86 and 1.12 years for the US and Car
290 y colloidal, chemical and sublimated sulfur (doubling times of 2.2, 2.5, and 3.6 days, respectively).
292 earance half-lives and bacterial replication doubling times were estimated using a mathematical model
293 onin and carcinoembryonic antigen (and their doubling times), in addition to comprehensive imaging to
294 bor null mutations in MELK exhibit wild-type doubling times, cytokinesis, and anchorage-independent g
296 tcomes included the time from CA-125 markers doubling to retreatment among women who experienced a ri
297 hibiting uterine contractions ex-vivo, while doubling uterine drug concentration, decreasing fetal le
298 ope of the line on a plot of cell population doublings versus time, as an alternative, time-independe
299 of massive DNA loss followed by whole-genome doubling (WGD), which was associated with aggressive cli
300 em climate sensitivity is K (1sigma) per CO2 doubling, which is notably higher than fast-feedback est
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