ライフサイエンスコーパス: downregulate the expression of

1 ) is widely used in various plant species to downregulate the expression of a target plant gene.

2 Furthermore, ET-1 significantly downregulated the expression of a key microRNA, microRNA

3 well as the amount of DNA damage markers and downregulates the expression of a cancer-stemness marker

4 ASK1/p38 downregulates the expression of a Fas via NF-kappaB/SP1

5 ion of inhibitory receptor (ILT2/LILRB1) and downregulated the expression of activating receptors NKp

6 ntal cytotrophoblasts that invade the uterus downregulate the expression of adhesion receptors that a

7 Genistein and TSA significantly downregulated the expression of all MCM genes.

8 zinc fingers affect the ability of Su(s) to downregulate the expression of an insertion mutant allel

9 mpared to Nos and DTX alone respectively and downregulated the expression of anti-apoptotic factors a

10 Mutation of gacA/gacS downregulated the expression of approximately 17% of chr

11 Rearing in cyclic light at 400-lux downregulates the expression of ATPase-6, CO-III, and ND

12 PS-341 downregulated the expression of Bcl-2 and Bcl-xl in prot

13 In addition, DETANONOate downregulated the expression of Bcl-2 related gene (Bcl-

14 Antisense oligonucleotides targeted to bcl-x downregulated the expression of Bcl-x, and increased the

15 llular degradation of IkappaBalpha proteins, downregulates the expression of bcl-xl.

16 We demonstrate that K1 downregulates the expression of BCR complexes on the sur

17 Lexiscan also potently downregulated the expression of BCRP1, an efflux transpo

18 Downregulating the expression of beta4GalT5 by injection

19 d anti-estrogens (tamoxifen and ICI 164,384) downregulated the expression of both RARalpha and CRABPI

20 h BRCA1 expression and that HMGA1 is able to downregulate the expression of BRCA1 gene by binding dir

21 sites of Smad3 also increases its ability to downregulate the expression of c-myc.

22 inhibitor of the beta-catenin/TCF4 complex, downregulated the expression of c-myc.

23 Although AML1-ETO downregulates the expression of C/EBPalpha, changes in C

24 ontrast to CBL, BCR/ABL was found to rapidly downregulate the expression of CBL-B protein.

25 proportion of CMV-specific CD4+ T cells had downregulated the expression of CD28, a costimulatory mo

26 ow that both oncogenic proteins specifically downregulate the expression of CD48, a ligand of the nat

27 Mechanistically, TLX1 directly downregulates the expression of CHEK1 (encoding CHK1 che

28 ingly, HCV infection of Huh-7 hepatoma cells downregulated the expression of CLDN1 and occludin, prev

29 ts or inflammatory mediators, endocytosis is downregulated, the expression of co-stimulatory molecule

30 ed coordinated splicing changes predicted to downregulate the expression of core components of U1 and

31 -1) and renal epithelial cells, CNI markedly downregulated the expression of CXCR3-B, whereas express

32 arrested cells in G1 phase and significantly downregulated the expression of cyclin D2, cyclin D3, cd

33 ful effect of beta-carotene in A549 cells by downregulating the expression of CYP1A1/1A2, at least in

34 -4A2 and -4A3 reduced 20-HETE synthesis and downregulated the expression of CYP4A isoforms in renal

35 ell surface expression of langerin on LC but downregulated the expression of DC-SIGN on iDDC, as we p

36 s, mature osteoblasts surrounding the injury downregulate the expression of differentiation markers,

37 adipogenesis both in vivo and in vitro, and downregulates the expression of early markers of adipocy

38 onist for stretch-activated cation channels, downregulates the expression of ECE1 and a conduction ce

39 ced to express R-cadherin, they dramatically downregulate the expression of endogenous E- and P-cadhe

40 ore, inhibition of RA synthesis in the flank downregulates the expression of endogenous Hoxb-8 and re

41 t is both oxidized and glycosylated potently downregulates the expression of endothelial nitric oxide

42 We found that Drosophila miR-263a downregulates the expression of epithelial sodium channe

43 that miR-27a promoted ERK phosphorylation by downregulating the expression of ERK inhibitor sprouty2

44 ypothesized that this insert may function to downregulate the expression of F protein by interfering

45 veral viruses encode microRNAs that directly downregulate the expression of factors of the innate imm

46 TGF-beta1 also downregulated the expression of Fas on Lin- BM cells.

47 anslocated by the T3SS, whereas the bacteria downregulate the expression of FliC to evade innate immu

48 Furthermore, FGF alone could downregulate the expression of four Fzd Wnt receptor gen

49 Inactivation of gadE markedly downregulated the expression of gadA, gadB, and gadC and

50 increased DNA methyltransferase activity to downregulate the expression of genes like the IFN-gamma

51 t genes, with maximal induction at 5muM; and downregulate the expression of genes related to the infl

52 nd to upregulate p21(Cip-Waf1), whereas they downregulated the expression of genes for cell-cycle reg

53 e receptor (TLR)-4 pathway transcriptionally downregulates the expression of GRK2 and GRK5 in respons

54 Our previous research showed that PRRSV downregulates the expression of heme oxygenase-1 (HO-1),

55 including the Skp1-like protein SKR-5, while downregulating the expression of HSP16-type chaperones.

56 and levels of the MtsA protein but does not downregulate the expression of htsA and ftsB.

57 Human cytomegalovirus downregulates the expression of human class I major hist

58 of HIF1alpha with p300/CBP coactivators and downregulates the expression of hypoxia-inducible genes.

59 Furthermore, PGE2 downregulated the expression of IL-2 receptor alpha (CD2

60 as now been investigated through genetically downregulating the expression of individual genes or sil

61 ATF3), a stress-inducible proapoptotic gene, downregulates the expression of IRS2 in beta-cells.

62 o protect against L1 retroposition, the cell downregulates the expression of L1 proteins by various m

63 te that GA disrupts latent KSHV infection by downregulating the expression of latency-associated nucl

64 versely, hyperinsulinemic culture conditions downregulated the expression of lipin 1beta, PGC-1alpha,

65 with the transactivation function of EBNA2, downregulates the expression of LMP1 and LMP2a, and inhi

66 vating FGF receptor mutations in osteoblasts downregulated the expression of many genes reported as t

67 CS outcompetes NFkappaB nuclear import, thus downregulating the expression of many genes controlled b

68 Moreover, in addition to downregulating the expression of matrix metalloproteinas

69 Blockade of FGF signaling downregulates the expression of members of the RAR signa

70 e identify a novel mechanism used by KSHV to downregulate the expressions of MHC-II genes.

71 Genetic silencing of HER3 but not HER2 downregulated the expression of MICA/B, and HER3 overexp

72 We demonstrate that sleep deprivation downregulates the expression of microRNA (miR)-19b, a ne

73 treatment upregulated miR-200 expression and downregulated the expression of miR-21, and the downregu

74 and deacetylating H3K9 at these sites, SIRT6 downregulates the expression of mitogen-activated protei

75 QD) complexed with MMP-9-siRNA (nanoplex) in downregulating the expression of MMP-9 gene in brain mic

76 jection with specific small interference RNA downregulates the expression of mRNA for PTPN13 and bloc

77 scriptional regulatory protein that normally downregulates the expression of mtrCDE.

78 dition to MtrR, another repressor (MpeR) can downregulate the expression of mtrF.

79 Escherichia coli sRNAs, OmrA and OmrB, that downregulate the expression of multiple targets, most of

80 onstrate that stimulation with trophic forms downregulated the expression of multiple genes normally

81 ne the strength of glutamatergic synapses by downregulating the expression of multiple PRPs and plays

82 Anti-CD27 and anti-PD-L1 synergized by downregulating the expression of multiple quiescence-rel

83 f EGF and addition of serum, the progenitors downregulate the expression of nestin and express cell-t

84 neural nitric oxide synthase (NOS) appear to downregulate the expression of NKX2.1 as they exit the n

85 ssion of Shox2 in the developing mouse heart downregulates the expression of Nkx2.5 and causes cardia

86 is the first example of a compound shown to downregulate the expression of ORF50/Rta and therefore p

87 such as dnsf1, dsec23, dsed5, and drab1) and downregulates the expression of others (such as dergic53

88 v-Src downregulated the expression of Pag1, a lipid raft-assoc

89 awal induced-apoptosis, at least in part, by downregulating the expression of pro-apoptotic Bax prote

90 ptotic) tumor plasma cells, bone marrow mDCs downregulate the expression of proteasome subunits in th

91 duced by a high fat-diet or Bif-1 deficiency downregulates the expression of proteins involved in the

92 Furthermore, we found that ABC294640 downregulated the expression of pS6 and directed c-Myc a

93 Injury to the corneal epithelium downregulates the expression of PTEN at wound edges, all

94 Knockdown of LXRalpha/beta or SREBP-1c downregulated the expression of RALDH genes, which could

95 lesterol-lowering agent (pravastatin sodium) downregulated the expression of RALDH1 and 2 genes in se

96 ession vector containing AP4 coding sequence downregulates the expression of reporter constructs cont

97 Interestingly, laminar shear stress downregulated the expression of S1P lyase (Sgpl) and S1P

98 Notably, JQ1 downregulated the expression of several genes controlled

99 Cytokinin downregulates the expression of several key regulatory g

100 Moreover, 1,25(OH)(2)D(3) downregulates the expression of some members of the Hh p

101 discuss this pathway as a means for cells to downregulate the expression of Stau1 binding transcripts

102 and immunocytochemistry staining showed AME downregulates the expression of such cell surface marker

103 bit cell growth and induce apoptosis through downregulating the expression of survivin in breast canc

104 IFN-gamma can mimic influenza infection and downregulate the expression of the class A scavenger rec

105 n the TRPV genes osm-9 or ocr-2 dramatically downregulate the expression of the gene encoding the 5HT

106 of CXCR3, and high amounts were necessary to downregulate the expression of the NKp30 activating rece

107 e possibility of using ribozymes in maize to downregulate the expression of the stearoyl-acyl carrier

108 mvT*s were found to downregulate the expression of the tyrosine phosphatase

109 c gene ubiquitin-conjugating enzyme E2N, and downregulated the expression of the anti-apoptotic gene

110 In addition, ZAT12 downregulated the expression of the CBF genes indicating

111 al differentiation markers MAP2 and NeuN and downregulates the expression of the cell cycle arrest pr

112 Interestingly, we found that treRNA downregulates the expression of the epithelial marker E-

113 rotonin reuptake inhibitor (SSRI) citalopram downregulates the expression of the human immunodeficien

114 Similarly, the knockdown of endogenous Dax-1 downregulates the expression of the steroidogenic gene p

115 tes cholesterol efflux and HDL biogenesis by downregulating the expression of the ABC transporters, A

116 that the PNR element plays a dual role, both downregulating the expression of the alpha-MHC gene in c

117 n also control gene expression indirectly by downregulating the expression of the brinker gene, which

118 investigate the pathological consequences of downregulating the expression of the putative glycosyltr

119 onize antiinflammatory TGF-beta signaling by downregulating the expression of the TGF-beta type II re

120 omplexes with HDAC play an important role in downregulating the expression of the tumor suppressor ge

121 d EBV upregulated the expression of TLR7 and downregulated the expression of TLR9 in naive B cells.

122 nslocation from the nucleus to cytoplasm and downregulated the expression of toll-like receptor 4 (TL

123 DL-inducible target gene in macrophages that downregulates the expression of Toll-like receptor (TLR)

124 an early-onset form of Parkinson's disease, downregulated the expression of two uncoupling proteins

125 In addition, exercise/HIF-1alpha downregulates the expression of TXNIP, a well-known nega

126 Immobilization downregulated the expression of type I MyoHC mRNA to 0.7

127 Moreover, angiostatin treatment downregulated the expression of vascular endothelial gro

128 Cultured monocytes spontaneously downregulate the expression of viral entry restriction f

129 transactivation of canonical Wnt signaling, downregulate the expression of Wnt target genes, and inh

130 s series suppresses canonical Wnt signaling, downregulates the expression of Wnt target genes, and in

131 protein dosage compensation complex (DCC) to downregulate the expression of X-linked genes only in he

132 gulates GAX primarily through its ability to downregulate the expression of ZEB2.