ライフサイエンスコーパス: downmodulation

1 deletions of amino acids necessary for MHC-I downmodulation.

2 cleavage and ubiquitinylation, mediated P-gp downmodulation.

3 , and was not the result of impaired TCR/CD3 downmodulation.

4 ious virus but largely refractory to TCR-CD3 downmodulation.

5 tion and with the extent of cell surface TCR downmodulation.

6 ected bystander cells, thereby inducing CD83 downmodulation.

7 veal a new cellular pattern of APC/C subunit downmodulation.

8 depends on both MAPK activation and miR-23b downmodulation.

9 primary isolates of HIV-1 can mediate HLA-C downmodulation.

10 MMP25) as a proteinase responsible for CD16 downmodulation.

11 have been determined to be critical for CD4 downmodulation.

12 to loss of NK1.1 expression and partial CD4 downmodulation.

13 cell-surface expression correlates with CD16 downmodulation.

14 IgM internalization was correlated with CD19 downmodulation.

15 CR3 ligand upregulation together with CXCL12 downmodulation act as exit signals driving effector NK c

16 but was only about 60% as effective for CD4 downmodulation and 30% as effective for infectivity enha

17 escued CD4+ T cells from CD4XL-induced Bcl-2 downmodulation and apoptosis induction.

18 ion through inhibition of signaling/receptor downmodulation and Fc-driven effector interactions.

19 In contrast, CD4 downmodulation and infectivity enhancement may require a

20 deficiency in Sema7A leads to defective TCR downmodulation and T cell hyperresponsiveness.

21 ell development and new EPOR responses, EPOR downmodulation and trafficking, and novel erythropoiesis

22 d ligand internalization, defective receptor downmodulation, and enhanced growth signaling.

23 The mechanism of this downmodulation appears to be distinct from Vpu-mediated

24 appears to be distinct from Vpu-mediated CD4 downmodulation because Vpu-expressing cells that failed

25 ) T cells are largely refractory to receptor downmodulation but are main producers of infectious HIV-

26 The mechanism of MHC-I downmodulation by Nef has not been clearly elucidated, a

27 action, our results suggest that class I MHC downmodulation by Nef may be performed exclusively by ra

28 r data demonstrate that ligation induces TCR downmodulation by preventing recycling rather than induc

29 ow that, whereas CTLA-4 is required for CD80 downmodulation, CD28-CD80 interactions are critical for

30 layed receptor-induced T cell receptor (TCR) downmodulation, enhanced TCR signaling, and increased pr

31 igen induces early T-cell activation and TCR downmodulation, followed by an intermediate stage of ane

32 Ligand expression is tightly regulated, with downmodulation following DETC activation.

33 TCR downmodulation following ligation by MHC:peptide complex

34 proteins promoted virus release and tetherin downmodulation from the cell surface, and in the context

35 differing in their T cell receptor (TCR)-CD3 downmodulation function in HIV-infected human lymphoid a

36 ir target cells and suggest that the TCR-CD3 downmodulation function of Nef may promote a selective p

37 IgM and IgD receptor downmodulation, HS1 and ERK activation, chemokine secret

38 the specific requirements for CD4 and HLA-A2 downmodulation in a SupT1 T-cell line.

39 ously reported to inhibit Nef-mediated MHC-I downmodulation in astrocytic cells, did not directly aff

40 importantly, fail to undergo the spontaneous downmodulation in disease normally observed during late

41 from wild-type mice exhibited MCP-1-induced downmodulation in MCP-1 binding and a recovery of bindin

42 the absence of colitis, suggesting that the downmodulation in proinflammatory cytokine secretion was

43 , a previously unrecognized regulator of TCR downmodulation in TH2 cells, contributes to asthma patho

44 from the AP-1 interaction required for MHC-I downmodulation in that it was mediated through the dileu

45 activated lymphoblasts was associated with a downmodulation in viral burden in vivo.

46 ancer cells enhances metastasis, whereas its downmodulation inhibits metastasis in mouse models, and

47 Furthermore, TCR downmodulation is mediated by the intracellular retentio

48 h collectively trigger the dynamin-dependent downmodulation, lysosomal sequestration and degradation

49 ensive chemotherapy, and the degree of Bcl-2 downmodulation may correlate with response to therapy.

50 The differential timing of CD4 and HLA-A2 downmodulation may have implications for HIV pathogenesi

51 These data suggest that HLA-A2 downmodulation may require certain threshold levels of a

52 of the major miRNAs identified, by inducing downmodulation of 5 increased miRNAs and up-modulation o

53 reased but also prolonged in duration due to downmodulation of a phosphatase-mediated MET-negative fe

54 YXXL motifs within the BLV CTM contribute to downmodulation of a protein containing this domain.

55 s from cytotoxic T-lymphocyte recognition by downmodulation of a subset of MHC-I (HLA-A and -B).

56 Consistent with these results, downmodulation of ABCG2 or ABCC2 resulted in the inabili

57 Furthermore, downmodulation of AFAP-110 resulted in decreased cell-ma

58 Importantly, downmodulation of autophagy genes (ATG5 or ATG10) rescue

59 sting that Par-4-mediated apoptosis requires downmodulation of Bcl-2 levels.

60 member of the Bcl-2 family and reversed the downmodulation of Bcl-2 protein.

61 growth inhibition, increases apoptosis and a downmodulation of Bcl-xL expression in head and neck tum

62 Evidence was obtained indicating that downmodulation of Bim by IL-4 occurred in a posttranscri

63 e AP-1 as a cellular cofactor for Nef in the downmodulation of both CD28 and CD8beta.

64 with hnRNP A1 shuttling activity resulted in downmodulation of C/EBPalpha, the major regulator of gra

65 ficant upregulation of CC chemokines and the downmodulation of CCR5 expression in CD4(+) T cells, as

66 Monocyte migration was accompanied by downmodulation of CD14 expression and by the phosphoryla

67 Downmodulation of CD4 and TCR-CD3 is highly effective in

68 V-1) Vpr protein may also play a role in the downmodulation of CD4 from the surfaces of infected cell

69 66 on activated CD4 T cells, contributing to downmodulation of CD4 T-cell activation, proliferation,

70 was, in part, responsible for IL-21-mediated downmodulation of CD4(+) T-cell proliferation induced by

71 Downmodulation of CD4, but not counteraction of tetherin

72 Infection of mDCs with HSV-1 results in downmodulation of CD83, resulting in reduced T cell stim

73 Both downmodulation of CD84 expression and its immune-mediate

74 and does not interfere with CTLA-4-mediated downmodulation of CD86 expression on APCs.

75 Half-maximal downmodulation of cell surface CD4 required very little

76 Productive infection was associated with downmodulation of cell surface CD83, CD1a, CD80, CD86, I

77 ell death is nonapoptotic and is preceded by downmodulation of cell surface molecules involved in sig

78 Furthermore, we noted strong downmodulation of CXCR4 on CLL B cells that migrated int

79 Downmodulation of CXCR4 was abolished by mutations that

80 We propose that downmodulation of cyclin D1 is a novel and effective the

81 ated to the inhibition of PXR activation and downmodulation of cyp3a11 and mdr-1 genes and proteins.

82 regulation of toll-like receptor signaling, downmodulation of cytokine responses, and termination of

83 d following exposure to VPA, consistent with downmodulation of cytotoxic gene expression of granzyme

84 We hypothesized that downmodulation of death receptors (DRs) in addition to a

85 nocytes, but not dermal fibroblasts, through downmodulation of EGF receptor (EGFR) signaling.

86 strategies, we examined the hypothesis that downmodulation of EGFR would reduce the proliferation of

87 sion of antigen-presenting cell function and downmodulation of filarial antigen-specific T cell respo

88 In contrast, 50% downmodulation of HLA-A2 by Nef required 16 to 24 h and

89 Here, we directly compared downmodulation of HLA-A2 in HIV-infected HeLa cells to t

90 Nef protein resulted in a much more dramatic downmodulation of HLA-A2 in T cells than in HeLa cells.

91 Now we report that HIV-1-mediated downmodulation of HLA-C was associated with reduced bind

92 limited effects if the therapeutic goal is a downmodulation of immune responses (e.g. autoimmunity).

93 diated cellular transformation also involves downmodulation of important molecules such as Gadd153 th

94 re, this RNA decoy can inhibit MA20-mediated downmodulation of insulin receptor expression on human l

95 in these studies that may be related to the downmodulation of interleukin-12 receptor expression by

96 Furthermore, downmodulation of IRF-3 levels altered the expression pr

97 Downmodulation of kit expression was detected in normal

98 reatment with FTY720, an agonist that causes downmodulation of lymphocyte S1P1, CCR7-deficient T cell

99 ) from cytotoxic T lymphocytes (CTL) through downmodulation of major histocompatibility complex class

100 Downmodulation of MDM2 increased APE1 level, suggesting

101 vading CD8(+) T cell-mediated elimination by downmodulation of MHC I levels-a mechanism that may be e

102 data provide an explanation for differential downmodulation of MHC-I allotypes by Nef.

103 Downmodulation of Mtbp in osteosarcoma cells derived fro

104 Thus, downmodulation of NF-kappa B/Rel reduces c-Myc expressio

105 KIM-1 with p85 and subsequent PI3K-dependent downmodulation of NF-kappaB.

106 We demonstrate that downmodulation of P-gp expression and function coincided

107 The development of apoptosis resistance and downmodulation of p27(kip1) may contribute to the increa

108 Downmodulation of p53 in response to antigen stimulation

109 ents induced differentiation and triggered a downmodulation of PKD levels, autophosphorylation at ser

110 hibited S1P1 chemotactic function and led to downmodulation of S1P1.

111 A significant reduction in the HIV-induced downmodulation of surface CD4 was observed in viruses la

112 Thus, downmodulation of Syk expression and phosphorylation in

113 As a consequence, Nef-mediated downmodulation of TCR-CD3, which distinguishes most prim

114 ects of RA in SCCHN patients may be due to a downmodulation of TGF-alpha and EGFR mRNA production.

115 ulatory effect of FimW is most likely due to downmodulation of the active FimZ protein.

116 Because pharmacological downmodulation of the AP emerges as a broad-spectrum tre

117 Vpr does not play a role in the HIV-induced downmodulation of the CD4 receptor.

118 ultiple myeloma microenvironment, with rapid downmodulation of the chemokine receptor CXCR3 on NK cel

119 hat IL-7 exerts a synergistic effect through downmodulation of the ectoenzyme CD39, which converts AT

120 Downmodulation of the ERK1/2 and NF-kappa B pathways inh

121 The decrease in antigen presentation and the downmodulation of the immunoproteasome subunits in JAWS

122 ing a Y. enterocolitica infection may be the downmodulation of the inflammatory response.

123 ers from previously described mechanisms for downmodulation of the Jak-STAT pathway.

124 lishment of persistent infection resulted in downmodulation of the level of plasma viremia following

125 s type 1 (HIV-1) infection is established by downmodulation of the principal virus receptor, CD4.

126 s expressed NKG2D ligands, which resulted in downmodulation of the receptor.

127 Downmodulation of TNC by shRNA lentiviruses significantl

128 erative responses of CD4(+) T cells required downmodulation of tumor suppressor p53.

129 silencing by siRNA rescued the Ang2-mediated downmodulation of VEGF, suggesting an essential role for

130 onoclonal antibody specific for ROR1 induced downmodulation of vimentin and inhibited cancer cell mig

131 en if cytokine treatments on their own exert downmodulation of VLA4 function, the target progenitor c

132 4 expression; however, the effect of the CD4 downmodulation on DC-mediated HIV-1 transmission has not

133 Downmodulation or loss-of-function mutations of the gene

134 Genetic downmodulation or pharmacologic inhibition of TAK1 activ

135 Moreover, although surface GABA(A)R downmodulation plays a key role in pathological disinhib

136 CD244 downmodulation required simultaneous signaling via both

137 internalization rather than ligation-induced downmodulation serves as the force that drives serial li

138 ay of biological processes, such as receptor downmodulation, signal transduction, protein processing

139 ost cells, among cells with the greatest TCR downmodulation, some produce only IFN-gamma and not IL-2

140 ies insufficient to promote significant cTCR downmodulation, suggesting a role for functional exhaust

141 did not induce beta-chemokines or cause CCR5 downmodulation, suggesting direct blocking of envelope b

142 C:peptide complexes, despite significant TCR downmodulation, suggesting that constitutive internaliza

143 ntal autoimmune encephalomyelitis during TCR downmodulation, Tg mice are protected from disease.

144 cells producing only IFN-gamma show less TCR downmodulation than cells producing both cytokines, cons

145 ll depletion completely reverses this immune downmodulation to an immune upregulation that leads to f

146 cTCR downmodulation to densities below this critical minimum

147 However, CD3 downmodulation was restricted to infected cells, while t

148 n kinetics of epitope expression and class I downmodulation were compared.

149 lization were involved in FcgammaRIIIA/CD16A downmodulation when the latter was engaged.