ライフサイエンスコーパス: dpp

1 dpp encodes a member of the Transforming Growth Factor-b

2 dpp is rapidly activated by wounds and represses the pro

3 dpp overexpression promotes PGC proliferation and causes

4 dpp signaling is known to be essential for maintaining G

5 dpp- and piwi-dependent signaling act synergistically in

6 h [Cu(I)(dmp)(2)](+) and [Cu(I)(dpp)(2)](+) (dpp = 2,9-diphenyl-1,10-phenanthroline) in solvents with

7 ining the trimetallic chromophore [{(bpy)2Ru(dpp)}2Ru(dpp)](6+) (Ru3) with [Rh(bpy)Cl2](+) or [RhCl2]

8 (dpp)RhCl2(bpy)](PF6)7 (Ru3Rh) or [{(bpy)2Ru(dpp)}2Ru(dpp)]2RhCl2(PF6)13 (Ru3RhRu3) (bpy = 2,2'-bipyr

9 2](+) catalytic fragments to form [{(bpy)2Ru(dpp)}2Ru(dpp)RhCl2(bpy)](PF6)7 (Ru3Rh) or [{(bpy)2Ru(dpp

10 trimetallic chromophore [{(bpy)2Ru(dpp)}2Ru(dpp)](6+) (Ru3) with [Rh(bpy)Cl2](+) or [RhCl2](+) catal

11 2(bpy)](PF6)7 (Ru3Rh) or [{(bpy)2Ru(dpp)}2Ru(dpp)]2RhCl2(PF6)13 (Ru3RhRu3) (bpy = 2,2'-bipyridine and

12 alytic fragments to form [{(bpy)2Ru(dpp)}2Ru(dpp)RhCl2(bpy)](PF6)7 (Ru3Rh) or [{(bpy)2Ru(dpp)}2Ru(dpp

13 eporter gene carrying a 375-bp region from a dpp intron (dppMX-lacZ) revealed that the Wingless and D

14 flies in trans-heterozygous with dpp(H46), a dpp null allele.

15 diated by specific Biniou binding sites in a dpp enhancer element, which suggests that Biniou serves

16 llele in combination with a single copy of a dpp(s-hc) produces defects in the ventral adult head.

17 Here we demonstrate that a dpp enhancer element, which directs expression of a repo

18 uce or eliminate Wingless signalling abolish dpp reporter gene expression in parasegment 3 and reduce

19 ss and Dpp pathways are required to activate dpp expression in posterior spiracle formation.

20 oforms differ in their abilities to activate dpp in mesodermal tissues during embryogenesis.

21 rminal binding protein and Daughters against dpp.

22 ed new alleles of tkv, punt, Mothers against dpp (Mad) and Medea (Med), all of which are known to med

23 he receptors to the nucleus, Mothers against dpp (Mad) and Medea (Med); and, finally, a large zinc-fi

24 recovered new alleles of the Mothers against dpp (Mad) and Medea genes.

25 Mothers against dpp (Mad) mediates Decapentaplegic (DPP) signaling throu

26 and nuclear translocation of Mothers against dpp (Mad), a receptor-specific Smad that can bind DNA an

27 dosage of thickveins (tkv), Mothers against dpp (Mad), or STAT92E (aka marelle), respectively, suppr

28 ty of the BMP-specific Smad, Mothers against dpp (Mad).

29 tion of a downstream phospho-Mothers against dpp (p-Mad) gradient and the regulation of the patternin

30 a predicted gene adjacent to Mothers against dpp in Drosophila melanogaster.

31 , thickveins, saxophone, and Mothers against dpp.

32 rt a detailed study of one of those alleles (dpp(F11)).

33 We have been analyzing dpp expression in two groups of dorsal ectoderm cells at

34 We demonstrate that gbb-60A and dpp genetically interact and that specific aspects of th

35 a slight delay in the appearance of bcd and dpp mRNAs.

36 PF6)13 (Ru3RhRu3) (bpy = 2,2'-bipyridine and dpp = 2,3-bis(2-pyridyl)pyrazine) catalyze the photochem

37 th local and long-range functions of gbb and dpp in the wing are different.

38 clude that the relationships between gbb and dpp in the wing disk represent novel paradigms for how m

39 ax), thus, the cooperativity between gbb and dpp is not achieved by signaling through distinct recept

40 ults indicate that signaling by both gbb and dpp may contribute to the development of some tissues, w

41 dentical to loss of dpp(s-hc)/dpp(s-hc), and dpp(hc)/+;opa/+ mutant combinations.

42 Loss of hh and dpp results in defects in CC proliferation and migration

43 gulators of eye development including hh and dpp, known genes that have not been studied previously w

44 Thus a pathway that includes opa and dpp expression in the peripodial epithelium is crucial t

45 ly activated by a combination of eya, so and dpp signaling, and only indirectly activated by ey, wher

46 Epistasis experiments reveal that sog and dpp act downstream of, or in parallel to, the Toll recep

47 Here, we present evidence that sog and dpp also play opposing roles during oogenesis in pattern

48 This interplay between sog and dpp determines the extent of the neuroectoderm and subdi

49 aden the role previously defined for sog and dpp in establishing the embryonic DV axis and reveal a n

50 Within this region, wg and dpp are expressed in domains that are mutually exclusive

51 lones indicate that the regulation of wg and dpp expression is coordinated in both axes, and that sli

52 is unique in that it also deregulates wg and dpp in the A/P axis.

53 ence to characterize the functions of wg and dpp in the red flour beetle, Tribolium castaneum, which

54 Expression of wg and dpp is activated at the posterior edge of the anterior c

55 CI levels results in misexpression of wg and dpp, while CI misexpression in the posterior disrupts di

56 is in turn regulated by the dpp pathway, as dpp signalling is required for labial expression but rep

57 tions that appear to disrupt transvection at dpp.

58 gnaling, suggesting that gbb acts to augment dpp signaling in the same way as scw is proposed to do i

59 s the reciprocal of the relationship between dpp and scw in the embryo.

60 Ru(dpp)}2 RhCl2 ](5+) (bpy=2,2'-bipyridine, dpp=2,3-bis(2-pyridyl)pyrazine).

61 n which the bone morphogenetic protein (BMP) dpp is an important inhibitor of inflammation following

62 We show that C15 expression requires both dpp and zen, thus forming a genetic feed-forward loop.

63 mef2 expression is mediated through a 460-bp dpp-responsive regulatory module, which involves the fun

64 tyl)-dpp-BIAN)(2)] (7), (1,2-di-(tert-butyl)-dpp-BIAN) (8), and (1-(tert-butyl)-2-OH-dpp-BIAN) (9) ar

65 cterizations of [Li(4)][(1,2-di-(tert-butyl)-dpp-BIAN)(2)] (7), (1,2-di-(tert-butyl)-dpp-BIAN) (8), a

66 In the current studies we demonstrate, by dpp mutant rescue, that cleavage at the S2 site of proDp

67 and we have identified TGF-beta (encoded by dpp) as such a molecule in germarium.

68 al, and Dad, that are known to be induced by dpp signaling.

69 ivated by wg signaling, as in females, or by dpp signaling, as in males.

70 tem and that temporal control is provided by dpp autoregulation.

71 ase, dll is activated by wg but repressed by dpp.

72 wing blade primordia devoid of compartmental dpp expression maintain relatively normal rates of cell

73 ed analysis of six BMP signaling components (dpp, gbb, scw, tkv, sax, sog) by RNA interference reveal

74 ese dTcf binding sites to facilitate correct dpp expression in the visceral mesoderm.

75 decapentaplegic (dpp) is a direct target of Ultrabithorax (Ubx) in parase

76 decapentaplegic (dpp), the Drosophila homolog of human bone morphogenetic

77 leg disc, wingless (wg) and decapentaplegic (dpp) are expressed in a ventral-anterior and dorsal-ante

78 viate repression of eya and decapentaplegic (dpp) expression by the zinc-finger transcription factor

79 hort gastrulation (sog) and decapentaplegic (dpp) genes function antagonistically in the early Drosop

80 ptc), gooseberry (gsb), and decapentaplegic (dpp) genes.

81 ar (osk), bicoid (bcd), and decapentaplegic (dpp) transcripts are normal, with a slight delay in the

82 rfamily members, dawdle and decapentaplegic (dpp), in response to wounding and infection in adult Dro

83 including wingless (wg) and decapentaplegic (dpp), is required for allocating and patterning the appe

84 y factors wingless (wg) and decapentaplegic (dpp).

85 ncoded by wingless (wg) and decapentaplegic (dpp).

86 ion genes wingless (wg) and decapentaplegic (dpp).

87 morphogenesis of the CC are decapentaplegic (dpp) and its antagonist short gastrulation (sog), as wel

88 The Drosophila BMP, decapentaplegic (dpp), controls morphogenesis of the ventral adult head t

89 gnaling molecule encoded by decapentaplegic (dpp) prevents activation of salivary gland genes by SCR

90 e product of the Drosophila decapentaplegic (dpp) locus is a well-characterized member of this family

91 ing growth factor-beta gene decapentaplegic (dpp) is expressed in an asymmetric fashion about its sec

92 ecules encoded by the genes decapentaplegic (dpp) and wingless (wg) play key roles.

93 he signaling molecule genes decapentaplegic (dpp) and wingless (wg).

94 anscription of target genes decapentaplegic (dpp), patched (ptc) and engrailed (en) in a dose-respons

95 ncluding the hedgehog (hh), decapentaplegic (dpp), and Toll pathways.

96 e Drosophila BMP2/4 homolog decapentaplegic (dpp), we have used clonal analysis to define the functio

97 e Drosophila BMP2/4 homolog decapentaplegic (dpp), while others do not.

98 utants, but is unaltered in decapentaplegic (dpp) or punt mutants, suggesting that the stage 5 calciu

99 -responsive genes including decapentaplegic (dpp) and wg.

100 wnstream targets, including decapentaplegic (dpp), a TGFbeta homolog.

101 sion at the margins induces decapentaplegic (dpp), optomotor blind (omb), and aristaless in adjacent

102 or the TGF-beta-like ligand decapentaplegic (dpp).

103 hila TGF-beta family member decapentaplegic (dpp) contributes to the development of adult structures

104 le of the BMP family member decapentaplegic (dpp) in the process of head formation, as we have identi

105 enance of the expression of decapentaplegic (dpp) and becomes essential for vein differentiation.

106 Activation of decapentaplegic (dpp) expression in the posterior eye disc eliminates wg

107 r the correct expression of decapentaplegic (dpp), a Transforming Growth Factor (beta) family member,

108 rated two unique alleles of decapentaplegic (dpp), a transforming growth factor-beta family member wi

109 of either unpaired (upd) or decapentaplegic (dpp).

110 t Lsd1 functions to repress decapentaplegic (dpp) expression in adult germaria.

111 The decapentaplegic (dpp) gene directs numerous developmental events in Droso

112 upon the activation of the decapentaplegic (dpp) gene in a stripe of cells just anterior to the comp

113 The decapentaplegic (dpp) gene influences many developmental events in Drosop

114 The decapentaplegic (dpp) gene, which encodes a transforming growth factor be

115 l Ubx molecular target, the decapentaplegic (dpp) gene, within the embryonic mesoderm.

116 atory heldout region of the decapentaplegic (dpp) locus in Drosophila melanogaster.

117 signaling components of the decapentaplegic (dpp) pathway also differentiate.

118 ng the genes wingless (wg), decapentaplegic (dpp) and distalless (dll).

119 band elongation, widespread decapentaplegic (dpp) expression in the dorsal ectoderm patterns the unde

120 ions that disrupt the transvection-dependent dpp phenotype are also dominant maternal enhancers of re

121 he screen exploited a transvection-dependent dpp phenotype: heldout wings.

122 egative form of the protein that derepresses dpp but not ptc.

123 the eye/antennal disc, there is 3' directed dpp expression in both the DP and PE associated with cel

124 at ectopic differentiation driven by ectopic dpp expression or loss of wingless function requires hh.

125 nt with this is our observation that ectopic dpp induces the expression of hh along the anterior marg

126 oding factors from the hedgehog, Notch, EGF, dpp, and wingless pathways are activated by the ecdysone

127 re, we demonstrate that in tor(GOF) embryos, dpp is ectopically expressed and thus may contribute to

128 n is restricted to the domains of endogenous dpp expression, despite ubiquitous expression of altered

129 utant for thick veins, encoding an essential dpp receptor, loses the ability to clonally populate a n

130 For example, dpp signaling acts by silencing transcription of the dif

131 At maximum germ band extension, dpp dorsal ectoderm expression becomes restricted to the

132 Finally, dpp was specifically expressed in the CA cells of ring g

133 elationship is similar to that described for dpp and the BMP screw (scw) in the embryo, we show that

134 nscription is upregulated in GSCs mutant for dpp and gbb.

135 of thick veins (tkv), a type I receptor for dpp.

136 opa is required for dpp expression in the lateral peripodial epithelium, but

137 on of labial and homothorax are required for dpp expression in the peripodial epithelium, while the H

138 ) and homothorax (hth) are also required for dpp expression in this location, as well as in PS3, at t

139 two maternally provided factors required for dpp's role in embryonic dorsal-ventral pattern formation

140 A 420 bp element from dpp contains EXD binding sites necessary for expressing

141 mesoderm in a pattern indistinguishable from dpp, has two functional dTcf binding sites.

142 n increased dosage of the BMP encoding gene, dpp+.

143 A Dpp > dpp autoregulatory loop maintains BMP signaling, which l

144 dergonic with respect to the emissive Ru --> dpp (3)MLCT excited and cannot be formed by static elect

145 head defects identical to loss of dpp(s-hc)/dpp(s-hc), and dpp(hc)/+;opa/+ mutant combinations.

146 e studied both [Cu(I)(dmp)(2)](+) and [Cu(I)(dpp)(2)](+) (dpp = 2,9-diphenyl-1,10-phenanthroline) in

147 Despite early differences in dpp expression, wg, Dll and Exd are expressed in similar

148 The divergence in dpp expression is surprising given that all other compar

149 To identify components involved in dpp signaling, we carried out a genetic screen for domin

150 Lowering Dpp levels (in dpp heterozygotes or hypomorphic alleles) results in a '

151 Conversely, mutations in dpp or its receptor (saxophone) accelerate stem cell los

152 cer of partial loss-of-function mutations in dpp.

153 re it antagonizes CI repression resulting in dpp and wg expression immediately anterior to the compar

154 suggesting that Shn has an essential role in dpp signal transduction in the developing wing.

155 Salmonella challenge revealed that in dpp mutants the misregulation of this cascade also preve

156 Hyperactivation of Zfh1, Srp, and Ush in dpp mutants leads to hyperplasia of plasmatocytes.

157 uires regulation of several genes, including dpp, piwi, pumilio, and bam.

158 er peripodial but not DP expression of known dpp targets.

159 In embryos lacking dpp signaling, increasing the level of TKV activity prom

160 ion of antimicrobial peptides; flies lacking dpp function display persistent, strong antimicrobial pe

161 We also detect differences in later dpp expression, which suggests that dpp likely plays a r

162 Like dpp, Medea is essential for embryonic dorsal/ventral pat

163 th factors are also required for maintaining dpp expression after germ band retraction in the dorsal

164 dea (Med), all of which are known to mediate dpp signaling.

165 wing and plays a distinct role in mediating dpp-dependent vein differentiation at this stage.

166 Moreover, dpp hypomorphic mutants also induced precocious br expre

167 ied a class of cis-regulatory dpp mutations (dpp(s-hc)) that specifically disrupts expression in the

168 refore we conducted a genetic screen for new dpp signaling pathway components.

169 The secreted TGF-beta genes Nv-dpp, Nv-BMP5-8, six TGF-beta antagonists (NvChordin, NvN

170 Finally, we show that early activation of dpp depends on hedgehog (hh) expression in the eye anlag

171 Activation of dpp is mediated by specific Biniou binding sites in a dp

172 ta suggest that lilli may be an activator of dpp expression in embryonic dorsal-ventral patterning an

173 netic interactions between mutant alleles of dpp and a collection of chromosomal deficiencies.

174 ers of recessive embryonic lethal alleles of dpp and screw.

175 With two independent conditional alleles of dpp, we find that the stripe of Dpp is essential for win

176 re valuable new reagents for the analysis of dpp function and molecular evolution.

177 Our analysis of dpp(F11) suggests a model for the integration of Wg and

178 e sequences responsible for these aspects of dpp expression in a reporter gene.

179 Intriguingly, several aspects of dpp posterior spiracle expression and function are simil

180 Here, we analyze a new class of dpp cis-regulatory mutations, which specifically disrupt

181 olecule to induce RNAi-mediated depletion of dpp and characterise the spatial and temporal requiremen

182 nk visceral mesoderm primordia downstream of dpp, tinman, and bagpipe and is maintained in all types

183 Moreover, we show that duplications of dpp are able to rescue many of the phenotypes associated

184 eral mesoderm but also for the expression of dpp in parasegment 7, which governs proper midgut morpho

185 way and controls the localized expression of dpp in the leading-edge cells.

186 affected during MF initiation, expression of dpp in the MF is dramatically reduced in optix mutant cl

187 ding the loss of JNK-dependent expression of dpp mRNA in LE cells, and decreased epidermal F-actin st

188 d lobes, and to changes in the expression of dpp, Distal-less, and Engrailed.

189 ehog signaling, regulates gene expression of dpp, the ortholog of mammalian BMP-2.

190 nctionally with the established functions of dpp, suggesting that both BMPs contribute to the same pr

191 e in others, gbb may signal independently of dpp.

192 Adult-specific knockdown of dpp in escort cells substantially rescued piwi tumors, d

193 re enhanced by the simultaneous knockdown of dpp.

194 the veins that require the highest levels of dpp signaling, suggesting that gbb acts to augment dpp s

195 of function allele, cmi(1), enhances loss of dpp function phenotypes in genetic epistasis tests.

196 one causes head defects identical to loss of dpp(s-hc)/dpp(s-hc), and dpp(hc)/+;opa/+ mutant combinat

197 quired for the initiation and maintenance of dpp expression in the posterior-most branches of the tra

198 At this time, mechanisms of dpp signaling have not yet been fully described.

199 Overexpression of dpp blocks germline stem cell differentiation.

200 a americana, the early expression pattern of dpp differs radically from the Drosophila pattern, sugge

201 deed, comparison of the mutant phenotypes of dpp and gbb hypomorphs and null clones shows that both B

202 ich when misexpressed cause a broad range of dpp(-) mutant phenotypes.

203 cally disrupt a previously unknown region of dpp expression, controlled by enhancers in the 5' regula

204 We speculate that this lessens repression of dpp dorsally, and thus creates a permissive condition un

205 However, the spatial-temporal requirement of dpp for growth and patterning remained largely unknown.

206 y sequences that activate the third round of dpp dorsal ectoderm expression are found in the dpp disk

207 Here we show that a third round of dpp dorsal ectoderm expression initiates during germ ban

208 This round of dpp expression is also restricted to LE cells but Dpp si

209 so show that the activation of this round of dpp expression is dependent upon prior Dpp signals, the

210 the developing heart and that this round of dpp expression may be activated by combinatorial interac

211 thod was used for the efficient silencing of dpp gene activity in the adult wing, and the analysis of

212 ic screen for maternal-effect suppressors of dpp haplo-insufficiency.

213 ed seven independent dominant suppressors of dpp, Su(dpp), which were recovered as second-site mutati

214 miting its expression and indirectly that of dpp to the lateral side of the disc.

215 e at least partially redundant with those of dpp.

216 tyl)-dpp-BIAN) (8), and (1-(tert-butyl)-2-OH-dpp-BIAN) (9) are described.

217 at optix expression does not depend on hh or dpp, we propose that optix functions together with hh to

218 ling does not affect the expression of wg or dpp, indicating that it interacts with Wg and Dpp at the

219 n ceases in the ovary by 3 days post partum (dpp), but continues in the testis through adulthood.

220 During imaginal disc patterning, dpp and wg cooperatively activate dll and also indirectl

221 derlying DP, suggesting that this peripodial dpp signaling source supports cell survival in the DP.

222 l(2)](5+) (where phen = 1,10-phenanthroline, dpp = 2,3-bis(2-pyridyl)pyrazine), was studied in aceton

223 d markedly via c-Kit; 3) that socs-3, plfap, dpp-1, and cacy-bp gene transcription is induced via ER-

224 that the neurotransmitter glutamate promotes dpp expression in the CA, which stimulates JH biosynthes

225 onor spacer ligand 1,3-di(4-pyridyl)propane (dpp) lead in a single reaction vial to the simultaneous

226 Reduced dpp expression was detected in larvae mutant for Nmdar1,

227 se gradient can form in embryos with reduced dpp gene dosage, but the peak level is reduced.

228 e dpp(F11) enhancer trap accurately reflects dpp mRNA accumulation in leading edge cells of the dorsa

229 to understand how multiple factors regulate dpp expression, we chose to focus on a single dpp enhanc

230 optix functions together with hh to regulate dpp in the MF, serving as a link between the RD network

231 onal coactivator Nejire (CBP/p300) regulates dpp(F11) expression in these cells.

232 c finger transcription factor that regulates dpp target genes in Drosophila.

233 controls wing vein patterning by regulating dpp transcription directly or indirectly through the 3'

234 we have identified a class of cis-regulatory dpp mutations (dpp(s-hc)) that specifically disrupts exp

235 Here, by removing dpp from the stripe at different time points, we show th

236 0.73 V vs Ag/Ag(+), and two quasi-reversible dpp/dpp(-) couples with E(1/2) = -1.11 and -1.36 V vs Ag

237 nto aqueous solutions containing [{(bpy)2 Ru(dpp)}2 RhCl2 ](5+) (bpy=2,2'-bipyridine, dpp=2,3-bis(2-p

238 henium(II)-containing complex, [((phen)(2)Ru(dpp))(2)RhCl(2)](5+) (where phen = 1,10-phenanthroline,

239 The results show that certain [Ru(dpp)3]2+-doped Octyl-triEOS/TEOS composites form uniform

240 -diphenyl-1,10-phenanthroline) chloride ([Ru(dpp)3]2+), and an oxygen-insensitive fluorescent dye, Or

241 -diphenyl-1,10-phenanthroline dichloride (Ru(dpp)(3)Cl(2)) is reported.

242 tribution of these rates is measured for (Ru(dpp)(3)Cl(2)) on a quartz surface.

243 henyl-1,10-phenanthroline)ruthenium(II) ([Ru(dpp)(3)](2+)) doped sols onto wavelength tuned reflectiv

244 henyl-1,10-phenanthroline)ruthenium(II) ([Ru(dpp)3]2+) sequestered within the xerogels.

245 selectively reflect the O(2) responsive [Ru(dpp)(3)](2+) emission toward the detector to enhance the

246 nals (wingless, hedgehog, unpaired, Serrate, dpp) and transcription factors (engrailed, dead ringer).

247 d, lowering the level of 60A impairs several dpp-dependent developmental processes examined, includin

248 ecification mechanism has been debated since dpp expression in more basal insect species differs dram

249 pp expression, we chose to focus on a single dpp enhancer element, the dpp heldout enhancer, from the

250 is of this 358 bp wing- and haltere-specific dpp enhancer, which demonstrates a direct transcriptiona

251 independent dominant suppressors of dpp, Su(dpp), which were recovered as second-site mutations that

252 We show that Su(dpp)(YE9) maps to eIF4A and that this allele is associat

253 Most of the Su(dpp) mutants exhibited increased cell numbers of the amn

254 e unexpected identification of one of the Su(dpp) mutations as an allele of the eukaryotic translatio

255 We have determined that dpp posterior ectoderm expression begins during germ ban

256 ses of tracheal development, suggesting that dpp expression confers a distinct identity upon posterio

257 in later dpp expression, which suggests that dpp likely plays a role in limb segmentation in Schistoc

258 omeodomain genes is in turn regulated by the dpp pathway, as dpp signalling is required for labial ex

259 In imaginal discs, the dpp gene has been shown to be activated by Hedgehog sign

260 focus on a single dpp enhancer element, the dpp heldout enhancer, from the 3' cis regulatory disc re

261 we demonstrate that lacZ expression from the dpp(F11) enhancer trap accurately reflects dpp mRNA accu

262 dorsal ectoderm expression are found in the dpp disk region.

263 r, mutation of the dTcf binding sites in the dpp enhancer results in ectopic expression of reporter g

264 EH-secreting neurosecretory cells and in the dpp expression domain, implying that AF1 is dispensable

265 events appear to be new insertions into the dpp transcription unit.

266 s not appear to affect the high point of the dpp gradient, but, rather, appears to be required for lo

267 ition to regulation by Ci, expression of the dpp heldout enhancer is spatially determined by Drosophi

268 h the unexpectedly complex regulation of the dpp heldout enhancer, analysis of a Ci consensus site re

269 rom the 3' cis regulatory disc region of the dpp locus.

270 netic screen as a dominant suppressor of the dpp overexpression-induced GSC tumor phenotype.

271 o maintain optimal signaling capacity of the dpp pathway, possibly by forming biologically active het

272 n, suggesting that the ancestral role of the dpp/chordin antagonism during gastrulation may have been

273 nal null allele, one study proposed that the dpp stripe is critical for patterning but not for growth

274 e at different time points, we show that the dpp stripe source is indeed required for wing disc growt

275 the primary function of dTcf binding to the dpp enhancer is repression throughout the visceral mesod

276 on of a local transposition event within the dpp locus that meets two specific criteria.

277 Therefore, dpp is probably one of the mitotic signals that promote

278 These dpp-expressing cells become tracheal cells in the poster

279 The pupal lethality of these dpp mutants was partially rescued by an exogenous JH ago

280 te Zic family, as dominant enhancers of this dpp head mutation.

281 s observed, which is likely mediated through dpp signaling pathway.

282 Thus, dpp signaling helps define a niche that controls germlin

283 ng to their downstream placement relative to dpp and zen, our studies reveal roles for the scyl and c

284 a gene that is downregulated in response to dpp, thus implicating Shn in both activation and repress

285 a partially ventralized phenotype similar to dpp embryonic lethal mutations.

286 Similar to dpp, gbb encodes another Bmp niche signal that is essent

287 4 transforms to an anhydrous phase [Cu(tzc)(dpp)]n (6I) via the intermediate monohydrate phase [Cu(t

288 fferent single-crystalline solvates [Cu(tzc)(dpp)]n.0.5C6H14.0.5H2O (1), [Cu(tzc)(dpp)]n.4.5H2O (2),

289 1), [Cu(tzc)(dpp)]n.4.5H2O (2), and [Cu(tzc)(dpp)]n.1.25C6H14 (3).

290 f an additional forth solvate phase [Cu(tzc)(dpp)]n.2H2O (4).

291 Cu(tzc)(dpp)]n.0.5C6H14.0.5H2O (1), [Cu(tzc)(dpp)]n.4.5H2O (2), and [Cu(tzc)(dpp)]n.1.25C6H14 (3).

292 the intermediate monohydrate phase [Cu(tzc)(dpp)]n.H2O (5).

293 Cuticle studies on a unique dpp mutant lacking this enhancer showed that it is requi

294 We present evidence that when dpp signaling is compromised, lowering the level of 60A

295 anscription is induced via ER-HY343, whereas dpp-1 and cacy-bp gene expression is also supported by E

296 sternite and medio-lateral tergite, whereas dpp expression is confined to the pleura and the dorsal

297 Tribolium embryos in which dpp had been downregulated had defects in the dorsalmost

298 p signalling in a mutant background in which dpp is expressed throughout the embryo.

299 icates that gbb functions cooperatively with dpp to maintain male GSCs, although gbb alone is essenti

300 d in viable flies in trans-heterozygous with dpp(H46), a dpp null allele.