ライフサイエンスコーパス: drastic

1 We attribute such a drastic absorbance increase to ground-state ligand/QD or

2 me maintenance (MCM) helicase in addition to drastic accumulation of sumoylated nucleolar RENT and in

3 ns of the hexon and penton are mediated by a drastic alpha-helix-to-beta-strand structural transition

4 ting a comparable effect to that of the most drastic ALS-causing mutations known.

5 Drastic alteration in macronutrients causes large change

6 ed, demonstrating site selectivity without a drastic alteration of electronic structure.

7 Rapid adaptive changes can result from the drastic alterations humans impose on ecosystems.

8 nstrate that O antigen production results in drastic alterations of many phenotypes and the density o

9 This drastic and counterintuitive increase is shown to be due

10 Moreover, a drastic and recurrent alteration of the mitochondrial ne

11 ropogenic warming and the immediate need for drastic and sustained cuts in carbon emissions.

12 Adding ligands to molecules can have drastic and unforeseen consequences in the final product

13 e find that sulindac sulfide does not induce drastic architectural changes in the fibrillar structure

14 the pigments and volatile changes are not as drastic as observed at 75 and 90min of boiling.

15 Adolescence is characterized by drastic behavioral adaptations and comprises a particula

16 Rabies virus induces drastic behaviour modifications in infected hosts.

17 hydrogen bond network whereby alteration has drastic biological consequences.

18 the initiating step of HER and explained the drastic catalytic activity difference of the two POM@MOF

19 to use these cells in vivo have resulted in drastic cell death caused by mechanical, metabolic, and/

20 H(+) vacuolar-type ATPase (V-ATPase) caused drastic cell swelling and depolarization, and also inhib

21 festyle of Sinorhizobium meliloti requires a drastic cellular differentiation that includes genome am

22 Such a drastic change in chemistry at the centrifugal barrier w

23 Upon a drastic change in environmental illumination, zebrafish

24 CRMP5 overexpression triggered a drastic change in mitochondrial morphology, increased th

25 rich bird guano, C. neoformans experiences a drastic change in nutrient availability during host infe

26 rinated carbon is already enough to induce a drastic change in the adsorption properties of molecules

27 r, molecular dynamics simulations revealed a drastic change in the dynamics and a movement of the int

28 es calculations show that this is due to the drastic change in the local oxygen coordination environm

29 ect to Cytochalasin D treatment to provoke a drastic change in the power law coefficient and to demon

30 e addition of water to the system leads to a drastic change in the selectivity of methane activation

31 rough in targeted cancer therapy and marks a drastic change in the treatment of non-small cell lung c

32 (EHT) is a key developmental process where a drastic change of endothelial cell morphology leads to t

33 A capsize, namely a drastic change of polarization to the perpendicular dire

34 A drastic change of the shell morphology was observed by c

35 The role of such drastic changes in any system is unclear, although there

36 f MECII impaired spatial memory and elicited drastic changes in CA1 place cells in a familiar environ

37 move expression noise rather than by causing drastic changes in expression levels.

38 hat small changes in these functions lead to drastic changes in extinction dynamics.

39 ur results suggest grasslands are poised for drastic changes in function and highlight the need for l

40 subtle genetic differences that can lead to drastic changes in fungal pathogen lifestyles.

41 Drastic changes in gene expression occur after adult fem

42 binding occurs at the Zn(II) core leading to drastic changes in its absorption behavior which can be

43 Photosynthetic organisms are exposed to drastic changes in light conditions, which can affect th

44 Small changes in gene expression can lead to drastic changes in lineage commitment, cellular function

45 escence, a reversible cell cycle arrest with drastic changes in metabolism allowing cells to remain v

46 e only a subset of these variants results in drastic changes in proteins, we focused on variations th

47 pirical evidence regarding the occurrence of drastic changes in RUE (assessment of the timing, the di

48 This is accompanied by drastic changes in the degree of sister chromatid intert

49 lculations indicate that these motions cause drastic changes in the electronic structure.

50 y represents an avenue for rapid response to drastic changes in the environment.

51 ological niche models supported inference of drastic changes in the extent of its breeding range over

52 ion of science, particularly in the light of drastic changes in the information landscape and the inc

53 Moreover, drastic changes in the live bacterial community structur

54 Metabolomic analyses also revealed drastic changes in the profile of sterols, ubiquinones,

55 nety-nine percent of Treg depletion provoked drastic changes in the tumor microenvironment, such as s

56 achieving perceptual stability, despite the drastic changes introduced by oculomotor behavior in rea

57 t in all modelled projections, with the most drastic changes occurring under high emissions; all rang

58 Drastic changes of organization, such as epithelial-mese

59 The spectroscopic consequences of such drastic changes to the ligand field represent important

60 Despite such drastic changes to the protein sequence, FS indels and N

61 increasing age, the immune system undergoes drastic changes, and older individuals have declined res

62 omatin compaction, whereas dim-3 caused more drastic changes, specifically decreasing interactions be

63 ntages of nanoscale architectures, including drastic concentration of electric field, possibility of

64 93.5%) of moldy plus fermented grains, named drastic conditions (DC).

65 Drastic conformation changes and reorganization of these

66 Under conditions of stress they undergo drastic conformational rearrangements in order to bind t

67 impacted by drier climatic conditions, with drastic consequences for the functions and services they

68 y processes in fisheries management can have drastic consequences on a species' long-term viability [

69 hanisms, while if PSI is affected, there are drastic consequences on growth.

70 emperature, interactions do not have equally drastic consequences.

71 that interpolates between wild-type and more drastic conventional mutations, reinforcing the evaluati

72 perovskites under high pressure: during the drastic cubic-orthorhombic structural transformation at

73 astewater treatment since it causes a quick, drastic decay of organic matter content.

74 has gained significance as a consequence of drastic declines in amphibians, where the fungus Batrach

75 flow among L. auriculata populations showed drastic declines in comparison with historical gene flow

76 ard and headwater-ward range contraction and drastic declines in habitat suitability for most extant

77 ifferent receptor inhibitors and achieving a drastic decrease in both processes using MIF inhibitor.

78 f Nkx6.1 in newly formed beta-cells caused a drastic decrease in early postnatal beta-cell proliferat

79 cts predominantly on CD4(+) cells, causing a drastic decrease in FoxP3(+) T reg cells and an increase

80 e strikingly, G0S2 knockout mice displayed a drastic decrease in hepatic TG content and were resistan

81 and death of host cells), were reflected by drastic decrease in impedance signal response detected a

82 n, providing a quantitative rationale to the drastic decrease in inhibitory potency against the V27A

83 A drastic decrease in lattice thermal conductivity down be

84 Renal transplant was marked by a drastic decrease in levels of catalytic IgG over 3 mo fo

85 these data, miR-155-deficient mice showed a drastic decrease in LRV1-induced disease severity, and l

86 A drastic decrease in miR172c and high AP2-1 mRNA levels w

87 to mimic the effect of methylation caused a drastic decrease in PR activity.

88 Only a drastic decrease in the expression level or/and redox ac

89 gh seemingly contradictory, this is due to a drastic decrease in the nanocrystal nucleation events in

90 DMSO causes a drastic decrease in the range of the steric hydration re

91 e rapid delayed rectifier K(+) current and a drastic decrease in the slow delayed rectifier K(+) curr

92 tract (FRT) during ART that result in such a drastic decrease in transmission were not studied and re

93 r-layer electronic couplings may result in a drastic decrease of charge mobilities by utilizing field

94 ead of one) dimesitylboron groups leads to a drastic decrease of emission quantum yields.

95 ect the RNA structure of this signal lead to drastic decreases (10- to 50-fold) in viral RNA packagin

96 tine, plasma, and intestinal content, led to drastic decreases in the mRNA levels of intestinal fibro

97 eletion in Saccharomyces cerevisiae causes a drastic defect in mRNA synthesis that is compensated by

98 for signaling, were not exchangeable without drastic deficiencies in folding, plasma membrane targeti

99 nd synapse differentiation associated with a drastic deficit in AChR clusters and excessive growth of

100 1 artificial microRNA lines phenotype show a drastic delay in the grain germination process.

101 ed in mutant Orai1-SS channels carrying more drastic deletions that removed the STIM1 binding sites (

102 them from populations that underwent recent drastic demographic declines or founder events, and impl

103 lation imbalanced Fermi gas, but with a more drastic departure from the regular 3D balanced case, fea

104 such episodes have the potential to induce a drastic destabilization of the Sahelian agroecosystem.

105 For example, drastic differences between viral and cellular membrane

106 Drastic differences between viral and cellular membrane

107 clear polarization relaxometry, we show that drastic differences exist in water motion within a dista

108 etected at 50 or 37kDa on Western blot, with drastic differences in antibody affinity for these bands

109 the results of the former approach revealed drastic differences in chemical behavior of extended str

110 The simulations also reveal drastic differences in deformation mechanisms between na

111 mouse embryonic fibroblasts (MEFs) and found drastic differences in multiple cellular functions durin

112 alyses of the drivers and correlates of such drastic differences in substitution rates across a diver

113 nce transposable element activity, there are drastic differences in the abundance of transposable ele

114 te that these phenotypic differences reflect drastic differences in the populations of enhancers that

115 t decrease in the line tension and thus to a drastic disruption of the domain structures at a much lo

116 orhombic phase, with significant, albeit not drastic, distortion of the anion framework.

117 Strikingly, 5 of 7 mutations exhibited a drastic dominant-negative effect on wild-type KV 7.2 or

118 This interaction is further supported by the drastic down-regulation in the phyC(AB) mutant of the ce

119 ing power by only a few percent results in a drastic drop in on/off ratio by more than one order of m

120 g: (1) a massive cutaneous vasodilation; (2) drastic drops in deep brain temperature (reaching a nadi

121 lizes both PrP variants, but produces a more drastic effect in the less stable GHaPrP.

122 This drastic effect is attributed to their specific structura

123 ages a minute change in the image can have a drastic effect on recognition, thus identifying features

124 or at the tetramer assembly interface have a drastic effect on the ability of kLANA binding.

125 orporation of a few percent of N atoms has a drastic effect on the electronic structure of the alloys

126 The scaling exponent has a drastic effect on the optimal design of shell shapes.

127 nstrate how disruption of this interface has drastic effects on both the oligomerization and function

128 well as its interplay with the ADC can have drastic effects on cell apoptosis versus survival.

129 tween torsional and vibronic modes and their drastic effects on charge-transfer dynamics, thus settin

130 dine dimers in DNA by solar UV radiation has drastic effects on microorganisms.

131 building blocks of these assemblies can have drastic effects upon the final morphology or function of

132 We observe a drastic elastic-mechanical softening in highly doped BDD

133 Time-lapse ex vivo imaging revealed a drastic elimination of serum/LIF ESCs during early devel

134 Drastic emissions cuts, such as those represented by RCP

135 d in the mouse DC by the YSK12-MEND showed a drastic enhancement in cytokine production, resulting in

136 The drastic enhancement in mechanical properties is found to

137 of torsion in a rotational DAC (RDAC) offers drastic enhancement of the pressure self-focusing effect

138 -induced developmental arrest, a natural and drastic environmental change, leads to the generation of

139 lization in the Middle East have resulted in drastic environmental changes and increased allergens pr

140 primed pluripotent states is accompanied by drastic epigenetic rearrangements.

141 The degeneration also accompanies drastic ER disorganization, that is, an aberrant increas

142 for two of the populations corresponds to a drastic expansion of an ancient human civilization in th

143 enerate elements in mRNAs and have undergone drastic expansions in higher metazoan genomes.

144 interactions, subdiffusive dynamics, and the drastic exponential slowing of DNA, up to approximately

145 oxidant, showing that samples that underwent drastic extraction processes could not tolerate addition

146 ant and show reduced NHEJ efficiency, with a drastic failure to up-regulate RAD51 expression and mani

147 duction in vesicular ATP is accompanied by a drastic fall in the quantal release of catecholamines.

148 ance between strong global demethylation and drastic focused remethylation.

149 how that the SOD1 inhibitor LCS-1 leads to a drastic fragmentation and swelling of the matrix, sugges

150 They carried mutations inducing a drastic gain-of-function effect leading to permanently o

151 g the curling edge, followed by an immediate drastic gasification of L-N2 , further peeling off h-BN.

152 tivation of hundreds of enhancers along with drastic genome-wide reduction of HNF4A and HNF4G occupan

153 HCMV can remain relatively stable or undergo drastic genomic changes that are suggestive of the emerg

154 sphate transporter (pgk3.2 tpt3) displayed a drastic growth phenotype, but they were viable.

155 We observed frequent drastic heteroplasmy frequency shifts between generation

156 e cover, which can partly explain the recent drastic ice reduction in the Arctic Ocean.

157 nce has accumulated in recent decades on the drastic impact of climate change on biodiversity.

158 The particle stability had no drastic impact on the silver release as most of the Ag N

159 Accountable Care Organizations will have a drastic impact on the ways in which anesthesiologists ar

160 gosome foci, whereas silencing Tid1 leads to drastic impairment of autophagy as induced by nutrient d

161 sults in extensive twinning and a subsequent drastic improvement in the yield (>85%) of formation of

162 These data indicate that without drastic improvements in control measures, the numbers of

163 tein) in PCa samples, and this is especially drastic in metastatic and/or high Gleason score tumor sa

164 s motoneuron firing pattern, which were more drastic in MLF of animals.

165 The increase was more drastic in St. Croix than in Fort Lauderdale, where 25%

166 This contrast is found to be even more drastic in the case of their peripherally annulated coun

167 andscape is progressively established with a drastic increase at the 8-cell stage.

168 Climatic projections showed a drastic increase in air temperature and a mild decrease

169 Gna13-deficiency triggers a drastic increase in both osteoclast number and activity

170 lexity vascular networks in cotyledons and a drastic increase in both provascular and vascular discon

171 iferous tubules of C/C testes, we recorded a drastic increase in cells with DNA fragmentation.

172 A drastic increase in current density was observed with de

173 he linker-exchanged ZIF-8 membranes showed a drastic increase in propylene permeance by about four ti

174 ilon in immune-competent mice, we observed a drastic increase in T cell survival, which was accompani

175 and glass formation, and should facilitate a drastic increase in the discovery rate of metallic glass

176 Here we report advances that lead to a drastic increase in the measurement throughput of multip

177 over, and it was found that there had been a drastic increase in the preference of CBCT over OPG in r

178 lung consolidation were found on CT, with a drastic increase in uptake for both (18)F-FDS and (18)F-

179 To deal with the drastic increase of sequenced genomes, RSAT public sites

180 Finally, a drastic increase of the domain fraction of the liquid-co

181 in the external magnetic field results in a drastic increase of the inductive voltage, as well as in

182 edly severe clinical relapses accompanied by drastic increases in new or enhancing lesions seen on ma

183 This had a drastic influence on the dynamics of the remnant, which

184 evealed that the inclusion of a cation had a drastic influence on the obtained results.

185 controls, EtOH-exposed hepatocytes showed a drastic inhibition in beta-AR/cAMP-induced LD breakdown

186 proximal phenylalanines with alanines caused drastic inhibition of infectious virion production and c

187 In the drastic kinase-off lesion of CCW B, the alpha1 helices u

188 space-charge, become dominant and result in drastic kinetic changes to the electroactivity of the ra

189 enging goal, which will ultimately lead to a drastic limitation of the experimental tests required to

190 CHH methylation during seed development and drastic loss of CHH methylation during germination.

191 We found a drastic loss of H3K9me2 at heterochromatic chromocenters

192 o the C-C bonds of polyhedranes results in a drastic lowering of the structural strain.

193 ck of experimental evidence obtained without drastic manipulation of the midgut and its content.

194 le intermediates and this contributes to the drastic mismatch in selectivities.

195 plotypic diversity occurred, indicative of a drastic mitochondrial bottleneck, caused by massive colo

196 zyme sequestrations coincide with reversible drastic mitochondrial reorganization and concomitant los

197 The observed differences can be explained by drastic modification of the ligand field states due to t

198 mutational patterns, including gene loss or drastic modifications of the protein structure.

199 with nanoceria at pH 9, P. aeruginosa showed drastic morphological changes as a result of cellular st

200 tive symptoms of the disease, which comprise drastic morphological changes in the infected shoots.

201 ve movements of calsequestrin accompanied by drastic morphological SR changes in fully depleted cells

202 ing direction and association strength, more drastic mutations change both features and could lead to

203 ting along the array plane, which leads to a drastic narrowing of plasmon resonance lineshapes (down

204 ng-standing failure to identify the need for drastic national reductions in sugars intakes reflects s

205 ant mice exacerbated cystogenesis and caused drastic nephron damage and renal fibrosis, leading to ki

206 Finally, drastic neuronal loss caused manifestations mimicking hu

207 ent on the emissions scenario, with the most drastic one shifting 38% of the current distribution by

208 s but not unique geometries within each, and drastic peak broadening has been the bane of protein ana

209 exodus of neural lineages out of the CNS and drastic perturbations to CNS structure.

210 enerate its correct anatomical pattern after drastic perturbations.

211 Such a drastic phase change has been theoretically highlighted

212 Arabidopsis thaliana, the xylem undergoes a drastic phase transition from a parenchyma-producing pha

213 ivation of PHD2 and HIF-1alpha resulted in a drastic PHD3 reduction with consequent overexpression of

214 -down of Kmt6 in the KMT6(kd) strain shows a drastic phenotype affecting fungal growth and developmen

215 Overexpression of miR156 in potato caused a drastic phenotype resulting in altered plant architectur

216 inger Nuclease technology, which resulted in drastic phenotypic and biochemical changes.

217 o life in the High Arctic and have undergone drastic physiological changes in response to Arctic clim

218 ors such as azobisisobutyronitrile lead to a drastic rate enhancement.

219 e showed that binding of daptomycin led to a drastic rearrangement of fluid lipid domains, affecting

220 The formation of CDRs involves a drastic rearrangement of the cytoskeleton, which is regu

221 sites of either the GFLD or CuBD result in a drastic reduction in APP cis-orientated dimerization.

222 A drastic reduction in both sample preparation time (94% f

223 uffice for optimal performance, leading to a drastic reduction in computational requirements.

224 A drastic reduction in cytokine production was observed in

225 reas abrogation of receptor binding led to a drastic reduction in efficacy.

226 Simulations show that a drastic reduction in fishing mortality has resulted in a

227 ransfer (CT) type states can lead to similar drastic reduction in fluorescence QY as seen experimenta

228 ments in sequencing technology have led to a drastic reduction in genome sequencing costs.

229 acterized by very small plaque formation and drastic reduction in infectious virus production, while

230 not observed in our model, which presented a drastic reduction in lactate generation and release by i

231 The dieback was accompanied by a drastic reduction in local invertebrate biodiversity.

232 A drastic reduction in nucleotide diversity ( approximatel

233 The resulting Ala96Leu mutant showed a drastic reduction in oxidase activity using molecular ox

234 ed by compromised epidermal differentiation, drastic reduction in profilaggrin processing, reduced la

235 ed fitness compared with the wild type and a drastic reduction in seed set.

236 The Sox17(+/-) gallbladder also showed a drastic reduction in sonic hedgehog expression, leading

237 he IxM cargo-binding site of Sec24C led to a drastic reduction in sorting of all three Q-SNAREs into

238 of the wider ecological consequences of this drastic reduction in the archipelago's only large native

239 uQlust represents a drastic reduction in the computational complexity and me

240 ments in sequencing technology have led to a drastic reduction in the cost of sequencing a genome.

241 There was also a drastic reduction in the failure rate for underrepresent

242 s in harsh environments, is accompanied by a drastic reduction in the fraction of active ribosomes.

243 o selection for extreme phenotypes without a drastic reduction in the genetic variation.

244 Loss of CX26 resulted in a drastic reduction in the GJP area and protein level and

245 monas syringae pv tomato DC3000 results in a drastic reduction in the levels of ubiquitinated XBAT35.

246 gene in Synechocystis sp., however, caused a drastic reduction in the plastoquinone content to levels

247 resulting in incurable visual impairment and drastic reduction in the Quality of life of the patients

248 transmetalation of TPE-boronic acid causing drastic reduction in the solubility of the resulting pro

249 hysical interactions with S. mutans suffered drastic reduction in their abundance, whereas S. mutans'

250 trate that two separate age-related defects--drastic reduction in true naive T cell precursors and im

251 cells harboring CYP24A1 shRNA resulted in a drastic reduction in tumor volume when mice were subject

252 AMHD1 hydrolyzes Ara-CTP, which results in a drastic reduction of Ara-CTP in leukemic cells.

253 nuous flow can be eliminated, resulting in a drastic reduction of cutting forces.

254 Deep brain stimulation allows drastic reduction of dopaminergic medication and, thus,

255 nificantly better to GC than Pt, and allowed drastic reduction of electrode size while maintaining sa

256 The drastic reduction of fungal CFI proteins in carbon-starv

257 growth of CSCs proportion shortly after the drastic reduction of it.

258 of a single dose of anti-CD20 resulted in a drastic reduction of liver inflammation accompanied by a

259 servation that many tumor cells often have a drastic reduction of MHC class I molecules, yet these ce

260 ated cortical cell divisions, resulting in a drastic reduction of nodule numbers.

261 in presenilin-1 revealed that all result in drastic reduction of normal carboxypeptidase function.

262 econdary flightlessness, a process involving drastic reduction of the flight muscles and enlargement

263 elongated pillar beds is that they enable a drastic reduction of the footprint of pillar array colum

264 n turn, stabilization of H3K27me3 leads to a drastic reduction of the iNKT cell population.

265 Results have shown that a drastic reduction of the reflux rate at an early stage o

266 Recent studies, however, show that a drastic reduction of this reservoir is insufficient for

267 expected to result in loss of function and a drastic reduction of XYLT1 cDNA level was demonstrated i

268 At 9.4T, T2-weighted MRI detected drastic reduction on signal intensity and T2 values of t

269 cell development at early stages, leading to drastic reductions in iNKT-cell numbers in the thymus an

270 r in control atrial cells than in cAF cells, drastic reductions in kiCa were required to produce alte

271 ycle of human cytomegalovirus (CMV) leads to drastic reorganization of domains in the host cell nucle

272 Due to the drastic reorganization of SAMN surface, the prepared mag

273 cations with Sn(4+) cations would require a drastic reorganization of the anion framework, which is

274 lipid accumulation, and we hypothesized that drastic repatterning of metabolism also followed this bi

275 Because of the drastic reproductive loss of A. aegypti females satyrize

276 In mammals, chromatin organization undergoes drastic reprogramming after fertilization.

277 BW larvae infestation, cotton plants undergo drastic reprogramming of the transcriptome and the volat

278 Similar, but even more drastic, results were observed with two-motor complexes

279 is compatible with a gradual, rather than a drastic saltation event.

280 tion of bilaterian features, or as a case of drastic secondary loss of complexity.

281 Intriguingly, this A24R variant underwent a drastic selective sweep during passaging, despite enhanc

282 When these drastic shape changes occur rapidly, cell volume and sur

283 he fight against tuberculosis will require a drastic shift from a strategy focused on control to one

284 the closed conformation of M2-1 leading to a drastic shift in the conformational landscape of M2-1.

285 This scenario supposes a drastic shift of heat supply systems from a fossil fuel

286 hat even rare long-range jumps can lead to a drastic speedup--as air-traffic-mediated epidemics show-

287 DCAF1 deletion leads to a drastic stabilization of p53 protein, which can be attri

288 However, blocking the same routes had drastic strain-specific consequences on the establishmen

289 ynamics simulations at 900 K do not show any drastic structural changes up to 10 ps.

290 lasticity of prothrombin in solution and the drastic structural difference between its alternative co

291 moter region of the c-Myc gene, resulting in drastic suppression of c-Myc expression.

292 xtravasation potential, with a corresponding drastic suppression of metastatic nodule formation in th

293 's disease (AD) but at the same time display drastic synapse loss, even in the absence of amyloid.

294 running circadian period similar to, or more drastic than, six other clock components.

295 Health care in the USA is undergoing a drastic transformation under the Patient Protection and

296 riments and optical modeling demonstrate the drastic type I/type II transition.

297 re variations in their environment such as a drastic variability in the nutrient concentration in soi

298 and decreasing soil pH, but did not exhibit drastic variations as a function of Tl speciation.

299 activity of the model LS films again showed drastic variations due to presence of different sized NP

300 and providing protection against short term drastic weather fluctuations like frost, heat, rain, and