ライフサイエンスコーパス: downmodulate

1 in turn, the phagocytic capacity of DCs, are downmodulated.

2 -presenting capacity of leukemia B cells are downmodulated.

3 length receptor (FL-AR) is transcriptionally downmodulated.

4 e phagocytic receptor Bai1 was progressively downmodulated.

5 a cellular receptor for HHV-6, and CD3 were downmodulated.

6 the number of B cells in Peyer's patches and downmodulated adaptive immune responses to KRV, but did

7 First, expression of CD8 was downmodulated after infection.

8 center reaction, does so in part by directly downmodulating AID expression.

9 erial antigens and CpG oligodeoxynucleotides downmodulate airway allergic inflammation by mechanisms

10 notherapies that regulate TIM-1 function may downmodulate allergic inflammatory diseases.

11 However, the immunological mechanisms that downmodulate and protect against the development of thes

12 Flavopiridol downmodulates antiapoptotic proteins associated with res

13 ay serve as a platform to test strategies to downmodulate antigen and inhibit incompatible RBC cleara

14 Inhibitory receptors such as CD22 can downmodulate autoreactive BCR responses.

15 cient than its nonraft mutant counterpart at downmodulating both cell surface CD4 and class I major h

16 nt in these cells, and its expression can be downmodulated by antisense oligonucleotides (AO).

17 CXCR4 and that the chemoattraction could be downmodulated by culture ex vivo.

18 phocytes, and human T cell reactivity can be downmodulated by forced expression of Siglec-5.

19 chemokine formation of PML was specifically downmodulated by insulin via insulin receptor-mediated i

20 nt with its tumor suppressor role, miR-30 is downmodulated by oncogenic signals such as epidermal gro

21 gen-activated protein (MAP) kinase, which is downmodulated by PTEN and additive to a FAK pathway regu

22 tors, APOBEC3G and CC chemokines, the latter downmodulating CCR5 molecules.

23 n CLL cells and that administering ibrutinib downmodulates CD20 (MS4A1) expression in vivo.

24 HuM291 bound to and effectively downmodulated CD3 from chimpanzee PBMCs and stimulated s

25 substantial fraction of circulating T cells downmodulated CD3 zeta (fraction of T cells expressing C

26 red CD8(+) T cells underwent rapid turnover, downmodulated CD8 expression, and lost cytotoxic functio

27 enhance the infectivity of virus particles, downmodulate cell surface proteins, and associate with m

28 Nef can cause T-cell activation and downmodulates cell surface signaling molecules.

29 ; however, the mechanisms by which IFN-gamma downmodulates cellular responses is not well understood.

30 CD4(+) CD25(+) regulatory T cells (Tregs) downmodulate chronic inflammation by suppressing the act

31 Compared to wild-type Nef, LAT-Nef downmodulated class I MHC nearly as effectively as the w

32 H. polygyrus bakeri infection downmodulated CLEC mRNA expression in these cells.

33 elf and environmental Ags, acting in part by downmodulating costimulatory molecules on the surface of

34 te that mucosally derived SDF-1 continuously downmodulates CXCR4 on resident HIV target cells, thereb

35 N-(4-hydroxyphenyl)retinamide (4-HPR), which downmodulates cyclin D1, induced G1 arrest and apoptosis

36 relatively resistant to maturation, and can downmodulate effector T cell responses.

37 receptor expressed by activated T cells that downmodulates effector functions and limits the generati

38 SHP-2/FAK/Grb2/Sos-1/MAPK activation loop to downmodulate EGFRvIII-mediated migration and transformat

39 ytokine production, and proliferation and to downmodulate expression of the T cell receptor.

40 BCR signalling in B cells at least partly by downmodulating expression of surface IgM but not IgD BCR

41 e presence of exogenous fatty acid partially downmodulate FAS expression and increase mean cell volum

42 Nef-expressing cells downmodulated FcgammaRI, FcgammaRII, and upregulated HLA

43 Our data suggest that HIV-1 nef downmodulated FcgammaRs in myeloid cells in a manner sim

44 Importantly, CD16 cell-surface expression is downmodulated following NK cell activation and, in parti

45 ic proteins had similar stabilities but were downmodulated from the cell surface at three different r

46 gnaling and indicate a role for vitamin C in downmodulating GM-CSF signaling responses.

47 Furthermore, ICOS-Fc downmodulated hepatocyte growth factor facilitated the e

48 viral strains with differential abilities to downmodulate HLA-C.

49 at the Vpu protein of primary HIV-1 isolates downmodulate HLA-C.

50 It is widely held that HIV-1 Nef downmodulates HLA-A and -B to protect infected cells fro

51 We show that ectopic expression of LANA can downmodulate IFN-gamma-mediated activation of a subset o

52 Salmonella enterica serovar Typhimurium can downmodulate IL-8 production after invasion of intestina

53 l processes and all time points studied were downmodulated immune response signatures.

54 H2-M levels were slightly downmodulated in both CD8alpha(-) and CD8alpha(+) DCs.

55 CX3CL1 expression was downmodulated in HER2/neu tumors, yet, paradoxically, ad

56 report that the expression of DO is markedly downmodulated in human germinal center B cells.

57 hla are upregulated while spa expression is downmodulated in the pknB mutant compared to the level i

58 of CD45 is thus required for two reasons-to downmodulate inducible TCR signaling during positive sel

59 le regulatory T cells (Tregs) are thought to downmodulate inflammatory reactions.

60 t these antiinsulin receptor antibodies from downmodulating insulin receptor expression by up to 80%

61 ogression depends in part on mechanisms that downmodulate intrinsic immune surveillance.

62 nes enhanced invasion, whereas its silencing downmodulated invasion of pancreatic cell lines in a Mat

63 P physically associates with cyclin-CDK2 and downmodulates its kinase activity.

64 that enhances keratinocyte proliferation and downmodulates keratinocyte differentiation.

65 ar infections that result from S. aureus, by downmodulating key staphylococcal global regulons and st

66 infiltration by inflammatory macrophages and downmodulated LCMV-specific T-cell responses by limiting

67 Interestingly, Y487 mutants were downmodulated less efficiently than Y498 mutants, which

68 that Nedd4 family E3s, in particular Itchy, downmodulate LMP2A activity in B-cell signaling.

69 ation, thereby suggesting that Ly-6A acts to downmodulate lymphocyte responses.

70 re, a subset of the CD34hiM-CSFRhi cells had downmodulated M-CSFR (29% to 38%).

71 Ibrutinib also downmodulated Mcl1 levels in CLL cells in vivo and in co

72 During progressive growth, CTVT downmodulates MHC antigen expression.

73 onents of IFN-gamma and LPS gene profiles by downmodulating MHC class II and costimulatory molecules,

74 is thought to promote HIV immune evasion by downmodulating MHC-I and protecting infected cells from

75 TosEF, on the other hand, downmodulate motility when overexpressed by preventing t

76 On the other hand, HIV NL4.3 Vpu downmodulated NF-kappaB-dependent transcription.

77 abilities of Nef from EC and progressors to downmodulate NKG2D ligands.

78 Furthermore, CXCR4 is selectively downmodulated on intestinal lymphocytes within the setti

79 e MDM2 protein has been shown to bind to and downmodulate p53 function, and to have oncogenic capacit

80 The PBK-p53 interaction appears to downmodulate p53 transactivation function as indicated b

81 e results in failure of extracellular NAD to downmodulate p56lck kinase activity.

82 ation via an IkappaBalpha/Akt pathway and by downmodulating pathways generating oxidative stress.

83 Interleukin-10 (IL-10) downmodulates phagocytic immune responses and accentuate

84 othesized that differentiation inducers will downmodulate PKD to allow differentiation to proceed.

85 ndent NF-kappaB activation, possibly through downmodulating pre-TCR signaling in DP thymocytes.

86 levant and polarization-associated genes and downmodulating proinflammatory cytokine production.

87 These data indicate that TNFRp75 shedding downmodulates protective immune function and reduces hos

88 y RAG1/2 activity in pre-B cells was able to downmodulate RAG1/2 expression and activity, confirming

89 d function of Nef and, whereas the number of downmodulated receptors by Nef is rising, so are the exp

90 cord blood harvest may benefit from means to downmodulate ROS.

91 eated with FTY720, an immunosuppressant that downmodulates S1P receptors.

92 FasL but FasL expression declined during the downmodulated stage of infection.

93 In comparison, HIV-1 Nef efficiently downmodulated surface CD4 in all the experimental settin

94 of TRAIL-R and TCR represents a mechanism to downmodulate T cell immune responses.

95 We found that Nef efficiently downmodulates TCR-CD3 in naive and memory CD4(+) T cells

96 ic acid in cytokine-supported CD34+ cultures downmodulated telomerase activity.

97 ed by TGF-alpha and EGFR and strategies that downmodulate TGF-alpha or EGFR inhibit SCCHN cell prolif

98 suggest that tyrosyl-phosphorylated CD22 may downmodulate the activity of this complex by dephosphory

99 r CXCR4 for entry into target cells strongly downmodulate the cell surface expression of CXCR4.

100 Several retroviruses downmodulate the cell surface expression of envelope (En

101 bind the AP-1 and AP-2 clathrin adaptors to downmodulate the expression of CD4 and CD28 by recruitin

102 in HIV-infected individuals and are known to downmodulate the expression of the receptors for SIV.

103 observation that HIV-2 did not significantly downmodulate the expression of the unrelated murine leuk

104 exposure of phosphatidylserine, which could downmodulate the inflammatory response, while also promo

105 believed to exert active inhibitory gating, downmodulate the temporal width of LRD in slower ongoing

106 kinetics suggested that IL-10 may eventually downmodulate the Th1-like cytokine response to B. abortu

107 DNA-HSP65 or CpG/CFP to allergic recipients downmodulated the allergic response.

108 Moreover, ICOS-Fc downmodulated the phosphorylation of focal adhesion kina

109 Finally, VSL#3 significantly downmodulated the response of TLR2-, TLR3-, TLR4-, and T

110 oncise review, we detail how PDE4 inhibition downmodulates the B-cell receptor (BCR)-related kinases

111 We show that D-Mtb downmodulates the gene Rv3875 encoding for ESAT-6, which

112 gest that a selective activation of mGluR1/5 downmodulates the NMDA receptor channel in a membrane-de

113 ases and show that, by targeting JAKs, PTPRG downmodulates the rapid activation of integrin affinity

114 the CD3-zeta subunit of the CD3 complex and downmodulates the T-cell receptor (TCR)-CD3 complex.

115 zation of metastatic breast cancer cells and downmodulating the cytotoxic response of microglia.

116 ypothesis that IL-10 plays a central role in downmodulating the Th1 response after L. amazonensis inf

117 a set of genes whose expression is precisely downmodulated upon culture of splenic transitional B cel

118 t, upon serum deprivation, cyclin D1 mRNA is downmodulated without any decline in its rate of transcr