ライフサイエンスコーパス: downregulation

1 , upregulation) and loss of functions (i.e., downregulation).

2 etics and the extent of virus-mediated HLA-C downregulation.

3 nation by SCF(Skp2/Cks1) is required for p27 downregulation.

4 STAT3 upregulation and another with SMAD2/3 downregulation.

5 -induced EMT despite global microRNA (miRNA) downregulation.

6 CL12 is impaired by SOS1, ARHGEF1, and DOCK2 downregulation.

7 VTA DA neurons primarily due to CB1 receptor downregulation.

8 TH2 cells through SERPINB3 and SERPINB4 mRNA downregulation.

9 showed that alcohol exposure leads to PCSK9 downregulation.

10 Ps and microRNAs, usually resulting in their downregulation.

11 activated ASS1 is associated with HIF-1alpha downregulation.

12 n-5, VE-PTP, and vWf promoters, causing gene downregulation.

13 prevented macrophage infiltration and Klotho downregulation.

14 d markedly in their absolute MHC-A and MHC-B downregulation abilities, all lentiviral Nef lineages do

15 carriage of Nef variants with enhanced MHC-B downregulation ability is associated with reduced breadt

16 terminant of differential HLA-A versus HLA-B downregulation activity.

17 e proteins promote ubiquitin-linked receptor downregulation after prolonged activation.

18 , which in turn could modify beta-2 receptor downregulation and associated tolerance induced by LABA.

19 Both genetic downregulation and chemical inhibition were used to inve

20 ubsequent major histocompatibility complex-1 downregulation and immune escape of HIV-infected cells r

21 Gene downregulation and overexpression studies of NOG1-1 and

22 robably diminishing CsA-induced renal Klotho downregulation and oxidative stress.

23 self is pivotal for MCL survival because its downregulation and pharmacologic inhibition induced cyto

24 utilizes both activity-dependent transporter downregulation and regulation of transporter synthesis b

25 moter methylation of let-7, resulting in its downregulation and subsequent SOX2 upregulation.

26 Ti compete with this process leading to both downregulation and upregulation of gene expression.

27 recipitation, small interfering RNA-mediated downregulation, and pharmacologic inhibition.

28 ulant MPs, endothelial nitric oxide synthase downregulation, and reduced nitric oxide-mediated inhibi

29 CD4 downregulation by Nef and Vpu dramatically reduces expos

30 lely an activator of transcription, and gene downregulation by p53 is indirect and requires p21.

31 death and clarify the mechanisms behind its downregulation by proinflammatory cytokines.

32 WKY macrophages overexpress Cp and its downregulation by RNA interference decreases markers of

33 To rescue Kv4 complex downregulation, cDNA constructs encoding Kv4.3, KChIP1,

34 splicing affects proliferation genes, whose downregulation coincides with cell cycle defects, senesc

35 e inhibitors abolished hypoxia-induced DUSP2 downregulation, COX-2 overexpression, cancer stemness, t

36 Tau downregulation decreases upstream binding factor recruit

37 Either Mdm2 overexpression or Cdc25C downregulation delays cell cycle progression through the

38 These findings indicate that IRE1-XBP1 downregulation distinguishes GCB DLBCL from other DLBCL

39 ultiple KIRs reduced the likelihood of Zap70 downregulation during continuous activation, regardless

40 ressed by CFs and to undergo transcriptional downregulation during late cardiac remodeling.

41 e basolateral amygdala and showed functional downregulation following successful fear extinction in S

42 Nef position 9 that contributes to the MHC-B downregulation function in HIV-1 subtype C and show that

43 Mechanisms responsible for Th1 cell downregulation, however, remain widely unknown.

44 TET2 and TDG downregulation impairs the acquisition of such different

45 ives acyl-CoA toward lipid synthesis and its downregulation improves mitochondrial biogenesis, respir

46 ucosal barrier disruption and tight junction downregulation in a mouse model of house dust mite aller

47 Parkin downregulation in breast cancer cells promotes metastasi

48 nstructed assembly and disassembly to target downregulation in cancer cells by designing peptidic pre

49 emotherapy, it remains challenging to target downregulation in cancer cells.

50 alpha T cells that are generated through CD4 downregulation in CD4(+) T cells.

51 Given prevalent miR-140-5p downregulation in other cancers and major impact of Pin1

52 ly expressed out of which 478 contigs showed downregulation in root wood and 2263 contigs were up-reg

53 Additionally, vigilin downregulation in target cells led to a significant incr

54 JAK2 similarly impaired autophagy and led to downregulation in the expression of lysosomal genes and

55 V600E)-mutant melanomas caused profound CD73 downregulation in tumor cells.

56 ibitors, but the mechanism underlying 4E-BP1 downregulation in tumors remains unclear.

57 lls with stem cell characteristics, and Lgr6 downregulation in vivo causes increased epidermal prolif

58 rmore, we observed that miR-126* and miR-126 downregulation increased E-selectin and VCAM1, respectiv

59 on beta-catenin pathway activity, as YAP/TAZ downregulation induced by SCD1 blockade can be rescued b

60 e substrate-specifying MMS19 protein and its downregulation is a common feature in cancer and is evol

61 Recently we showed that miR-152 downregulation is associated with breast cancer developm

62 We report here that MCL-1 downregulation is associated with cytokine-mediated kill

63 lls toward the extrafollicular area, whereas downregulation is essential for GC formation.

64 id of AGMs and rhesus macaques (in which CD4 downregulation is not observed).

65 is study, we show that the mechanism of this downregulation is posttranslational and identify a C-ter

66 PYK2 downregulation, l-cysteine supplementation, or CSE overe

67 t with the hypothesis that potassium current downregulation leads to abnormal repolarization in HFpEF

68 Socs3 downregulation may also contribute to Stat3 activation.

69 This downregulation not only enhances cold sensitivity of hig

70 ated) in MET mice; strikingly, similar Npas4 downregulation occurred in the prefrontal cortex of huma

71 naling, whereas binge eating resulted in the downregulation of a gene set enriched for decreased myel

72 and TLR7 ligands correlated with significant downregulation of a key regulator of vascular homeostasi

73 We hypothesized that downregulation of a shear stress-sensitive transcription

74 ion stimulated Sirtuin-1 and Foxo3alpha with downregulation of acetylated p53 expression and prevente

75 vented hnRNP F stimulation of Foxo3alpha and downregulation of acetylated p53 expression.

76 ut the aid of other immune cells through the downregulation of activation kinases.

77 to net nutrient flux into the cell and that downregulation of active transporters (activity-dependen

78 cant miRNA hypoediting which correlated with downregulation of ADAR2 both in metadata and qRT-PCR bas

79 Downregulation of AMOTL2 is found in human liver cancers

80 cells and ovarian cancer stem cells and (ii) downregulation of beta-catenin is partially driving effe

81 Furthermore, the downregulation of beta-defensin 1 and E-cadherin, and up

82 es HCC cell survival, prevents apoptosis via downregulation of BIM and achieves immunosuppression by

83 activation of FGFR/MEK/Erk1/2 signaling and downregulation of bone morphogenetic protein signaling,

84 ction by inducing quiescence in part through downregulation of c-Myc.

85 f PU.1 with target gene promoters and led to downregulation of canonical PU.1 transcriptional targets

86 The downregulation of capn12 expression in zebrafish was ass

87 gh fiber and acetate were accompanied by the downregulation of cardiac and renal Egr1, a master cardi

88 reased plasma membrane Ca(2+) currents after downregulation of Cav2.3 ion channel expression, in a pr

89 rons from delayed death in vitro and in vivo Downregulation of Cdc25A led to reduction in retinoblast

90 cycle arrest through upregulation of p27 and downregulation of CDK4, CDK6, and cyclin D3.

91 ry upregulation of CCR5 expression and rapid downregulation of cellular gene transcription.

92 We found downregulation of CLASP2 in migrating neurons leads to m

93 Specifically, there is downregulation of clock genes including Ciart, Per2, Npa

94 ernal cow's milk (CM) elimination results in downregulation of CM-specific IgA antibody levels in BM,

95 pharmacological interrogation suggested that downregulation of cortico-STN transmission in PD mice wa

96 on, raising an important question of whether downregulation of COUP-TFII expression is required for p

97 pharmacological (AACOCF3) and ShRNA mediated downregulation of cPLA2 resulted in reduced LDs, and inc

98 We further demonstrate that downregulation of Cygb prevents angiotensin-mediated hyp

99 linear mixed-effects model showed consistent downregulation of Dgat1, Cd36, Fiaf and upregulation of

100 n which NK-cell education prevents or delays downregulation of DNAM-1.

101 Downregulation of DNMT3B results in decreased non-CpG me

102 Downregulation of Drosophila A2BP1 in the proneural clus

103 xia-inducible factor 1 (HIF-1), followed the downregulation of E-cadherin, and produced heterogeneous

104 pression in EGFR-addicted tumor cells led to downregulation of EGFR protein and tumor cell growth inh

105 Thus, downregulation of endolysosome levels by Qki loss helps

106 MiR-204-I protected against HFD-induced downregulation of endothelial Cav1.

107 ved significant upregulation of miR-519d and downregulation of EphA4, in the latter case correlated i

108 or proteins NUMB and NUMBL were required for downregulation of ERBB2 signaling in maturing trabeculae

109 D2) glomeruli and demonstrated a significant downregulation of essential mitochondrial genes in glome

110 Loss of venom genes is primarily due to downregulation of expression in the gland rather than ge

111 nti-apoptotic signaling pathways, as well as downregulation of extracellular matrix signaling pathway

112 in microfibrils, in part by transcriptional downregulation of Fbn2 mRNA expression.

113 sion of mutant htt in neurons results in the downregulation of Foxp1 Elevating expression of isoform-

114 ng cytotoxic T lymphocytes, concomitant with downregulation of Foxp3(+) T cells.

115 elated to PPAR-mediated lipid metabolism and downregulation of genes in the retinol metabolism in wil

116 in BVE(Cyp24a1-null) cells, associated with downregulation of genes involved in EMT, tumor invasion,

117 ong with upregulation of lipogenic genes and downregulation of genes related to fatty acid oxidation.

118 RNA sequencing showed an expected downregulation of genes within DNA damage repair pathway

119 mice associates with lipid peroxidation and downregulation of glutathione metabolism proteins, featu

120 The mechanism identified involved downregulation of gp130 and IL6Ralpha in breast cancer p

121 roduced by tumor cells caused HDAC2-mediated downregulation of granulocyte-specific chemokine express

122 urrent genetic defect in ccRCC that leads to downregulation of hitherto unsuspected epigenetic factor

123 atural killer and CD8(+) T cells, epigenetic downregulation of HLA-E by high-risk HPV E7 may contribu

124 sistence of MCV has been attributed to viral downregulation of host cell immune responses such as NF-

125 nscriptionally active genes, and lead to the downregulation of host gene expression in a HUSH-, MORC2

126 naling through EP2/EP4-->induction of cAMP-->downregulation of IFN regulatory factor 1 expression and

127 old allodynia is largely due to a functional downregulation of IKD in both high-threshold CSNs and in

128 miR-24-overexpressing T cells led to further downregulation of IL-4 and GATA3 expression, suggesting

129 Downregulation of individual transporters significantly

130 ted renal inflammation and fibrosis with the downregulation of inflammatory cytokines and fibrotic ge

131 of regulators with demonstrated roles in the downregulation of inflammatory pathways and maintenance

132 PCS effected downregulation of iNOS protein expression (27%), NO prod

133 Downregulation of INPP5K orthologs in zebrafish embryos

134 significantly prevented lung metastasis with downregulation of integrin alphavbeta6 and no toxicity.

135 nate on the Akt-survival pathway, leading to downregulation of interleukin-1 receptor-associated kina

136 by the concomitant presence of S. aureus The downregulation of IP-10 by S. aureus was mediated by com

137 ined p53 expression that was associated with downregulation of its negative regulator MDM2.

138 uted to miR-26a, as confirmed by significant downregulation of its proven targets, namely cyclin-depe

139 XIN upregulated miR-411-5p together with the downregulation of its target, Topoisomerase 2 alpha (TOP

140 antar thickening, upregulate K16 with robust downregulation of its type II keratin binding partner, K

141 PFC pyramidal neurons, confirming functional downregulation of KCa2 channel activity by mGlu5 recepto

142 ition 509 of the KCC2 promoter that leads to downregulation of KCC2 transcription in prenatally expos

143 s in UNx EPI cardiomyocytes was secondary to downregulation of KChIP2 but not Kv4.2, Kv4.3, and Kv1.4

144 Electronegative LDL may underlie downregulation of KChIP2 in CKD.

145 Deficiency of ID2 in BMDCs led to downregulation of KDR, suppression of proangiogenic myel

146 umors appear to obtain an advantage from the downregulation of key components of the molecular machin

147 This was associated with a significant downregulation of key pluripotency marker expression, di

148 In murine transplant models, pharmacologic downregulation of kidney-derived EPO prevented spontaneo

149 rt allograft survival, whereas pharmacologic downregulation of kidney-derived EPO reduced the express

150 heterozygous mouse model, we establish that downregulation of Kir2.1 results in significant decrease

151 mbryonic fibroblasts resulted in significant downregulation of LATS.

152 This is evidenced by accumulation of p62 and downregulation of LC3-I/II conversion as well as reduced

153 of the PDAC tumor microenvironment, whereas downregulation of LCN2-specific receptor SLC22A17 blocke

154 n decreased hepatic lipidosis partly through downregulation of lipogenic and/or upregulation of beta-

155 Among other LRRC8 subunits, downregulation of LRRC8D strongly inhibited release of t

156 deletion of LRRC8C+LRRC8E, but unaffected by downregulation of LRRC8D.

157 or LRRC8C+LRRC8E, but largely unaffected by downregulation of LRRC8D.

158 e that was attributed to loss of insulin and downregulation of many beta cell functional genes.

159 te ERK activation possibly through prolonged downregulation of MAPK phosphatase-1 (MKP-1).

160 aciclib that synergized with ABT-263 through downregulation of MCL-1.

161 The FKBP12-mediated downregulation of MDM2 in response to doxorubicin or nut

162 mm's canal; and proteomic analysis confirmed downregulation of metabolic and structural proteins.

163 Persistent downregulation of methyltransferase DNMT3b and deacetyla

164 Downregulation of METTL3 results in cell cycle arrest, d

165 An elevation of LC3-II and LAMP1 and downregulation of Mfn2 in mitochondrial fractions sugges

166 in a Trem2-independent manner that involves downregulation of microglia checkpoints, followed by act

167 ed that in BOECs from patients with PAH, the downregulation of microRNA-124 (miR-124), determined wit

168 /+) (WT) and trkB.T1(-/-) (KO) mice revealed downregulation of migration and proliferation pathways i

169 isolated from patients with PAH demonstrate downregulation of miR-124, leading to the metabolic and

170 Subsequent miRNA-profiling revealed downregulation of miR-16 and miR-103 in the jejunum of I

171 is in NiggV-infected mice showed significant downregulation of miRNAs involved in dampening fibrosis

172 Moreover, loss of GMPR accompanies downregulation of MITF in vemurafenib-resistant BRAF(V60

173 Accordingly, downregulation of MITF induces invasion in melanoma cell

174 ted silencing of Meg3 in CFs resulted in the downregulation of Mmp-2 transcription, which, in turn, w

175 Specifically, constitutive downregulation of molecular chaperones was observed, whi

176 The downregulation of monocyte IMPDH2 and TMEM134 in childho

177 t overlaps with GCN2 but is not required for downregulation of mTORC1 during asparaginase.

178 ted with upregulation of STAT1 and CASP3 and downregulation of neprilysin in both zones, suggesting r

179 (a serine protease inhibitor) expression and downregulation of neutrophil elastase (NE) expression in

180 icroarray gene expression analysis indicated downregulation of NF-E2 related factor 2 (Nrf2) and its

181 ficantly dysregulated, including significant downregulation of NLRX1 in brain injury following aneury

182 Further, artificial microRNA (aMIR) mediated downregulation of NnCYP76B6 resulted in reduction of mRN

183 6 transcription factor, which parallels with downregulation of Notch1, a critical factor for T cell d

184 ed HR also exhibit STAT6 phosphorylation and downregulation of Notch1, leading to inhibition of lymph

185 serine 1 phosphorylation (H4S1ph), and that downregulation of Nt-acetylation of histone H4 facilitat

186 y to differentiate in vitro and in vivo upon downregulation of OCT4 expression.

187 mber of the polyps that accompanied with the downregulation of oncogenic signaling molecules (iNOS, S

188 Downregulation of oo18 RNA-binding proteins (ORBs) in an

189 resulted in pervasive, long-range, and trans downregulation of OR transcription, whereas pre-assembly

190 A significant downregulation of p-mTOR, p-Raptor, and p-S6RP was obser

191 Downregulation of p38 MAPK activity via RNA interference

192 We also observe transcriptional downregulation of pathways mediating energy metabolism,

193 nsfected human organ-cultured corneas showed downregulation of PAX6 and DKK1 and upregulation of kera

194 two decorations is most likely caused by the downregulation of phoPQ and pmrAB expression.

195 Downregulation of PI3K-C2alpha causes spindle alteration

196 Downregulation of PLIN2 ameliorates the effects of fatty

197 QT prolongation, delayed repolarization from downregulation of potassium currents, and multiple reent

198 during in vitro adipogenesis causes dramatic downregulation of Ppargamma2 expression as well as adipo

199 The subsequent downregulation of pre-rRNA level led to attenuated endop

200 c acid N-acetylneuraminic acid (Neu5Ac), and downregulation of pro-oncogenic cytokines interleukin-6

201 We show that downregulation of RBFOX1 leads to destabilization of mRN

202 We also demonstrated downregulation of renal PPARGC1A expression in a patient

203 Within 2 hr of immature INP birth, downregulation of repressor activities alleviates Rpd3-m

204 expression in aerobic conditions, results in downregulation of respiratory pathways and enhanced grow

205 f nuclear localization, we demonstrated that downregulation of RIbeta, but not of RIIbeta, decreased

206 ow that Swi/Snf regulates nutrient-dependent downregulation of ribosomal protein encoding RNAs, leadi

207 Downregulation of ROCK1 by small interfering RNA (siRNA)

208 ing the effect of Y-27632 treatment, whereas downregulation of ROCK2 had no effect.

209 Previous studies have demonstrated downregulation of ROS-producing extracellular superoxide

210 migratory due in part to the post-metastatic downregulation of S100A4 and GRM3.

211 expression and hCPC growth kinetics revealed downregulation of select P2 receptors, including P2Y2R,

212 is, disorganized epidermal architecture, and downregulation of several differentiation markers, inclu

213 Downregulation of SFRP1 with RS and polydextrose could r

214 , and by breaking the feedback loop, cause a downregulation of sialidase and TGF-beta1 accumulation.

215 Downregulation of SiPHT1;2 had the strongest effect on t

216 ancer cachexia, Mstn expression coupled with downregulation of SIRT6.

217 n of acetylated p53 expression and prevented downregulation of Sirtuin-1 and Foxo3alpha expression in

218 The underlying mechanisms likely involve the downregulation of SOCS3 by JNK inhibition.

219 In addition, downregulation of Sp1 results in its decreased binding t

220 not mutations of CovS did not result in the downregulation of speB transcription at stationary growt

221 We further report that downregulation of STAT3 signaling is responsible for TLR

222 and fibronectin expression, accompanied with downregulation of STAT3 signaling.

223 transcriptional activity, leading to global downregulation of STAT5-regulated genes in patient T cel

224 ectin-1 interaction is likely the key to the downregulation of surface Nectin-1.

225 istance against ovarian cancer cells through downregulation of survivin.

226 Cargo secretion is unaffected by downregulation of syntaxin 17, a SNARE promoting autopha

227 cupancy and eRNA synthesis, concomitant with downregulation of target genes.

228 rough in utero electroporation, we show that downregulation of TBC1D23 affects cortical neuron positi

229 Additionally, we show that downregulation of TCF7L1 and its paralogue TCF7L2 reduce

230 ever, the molecular mechanism underlying the downregulation of TDP1 in ATL cells remains elusive.

231 ting Smad3 phosphorylation, resulting in the downregulation of TGF-beta1-induced fibrotic gene expres

232 inhibitors was accompanied by a significant downregulation of Th17-associated genes IL-17A, IL-22, a

233 iptomic and proteomic changes, including the downregulation of the catalase KatG, an activating enzym

234 dependent promoter hypermethylation leads to downregulation of the chemokine CXCL14 and suppression o

235 over-activity of the enzyme GSK3beta and the downregulation of the defense pathway Nrf2-EpRE observed

236 duration or nuclear shape but solely to the downregulation of the diffusion barrier in the nuclear e

237 e and brain metastasis models, we found that downregulation of the DNA methyltransferase DNMT1 induce

238 Here, we report that hypoxia-mediated downregulation of the dual specificity phosphatase 2 (DU

239 omoted cellular survival under stress due to downregulation of the E3 ligase RNF144A.

240 a more functional phenotype characterized by downregulation of the exhaustion markers PD-1 and LAG-3.

241 For example, downregulation of the female-specific hub gene Dusp6 in

242 molecular mediator of the IL-1beta-dependent downregulation of the glial glutamate-aspartate transpor

243 on sites, which leads to Merlin degradation, downregulation of the Hippo pathway, nuclear Yap translo

244 d PPARGC1A inhibition, which overlapped with downregulation of the HNF-1beta transcriptional network.

245 tamin D receptor and responded to 1,25D with downregulation of the IL-23 receptor pathway.

246 ity, negatively impacting their survival via downregulation of the IL-7R.

247 he development of herpetic neuralgia through downregulation of the inwardly rectifying K(+) channel K

248 lly associated in the anterior insula with a downregulation of the kappa opioid receptor (Kappa), as

249 This phenotype was associated with downregulation of the MAPK, PI3K/Akt, and TGFbeta signal

250 s effective in PTEN-deficient DLBCLs through downregulation of the oncogenic transcription factor MYC

251 H2O2 induces miR-500a-5p overexpression and downregulation of the oxidative stress targets TXNRD1 an

252 RATIONALE: Downregulation of the pacemaking ion channel, HCN4 (hype

253 from S1P receptor 2, resulting in selective downregulation of the prosurvival protein MCL1.

254 the upregulation of virulence genes and the downregulation of the protease SpeB.

255 xymethylation, likely mediating the observed downregulation of the receptor.

256 X3 Loss of RUNX3 resulted in transcriptional downregulation of the redox regulator heme oxygenase-1 (

257 lved in circadian rhythm in both tissues and downregulation of the renin-angiotensin system in the ki

258 In summary, the BBB is disrupted by downregulation of the Shh pathway and breakdown of TJPs,

259 g early stages of palatogenesis as well as a downregulation of the Shh signaling pathway in the palat

260 ase in oncogenic signaling, as manifested by downregulation of the transcription factor Sp1.

261 These changes were also accompanied by downregulation of the transcriptional activity and reloc

262 of the exosomal effects on GSCs, in part via downregulation of the tumor-suppressive nuclear receptor

263 Elimination of CVB3 led to a downregulation of these alarmins.

264 ated inversely with CD8, CD69, and GZMB, and downregulation of these markers associated with decrease

265 However, overexpression or downregulation of these microRNAs causes no significant

266 Downregulation of these proteins led to reduced relative

267 all 3 models of anaphylaxis, and subsequent downregulation of this receptor was observed.

268 lly related genes, which further induced the downregulation of those genes.

269 hibited priming of IL-6-related pathways and downregulation of TNF-alpha upstream elements.

270 wever, the mechanisms underlying appropriate downregulation of trabecular ERBB2 signaling are little

271 Downregulation of transcription depends on ATM kinase ac

272 iciency and mediate the post-transcriptional downregulation of transcripts that encode Cu proteins, s

273 lay of repolarization (P=0.001) and revealed downregulation of transient outward potassium current (I

274 p16 overexpression led to downregulation of TRIP12, which in turn led to increased

275 tes oppose brain metastasis by mediating the downregulation of TRPA1 through exosome-delivered miRNA-

276 deoxy-hexose, (P < 0.01)), with significant downregulation of tryptophan metabolism metabolites (e.g

277 or-kappaB (NF-kappaB) activity, resulting in downregulation of tumor necrosis factor-alpha (TNF-alpha

278 increased iron accumulation and compensatory downregulation of uptake pathways.

279 s inside-out auto-activation that drives the downregulation of VLA5 and the upregulation of VLA3 to s

280 ury expression domain is affected, including downregulation of Wnt genes at the oral pole.

281 . describe mechanisms of glucocorticoid (GC) downregulation of wound healing by interaction with the

282 lly, we observed a novel LMX1BR246Q-mediated downregulation of WT1(-KTS) isoforms in podocytes.

283 o VP without light activation demonstrated a downregulation of YAP-TEAD-associated downstream signali

284 Furthermore, we find that downregulation of yars-2/tyrosyl-tRNA synthetase, an NMD

285 Interestingly, downregulation of ZFP804A decreases NRGN expression and

286 degree of DNA disruption and subsequent mRNA downregulation, only disruption of Myh6 was sufficient t

287 he development of chemotherapy via targeting downregulation (or loss of functions) in cancer cells.

288 In investigating the cause of GATA1 downregulation, our gene-expression study revealed the p

289 for effective brain colonization, and Ttyh1 downregulation particularly affected this cellular subty

290 spho-Myosin, followed by Pkn-mediated Myosin downregulation, possibly through Rok inhibition.

291 e to effector phenotype associated with CD27 downregulation, retaining proliferative capacity and TCR

292 We term this phenomenon rapid recovery gene downregulation (RRGD), whereby mRNA abundance rapidly de

293 a (PC), via either somatic mutations or mRNA downregulation, suggesting an important tumour suppresso

294 xpression and cisplatin resistance while its downregulation suppresses PARP-1 and PAR protein express

295 ncer-driving pathways including global miRNA downregulation, the miR-140-5p/Pin1 axis may play a majo

296 Strikingly, CCND2 downregulation was consistently observed in the advanced

297 Vpu-mediated BST-2 downregulation was shown to decrease ADCC responses by l

298 As expected, the effects triggered by BCL11B downregulation were in accordance with that triggered by

299 n induces PRC2 complex dissociation and EZH2 downregulation, which in turn reduces EZH2-mediated H3 t

300 gnaling with oral vitamin D3 but significant downregulation with UVB.Correcting vitamin D deficiency