ライフサイエンスコーパス: down-regulate

1 cytokine/tyrosine-kinase (TK) receptors were down regulated.

2 mitochondrial function, were inversely found down-regulated.

3 PI5, while virulence genes were dramatically down-regulated.

4 as up-regulated, whereas pyruvate kinase was down-regulated.

5 ed collaterals including miRNA-352 which was down-regulated.

6 ivision and development were most frequently down-regulated.

7 els of IRF5 mRNA and protein expression were down-regulated.

8 nase phosphatase-1 messenger RNA levels were down-regulated.

9 ells in which the isoforms were specifically down-regulated.

10 six mitochondrion-related nuclear genes was down-regulated.

11 roteins a V-ATPase and a 14-3-3 protein were down-regulated.

12 epithelial markers, such as E-cadherin, are down-regulated.

13 Adenomatosis polyposis coli down-regulated 1 (APCDD1) has recently been identified a

14 CNL13 is Sr13CNL13 transcripts were slightly down-regulated 2-6 days after Pgt inoculation and were n

15 r beta and insulin receptor substrate 1 were down-regulated 2-fold by Kcne2 deletion, characteristic

16 al precursor cell-expressed, developmentally down-regulated 8 (NEDD8) moieties from cullins (thus ter

17 s to evolve and become resistant to drugs by down-regulating accurate DNA repair.

18 and investigated whether inhibitory signals down-regulate adaptive immune responses in patients with

19 However, the mechanisms by which p63 is down-regulated after acute OE injury remain unknown.

20 Rho-associated protein kinase 2 (ROCK2) was down-regulated after EM2 treatment.

21 a-5p is highly expressed in VSMCs, but it is down-regulated after vascular injury in vivo.

22 VSG while genes in inflammatory pathways are down-regulated after VSG.

23 Lyn has been shown to down-regulate allergen-induced airway inflammation.

24 atocyte nuclear factor-4alpha, that is early down-regulated and induces a transcriptional repression

25 demonstrations that miR-140-5p is frequently down-regulated and inversely correlated with Pin1 overex

26 iation genes (KRT1, KRT10, DSC1, DSG1) being down-regulated and late differentiation genes (SPRR2, SP

27 ntaining the mitotic cell cycle were rapidly down-regulated and senescence genes were strongly up-reg

28 ce the canonical miRNA biogenesis pathway is down-regulated and specific miRNAs are generated by an a

29 nal category of 'photosynthesis' as the most down-regulated and the category of 'cell wall/membrane b

30 of the light-harvesting antenna were greatly down-regulated and the phycobilisome composition was alt

31 ixty-two and 219 proteins were significantly down-regulated and up-regulated in insulinomas, respecti

32 In diabetes, IRS-1 is down-regulated, and cells become resistant to insulin.

33 n mom1-3 ovules, both SUF4 and EC1 genes are down-regulated, and EC1 genes show higher levels of hist

34 ull-length winter Hvvrn1 allele was strongly down-regulated, and flowering was delayed by high temper

35 ch is mainly stabilized by Cx43 in vivo, was down-regulated, and its characteristic staining remained

36 n KCNE3 partners KCNC4 and KCNH2 (mERG) were down-regulated, and KCNK4 (TRAAK) was up-regulated (P <

37 re: 99% of them during early maturation were down-regulated, and preferentially associated with DNA r

38 umulated, W1-COE and its paralog W2-COE were down-regulated, and the phenotype was nonglaucous and be

39 corresponding to how quickly a gene is up or down regulated as well as where in the trajectory such r

40 es in the CHH context were transcriptionally down-regulated as seeds mature: 99% of them during early

41 regulation of axon extension processes were down-regulated at 3 h.

42 tor expressions studied in mouse aortas were down-regulated at 6 and 18 hours in endotoxemic mice and

43 In total, AHO treatment led to 17 up- and 6 down-regulated at least 2 folds (Wald test, P < 0.05) mi

44 ARID5B expression is down-regulated at the double-negative 2-4 stages in norm

45 osomes to up-regulate anabolic processes and down-regulate autophagy.

46 ia loss in mitochondrial membrane potential, down-regulated autophagy, and inhibited hepatocyte cell

47 re differentially expressed (up-regulated or down-regulated) between GAgP and H.

48 od after DNA damage where it would otherwise down-regulate BMI1, impairing DNA repair.

49 Elevated miR-15a and miR-16 levels down-regulated BMI1 and other polycomb group proteins li

50 We found that HNK treatment effectively down-regulated both c-Met phosphorylation and Ras activa

51 TB4 suppression down-regulated both integrin linked kinase (ILK), an act

52 alpha, IL-6, IL-12, TGF-beta, and VEGF) were down regulated by DMDD.

53 y flux through pyruvate dehydrogenase), were down-regulated by beta-lapachone treatment.

54 enty four genes were up-regulated and 9 were down-regulated by both ligands.

55 d regulation of immune system processes were down-regulated by caffeine at 3 h.

56 In most Brachypodium accessions BdODDSOC2 is down-regulated by cold, and in one of the winter accessi

57 well as other copper-deficiency markers are down-regulated by copper.

58 The expression of spl was down-regulated by cytokines in INS1E cells and rat islet

59 ng extracellular proteins were most strongly down-regulated by Etv4 and Etv5 siRNAs.

60 that leaf hydraulic conductance (Kleaf) was down-regulated by exogenous ABA, with strong variations

61 amic chemical networks being up-regulated or down-regulated by external triggers is one of the challe

62 Down-regulated by HFD were genes related to neuron proje

63 An analysis of genes commonly down-regulated by IFN suggests that epigenetic regulatio

64 luronic acid-CD44 independent manner that is down-regulated by inhibitors of the JAK/STAT pathway and

65 cle-based catalyst can be reversibly up- and down-regulated by light.

66 teins, vimentin and L-plastin, were strongly down-regulated by miR-375.

67 vels of Cu/Zn superoxide dismutase (CSD) are down-regulated by miR398.

68 st executive functions can be rapidly up- or down-regulated by modulating theta phase coupling of dis

69 Importantly, SL synthesis is down-regulated by mutations in genes of the Nod LCO sign

70 xperiments revealed that vascular IGF-1R was down-regulated by platelet miR-223.

71 ed in leptin-deficient mice and, conversely, down-regulated by the anti-diabetic drug rosiglitazone.

72 Here we report that Atgl is down-regulated by the basal transcription factor Sp1 in

73 In contrast, the expression of TRIM59 was down-regulated by TLR3 and TLR4 ligands in both human an

74 Tumor-conditioned medium down-regulated C/EBPalpha expression, suggesting tumor s

75 ylose (up to +153%) release, suggesting that down-regulating CAD1 is a promising strategy for improvi

76 otho confers cardiac and renal protection by down-regulating calcium-permeable transient receptor pot

77 immunity, promoting beneficial bacteria, and down-regulating cancer-cachexia associated bacteria.

78 B cell stimulation was sufficient to down-regulate canonical autophagy transiently while trig

79 t dimerization-defective Nef mutants fail to down-regulate CD4 and validate the Nef dimerization inte

80 no toxicity of Inh2-B1, and its abilities to down-regulate cell wall hydrolase genes and disrupt the

81 how that the hormone ecdysone is required to down-regulate Chinmo/Imp and activate Syncrip, plus two

82 ulus tremula x Populus alba) by specifically down-regulating CINNAMYL ALCOHOL DEHYDROGENASE1 (CAD1) b

83 Included in the down-regulated class was the microtubule bundling protei

84 CNTFRalpha was significantly correlated with down-regulated CNTFRalpha gene expression and longer LGG

85 adapted network composed of up-regulated and down-regulated constituents.

86 ow-derived macrophages (BMDMs) significantly down-regulates Cox-2 protein expression, whereas Cox-1 l

87 ey Neur target and that Neur acts via Sdt to down-regulate Crb.

88 cidualization is an important contributor to down-regulated CTB invasion in sPE.

89 stress (high, uniform laminar) specifically down-regulated DACH1, while the remodeling artery-type f

90 rphology and acquire high, laminar flow that down-regulates DACH1.

91 dult female WD offspring was associated with down-regulated DRD1 in the NAc and with up-regulated Lep

92 hase, biosynthesis, and Hym hydrogenase were down-regulated during C2H2 inhibition, consistent with t

93 The expression of bta-miR-23a was down-regulated during differentiation of PDGFRalpha(+) p

94 showed that the biomarker was significantly down-regulated during inflammation induced by acute cont

95 r 2 (HER2) and HER2/HER3 heterodimers and by down-regulating EGFR via a mechanism involving its degra

96 have further found that EnR stress response down-regulates ERalpha expression through the protein ki

97 The 300 mg/kg Geniposide also down-regulated expression of Farnesoid X receptor (FXR),

98 e to attenuate BLM-induced-fibrosis in mice, down regulate extracellular matrix genes expression, and

99 Additionally, activity in the network was down-regulated for acceptability, but not blame, judgmen

100 000117266, whose expression was dramatically down-regulated from P1 to P28 and was also sensitive to

101 Cigarette smoke exposure down-regulated FZD4 expression in vitro and in vivo, alo

102 nition of factors that up-regulate (GEF) and down-regulate (GAP) RAS activity.

103 yte potential, whereas Delta-like1 signaling down-regulates GATA2 and impairs myeloid development.

104 tly, we found that depletion of this protein down-regulated gene expression of several TGFbeta-respon

105 ne Ontology (GO) revealed a large cluster of down regulated genes that encode translational proteins,

106 lination conditions showed that up to 79% of down-regulated genes are shared between conditions and i

107 Most of the early down-regulated genes had mRNA half-lives longer than 2 h

108 his study identified 72 up-regulated and 183 down-regulated genes in FVB/N Cd151 (-/-) compared to Cd

109 0, 78, and 72 up-regulated and 17, 13, and 6 down-regulated genes in P. xylostella after destruxin A

110 revealed hundreds of simultaneously up- and down-regulated genes that are involved in endometrial re

111 nd an enrichment of RALY mRNA targets in the down-regulated genes upon RALY silencing.

112 , we observed that putative causal genes and down-regulated genes were affected by a loss of genetic

113 A total of 519 down-regulated genes were associated with diminished DHS

114 al of 132 differentially up-regulated and 39 down-regulated genes were identified in the pretreated l

115 Indeed, 69% of the most significantly down-regulated genes were myelin-related.

116 increased synthesis and RNA stability while down-regulated genes were suppressed either by reduced s

117 ybridization histochemistry for two strongly down-regulated genes, myelin oligodendrocyte glycoprotei

118 umors releases the differentiation block and down-regulates genes controlling ribosome biogenesis.

119 n D reduces frequency of Th1 and Th17 cells, down-regulates genes in key signaling pathways and epige

120 r 2 expression both in vivo and in vitro and down-regulates genes involved in migration and prolifera

121 enhancing the expression of neural genes and down-regulating genes specific to alternative fates.

122 ation undergoes endocrine differentiation by down-regulating GP2 and CD142 and turning on NEUROG3, a

123 orphological changes and one week later were down-regulated gradually, while those in Modules 2 and 3

124 Soluble klotho down-regulates growth factor-driven PI3K signaling, cont

125 ted seven proteins (six up-regulated and one down-regulated) had consistent mRNA expression.

126 e major biological processes: Notch pathway, down-regulated Hedgehog/Wnt pathway, and cell cycle.

127 lation exhibit an altered expression in RALY-down-regulated HeLa cells, consequently causing impairme

128 umab was found to selectively cross-link and down regulate HER2 homodimers from the plasma membranes

129 l inactivation of Zpr1 gene in motor neurons down-regulates HoxA5 and causes defects in the function

130 CAM1 cells revealed two miRNAs significantly down-regulated (hsa-miR-30a-3p by 6.73-fold and hsa-miR-

131 Thus, the cell must precisely up- and down-regulate IFNalpha to achieve immune system homeosta

132 in approximately 2% of the human population, down-regulated IL-36R signaling by a decrease of interac

133 on of several key slit diaphragm protein was down regulated in pGR KO mice.

134 ZPR1 is down regulated in SMA patients.

135 are significantly (threefold or more) up- or down-regulated in a scmR deletion mutant (DeltascmR) Met

136 Notably, when Alk4 was down-regulated in adult wild-type mice, muscle mass decr

137 p-regulated during postnatal development and down-regulated in aging, displaying an "up-down" pattern

138 esis, including c-MYC, c-MYB, and VEGF, were down-regulated in association with a decline in hypoxic

139 (Sec14l3) - a putative target of Creb1 - was down-regulated in both asthma models and in NHBE cells u

140 qPCR indicated that the expression of FT is down-regulated in both OsbHLH068-overexpressing Arabidop

141 shoots, while a different set of genes were down-regulated in cbl1 but not in WT roots.

142 h matriptase and prostasin are significantly down-regulated in colonic tissues from human subjects wi

143 In Salix, Rubisco activase transcripts were down-regulated in contaminated trees across all 10 culti

144 he transcription factor EB (TFEB), which was down-regulated in cystinosis.

145 -214, and LHX6 expression was detected to be down-regulated in erlotinib-resistant HCC827 cells.

146 cript; miR-198 expression in healthy skin is down-regulated in favor of FSTL1 upon wounding, which en

147 The expression of miR-101 was down-regulated in fibrotic lungs from patients with IPF

148 We have shown that peach PpeS6PDH gene is down-regulated in flower buds after dormancy release, co

149 In clinical samples, miR-125b-5p was down-regulated in gallbladder cancer whereas Bcl2 was up

150 in clinical samples to identify miR-125b-5p down-regulated in gallbladder cancer.

151 ic enzyme cystathionine-gamma-lyase (CSE) is down-regulated in growth-restricted placentas.

152 he expression of P2Y6 receptors was markedly down-regulated in human GC cells and primary GC tissues

153 cular secreted frizzled-related protein 2 is down-regulated in ICU-acquired weakness patients and mic

154 BER genes NEIL3 was down-regulated in IFN-treated patients.

155 ressed in smooth muscle-enriched tissues and down-regulated in in vitro models of VSMC phenotypic mod

156 We found that miRNA-122 (miR-122) is down-regulated in liver biopsy specimens of patients wit

157 5 in HCV-induced HCC, as IRF5 expression was down-regulated in livers from HCV-positive versus HCV-ne

158 w that caveolin-1 expression is dramatically down-regulated in lung adenocarcinomas from lung cancer

159 SHP2 was down-regulated in lungs and lung fibroblasts obtained fr

160 ere also found up-regulated in SP and MD and down-regulated in LW.

161 P) assays, we found that ALOX5 is especially down-regulated in MLL-rearranged AML, via transcription

162 ear factor 4A-driven gene network, which was down-regulated in mouse hepatocyte nuclear factor 4A kno

163 rganic compounds, 26 were up-regulated and 2 down-regulated in NAFLD patients.

164 of the gibberellin biosynthesis pathway, is down-regulated in OsbZIP48(OE) and up-regulated in OsbZI

165 A fifth miRNA, mir-6722, was down-regulated in persons with AD and mild cognitive imp

166 n PGK mutants showed that PGK1 and PGK3 were down-regulated in pgk3.2 and pgk1.1, respectively.

167 ed in gametogenesis in Chlamydomonas pCRY is down-regulated in pregametes and gametes, and in the pcr

168 hermore, we show that while NEAT1 is acutely down-regulated in response to neuronal activity, repeate

169 sites were identified as up-regulated and 45 down-regulated in response to PDGF stimulation.

170 ever, phosphatase activity was most strongly down-regulated in response to phosphorus addition in spe

171 qPCR and Western blotting were significantly down-regulated in retinas of STZ-rats and in human diabe

172 or, secreted frizzled-related protein 2, was down-regulated in skeletal muscle of ICU-acquired weakne

173 Interestingly, miR-218-5p was significantly down-regulated in smokers without airflow limitation and

174 Because IRS-1 is down-regulated in states of insulin resistance that occu

175 We report that hsa-miR-31-5p (miR-31) is down-regulated in TFH; we showed that BCL6 suppresses mi

176 replicating protein SSBP1 were significantly down-regulated in TFV and ADV treated HK-2 cells compare

177 ere differentially up-regulated and 400 were down-regulated in the fast muscle compared with slow mus

178 respectively; P < 0.05); both pathways were down-regulated in the greatest-ADG compared with least-A

179 of both matriptase and prostasin are rapidly down-regulated in the initiating inflammatory phases of

180 w that Msi1 protein levels are significantly down-regulated in the kidneys following fibrosis.

181 Megalin mRNA was down-regulated in the KO embryonic spinal cord (SC) and

182 ansforming growth factor-beta1 expression is down-regulated in the Lamc3(-/-) retina, and SMAD signal

183 or (SP) and medium (MD) flours qualities and down-regulated in the low (LW) ones.

184 We found that miR-663 was down-regulated in the mtDNA-depleted Rho(0) line.

185 ian Hedgehog pathway genes are significantly down-regulated in the mutant mice.

186 beta cell transcriptional network that were down-regulated in the Nkx2.2(KO) mice, were maintained i

187 uscle, the 32 miRNAs was up-regulated and 27 down-regulated in the slow muscle.

188 "ts-53," respectively), ts-46, and ts-47 are down-regulated in these malignancies.

189 Siglec-7 was expressed on beta-cells and down-regulated in type 1 and type 2 diabetes and in infi

190 in nonpigmented melanoma cells, was severely down-regulated in vitiligo cell line PIG3V and skin biop

191 pression of synapsin genes SYN1 and SYN2 was down-regulated in vivo and in vitro by alphaSyn oligomer

192 me that NCX1 mRNA and protein expression was down-regulated in Wilms tumor and RCC.

193 nslation of mitochondrial proteins is highly down-regulated in yeast lacking RP paralogs required for

194 S-palmitoylation sites on 254 proteins were down-regulated in Zdhhc13-deficient mice, representing p

195 ntial of these properties in nanomedicine to down-regulate inflammatory pathways or to be employed as

196 Treatment with BAY 11-7082 or BBG also down-regulated iNOS, nitrotyrosine, and poly-ADP-ribosyl

197 We also found that MSA down-regulated integrin beta3 at the levels of mRNA and

198 of iron, the double mutant does not up- and down-regulate iron deficiency-induced and -repressed gen

199 f Clrn1 in hair cells during development and down regulate it postnatally.

200 TCF) to the first exon of the hTERT gene can down-regulate its expression.

201 aliana as JA hydroxylases and show that they down-regulate JA-dependent responses.

202 l lymphoma (CBL) family E3 ubiquitin ligases down-regulate JAK2 stability and signaling via the adapt

203 ed to remove ARF1 and kinesin from LDs, thus down-regulating LD transport and sER-LD contacts.

204 but in aggressive osteosarcomas, miR-874 is down-regulated, leading to elevated CCNE1 expression and

205 d -2 in the nucleus accumbens (NAc) and with down-regulated Lepr in the ventral tegmental area (VTA).

206 ive increase in cellulose content in the CSE down-regulated lines resulted in up to 62% more glucose

207 Up-regulated IL-6, IL-8, CD38, and CD69 and down-regulated macrophage-derived chemokine, human leuko

208 sociated Th2-type cytokines, IL-4 and IL-13, down-regulates matriptase as well as prostasin through p

209 p38 mitogen-activated protein kinase (MAPK), down-regulating matrix metalloproteinases, collagen, and

210 In PAH, elevated miRs (notably miR-138) down-regulate MCU directly and also by decreasing MCU's

211 or pharmacological inhibition of cathepsin B down-regulated mechanistic target of rapamycin activity

212 s of transforming growth factor-beta1, which down-regulates melanogenic enzymes such as tyrosinase to

213 -receptor protein-tyrosine phosphatases that down-regulate Met phosphorylation.

214 re generally, we found that SIRT1 inhibition down-regulates metabolic pathways, including glycolysis

215 revealed miR-132 as one of the most severely down-regulated miRNAs at the intermediate and late Braak

216 ficantly up-regulated and four significantly down-regulated miRNAs.

217 ion by up-regulating a cohort of miRNAs that down-regulates mRNAs that encode proteins critical for t

218 ar YAP enhances gemcitabine effectiveness by down-regulating multidrug transporters as well by conver

219 or the myotubularin coding gene Mtm1) that a down-regulated myostatin pathway can be reactivated by c

220 MBL) protein modulates osteoclastogenesis by down regulating NF-kappaB activation.

221 MCL reduced IL-6 secretion through down-regulating NF-kappaB activation and improved the su

222 ttempt to maintain global O-GlcNAcylation by down-regulating O-GlcNAcase expression.

223 pression of clustered genes was consistently down-regulated only in hta9/hta11, previously associated

224 ages of development to define genes that are down-regulated or up-regulated by the lec1 mutation.

225 Further, the MEK1/2 inhibitor treatment down-regulated pathogenic pro-inflammatory and helper T

226 tly inactivated RAF/ERK, upregulated BIM and down-regulated PD-L1 expression in HCC, and facilitated

227 ealthy tendon cells with 15-epi-LXA4 or MaR1 down-regulated PGE2 and PGD2 production.

228 718 modulates PI3K/Akt signaling by directly down-regulating phosphatase and tensin homolog (PTEN), t

229 inhibitory effects on VSMC migration through down-regulated phosphorylation of target proteins (HSP27

230 Cytokinin also down-regulates PIN3, promoting auxin accumulation in the

231 Further characterization of the OsGRXS17 down-regulated plants revealed an elevation in H2O2 prod

232 meliorated pathology scores in pancreas, and down-regulated production of IL-17 and IFN-gamma in CD4(

233 miR-21 down-regulated programmed cell death 4 and programmed ce

234 ied 518 twofold up-regulated and 811 twofold down-regulated proteins common to both AUY922 and ganete

235 nducted an iTRAQ proteomic screen of up- and down-regulated proteins in a murine model of RD to ident

236 m large ordered domains for endocytosis, and down-regulates raft-dependent PI3K/Akt signaling.

237 Subsequently, these programs down-regulate SCP-gene and up-regulate chromaffin cell-g

238 In SCY2 down-regulated seedlings, several thylakoid membrane pro

239 We also found that HuR down-regulates several microRNA expressions, which could

240 tional transcriptome of endothelial cells by down-regulating several genes important for invasion and

241 Results show pro-inflammatory cytokines were down-regulated significantly post antibiotic treatment i

242 sophila melanogaster Neur interacts with and down-regulates specific Sdt isoforms containing a Neur b

243 n ameliorated airway mucus hypersecretion by down-regulating STAT6 and its binding to the MUC5AC prom

244 es splicing of AR pre-mRNA to discriminately down-regulate synthesis of AR-V transcripts, including A

245 ell immunoglobulin and mucin domain 3, which down-regulates T-helper cell type 1 proinflammatory resp

246 und 7 different miRNAs (1 up-regulated and 6 down-regulated), that were differentially expressed in T

247 tro, the lipidic mediator resolvin D1 (RvD1) down regulated the M1 type in patients with ApoE epsilon

248 The hydrogel was capable of down regulating the expression level of IL-1beta in LPS

249 r of metabolic gene expression, functions to down-regulate the expression of diverse genes encoding s

250 hat both endogenous and exogenous PGC-1alpha down-regulate the expression of numerous genes encoding

251 ppears to be a good candidate to efficiently down-regulate the increased legumain activity, possibly

252 ts MSCs locally, into fistulizing tracts, to down-regulate the local immune response and induce wound

253 ain-like receptor (NLR) family, was found to down-regulate the NF-kappaB pathway and stimulator of in

254 and the intracellular C-terminus (PC1-5TMC) down-regulate the phosphorylation of protein kinase R (P

255 tivate autophagy in BV2 microglial cells and down-regulate the production of pro-inflammatory cytokin

256 n of TNF-alpha and CCL5/RANTES cytokines and down-regulated the activity of NFkappaB and IRF3 transcr

257 Nutrient deprivation further severely down-regulated the conversion of 18:3 to 18:4, resulting

258 M. bovis bacillus Calmette-Guerin infection down-regulated the expression of CIITA/MHC-II by inducin

259 up-regulated the expression of gene mcyB and down-regulated the expression of genes ftsZ, psbA1, and

260 In MRSA infection mouse model, MCL down-regulated the expression of IL-6, TNF-alpha, MCP-1/

261 Additionally, BDE47 significantly down-regulated the expression of miR-23b in rats and in

262 Mechanistically, upon CXCL12 exposure, SC down-regulated the expression of several pain-associated

263 MR-409 also significantly down-regulated the expression of vascular endothelial gr

264 In vitro, baicalein down-regulated the TLR4/MyD88 signaling cascades (NF-kap

265 By contrast, IGSF1 strongly down-regulates the activin-Smad pathway, leading to redu

266 and production of the anaphylatoxin C3a, and down-regulates the expression of the Foxp3 gene and aner

267 mia and hypoxia in the bone environment, yet down-regulates the HIF-1alpha pathway in chondrocytes, t

268 n convertase subtilisin/kexin type 9 (PCSK9) down-regulates the low-density lipoprotein (LDL) recepto

269 We report here that miR-874 down-regulates the major G1/S phase cyclin, cyclin E1 (C

270 c T-lymphocyte associated protein 4 (CTLA4), down-regulates the T-cell-mediated immune response (call

271 Here, by down-regulating the expression levels of SCS A-beta in c

272 inly inhibited gene expression, specifically down-regulating the expression of genes of the late corn

273 genesis at nutritional Se levels not only by down-regulating the expression of integrin beta3 but als

274 factor in mediating the hypoxic response by down-regulating the expression of specific genes, includ

275 Down-regulating the expression of three autophagy-relate

276 When stably down-regulated, the mechanism is associated with spreadi

277 l ablation of NRF1 in gonocytes dramatically down-regulated these germline genes, blocked germ cell p

278 t induces let-7e expression, which, in turn, down-regulates TLR4 and further diminishes TLR4-mediated

279 The down-regulated transcript set overlapped with muscle unl

280 lism and tumor development.FoxO are commonly down-regulated transcription factors and tumor suppresso

281 pounds to exhibit dual-functionality by also down-regulating transcription of the entire chromosomal

282 sed genes (DEGs), revealing 1422 up- and 999 down-regulated transcripts with at least twofold change

283 xperiments based on the ability of Klotho to down-regulate TRPC6 channel activity confirm the importa

284 re, KL1 domain binds alpha2-3-sialyllactose, down-regulates TRPC6 channels, and exerts protection aga

285 To address whether noradrenaline can down-regulate TRPV1 channel activity in nociceptors and

286 h including reduced influx of leukocytes and down regulated tumor-promoting cyto-/chemokine profile i

287 kingly and transiently up-regulated and then down-regulated upon cell stimulation, our findings indic

288 demonstrate that ACKR2 expression is further down-regulated upon cell trauma, an important trigger fo

289 In contrast, MafB is strongly down-regulated upon elevated pro-inflammatory signaling

290 a-hydroxylase Cyp7a1 expression was strongly down-regulated upon prolonged inhibition of hepatic upta

291 d Pi3K/Akt/mTor signaling pathway genes were down-regulated upon vitamin D supplementation.

292 These target mRNAs are down-regulated upon WT1 depletion in cell culture and de

293 ) and 517 proteins (231 up-regulated and 286 down-regulated) were differentially expressed in the mam

294 rritin OsFER2 and ferredoxin OsFd1 mRNAs are down-regulated whereas the transcriptional iron regulato

295 that folate biosynthetic genes were largely down-regulated, whereas a gene of a putative folate-bind

296 in CEACAM1-transfected MCF7 cells, and when down-regulated with RNAi, abrogates lumen formation.

297 s earlier than normal MT channels, and being down-regulated with the emergence of the normal channels

298 iferation and EMT of stimulated RPE cells by down-regulating Wnt (beta-catenin, LEF1) and TGF-beta (S

299 NAs directed against each of these six genes down-regulated X-inactive specific transcript (XIST), a

300 mone and acts through multiple substrates to down-regulate yeast pheromone signaling.